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Guidelines for the primary prevention of stroke: a statement for healthcare professionals from the American Heart Association/American Stroke Association.

Data up to Jan 2025

Published2014
Citations2,520
References1177

Total Citations Per Year

Abstract

References (1177)

Magnesium Replacement Improves the Metabolic Profile in Obese and Pre-Diabetic Patients with Mild-to-Moderate Chronic Kidney Disease: A 3-Month, Randomised, Double-Blind, Placebo-Controlled Study

2017 • 28,714 citations

Summary of the Second Report of the National Cholesterol Education Program (NCEP) Expert Panel on Detection, Evaluation, and Treatment of High Blood Cholesterol in Adults (Adult Treatment Panel II)

1993 • 28,274 citations

The Seventh Report of the Joint National Committee on Prevention, Detection, Evaluation, and Treatment of High Blood Pressure<SUBTITLE>The JNC 7 Report</SUBTITLE>

2003 • 25,662 citations

Executive Summary of the Third Report of the National Cholesterol Education Program (NCEP) Expert Panel on Detection, Evaluation, and Treatment of High Blood Cholesterol in Adults (Adult Treatment Panel III)

2001 • 24,089 citations

A New Method for Measuring Daytime Sleepiness: The Epworth Sleepiness Scale

1991 • 15,710 citations

Risks and Benefits of Estrogen Plus Progestin in Healthy Postmenopausal Women: Principal Results From the Women's Health Initiative Randomized Controlled Trial

2002 • 15,184 citations

Harmonizing the Metabolic Syndrome

2009 • 12,951 citations

Seventh Report of the Joint National Committee on Prevention, Detection, Evaluation, and Treatment of High Blood Pressure

2003 • 12,553 citations

Should We STOP Angiotensin Converting Enzyme Inhibitors/Angiotensin Receptor Blockers in Advanced Kidney Disease?

2016 • 11,500 citations

Aspirin plus Clopidogrel as Secondary Prevention after Stroke or Transient Ischemic Attack: A Systematic Review and Meta-Analysis

2014 • 11,326 citations

Dabigatran versus Warfarin in Patients with Atrial Fibrillation

2009 • 10,717 citations

Age-specific relevance of usual blood pressure to vascular mortality: a meta-analysis of individual data for one million adults in 61 prospective studies

2002 • 9,810 citations

Clinical guidelines on the identification, evaluation, and treatment of overweight and obesity in adults: The evidence report

1998 • 9,277 citations

The metabolic syndrome—a new worldwide definition

2005 • 8,997 citations

Prevalence of Overweight and Obesity in the United States, 1999-2004

2006 • 8,878 citations

Rivaroxaban versus Warfarin in Nonvalvular Atrial Fibrillation

2011 • 8,749 citations

ACC/AHA Guidelines for the Management of Patients With ST-Elevation Myocardial Infarction—Executive Summary

2004 • 8,563 citations

Apixaban versus Warfarin in Patients with Atrial Fibrillation

2011 • 8,304 citations

Effect of intensive blood-glucose control with metformin on complications in overweight patients with type 2 diabetes (UKPDS 34)

1998 • 7,971 citations

2014 Evidence-Based Guideline for the Management of High Blood Pressure in Adults

2013 • 7,509 citations

Effects of Intensive Glucose Lowering in Type 2 Diabetes

2008 • 7,428 citations

Guidelines for the Early Management of Patients With Acute Ischemic Stroke

2013 • 7,376 citations

10-Year Follow-up of Intensive Glucose Control in Type 2 Diabetes

2008 • 7,250 citations

Atrial fibrillation as an independent risk factor for stroke: the Framingham Study.

1991 • 7,128 citations

Intensive Blood Glucose Control and Vascular Outcomes in Patients with Type 2 Diabetes

2008 • 7,044 citations

2013 ACC/AHA Guideline on the Treatment of Blood Cholesterol to Reduce Atherosclerotic Cardiovascular Risk in Adults

2013 • 6,963 citations

Implications of Recent Clinical Trials for the National Cholesterol Education Program Adult Treatment Panel III Guidelines

2004 • 6,926 citations

Collaborative meta-analysis of randomised trials of antiplatelet therapy for prevention of death, myocardial infarction, and stroke in high risk patients

2002 • 6,825 citations

Efficacy and safety of cholesterol-lowering treatment: prospective meta-analysis of data from 90 056 participants in 14 randomised trials of statins

2005 • 6,633 citations

Intravenous Fluids and Acute Kidney Injury

2017 • 6,590 citations

Tight blood pressure control and risk of macrovascular and microvascular complications in type 2 diabetes: UKPDS 38

1998 • 6,576 citations

The metabolic syndrome

2010 • 6,321 citations

Randomized Trial of Estrogen Plus Progestin for Secondary Prevention of Coronary Heart Disease in Postmenopausal Women

1998 • 6,250 citations

Rosuvastatin to Prevent Vascular Events in Men and Women with Elevated C-Reactive Protein

2008 • 6,182 citations

Refining Clinical Risk Stratification for Predicting Stroke and Thromboembolism in Atrial Fibrillation Using a Novel Risk Factor-Based Approach

2009 • 6,122 citations

Markers of Inflammation and Cardiovascular Disease

2003 • 6,067 citations

Effect of Captopril on Mortality and Morbidity in Patients with Left Ventricular Dysfunction after Myocardial Infarction

1992 • 5,885 citations

Effects of intensive blood-pressure lowering and low-dose aspirin in patients with hypertension: principal results of the Hypertension Optimal Treatment (HOT) randomised trial

1998 • 5,793 citations

The Fourth Report on the Diagnosis, Evaluation, and Treatment of High Blood Pressure in Children and Adolescents

2004 • 5,756 citations

Heart Disease and Stroke Statistics—2010 Update

2009 • 5,669 citations

A Clinical Trial of the Effects of Dietary Patterns on Blood Pressure

1997 • 5,637 citations

Major Outcomes in High-Risk Hypertensive Patients Randomized to Angiotensin-Converting Enzyme Inhibitor or Calcium Channel Blocker vs Diuretic: The Antihypertensive and Lipid-Lowering Treatment to Prevent Heart Attack Trial (ALLHAT)

2002 • 5,558 citations

Cardiovascular morbidity and mortality in the Losartan Intervention For Endpoint reduction in hypertension study (LIFE): a randomised trial against atenolol

2002 • 5,471 citations

Inflammation, Aspirin, and the Risk of Cardiovascular Disease in Apparently Healthy Men

1997 • 5,442 citations

Prevalence of Obesity and Trends in the Distribution of Body Mass Index Among US Adults, 1999-2010

2012 • 5,369 citations

Effects on Blood Pressure of Reduced Dietary Sodium and the Dietary Approaches to Stop Hypertension (DASH) Diet

2001 • 5,241 citations

Heart Disease and Stroke Statistics—2014 Update

2013 • 5,158 citations

The Metabolic Syndrome and Total and Cardiovascular Disease Mortality in Middle-aged Men

2002 • 5,087 citations

The metabolic syndrome

2005 • 5,005 citations

Guidelines for the Prevention of Stroke in Patients With Stroke and Transient Ischemic Attack

2014 • 4,989 citations

Intensive Diabetes Treatment and Cardiovascular Disease in Patients with Type 1 Diabetes

2005 • 4,969 citations

Prospective Study of the Association between Sleep-Disordered Breathing and Hypertension

2000 • 4,895 citations

Tight blood pressure control and risk of macrovascular and microvascular complications in type 2 diabetes: UKPDS 38

1998 • 4,813 citations

Validation of Clinical Classification Schemes for Predicting Stroke

2001 • 4,810 citations

ACC/AHA Guidelines for the Management of Patients With Unstable Angina and Non–ST-Segment Elevation Myocardial Infarction: Executive Summary and Recommendations

2000 • 4,662 citations

Meta-analysis: Antithrombotic Therapy to Prevent Stroke in Patients Who Have Nonvalvular Atrial Fibrillation

2007 • 4,623 citations

2013 ACCF/AHA Guideline for the Management of ST-Elevation Myocardial Infarction

2012 • 4,541 citations

Glucose Control and Vascular Complications in Veterans with Type 2 Diabetes

2008 • 4,534 citations

Impact of Atrial Fibrillation on the Risk of Death

1998 • 4,449 citations

Body-mass index and cause-specific mortality in 900 000 adults: collaborative analyses of 57 prospective studies

2009 • 4,426 citations

Effects of Conjugated Equine Estrogen in Postmenopausal Women With Hysterectomy

2004 • 4,391 citations

Long-term cardiovascular outcomes in men with obstructive sleep apnoea-hypopnoea with or without treatment with continuous positive airway pressure: an observational study

2005 • 4,341 citations

A Comparison of Rate Control and Rhythm Control in Patients with Atrial Fibrillation

2002 • 4,278 citations

Effect of intensive blood-glucose control with metformin on complications in overweight patients with type 2 diabetes (UKPDS 34). UK Prospective Diabetes Study (UKPDS) Group.

