Topological ?frustration? in multispanning E. coli inner membrane proteins

Rapid and efficient site-specific mutagenesis without phenotypic selection.

1985 • 7,573 citations

Membrane protein structure prediction

1992 • 1,680 citations

Intracellular protein topogenesis

1980 • 1,378 citations

The spontaneous insertion of proteins into and across membranes: The helical hairpin hypothesis

1981 • 868 citations

The distribution of positively charged residues in bacterial inner membrane proteins correlates with the trans-membrane topology

1986 • 861 citations

Topogenic signals in integral membrane proteins

1988 • 715 citations

Control of topology and mode of assembly of a polytopic membrane protein by positively charged residues

1989 • 587 citations

Azide-resistant mutants of Escherichia coli alter the SecA protein, an azide-sensitive component of the protein export machinery.

1990 • 311 citations

Sequence of the leader peptidase gene of Escherichia coli and the orientation of leader peptidase in the bacterial envelope.

1983 • 307 citations

Membrane Proteins: From Sequence to Structure

1994 • 298 citations

Predicting the topology of eukaryotic membrane proteins

1993 • 272 citations

Fine-tuning the topology of a polytopic membrane protein: Role of positively and negatively charged amino acids

1990 • 221 citations

The role of charged amino acids in the localization of secreted and membrane proteins

1990 • 219 citations

Effects of two sec genes on protein assembly into the plasma membrane of Escherichia coli.

1985 • 217 citations

Nucleotide sequence of the secA gene and secA(Ts) mutations preventing protein export in Escherichia coli

1988 • 188 citations

Sec dependent and sec independent assembly of E. coli inner membrane proteins: the topological rules depend on chain length.

1993 • 145 citations

High-level expression of M13 gene II protein from an inducible polycistronic messenger RNA

1985 • 130 citations

Alterations in the extracellular domain of M13 procoat protein make its membrane insertion dependent on secA and secY

1988 • 128 citations

Characterization of cold-sensitive secY mutants of Escherichia coli

1990 • 107 citations

Different positively charged amino acids have similar effects on the topology of a polytopic transmembrane protein in Escherichia coli.

1992 • 94 citations

Distinct domains of an oligotopic membrane protein are Sec-dependent and Sec-independent for membrane insertion.

1992 • 83 citations

Decoding signals for membrane protein assembly using alkaline phosphatase fusions.

1991 • 73 citations

Leader Peptidase of Escherichia coli : Critical Role of a Small Domain in Membrane Assembly

1987 • 72 citations

The role of the polar, carboxyl-terminal domain of Escherichia coli leader peptidase in its translocation across the plasma membrane.

1986 • 68 citations

The cytoplasmic domain of Escherichia coli leader peptidase is a "translocation poison" sequence.

1988 • 61 citations

Sequence homology between bacteriorhodopsin and G‐protein coupled receptors: exon shuffling or evolution by duplication?

1993 • 53 citations

Proper insertion of a complex membrane protein in the absence of its amino-terminal export signal.

1991 • 52 citations

Organization and stability of a polytopic membrane protein: deletion analysis of the lactose permease of Escherichia coli.

1991 • 45 citations

Position-specific Asp-Lys pairing can affect signal sequence function and membrane protein topology.

1993 • 24 citations

Deleted Work

1955 • 0 citations