MHC antigens and cancer: implications for T-cell surveillance

A Gene Encoding an Antigen Recognized by Cytolytic T Lymphocytes on a Human Melanoma

1991 • 3,493 citations

Selective rejection of H–2-deficient lymphoma variants suggests alternative immune defence strategy

1986 • 2,102 citations

CD28-mediated signalling co-stimulates murine T cells and prevents induction of anergy in T-cell clones

1992 • 1,573 citations

Histocompatibility Testing 1965

1966 • 1,036 citations

Interleukin-2 production by tumor cells bypasses T helper function in the generation of an antitumor response

1990 • 926 citations

Treatment of Established Renal Cancer by Tumor Cells Engineered to Secrete Interleukin-4

1991 • 733 citations

INCIDENCE OF SKIN CANCER AFTER RENAL TRANSPLANTATION IN THE NETHERLANDS

1990 • 675 citations

Cytotoxic T cells recognize fragments of the influenza nucleoprotein

1985 • 669 citations

Interleukin 2 gene transfer into tumor cells abrogates tumorigenicity and induces protective immunity.

1990 • 628 citations

Adoptive T Cell Therapy of Tumors: Mechanisms Operative in the Recognition and Elimination of Tumor Cells

1991 • 619 citations

Tumor-specific cytolysis by lymphocytes infiltrating human melanomas.

1989 • 511 citations

Retroviral vector-mediated gamma-interferon gene transfer into tumor cells generates potent and long lasting antitumor immunity.

1990 • 414 citations

Reversal of Oncogenesis by the Expression of a Major Histocompatibility Complex Class I Gene

1985 • 375 citations

Rejection of transplantable AKR leukaemia cells following MHC DNA-mediated cell transformation

1984 • 359 citations

The gene coding for a major tumor rejection antigen of tumor P815 is identical to the normal gene of syngeneic DBA/2 mice.

1991 • 306 citations

Eradication of adenovirus E1-induced tumors by E1A-specific cytotoxic T lymphocytes

1989 • 300 citations

Exogenous expression of mouse interferon gamma cDNA in mouse neuroblastoma C1300 cells results in reduced tumorigenicity by augmented anti-tumor immunity.

1989 • 284 citations

High risk of squamous cell carcinoma of the cervix for women with HLA-DQw3

1991 • 268 citations

Linkage of a nasopharyngeal carcinoma susceptibility locus to the HLA regions

1990 • 252 citations

Human papillomavirus type 16 nucleoprotein E7 is a tumor rejection antigen.

1991 • 249 citations

Interleukin 7 induces CD4+ T cell-dependent tumor rejection.

1991 • 245 citations

Frequent down-regulation of major histocompatibility class I antigen expression on individual micrometastatic carcinoma cells.

1991 • 227 citations

Human T lymphocytes recognize a peptide of single point-mutated, oncogenic ras proteins.

1991 • 208 citations

Relation between Skin Cancer and HLA Antigens in Renal-Transplant Recipients

1991 • 185 citations

Human tumor-infiltrating lymphocytes: a marker of host response.

1985 • 166 citations

Expression of HLA-A,B,C antigens on primary and metastatic tumor cell populations of human carcinomas.

1991 • 160 citations

Shared human melanoma antigens. Recognition by tumor-infiltrating lymphocytes in HLA-A2.1-transfected melanomas.

1992 • 155 citations

Selective changes in expression of HLA class I polymorphic determinants in human solid tumors.

1989 • 150 citations

Diet and gastric cancer. A case‐control study in Belgium

1992 • 147 citations

Linkage of regression and malignant conversion of rabbit viral papillomas to MHC class II genes

1992 • 141 citations

T cell recognition of transforming proteins encoded by mutated ras proto-oncogenes.

1991 • 126 citations

Variation in MHC Antigenic Profiles of Tumor Cells and its Biological Effects

1981 • 120 citations

Loss of HLA-A,B,C allele products and lymphocyte function-associated antigen 3 in colorectal neoplasia.

1989 • 119 citations

Detection of Epstein-Barr virus messenger RNA in Reed-Sternberg cells of Hodgkin's disease by in situ hybridization with biotinylated probes on specially processed modified acetone methyl benzoate xylene (ModAMeX) sections [see comments]

1991 • 116 citations

Cytotoxic T lymphocyte clones from peripheral blood and from tumor site detect intratumor heterogeneity of melanoma cells. Analysis of specificity and mechanisms of interaction.

1989 • 104 citations

Selective loss of HLA-A or HLA-B antigen expression in colon carcinoma.

1989 • 101 citations

Clonal analysis of the cytolytic T-cell response to human tumors

1987 • 89 citations

Expression of HLA-A2 antigen in human melanoma cell lines and its role in T-cell recognition.

1991 • 63 citations

The role of surface HLA-A,B,C molecules in tumour immunity.

1992 • 60 citations

On a Possible Protective Effect of HLA-A11 Against Skin Cancer and Keratotic Skin Lesions in Renal Transplant Recipients

1991 • 51 citations

T cell responses to human malignant tumours.

1992 • 48 citations

Immunological Surveillance

1970 • 48 citations

Tumor-specific immunity can be enhanced by transfection of tumor cells with syngeneic MHC-class-II genes or allogeneic MHC-class-I genes

1991 • 44 citations

Fine peptide specificity of cytotoxic T lymphocytes directed against adenovirus-induced tumours and peptide-mhc binding

1991 • 44 citations

HLA antigen frequencies in renal transplant recipients and non-immunosuppressed patients with non-melanoma skin cancer

1993 • 41 citations

Antigen presentation in virus infection

1992 • 31 citations

Reduction of major histocompatibility complex class I antigens on invasive and high‐grade transitional cell carcinoma

1990 • 29 citations

MHC loss in colorectal tumours: evidence for immunoselection?

1992 • 26 citations

An analysis of T‐cell‐receptor variable‐region genes in tumor‐infiltrating lymphocytes within malignant tumors

1991 • 23 citations

Expression of MHC-class-I antigens in human carcinomas and sarcomas analyzed by isoelectric focusing

1991 • 20 citations

Tumor rejection antigens on BALB3T3 cells transformed by activated oncogenes.

1991 • 12 citations

Changes in HLA, A,B,C expression during “spontaneous” transformation of human urothelial cells in vitro

1987 • 10 citations

Promotion of tumor growth by transfecting antisense DNA to suppress endogenous H-2Kk MHC gene expression in AKR mouse thymoma

1991 • 10 citations

A NEW LOOK AT TUMOR IMMUNOLOGY - INTRODUCTION

1992 • 1 citations