1998 • 4,159 citations

A Novel User-Friendly Score (HAS-BLED) To Assess 1-Year Risk of Major Bleeding in Patients With Atrial Fibrillation

2010 • 4,096 citations

Epidemiology of Obstructive Sleep Apnea

2002 • 4,082 citations

Defining and Setting National Goals for Cardiovascular Health Promotion and Disease Reduction

2010 • 4,018 citations

Prevalence of Obesity and Trends in Body Mass Index Among US Children and Adolescents, 1999-2010

2012 • 3,954 citations

Heart Disease and Stroke Statistics—2009 Update

2009 • 3,914 citations

Mutation in blood coagulation factor V associated with resistance to activated protein C

1994 • 3,871 citations

2012 focused update of the ESC Guidelines for the management of atrial fibrillation

2012 • 3,854 citations

Prevention of coronary and stroke events with atorvastatin in hypertensive patients who have average or lower-than-average cholesterol concentrations, in the Anglo-Scandinavian Cardiac Outcomes Trial—Lipid Lowering Arm (ASCOT-LLA): a multicentre randomised controlled trial

2003 • 3,816 citations

Primary prevention of cardiovascular disease with atorvastatin in type 2 diabetes in the Collaborative Atorvastatin Diabetes Study (CARDS): multicentre randomised placebo-controlled trial

2004 • 3,776 citations

2009 Focused Update Incorporated Into the ACC/AHA 2005 Guidelines for the Diagnosis and Management of Heart Failure in Adults

2009 • 3,773 citations

Rosuvastatin to Prevent Vascular Events in Men and Women With Elevated C-Reactive Protein

2009 • 3,737 citations

A Quantitative Assessment of Plasma Homocysteine as a Risk Factor for Vascular Disease

1995 • 3,645 citations

Association of All-Cause Mortality With Overweight and Obesity Using Standard Body Mass Index Categories

2013 • 3,597 citations

Inflammation in Atherosclerosis

2012 • 3,528 citations

Aspirin in the primary and secondary prevention of vascular disease: collaborative meta-analysis of individual participant data from randomised trials

2009 • 3,420 citations

The Neuroendocrinology of Stress: A Never Ending Story

2008 • 3,415 citations

COLLABORATIVE OVERVIEW OF RANDOMIZED TRIALS OF ANTIPLATELET THERAPY .1. PREVENTION OF DEATH, MYOCARDIAL-INFARCTION, AND STROKE BY PROLONGED ANTIPLATELET THERAPY IN VARIOUS CATEGORIES OF PATIENTS

1994 • 3,408 citations

Effect of a Multifactorial Intervention on Mortality in Type 2 Diabetes

2008 • 3,390 citations

Effects of Intensive Blood-Pressure Control in Type 2 Diabetes Mellitus

2010 • 3,333 citations

Association of Sleep-Disordered Breathing, Sleep Apnea, and Hypertension in a Large Community-Based Study

2000 • 3,260 citations

Risk factors for ischaemic and intracerebral haemorrhagic stroke in 22 countries (the INTERSTROKE study): a case-control study

2010 • 3,169 citations

Effects of long-term fenofibrate therapy on cardiovascular events in 9795 people with type 2 diabetes mellitus (the FIELD study): randomised controlled trial

2005 • 3,163 citations

Systematic Review: Impact of Health Information Technology on Quality, Efficiency, and Costs of Medical Care

2006 • 3,131 citations

Heart Disease and Stroke Statistics—2009 Update

2008 • 3,119 citations

Prevalence of Hypertension in the US Adult Population

1995 • 2,997 citations

MRC/BHF Heart Protection Study of cholesterol-lowering with simvastatin in 5963 people with diabetes: a randomised placebo-controlled trial

2003 • 2,931 citations

Treatment of Hypertension in Patients 80 Years of Age or Older

2008 • 2,927 citations

Obstructive Sleep Apnea as a Risk Factor for Stroke and Death

2005 • 2,843 citations

2012 focused update of the ESC Guidelines for the management of atrial fibrillation

2012 • 2,818 citations

The Continuing Epidemics of Obesity and Diabetes in the United States

2001 • 2,803 citations

The Obesity Epidemic in the United States Gender, Age, Socioeconomic, Racial/Ethnic, and Geographic Characteristics: A Systematic Review and Meta-Regression Analysis

2007 • 2,797 citations

Using the Berlin Questionnaire To Identify Patients at Risk for the Sleep Apnea Syndrome

1999 • 2,796 citations

Stenting versus Endarterectomy for Treatment of Carotid-Artery Stenosis

2010 • 2,791 citations

Protected Carotid-Artery Stenting versus Endarterectomy in High-Risk Patients

2004 • 2,755 citations

The Health Consequences of Smoking: A Report of the Surgeon General

2004 • 2,735 citations

Diet and Lifestyle Recommendations Revision 2006

2006 • 2,727 citations

ACC/AHA/ESC 2006 Guidelines for the Management of Patients With Atrial Fibrillation

2006 • 2,724 citations

International consensus statement on preliminary classification criteria for definite antiphospholipid syndrome: Report of an International workshop

1999 • 2,708 citations

Niacin in Patients with Low HDL Cholesterol Levels Receiving Intensive Statin Therapy

2011 • 2,704 citations

Changing physician performance. A systematic review of the effect of continuing medical education strategies

1995 • 2,668 citations

Clinical Guidelines on the Identification, Evaluation, and Treatment of Overweight and Obesity in Adults: Executive Summary

1998 • 2,658 citations

Effects of Combination Lipid Therapy in Type 2 Diabetes Mellitus

2010 • 2,653 citations

Worldwide stroke incidence and early case fatality reported in 56 population-based studies: a systematic review

2009 • 2,651 citations

Use of blood pressure lowering drugs in the prevention of cardiovascular disease: meta-analysis of 147 randomised trials in the context of expectations from prospective epidemiological studies

2009 • 2,611 citations

The Metabolic Syndrome and Cardiovascular Risk

2010 • 2,574 citations

Guidelines for the primary prevention of stroke: a statement for healthcare professionals from the American Heart Association/American Stroke Association.

2014 • 2,520 citations

Nicotine replacement therapy for smoking cessation

2012 • 2,516 citations

Guidelines for the Early Management of Adults With Ischemic Stroke

2007 • 2,502 citations

The effects of lowering LDL cholesterol with statin therapy in people at low risk of vascular disease: meta-analysis of individual data from 27 randomised trials

2012 • 2,501 citations

Prevention of disabling and fatal strokes by successful carotid endarterectomy in patients without recent neurological symptoms: randomised controlled trial

2004 • 2,472 citations

Major Lipids, Apolipoproteins, and Risk of Vascular Disease

2009 • 2,461 citations

Apixaban in Patients with Atrial Fibrillation

2011 • 2,372 citations

Effects of different blood-pressure-lowering regimens on major cardiovascular events: results of prospectively-designed overviews of randomised trials

2003 • 2,365 citations

Cytochrome P-450 Polymorphisms and Response to Clopidogrel

2008 • 2,358 citations

The Fourth Report on the Diagnosis, Evaluation, and Treatment of High Blood Pressure in Children and Adolescents

2004 • 2,325 citations

A Comparison of Rate Control and Rhythm Control in Patients with Recurrent Persistent Atrial Fibrillation

2002 • 2,322 citations

Incidence, case fatality, and functional outcome of intracerebral haemorrhage over time, according to age, sex, and ethnic origin: a systematic review and meta-analysis

2010 • 2,307 citations

2008 Focused Update Incorporated Into the ACC/AHA 2006 Guidelines for the Management of Patients With Valvular Heart Disease

2008 • 2,271 citations

Clinical guideline for the evaluation, management and long-term care of obstructive sleep apnea in adults.

2009 • 2,255 citations

National Hospital Ambulatory Medical Care Survey: 1994 emergency department summary.

1996 • 2,237 citations

C-reactive protein concentration and risk of coronary heart disease, stroke, and mortality: an individual participant meta-analysis

2009 • 2,228 citations

Blood cholesterol and vascular mortality by age, sex, and blood pressure: a meta-analysis of individual data from 61 prospective studies with 55 000 vascular deaths

2007 • 2,221 citations

US Trends in Prevalence, Awareness, Treatment, and Control of Hypertension, 1988-2008

2010 • 2,171 citations

2013 AHA/ACC Guideline on Lifestyle Management to Reduce Cardiovascular Risk

2013 • 2,160 citations

Effect of Clopidogrel Added to Aspirin in Patients with Atrial Fibrillation

2009 • 2,144 citations

Effects of ramipril on cardiovascular and microvascular outcomes in people with diabetes mellitus: results of the HOPE study and MICRO-HOPE substudy. Heart Outcomes Prevention Evaluation Study Investigators.

2000 • 2,085 citations

Pharmacology and Management of the Vitamin K Antagonists

2008 • 2,084 citations

2013 ACCF/AHA Guideline for the Management of ST-Elevation Myocardial Infarction: Executive Summary

2012 • 2,077 citations

Percutaneous closure of the left atrial appendage versus warfarin therapy for prevention of stroke in patients with atrial fibrillation: a randomised non-inferiority trial

2009 • 2,045 citations

Genomewide Association Analysis of Coronary Artery Disease

2007 • 2,027 citations

A within-trial cost-effectiveness analysis of primary care referral to a commercial provider for weight loss treatment, relative to standard care—an international randomised controlled trial

2012 • 2,022 citations

Homocysteine and Atherothrombosis

1998 • 2,021 citations

Homocysteine and Risk of Ischemic Heart Disease and Stroke

2002 • 2,000 citations

Benazepril plus Amlodipine or Hydrochlorothiazide for Hypertension in High-Risk Patients

2008 • 1,998 citations

Prevalence of obesity in the United States, 2009-2010.

2012 • 1,989 citations

Effects of a fixed combination of perindopril and indapamide on macrovascular and microvascular outcomes in patients with type 2 diabetes mellitus (the ADVANCE trial): a randomised controlled trial

2007 • 1,978 citations

Efficacy of cholesterol-lowering therapy in 18 686 people with diabetes in 14 randomised trials of statins: a meta-analysis

2008 • 1,951 citations

A Randomized Trial of Low-Dose Aspirin in the Primary Prevention of Cardiovascular Disease in Women

2005 • 1,949 citations

SLCO1B1Variants and Statin-Induced Myopathy — A Genomewide Study

2008 • 1,939 citations

Clopidogrel plus aspirin versus oral anticoagulation for atrial fibrillation in the Atrial fibrillation Clopidogrel Trial with Irbesartan for prevention of Vascular Events (ACTIVE W): a randomised controlled trial

2006 • 1,924 citations

Homocysteine and cardiovascular disease: evidence on causality from a meta-analysis

2002 • 1,921 citations

Vitamin Status and Intake as Primary Determinants of Homocysteinemia in an Elderly Population

1993 • 1,920 citations

AHA Guidelines for Primary Prevention of Cardiovascular Disease and Stroke: 2002 Update

2002 • 1,909 citations

High Body Mass Index for Age Among US Children and Adolescents, 2003-2006

2008 • 1,908 citations

The Metabolic Syndrome

2008 • 1,889 citations

Adverse Cerebral Outcomes after Coronary Bypass Surgery

1996 • 1,874 citations

Guidelines for Prevention of Stroke in Patients With Ischemic Stroke or Transient Ischemic Attack

2006 • 1,866 citations

Fifteen year mortality in Coronary Drug Project patients: Long-term benefit with niacin

1986 • 1,857 citations

Plasma Homocysteine as a Risk Factor for Vascular Disease

1997 • 1,770 citations

Influences of Cardiorespiratory Fitness and Other Precursors on Cardiovascular Disease and All-Cause Mortality in Men and Women

1996 • 1,765 citations

ACC/AHA 2002 guideline update for the management of patients with chronic stable angina—summary article

2002 • 1,764 citations

Probability of stroke: a risk profile from the Framingham Study.

1991 • 1,753 citations

Genetic Determinants of Response to Clopidogrel and Cardiovascular Events

2008 • 1,696 citations

Definition and Evaluation of Transient Ischemic Attack

2009 • 1,692 citations

Postmenopausal Hormone Therapy and Risk of Cardiovascular Disease by Age and Years Since Menopause

2007 • 1,677 citations

Prospective Study of C-Reactive Protein and the Risk of Future Cardiovascular Events Among Apparently Healthy Women

1998 • 1,668 citations

Cerebrovascular Accidents in Sickle Cell Disease: Rates and Risk Factors

1998 • 1,667 citations

Prevalence of Patent Foramen Ovale in Patients with Stroke

1988 • 1,643 citations

Homocysteine Lowering with Folic Acid and B Vitamins in Vascular Disease

2006 • 1,639 citations

Review of the key results from the Swedish Obese Subjects (<scp>SOS</scp>) trial – a prospective controlled intervention study of bariatric surgery

2013 • 1,639 citations

Prognostic significance of visit-to-visit variability, maximum systolic blood pressure, and episodic hypertension

2010 • 1,630 citations

Clinical Guidelines on the Identification, Evaluation, and Treatment of Overweight and Obesity in Adults--The Evidence Report. National Institutes of Health.

1998 • 1,628 citations

Effects of Tamoxifen vs Raloxifene on the Risk of Developing Invasive Breast Cancer and Other Disease Outcomes&lt;SUBTITLE&gt;The NSABP Study of Tamoxifen and Raloxifene (STAR) P-2 Trial&lt;/SUBTITLE&gt;

2006 • 1,621 citations

Lipoprotein(a) as a cardiovascular risk factor: current status

2010 • 1,599 citations

A Common Variant on Chromosome 9p21 Affects the Risk of Myocardial Infarction

2007 • 1,588 citations

2007 Focused Update of the ACC/AHA 2004 Guidelines for the Management of Patients With ST-Elevation Myocardial Infarction

2007 • 1,561 citations

Fasting Compared With Nonfasting Triglycerides and Risk of Cardiovascular Events in Women

2007 • 1,538 citations

A Common Allele on Chromosome 9 Associated with Coronary Heart Disease

2007 • 1,532 citations

Cigarette Smoking Among Adults--United States, 2003

2005 • 1,531 citations

Warfarin versus aspirin for stroke prevention in an elderly community population with atrial fibrillation (the Birmingham Atrial Fibrillation Treatment of the Aged Study, BAFTA): a randomised controlled trial

2007 • 1,524 citations

The J-Curve Phenomenon in Hypertension

2016 • 1,513 citations

Safety and Efficacy of Recombinant Human α-Galactosidase A Replacement Therapy in Fabry's Disease

2001 • 1,508 citations

Metformin: An Old Drug for the Treatment of Diabetes but a New Drug for the Protection of the Endothelium

2015 • 1,504 citations

Primary Prevention of Hypertension&lt;SUBTITLE&gt;Clinical and Public Health Advisory From the National High Blood Pressure Education Program&lt;/SUBTITLE&gt;

2002 • 1,464 citations

Salt intake, stroke, and cardiovascular disease: meta-analysis of prospective studies

2009 • 1,452 citations

Homocysteine Lowering and Cardiovascular Events after Acute Myocardial Infarction

2006 • 1,424 citations

Dietary Guidelines for Americans, 2010

2011 • 1,418 citations

Efficacy of Carotid Endarterectomy for Asymptomatic Carotid Stenosis

1993 • 1,403 citations

Residual Lifetime Risk for Developing Hypertension in Middle-aged Women and Men

2002 • 1,393 citations

Poor Control of Risk Factors for Vascular Disease Among Adults With Previously Diagnosed Diabetes

2004 • 1,383 citations

Primary Prevention of Ischemic Stroke

2006 • 1,367 citations

Dabigatran versus Warfarin in Patients with Mechanical Heart Valves

2013 • 1,364 citations

Recurrent Cerebrovascular Events Associated with Patent Foramen Ovale, Atrial Septal Aneurysm, or Both

2001 • 1,361 citations

Prevention of stroke by antihypertensive drug treatment in older persons with isolated systolic hypertension. Final results of the Systolic Hypertension in the Elderly Program (SHEP). SHEP Cooperative Research Group

1991 • 1,361 citations

Lowering Homocysteine in Patients With Ischemic Stroke to Prevent Recurrent Stroke, Myocardial Infarction, and Death

2004 • 1,360 citations

Annual Smoking-Attributable Mortality, Years of Potential Life Lost, and Productivity Losses—United States, 1997–2001

2007 • 1,337 citations

Assessment of Cardiovascular Risk by Use of Multiple-Risk-Factor Assessment Equations

1999 • 1,333 citations

PREVENTION OF A FIRST STROKE BY TRANSFUSIONS IN CHILDREN WITH SICKLE CELL ANEMIA AND ABNORMAL RESULTS ON TRANSCRANIAL DOPPLER ULTRASONOGRAPHY

2015 • 1,318 citations

Infective Endocarditis in Adults

2001 • 1,315 citations

Endarterectomy for asymptomatic carotid artery stenosis. Executive Committee for the Asymptomatic Carotid Atherosclerosis Study

1995 • 1,308 citations

Effect of Intensity of Oral Anticoagulation on Stroke Severity and Mortality in Atrial Fibrillation

2003 • 1,281 citations

Influence of Weight Reduction on Blood Pressure

2003 • 1,276 citations

Dietary Approaches to Prevent and Treat Hypertension

2006 • 1,276 citations

Enzyme Replacement Therapy in Fabry Disease

2001 • 1,272 citations

ACC/AHA Guidelines for the Management of Patients With ST-Elevation Myocardial Infarction

2004 • 1,265 citations

Secondary Prevention by Raising HDL Cholesterol and Reducing Triglycerides in Patients With Coronary Artery Disease

2000 • 1,264 citations

Cardiorenal End Points in a Trial of Aliskiren for Type 2 Diabetes

2012 • 1,263 citations

Association between Plasma Homocysteine Concentrations and Extracranial Carotid-Artery Stenosis

1995 • 1,244 citations

Educational outreach visits: effects on professional practice and health care outcomes

2007 • 1,243 citations

The Metabolic Syndrome

2010 • 1,235 citations

Prevalence of the Metabolic Syndrome Defined by the International Diabetes Federation Among Adults in the U.S.

2005 • 1,192 citations

Obstructive Sleep Apnea–Hypopnea and Incident Stroke

2010 • 1,185 citations

ACC/AHA/ESC 2006 Guidelines for the Management of Patients With Atrial Fibrillation—Executive Summary

2006 • 1,182 citations

Traditional Framingham risk factors fail to fully account for accelerated atherosclerosis in systemic lupus erythematosus

2001 • 1,175 citations

Reducing the Health Consequences of Smoking: 25 Years of Progress. A Report of the Surgeon General.

1989 • 1,170 citations

ACC/AHA guidelines for the management of patients with valvular heart disease

1998 • 1,161 citations

Sleep Disorders and Sleep Deprivation: An Unmet Public Health Problem

2006 • 1,160 citations

Rhythm or rate control in atrial fibrillation—Pharmacological Intervention in Atrial Fibrillation (PIAF): a randomised trial

2000 • 1,156 citations

Effects of Protein, Monounsaturated Fat, and Carbohydrate Intake on Blood Pressure and Serum Lipids

2005 • 1,137 citations

The way I see it: House officers need formal career development

2002 • 1,137 citations

Serum Cholesterol Levels and Six-Year Mortality from Stroke in 350,977 Men Screened for the Multiple Risk Factor Intervention Trial

1989 • 1,123 citations

Health Outcomes Associated With Various Antihypertensive Therapies Used as First-Line Agents

2003 • 1,103 citations

Low-Fat Dietary Pattern and Risk of Cardiovascular Disease

2006 • 1,097 citations

Fruit and vegetable consumption and stroke: meta-analysis of cohort studies

2006 • 1,095 citations

Association of Atrial Fibrillation and Obstructive Sleep Apnea

2004 • 1,094 citations

2008 Focused Update Incorporated Into the ACC/AHA 2006 Guidelines for the Management of Patients With Valvular Heart Disease

2008 • 1,092 citations

Position statement. Part one: Immune function and exercise.

2011 • 1,091 citations

Fruit and Vegetable Intake in Relation to Risk of Ischemic Stroke

1999 • 1,084 citations

Risk of Bleeding With 2 Doses of Dabigatran Compared With Warfarin in Older and Younger Patients With Atrial Fibrillation

2011 • 1,080 citations

Prevalence and Clinical Outcome of Mitral-Valve Prolapse

1999 • 1,075 citations

Cardiac Myxomas

1995 • 1,068 citations

Major Hemorrhage and Tolerability of Warfarin in the First Year of Therapy Among Elderly Patients With Atrial Fibrillation

2007 • 1,059 citations

Obstructive Sleep Apnea, Obesity, and the Risk of Incident Atrial Fibrillation

2007 • 1,059 citations

Meta-analysis of relation between cigarette smoking and stroke.

1989 • 1,053 citations

Thromboembolic and bleeding complications in patients with mechanical heart valve prostheses.

1994 • 1,053 citations

Molecular and Cellular Basis of Cardiovascular Gender Differences

2005 • 1,044 citations

Ambulatory blood pressure after therapeutic and subtherapeutic nasal continuous positive airway pressure for obstructive sleep apnoea: a randomised parallel trial

2002 • 1,041 citations

MARKERS OF INFLAMMATION AND CARDIOVASCULAR DISEASE

2003 • 1,029 citations

2007 Focused Update of the ACC/AHA/SCAI 2005 Guideline Update for Percutaneous Coronary Intervention

2007 • 1,017 citations

Closure or Medical Therapy for Cryptogenic Stroke with Patent Foramen Ovale

2012 • 1,016 citations

Effects of Raloxifene on Cardiovascular Events and Breast Cancer in Postmenopausal Women

2006 • 1,014 citations

Waist circumference and waist-to-hip ratio as predictors of cardiovascular events: meta-regression analysis of prospective studies

2007 • 1,013 citations

Original Papers. Success and Predictors of Blood Pressure Control in Diverse North American Settings: The Antihypertensive and Lipid‐Lowering Treatment to Prevent Heart Attack Trial (ALLHAT)

2002 • 1,008 citations

Effects of Oral Potassium on Blood Pressure

1997 • 1,004 citations

Cardiovascular Events and Their Reduction With Pravastatin in Diabetic and Glucose-Intolerant Myocardial Infarction Survivors With Average Cholesterol Levels

1998 • 1,000 citations

U.S. Department of Agriculture and U.S. Department of Health and Human Services, Dietary Guidelines for Americans, 2010. 7th Edition, Washington, DC: U.S. Government Printing Office, January 2011

2011 • 996 citations

Atherosclerotic Disease of the Aortic Arch and the Risk of Ischemic Stroke

1994 • 983 citations

Summary Health Statistics for U.S. Adults: National Health Interview Survey, 2006

2007 • 976 citations

Cytochrome P450 2C19 polymorphism in young patients treated with clopidogrel after myocardial infarction: a cohort study

2008 • 970 citations

National Use of Postmenopausal Hormone Therapy

2004 • 969 citations

Retraction and Republication: Primary Prevention of Cardiovascular Disease with a Mediterranean Diet. N Engl J Med 2013;368:1279-90.

2018 • 965 citations

The prevention of progression of arterial disease and diabetes (POPADAD) trial: factorial randomised placebo controlled trial of aspirin and antioxidants in patients with diabetes and asymptomatic peripheral arterial disease

2008 • 962 citations

High prevalence of unrecognized sleep apnoea in drug-resistant hypertension

2001 • 952 citations

Randomized trial of rate-control versus rhythm-control in persistent atrial fibrillation

2003 • 952 citations

Effect of Medical Treatment in Stroke Patients With Patent Foramen Ovale

2002 • 948 citations

Lipoprotein(a) and Coronary Heart Disease

2000 • 945 citations

Closure of Patent Foramen Ovale versus Medical Therapy after Cryptogenic Stroke

2013 • 942 citations

Effect of Diuretic-Based Antihypertensive Treatment on Cardiovascular Disease Risk in Older Diabetic Patients With Isolated Systolic Hypertension

1996 • 942 citations

Cardiac arrhythmia and conduction disturbances during sleep in 400 patients with sleep apnea syndrome

1983 • 941 citations

Interatrial septal abnormalities and stroke

2000 • 940 citations

Clinical Implications of Obesity With Specific Focus on Cardiovascular Disease

2004 • 939 citations

Effect of aggressive versus conventional lipid lowering on atherosclerosis progression in familial hypercholesterolemia (ASAP): a prospective, randomised, double-blind trial

2001 • 937 citations

Variants conferring risk of atrial fibrillation on chromosome 4q25

2007 • 937 citations

Effect of Nasal Continuous Positive Airway Pressure Treatment on Blood Pressure in Patients With Obstructive Sleep Apnea

2003 • 935 citations

Association of Sleep-disordered Breathing and the Occurrence of Stroke

2005 • 932 citations

Antithrombotic Therapy for Atrial Fibrillation

2012 • 925 citations

The Burden of Adult Hypertension in the United States 1999 to 2000

2004 • 923 citations

A Prospective Study of Moderate Alcohol Consumption and the Risk of Coronary Disease and Stroke in Women

1988 • 921 citations

Trends in Hypertension Prevalence, Awareness, Treatment, and Control Rates in United States Adults Between 1988–1994 and 1999–2004

2008 • 921 citations

Cardiovascular Effects of Secondhand Smoke

2005 • 918 citations

A Clinical Trial of Estrogen-Replacement Therapy after Ischemic Stroke

2001 • 906 citations

ACC/AHA 2004 Guideline Update for Coronary Artery Bypass Graft Surgery: Summary Article

2004 • 901 citations

Contribution of Atrial Fibrillation to Incidence and Outcome of Ischemic Stroke

2005 • 888 citations

Alcohol Consumption and Risk of Stroke

2003 • 888 citations

Intensive Glycemic Control and the Prevention of Cardiovascular Events: Implications of the ACCORD, ADVANCE, and VA Diabetes Trials

2008 • 884 citations

Characteristics of Patients with Uncontrolled Hypertension in the United States

2001 • 881 citations

Effects of fibrates on cardiovascular outcomes: a systematic review and meta-analysis

2010 • 880 citations

Percutaneous Closure of Patent Foramen Ovale in Cryptogenic Embolism

2013 • 875 citations

ACC/AHA guideline for the management of patients with unstable angina and non-ST-segment elevation myocardial infarction

2002 • 868 citations

2007 Focused Update of the ACC/AHA 2004 Guidelines for the Management of Patients With ST-Elevation Myocardial Infarction

2008 • 867 citations

Continuous positive airways pressure for obstructive sleep apnoea in adults

2006 • 864 citations

Warfarin, Aspirin, or Both after Myocardial Infarction

2002 • 843 citations

10-year stroke prevention after successful carotid endarterectomy for asymptomatic stenosis (ACST-1): a multicentre randomised trial

2010 • 838 citations

PATENT FORAMEN OVALE IN YOUNG STROKE PATIENTS

1988 • 838 citations

Stroke prevention with the oral direct thrombin inhibitor ximelagatran compared with warfarin in patients with non-valvular atrial fibrillation (SPORTIF III): randomised controlled trial

2003 • 820 citations

A New Risk Scheme to Predict Warfarin-Associated Hemorrhage

2011 • 800 citations

Plasma Concentration of C-Reactive Protein and Risk of Ischemic Stroke and Transient Ischemic Attack: The Framingham Study

2001 • 799 citations

Physical Activity and Stroke Risk

2003 • 796 citations

Long-Term Results of Carotid Stenting versus Endarterectomy in High-Risk Patients

2008 • 796 citations

Guidelines for the Prevention of Stroke in Women

2014 • 796 citations

Long-term Use of CPAP Therapy for Sleep Apnea/Hypopnea Syndrome

1999 • 789 citations

Association of the Metabolic Syndrome With History of Myocardial Infarction and Stroke in the Third National Health and Nutrition Examination Survey

2003 • 779 citations

Stroke Incidence and Survival Among Middle-Aged Adults

1999 • 778 citations

Evidence-Based Guidelines for Cardiovascular Disease Prevention in Women: 2007 Update

2007 • 773 citations

Comparisons of percentage body fat, body mass index, waist circumference, and waist-stature ratio in adults

2008 • 770 citations

Antithrombotic Therapy in Atrial Fibrillation

2008 • 768 citations

A Risk Score for Predicting Stroke or Death in Individuals With New-Onset Atrial Fibrillation in the Community

2003 • 765 citations

Low-Dose Aspirin for Primary Prevention of Atherosclerotic Events in Patients With Type 2 Diabetes&lt;subtitle&gt;A Randomized Controlled Trial&lt;/subtitle&gt;

2008 • 764 citations

Migraine and cardiovascular disease: systematic review and meta-analysis

2009 • 760 citations

A Randomized Trial of Genotype-Guided Dosing of Warfarin

2013 • 756 citations

Guidelines for the Primary Prevention of Stroke A Guideline for Healthcare Professionals From the American Heart Association/American Stroke Association The American Academy of Neurology affirms the value of this guideline as an educational tool for neurologists.

2011 • 751 citations

Smoking-Attributable Mortality, Years of Potential Life Lost, and Productivity Losses—United States, 2000-2004

2009 • 749 citations

2011 ASA/ACCF/AHA/AANN/AANS/ACR/ASNR/CNS/SAIP/SCAI/SIR/SNIS/SVM/SVS Guideline on the Management of Patients With Extracranial Carotid and Vertebral Artery Disease: Executive Summary

2011 • 748 citations

Influenza Vaccination and Reduction in Hospitalizations for Cardiac Disease and Stroke among the Elderly

2003 • 741 citations

Stroke Prognosis and Abnormal Nocturnal Blood Pressure Falls in Older Hypertensives

2001 • 741 citations

Long-Term Follow-up after Tight Control of Blood Pressure in Type 2 Diabetes

2008 • 740 citations

Risk Factors for Subarachnoid Hemorrhage

2005 • 729 citations

Statins in Stroke Prevention and Carotid Atherosclerosis

2004 • 727 citations

Oral Anticoagulants vs Aspirin in Nonvalvular Atrial Fibrillation

2002 • 725 citations

Cigarette Smoking and Progression of Atherosclerosis

1998 • 724 citations

Stroke Incidence among White, Black, and Hispanic Residents of an Urban Community: The Northern Manhattan Stroke Study

1998 • 712 citations

A Pharmacogenetic versus a Clinical Algorithm for Warfarin Dosing

2013 • 708 citations

Effects of antihypertensive-drug class on interindividual variation in blood pressure and risk of stroke: a systematic review and meta-analysis

2010 • 707 citations

Common Carotid Intima-Media Thickness Measurements in Cardiovascular Risk Prediction

2012 • 706 citations

Stroke risk profile: adjustment for antihypertensive medication. The Framingham Study.

1994 • 702 citations

Effect of Rosuvastatin on Progression of Carotid Intima-Media Thickness in Low-Risk Individuals With Subclinical Atherosclerosis

2007 • 702 citations

Cardiac papillary fibroelastoma: a comprehensive analysis of 725 cases

2003 • 701 citations

Pharmacology of estrogens and progestogens: influence of different routes of administration

2005 • 701 citations

Nicotine replacement therapy for smoking cessation

2008 • 695 citations

Risk Factors for Intracerebral Hemorrhage in the General Population

2003 • 680 citations

The Lifetime Risk of Stroke

2006 • 680 citations

Ximelagatran vs Warfarin for Stroke Prevention in Patients With Nonvalvular Atrial Fibrillation

2005 • 678 citations

Age at stroke

2012 • 675 citations

Stroke with intermittent atrial fibrillation: incidence and predictors during aspirin therapy

2000 • 671 citations

Pregnancy and the Risk of Stroke

1996 • 671 citations

A Prospective Study of Maturity-Onset Diabetes Mellitus and Risk of Coronary Heart Disease and Stroke in Women

1991 • 664 citations

Risk of Embolism and Death in Infective Endocarditis: Prognostic Value of Echocardiography

2005 • 654 citations

Effects of β blockers and calcium-channel blockers on within-individual variability in blood pressure and risk of stroke

2010 • 650 citations

Extended-Release Niacin or Ezetimibe and Carotid Intima–Media Thickness

2009 • 649 citations

The Use of Transcranial Ultrasonography to Predict Stroke in Sickle Cell Disease

1992 • 649 citations

Aspirin for the Primary Prevention of Cardiovascular Events: A Summary of the Evidence for the U.S. Preventive Services Task Force

2002 • 648 citations

The Net Clinical Benefit of Warfarin Anticoagulation in Atrial Fibrillation

2009 • 648 citations

Stroke incidence, prevalence, and survival: secular trends in Rochester, Minnesota, through 1989.

1996 • 642 citations

HPS2-THRIVE randomized placebo-controlled trial in 25 673 high-risk patients of ER niacin/laropiprant: trial design, pre-specified muscle and liver outcomes, and reasons for stopping study treatment

2013 • 640 citations

Effectiveness of quality improvement strategies on the management of diabetes: a systematic review and meta-analysis

2012 • 635 citations

Risk of ischaemic stroke in people with migraine: systematic review and meta-analysis of observational studies

2004 • 631 citations

Medical (Nonsurgical) Intervention Alone Is Now Best for Prevention of Stroke Associated With Asymptomatic Severe Carotid Stenosis

2009 • 626 citations

Lipid management in the prevention of stroke: review and updated meta-analysis of statins for stroke prevention

2009 • 620 citations

Percutaneous Left Atrial Appendage Closure for Stroke Prophylaxis in Patients With Atrial Fibrillation

2013 • 619 citations

2007 Focused Update of the ACC/AHA/SCAI 2005 Guideline Update for Percutaneous Coronary Intervention

2008 • 611 citations

Fibromuscular dysplasia

2005 • 602 citations

Glucose-potassium-insulin infusions in the management of post-stroke hyperglycaemia: the UK Glucose Insulin in Stroke Trial (GIST-UK)

2007 • 602 citations

Aspirin for Prevention of Cardiovascular Events in a General Population Screened for a Low Ankle Brachial Index&lt;subtitle&gt;A Randomized Controlled Trial&lt;/subtitle&gt;

2010 • 599 citations

Effects of Diet and Sodium Intake on Blood Pressure: Subgroup Analysis of the DASH-Sodium Trial

2001 • 599 citations

Prevention of stroke and systemic embolism with rivaroxaban compared with warfarin in patients with non-valvular atrial fibrillation and moderate renal impairment

2011 • 597 citations

Discontinuing Prophylactic Transfusions Used to Prevent Stroke in Sickle Cell Disease

2005 • 597 citations

Diabetes, Plasma Insulin, and Cardiovascular Disease

2002 • 593 citations

Ventricular Dysfunction and the Risk of Stroke after Myocardial Infarction

1997 • 591 citations

Patent Foramen Ovale and Cryptogenic Stroke in Older Patients

2007 • 589 citations

Pathophysiology of Migraine

2012 • 583 citations

Efficacy of folic acid supplementation in stroke prevention: a meta-analysis

2007 • 583 citations

Migraine Intervention With STARFlex Technology (MIST) Trial

2008 • 578 citations

Antithrombotic and Thrombolytic Therapy for Valvular Disease

2012 • 576 citations

Complications of Diagnostic Cerebral Angiography: Evaluation of 19 826 Consecutive Patients1

2007 • 569 citations

A Meta-analysis of 16 Randomized Controlled Trials to Evaluate Computer-Based Clinical Reminder Systems for Preventive Care in the Ambulatory Setting

1996 • 568 citations

The Impact of Continuous Positive Airway Pressure on Blood Pressure in Patients With Obstructive Sleep Apnea Syndrome

2007 • 568 citations

Roles of Infectious Agents in Atherosclerosis and Restenosis

1997 • 566 citations

Thrombophilia, Clinical Factors, and Recurrent Venous Thrombotic Events

2005 • 566 citations

Collaborative overview of randomised trials of antiplatelet therapy--I: Prevention of death, myocardial infarction, and stroke by prolonged antiplatelet therapy in various categories of patients. Antiplatelet Trialists' Collaboration.

1994 • 566 citations

Prevalence and risk factors of carotid plaque in women with systemic lupus erythematosus

1999 • 565 citations

Low Circulating Folate and Vitamin B 6 Concentrations

1998 • 560 citations

Sickle Cell Disease: Basic Principles and Clinical Practice

1994 • 559 citations

ARBITER: Arterial Biology for the Investigation of the Treatment Effects of Reducing Cholesterol

2002 • 557 citations

Warfarin and Aspirin in Patients with Heart Failure and Sinus Rhythm

2012 • 553 citations

Efficacy of apixaban when compared with warfarin in relation to renal function in patients with atrial fibrillation: insights from the ARISTOTLE trial

2012 • 547 citations

Effect of Nocturnal Nasal Continuous Positive Airway Pressure on Blood Pressure in Obstructive Sleep Apnea

2007 • 541 citations

Prevention of Coronary and Stroke Events with Atorvastatin in Hypertensive Patients who have Average or Lower-than-Average Cholesterol Concentrations, in the Anglo-Scandinavian Cardiac Outcomes Trial???Lipid Lowering Arm (ASCOT-LLA)

2004 • 539 citations

Guidelines for Prevention of Stroke in Patients With Ischemic Stroke or Transient Ischemic Attack

2006 • 536 citations

The Protective Effect of Moderate Alcohol Consumption on Ischemic Stroke

1999 • 535 citations

Effect of Lowering LDL Cholesterol Substantially Below Currently Recommended Levels in Patients With Coronary Heart Disease and Diabetes

2006 • 534 citations

A Common Allele on Chromosome 9 Associated With Coronary Heart Disease

2007 • 531 citations

Anticardiolipin Antibodies and the Risk for Ischemic Stroke and Venous Thrombosis

1992 • 528 citations

Risk Factors for Early or Delayed Stroke After Cardiac Surgery

1999 • 528 citations

Aspirin for the Prevention of Cardiovascular Disease: U.S. Preventive Services Task Force Recommendation Statement

2009 • 526 citations

Independent predictors of stroke in patients with atrial fibrillation

2007 • 526 citations

Effects of fruit and vegetable consumption on plasma antioxidant concentrations and blood pressure: a randomised controlled trial

2002 • 524 citations

Diabetes mellitus, a predictor of morbidity and mortality in the studies of left ventricular dysfunction (SOLVD) trials and registry

1996 • 520 citations

Antithrombotic Therapy in Patients With Mechanical and Biological Prosthetic Heart Valves

2001 • 508 citations

Dietary Sodium Intake and Subsequent Risk of Cardiovascular Disease in Overweight Adults

1999 • 508 citations

Lipid-Related Markers and Cardiovascular Disease Prediction

2012 • 507 citations

Trends in Incidence, Lifetime Risk, Severity, and 30-Day Mortality of Stroke Over the Past 50 Years

2006 • 505 citations

Effect of Folic Acid and B Vitamins on Risk of Cardiovascular Events and Total Mortality Among Women at High Risk for Cardiovascular Disease

2008 • 503 citations

Autosomal Dominant Polycystic Kidney Disease

2008 • 502 citations

Comparison of Quality of Care for Patients in the Veterans Health Administration and Patients in a National Sample

2004 • 499 citations

Nonfasting Triglycerides and Risk of Ischemic Stroke in the General Population

2008 • 498 citations

Dietary Potassium and Stroke-Associated Mortality

1987 • 493 citations

Interventions That Increase Use of Adult Immunization and Cancer Screening Services

2002 • 492 citations

Controlled Trial of Transfusions for Silent Cerebral Infarcts in Sickle Cell Anemia

2014 • 491 citations

Screening for thrombophilia in high-risk situations: systematic review and cost-effectiveness analysis. The Thrombosis: Risk and Economic Assessment of Thrombophilia Screening (TREATS) study

2006 • 491 citations

Joint study of extracranial arterial occlusion. II. Arteriography, techniques, sites, and complications

1968 • 490 citations

SAFETY AND EFFICACY OF RECOMBINANT HUMAN a -GALACTOSIDASE A REPLACEMENT THERAPY IN FABRY'S DISEASE

2001 • 487 citations

Incidence and Risk Factors for Stroke in Pregnancy and the Puerperium

2005 • 486 citations

Dabigatran Versus Warfarin in Patients With Atrial Fibrillation

2011 • 484 citations

Long-term results of related myeloablative stem-cell transplantation to cure sickle cell disease

2007 • 483 citations

Case-control study of migraine and risk of ischaemic stroke in young women

1995 • 480 citations

Influenza as a trigger for acute myocardial infarction or death from cardiovascular disease: a systematic review

2009 • 479 citations

Primary Prevention of Stroke by Healthy Lifestyle

2008 • 479 citations

Potential source of cerebral embolism in migraine with aura

1999 • 477 citations

A sequence variant in ZFHX3 on 16q22 associates with atrial fibrillation and ischemic stroke

2009 • 473 citations

Deaths: final data for 2008.

2011 • 470 citations

Clinical and Echocardiographic Characteristics of Papillary Fibroelastomas

2001 • 468 citations

Excess Body Weight and Incidence of Stroke

2010 • 468 citations

Antiphospholipid Antibodies and Subsequent Thrombo-occlusive Events in Patients With Ischemic Stroke

2004 • 462 citations

Intake of Potassium, Magnesium, Calcium, and Fiber and Risk of Stroke Among US Men

1998 • 460 citations

Carotid artery intimal-medial wall thickening and plasma homocyst(e)ine in asymptomatic adults. The Atherosclerosis Risk in Communities Study.

1993 • 460 citations

Guide to Clinical Preventive Services: Report of the U S Preventive Services Task Force

1996 • 460 citations

Genetic risk factors for ischaemic stroke and its subtypes (the METASTROKE Collaboration): a meta-analysis of genome-wide association studies

2012 • 456 citations

Racial-Ethnic Disparities in Stroke Care: The American Experience

2011 • 455 citations

American Heart Association Prevention Conference IV: Prevention and Rehabilitation of Stroke

1997 • 455 citations

Prevalence and correlates of metabolic syndrome based on a harmonious definition among adults in the US*

2010 • 454 citations

ACC/AHA 2002 guideline update for the management of patients with chronic stable angina-summary article : a report of the American College of Cardiology/American Heart Association Task Force on Practice Guidelines

2003 • 450 citations

Intensive Glycemic Control and the Prevention of Cardiovascular Events: Implications of the ACCORD, ADVANCE, and VA Diabetes Trials

2009 • 450 citations

Low Risk of Ipsilateral Stroke in Patients With Asymptomatic Carotid Stenosis on Best Medical Treatment

2009 • 449 citations

Incidence of Stroke in Paroxysmal Versus Sustained Atrial Fibrillation in Patients Taking Oral Anticoagulation or Combined Antiplatelet Therapy

2007 • 449 citations

Dabigatran Association With Higher Risk of Acute Coronary Events

2012 • 448 citations

Drug Addiction

2003 • 448 citations

Beta-blockers for hypertension

2017 • 448 citations

Management of High Blood Pressure in African Americans&lt;subtitle&gt;Consensus Statement of the Hypertension in African Americans Working Group of the International Society on Hypertension in Blacks&lt;/subtitle&gt;

2003 • 445 citations

Incidence of a first thromboembolic event in asymptomatic carriers of high-risk antiphospholipid antibody profile: a multicenter prospective study

2011 • 445 citations

Migraine and stroke in young women: case-control study

1999 • 445 citations

Nonfasting Plasma Total Homocysteine Levels and Stroke Incidence in Elderly Persons: The Framingham Study

1999 • 443 citations

Risk of embolization after institution of antibiotic therapy for infective endocarditis

2002 • 440 citations

Cost-Effectiveness of Dabigatran Compared With Warfarin for Stroke Prevention in Atrial Fibrillation

2011 • 439 citations

Disparities in stroke incidence contributing to disparities in stroke mortality

2011 • 436 citations

Annual Smoking-Attributable Mortality, Years of Potential Life Lost, and Economic Costs—United States, 1995-1999

2002 • 434 citations

Physical activity and stroke. A meta-analysis of observational data

2004 • 434 citations

Blood Pressure Targets in Subjects With Type 2 Diabetes Mellitus/Impaired Fasting Glucose

2011 • 431 citations

First-line drugs for hypertension

2018 • 431 citations

Patent Foramen Ovale: Innocent or Guilty?

2005 • 429 citations

Management of High Blood Pressure in Blacks

2010 • 428 citations

Effect of Folic Acid Supplementation on Risk of Cardiovascular Diseases

2006 • 426 citations

Anti–β2-glycoprotein I, antiprothrombin antibodies, and the risk of thrombosis in the antiphospholipid syndrome

2003 • 422 citations

Recommendations for the Management of Patients With Unruptured Intracranial Aneurysms

2000 • 417 citations

Lipoprotein-Associated Phospholipase A2 Activity Is Associated With Risk of Coronary Heart Disease and Ischemic Stroke

2005 • 417 citations

The Effects of Tibolone in Older Postmenopausal Women

2008 • 415 citations

Mitral Annular Calcification and the Risk of Stroke in an Elderly Cohort

1992 • 415 citations

Impact of Thrombophilia on Risk of Arterial Ischemic Stroke or Cerebral Sinovenous Thrombosis in Neonates and Children

2010 • 411 citations

Mortality and Cardiovascular Events in Patients Treated With Homocysteine-Lowering B Vitamins After Coronary Angiography

2008 • 411 citations

C-terminal truncations in human 3′-5′ DNA exonuclease TREX1 cause autosomal dominant retinal vasculopathy with cerebral leukodystrophy

2007 • 410 citations

Severe Sleep Apnea and Risk of Ischemic Stroke in the Elderly

2006 • 409 citations

Stroke in a Biracial Population

2004 • 408 citations

The Warfarin/Aspirin study in heart failure (WASH): a randomized trial comparing antithrombotic strategies for patients with heart failure

2004 • 407 citations

Assessment of cardiovascular risk by use of multiple-risk-factor assessment equations

1999 • 406 citations

Abdominal Obesity and Risk of Ischemic Stroke

2003 • 406 citations

Screening and Behavioral Counseling Interventions in Primary Care to Reduce Alcohol Misuse: U.S. Preventive Services Task Force Recommendation Statement

2013 • 404 citations

A randomised controlled trial and cost-effectiveness study of systematic screening (targeted and total population screening) versus routine practice for the detection of atrial fibrillation in people aged 65 and over. The SAFE study

2005 • 403 citations

Embolic potential, prevention and management of mural thrombus complicating anterior myocardial infarction: A meta-analysis

1993 • 403 citations

Neurologic Manifestations of Infective Endocarditis

2000 • 402 citations

Randomized Trial of Warfarin, Aspirin, and Clopidogrel in Patients With Chronic Heart Failure

2009 • 401 citations

Ischemic Stroke Risk With Oral Contraceptives

2000 • 397 citations

Screening versus routine practice in detection of atrial fibrillation in patients aged 65 or over: cluster randomised controlled trial

2007 • 396 citations

Epidemiology of smoking-induced cardiovascular disease

2003 • 396 citations

Reduction of low-density lipoprotein cholesterol in patients with coronary heart disease and metabolic syndrome: analysis of the Treating to New Targets study

2006 • 393 citations

Aspirin for primary thrombosis prevention in the antiphospholipid syndrome: A randomized, double‐blind, placebo‐controlled trial in asymptomatic antiphospholipid antibody–positive individuals

2007 • 393 citations

Leisure-Time Physical Activity and Ischemic Stroke Risk

1998 • 393 citations

Genome-wide association study identifies a variant in HDAC9 associated with large vessel ischemic stroke

2012 • 393 citations

Aspirin for primary prevention of cardiovascular events in people with diabetes: meta-analysis of randomised controlled trials

2009 • 392 citations

Long‐term stroke risk in children with sickle cell disease screened with transcranial doppler

1997 • 390 citations

The ATHEROMA (Atorvastatin Therapy: Effects on Reduction of Macrophage Activity) Study

2009 • 382 citations

Thickening of the Carotid Wall

1996 • 381 citations

Continuous positive airways pressure for obstructive sleep apnoea in adults

2006 • 379 citations

Migraine Headache and Ischemic Stroke Risk: An Updated Meta-analysis

2010 • 375 citations

Cholesterol, coronary heart disease, and stroke in the Asia Pacific region

2003 • 374 citations

Screening and Behavioral Counseling Interventions in Primary Care To Reduce Alcohol Misuse: Recommendation Statement

2004 • 373 citations

Epidemiology of CVD in rheumatic disease, with a focus on RA and SLE

2011 • 372 citations

Light-to-Moderate Alcohol Consumption and the Risk of Stroke among U.S. Male Physicians

1999 • 371 citations

Systematic Review of Methods and Results of Studies of the Genetic Epidemiology of Ischemic Stroke

2003 • 370 citations

SNORING AND CEREBRAL INFARCTION

1985 • 369 citations

Influence of total cholesterol, high density lipoprotein cholesterol, and triglycerides on risk of cerebrovascular disease: the Copenhagen city heart study

1994 • 369 citations

Secular trends in stroke incidence and mortality. The Framingham Study.

1992 • 368 citations

Guidance on the emergent reversal of oral thrombin and factor Xa inhibitors

2012 • 367 citations

Educational, supportive and behavioural interventions to improve usage of continuous positive airway pressure machines in adults with obstructive sleep apnoea

2014 • 364 citations

Migraine, headache, and the risk of stroke in women

2005 • 364 citations

Genetic Heritability of Ischemic Stroke and the Contribution of Previously Reported Candidate Gene and Genomewide Associations

2012 • 364 citations

Ehlers-Danlos syndrome type IV

2007 • 364 citations

Cognitive functioning and brain magnetic resonance imaging in children with sickle Cell disease. Neuropsychology Committee of the Cooperative Study of Sickle Cell Disease.

1996 • 363 citations

Infarcts in the posterior circulation territory in migraine. The population-based MRI CAMERA study

2005 • 362 citations

Identification of Patients at Low Risk for Recurrent Venous Thromboembolism by Measuring Thrombin Generation

2006 • 362 citations

Myocardial Ischemic Events in Patients With Atrial Fibrillation Treated With Dabigatran or Warfarin in the RE-LY (Randomized Evaluation of Long-Term Anticoagulation Therapy) Trial

2012 • 360 citations

Alcohol consumption and the risk of morbidity and mortality for different stroke types - a systematic review and meta-analysis

2010 • 359 citations

The Epidemiology of Smoking

2002 • 358 citations

Migraine is associated with an increased risk of deep white matter lesions, subclinical posterior circulation infarcts and brain iron accumulation: The population-based MRI CAMERA study

2009 • 356 citations

Risk Factors for Intracerebral Hemorrhage in a Pooled Prospective Study

2007 • 355 citations

Status of the Epidemiology of Atrial Fibrillation

2007 • 354 citations

Risk Factors for Ischemic Stroke Subtypes

2006 • 353 citations

Preventive Care in the Emergency Department: Screening and Brief Intervention for Alcohol Problems in the Emergency Department: A Systematic Review

2002 • 351 citations

Performance of the HEMORR2HAGES, ATRIA, and HAS-BLED Bleeding Risk–Prediction Scores in Patients With Atrial Fibrillation Undergoing Anticoagulation

2012 • 349 citations

Precursors of extracranial carotid atherosclerosis in the Framingham Study

1994 • 349 citations

The relationship between the initiation of antimicrobial therapy and the incidence of stroke in infective endocarditis: An analysis from the ICE Prospective Cohort Study (ICE-PCS)

2007 • 348 citations

Serum Triglycerides as a Risk Factor for Cardiovascular Diseases in the Asia-Pacific Region

2004 • 348 citations

Effects of Conjugated Equine Estrogen on Stroke in the Women’s Health Initiative

2006 • 346 citations

Excess Stroke in Mexican Americans Compared with Non-Hispanic Whites: The Brain Attack Surveillance in Corpus Christi Project

2004 • 343 citations

Passive smoking and risk of coronary heart disease and stroke: prospective study with cotinine measurement

2004 • 342 citations

Oral Appliance Therapy Reduces Blood Pressure in Obstructive Sleep Apnea: a Randomized, Controlled Trial

2004 • 342 citations

Cost-Effectiveness of Dabigatran for Stroke Prophylaxis in Atrial Fibrillation

2011 • 341 citations

Genetic dissection and prognostic modeling of overt stroke in sickle cell anemia

2005 • 340 citations

Rivaroxaban compared with warfarin in patients with atrial fibrillation and previous stroke or transient ischaemic attack: a subgroup analysis of ROCKET AF

2012 • 340 citations

Primary and Secondary Neoplasms of the Heart

1997 • 336 citations

Stroke and Alcohol Consumption

1986 • 336 citations

Self-Measured Blood Pressure Monitoring in the Management of Hypertension

2013 • 335 citations

Passive smoking as well as active smoking increases the risk of acute stroke

1999 • 335 citations

Epidemiology and Etiology of Ischemic Stroke in Young Adults Aged 18 to 44 Years in Northern Sweden

1997 • 335 citations

Patent Foramen Ovale and the Risk of Ischemic Stroke in a Multiethnic Population

2007 • 334 citations

Intensive Glycemic Control and the Prevention of Cardiovascular Events: Implications of the ACCORD, ADVANCE, and VA Diabetes Trials

2008 • 334 citations

Cumulative Effects of High Cholesterol Levels, High Blood Pressure, and Cigarette Smoking on Carotid Stenosis

1997 • 329 citations

Alcohol and hypertension: gender differences in dose–response relationships determined through systematic review and meta‐analysis

2009 • 329 citations

Association of Obstructive Sleep Apnea With Risk of Serious Cardiovascular Events

2012 • 326 citations

Epidemiology of Ischemic Stroke in Patients With Diabetes

2005 • 325 citations

Prevalence and Correlates of Silent Cerebral Infarcts in the Framingham Offspring Study

2008 • 324 citations

Ischaemic stroke and combined oral contraceptives: results of an international, multicentre, case-control study

1996 • 323 citations

Homocysteine is a risk factor for cerebral small vessel disease, acting via endothelial dysfunction

2003 • 322 citations

Continuous Positive Airway Pressure Treatment of Mild to Moderate Obstructive Sleep Apnea Reduces Cardiovascular Risk

2007 • 322 citations

Prospective Study of Oral Contraceptives and Hypertension Among Women in the United States

1996 • 320 citations

High risk of thromboemboli early after bioprosthetic cardiac valve replacement

1995 • 319 citations

Normotensive Salt Sensitivity

1999 • 318 citations

Plasma Lipid Profile and Incident Ischemic Stroke

2003 • 318 citations

Surveillance for Certain Health Behaviors and Conditions Among States and Selected Local Areas — Behavioral Risk Factor Surveillance System, United States, 2015

2018 • 318 citations

High-Density Lipoprotein Cholesterol and Ischemic Stroke in the Elderly

2001 • 316 citations

Probable Migraine With Visual Aura and Risk of Ischemic Stroke

2007 • 315 citations

Smoking vs Other Risk Factors as the Cause of Smoking-Attributable Deaths

2000 • 315 citations

Changes in the Use of Postmenopausal Hormone Therapy after the Publication of Clinical Trial Results

2004 • 315 citations

Salt in Health and Disease — A Delicate Balance

2013 • 315 citations

Management of Patients With Atrial Fibrillation (Compilation of 2006 ACCF/AHA/ESC and 2011 ACCF/AHA/HRS Recommendations)

2013 • 312 citations

Short and long-term effects of smoking on arterial wall properties in habitual smokers

1993 • 310 citations

Association between the Current Use of Low-Dose Oral Contraceptives and Cardiovascular Arterial Disease: A Meta-Analysis

2005 • 309 citations

Systematic Review of Computed Tomographic Angiography for Assessment of Carotid Artery Disease

2004 • 309 citations

Impact of early transcranial Doppler screening and intensive therapy on cerebral vasculopathy outcome in a newborn sickle cell anemia cohort

2010 • 309 citations

Migraine Is Associated With Magnetic Resonance Imaging White Matter Abnormalities

2004 • 308 citations

Stroke in Young Adults Who Abuse Amphetamines or Cocaine

2007 • 306 citations

Rationale and design of IMPROVE-IT (IMProved Reduction of Outcomes: Vytorin Efficacy International Trial): Comparison of ezetimbe/simvastatin versus simvastatin monotherapy on cardiovascular outcomes in patients with acute coronary syndromes

2008 • 306 citations

Systemic embolism in mitral valve disease.

1970 • 305 citations

Body Size and Fat Distribution as Predictors of Stroke among US Men

1996 • 304 citations

Can Patients Be Anticoagulated After Intracerebral Hemorrhage?

2003 • 303 citations

An Effective Approach to High Blood Pressure Control

2013 • 301 citations

Increase in cardiovascular and cerebrovascular disease prevalence in rheumatoid arthritis.

2003 • 300 citations

Short-term Predictors of Incident Stroke in Older Adults

1996 • 300 citations

Night–day blood pressure ratio and dipping pattern as predictors of death and cardiovascular events in hypertension

2009 • 299 citations

Long-term alcohol consumption and the risk of atrial fibrillation in the Framingham Study

2004 • 297 citations

A Meta-analysis of Clinical Screening Tests for Obstructive Sleep Apnea

2009 • 295 citations

Is Prehypertension a Risk Factor for Cardiovascular Diseases?

2005 • 295 citations

Cardiovascular Morbidity and Mortality in Rheumatoid Arthritis

2008 • 294 citations

Effect of potassium-enriched salt on cardiovascular mortality and medical expenses of elderly men

2006 • 292 citations

Safety and efficacy of combined antiplatelet-warfarin therapy after coronary stenting

2007 • 291 citations

B vitamins in patients with recent transient ischaemic attack or stroke in the VITAmins TO Prevent Stroke (VITATOPS) trial: a randomised, double-blind, parallel, placebo-controlled trial

2010 • 289 citations

Preclinical Carotid Atherosclerosis in Patients with Rheumatoid Arthritis

2006 • 288 citations

Silent infarction as a risk factor for overt stroke in children with sickle cell anemia: A report from the Cooperative Study of Sickle Cell Disease

2001 • 287 citations

Discerning the Incidence of Symptomatic and Asymptomatic Episodes of Atrial Fibrillation Before and After Catheter Ablation (DISCERN AF)

2012 • 287 citations

Aortic Atherosclerotic Disease and Stroke

2006 • 286 citations

Impact of Continuous Positive Airway Pressure Therapy on Blood Pressure in Patients with Obstructive Sleep Apnea Hypopnea: A Meta-analysis of Randomized Controlled Trials

2007 • 286 citations

Aspirin plus warfarin compared to aspirin alone after acute coronary syndromes: an updated and comprehensive meta-analysis of 25 307 patients

2005 • 286 citations

Risk variants for atrial fibrillation on chromosome 4q25 associate with ischemic stroke

2008 • 284 citations

Alcohol Consumption and Risk of Atrial Fibrillation

2011 • 281 citations

Statin Therapy and the Risk of Intracerebral Hemorrhage

2012 • 281 citations

Implementation of Treatment Protocols in the Diabetes Control and Complications Trial

1995 • 281 citations

Anticoagulant and Antiplatelet Therapy Use in 426 Patients With Atrial Fibrillation Undergoing Percutaneous Coronary Intervention and Stent Implantation

2008 • 280 citations

Coagulation Studies, Factor V Leiden, and Anticardiolipin Antibodies in 40 Cases of Cerebral Venous Thrombosis

1996 • 278 citations

Lp(a) Lipoprotein, Vascular Disease, and Mortality in the Elderly

2003 • 276 citations

A Meta-Analysis of 94,492 Patients With Hypertension Treated With Beta Blockers to Determine the Risk of New-Onset Diabetes Mellitus

2007 • 276 citations

Comparison of idraparinux with vitamin K antagonists for prevention of thromboembolism in patients with atrial fibrillation: a randomised, open-label, non-inferiority trial

2008 • 274 citations

Potassium Intake, Stroke, and Cardiovascular Disease

2011 • 272 citations

Associations Between Lipoprotein(a) Levels and Cardiovascular Outcomes in Black and White Subjects

2011 • 272 citations

Outcomes After Cardioversion and Atrial Fibrillation Ablation in Patients Treated With Rivaroxaban and Warfarin in the ROCKET AF Trial

2013 • 271 citations

DOUBLE-BLIND STUDY OF THREE SODIUM INTAKES AND LONG-TERM EFFECTS OF SODIUM RESTRICTION IN ESSENTIAL HYPERTENSION

1989 • 270 citations

Oral Antithrombotic Agents for the Prevention of Stroke in Nonvalvular Atrial Fibrillation

2012 • 268 citations

Anticardiolipin antibodies are an independent risk factor for first ischemic stroke

1993 • 268 citations

Effect of treatment on the incidence of stroke and other emboli in 519 patients with severe thoracic aortic plaque

2002 • 267 citations

American Heart Association Guide for Improving Cardiovascular Health at the Community Level

2003 • 267 citations

Reduction in Stroke With Gemfibrozil in Men With Coronary Heart Disease and Low HDL Cholesterol

2001 • 265 citations

Sodium Intake and Risk of Death From Stroke in Japanese Men and Women

2004 • 265 citations

Different Risk Factors for Different Stroke Subtypes

1999 • 265 citations

Apixaban compared with warfarin in patients with atrial fibrillation and previous stroke or transient ischaemic attack: a subgroup analysis of the ARISTOTLE trial

2012 • 265 citations

Fasting Glucose Levels and Incident Diabetes Mellitus in Older Nondiabetic Adults Randomized to Receive 3 Different Classes of Antihypertensive Treatment

2006 • 265 citations

A score for predicting risk of death from cardiovascular disease in adults with raised blood pressure, based on individual patient data from randomised controlled trials

2001 • 265 citations

Alcohol Consumption and Risk of Atrial Fibrillation in Men and Women

2005 • 263 citations

Risk Factors for Ischemic Stroke

1998 • 263 citations

Heavy Snoring as a Cause of Carotid Artery Atherosclerosis

2008 • 262 citations

Nocturnal hypoxaemia and central-nervous-system events in sickle-cell disease

2001 • 260 citations

Increased incidence of cardiovascular disease in patients with rheumatoid arthritis: results from a community based study

2004 • 260 citations

Cerebral infarction in young adults

1998 • 259 citations

Increased Risk of Stroke in Patients With Coronary Artery Disease and Sleep Apnea

2008 • 258 citations

Drinking Frequency, Mediating Biomarkers, and Risk of Myocardial Infarction in Women and Men

2005 • 257 citations

Significant Association of Atrial Vulnerability With Atrial Septal Abnormalities in Young Patients With Ischemic Stroke of Unknown Cause

2000 • 257 citations

Familial aggregation of stroke. The Framingham Study.

1993 • 256 citations

Moving the Tipping Point

2010 • 256 citations

Cardiovascular morbidity and mortality in hypertensive patients with a history of atrial fibrillation

2005 • 254 citations

Duration of Diabetes and Risk of Ischemic Stroke

2012 • 254 citations

β 2 -Glycoprotein 1–Dependent Anticardiolipin Antibodies and Risk of Ischemic Stroke and Myocardial Infarction

2001 • 254 citations

Effects of a Perindopril-Based Blood Pressure–Lowering Regimen on the Risk of Recurrent Stroke According to Stroke Subtype and Medical History

2003 • 252 citations

Homocysteine-Lowering Therapy and Stroke Risk, Severity, and Disability

2009 • 252 citations

Subclinical Atherosclerosis in Rheumatoid Arthritis and Systemic Lupus Erythematosus

2008 • 251 citations

Randomized Trial of Folic Acid for Prevention of Cardiovascular Events in End-Stage Renal Disease

2004 • 251 citations

Declines in Hospital Admissions for Acute Myocardial Infarction in New York State After Implementation of a Comprehensive Smoking Ban

2007 • 249 citations

Auto-Titrating Versus Standard Continuous Positive Airway Pressure for the Treatment of Obstructive Sleep Apnea: Results of a Meta-analysis

2004 • 247 citations

Positive Airway Pressure Treatment for Obstructive Sleep Apnea

2007 • 244 citations

Emergence of Recreational Drug Abuse as a Major Risk Factor for Stroke in Young Adults

1990 • 242 citations

Effect of rheumatoid arthritis or systemic lupus erythematosus on the risk of First-Time acute myocardial infarction

2004 • 241 citations

Age and Outcomes After Carotid Stenting and Endarterectomy

2011 • 241 citations

Cardiovascular Morbidity and Mortality in the Atherosclerosis and Folic Acid Supplementation Trial (ASFAST) in Chronic Renal Failure

2006 • 241 citations

Migraine, vascular risk, and cardiovascular events in women: prospective cohort study

2008 • 240 citations

Cardiovascular manifestations associated with influenza virus infection

2008 • 239 citations

Healthy Lifestyle and the Risk of Stroke in Women

2006 • 237 citations

Subarachnoid Hemorrhage

2002 • 236 citations

Atherosclerosis of the thoracic aorta and aortic debris as a marker of poor prognosis: benefit of oral anticoagulants

1999 • 235 citations

Prevalence, Treatment, and Control of Diagnosed Diabetes in the U.S. National Health and Nutrition Examination Survey 1999–2004

2008 • 235 citations

Two self-management interventions to improve hypertension control: a randomized trial.

2009 • 235 citations

Influenza Vaccination as Secondary Prevention for Cardiovascular Disease

2006 • 234 citations

Carotid Endarterectomy for Asymptomatic Carotid Stenosis

2004 • 234 citations

Comparison of 12 Risk Stratification Schemes to Predict Stroke in Patients With Nonvalvular Atrial Fibrillation

2008 • 232 citations

Familial aneurysmal subarachnoid hemorrhage: a community-based study

1995 • 231 citations

Mobile Aortic Atheroma and Systemic Emboli: Efficacy of Anticoagulation and Influence of Plaque Morphology on Recurrent Stroke

1998 • 231 citations

Incidence of hypertension and stroke in relation to body fat distribution and other risk factors in older women.

1990 • 231 citations

Combined Anticoagulant–Antiplatelet Use and Major Bleeding Events in Elderly Atrial Fibrillation Patients

2004 • 231 citations

Lipid levels and the risk of ischemic stroke in women

2007 • 229 citations

Sneddon Syndrome with or without Antiphospholipid Antibodies: A Comparative Study in 46 Patients

1999 • 228 citations

Association of Aspirin Use With Major Bleeding in Patients With and Without Diabetes

2012 • 227 citations

Home Blood Pressure Management and Improved Blood Pressure Control

2011 • 227 citations

Silent Brain Infarction and Platelet Activation in Obstructive Sleep Apnea

2007 • 226 citations

Risk of Arterial Thrombosis in Relation to Oral Contraceptives (RATIO) Study

2002 • 225 citations

A Randomized Trial of Genotype-Guided Dosing of Acenocoumarol and Phenprocoumon

2013 • 222 citations

EFFECTS OF INTENSIVE BLOOD PRESSURE REDUCTION ON MYOCARDIAL INFARCTION AND STROKE IN DIABETES: A META-ANALYSIS IN 73,913 PATIENTS

2011 • 222 citations

Guidelines for the early management of adults with ischemic stroke: a guideline from the American Heart Association/American Stroke Association Stroke Council, Clinical Cardiology Council, Cardiovascular Radiology and Intervention Council, and the Atherosclerotic Peripheral Vascular Disease and Quality of Care Outcomes in Research Interdisciplinary Working Groups: The American Academy of Neurology

2007 • 222 citations

High-density lipoprotein-cholesterol and risk of stroke and carotid atherosclerosis: A systematic review

2007 • 221 citations

High-Density Lipoprotein Cholesterol and Other Risk Factors for Coronary Heart Disease in Female Runners

1996 • 221 citations

Prevalence of sleep disordered breathing in paroxysmal and persistent atrial fibrillation patients with normal left ventricular function

2008 • 220 citations

Sleep-disordered breathing: a novel predictor of atrial fibrillation after coronary artery bypass surgery.

1996 • 217 citations

The risk of stroke and death in patients with aortic and mitral valve endocarditis

2001 • 217 citations

HDL-Cholesterol, Total Cholesterol, and the Risk of Stroke in Middle-Aged British Men

2000 • 217 citations

Hyperhomocysteinemia but Not the C677T Mutation of Methylenetetrahydrofolate Reductase Is an Independent Risk Determinant of Carotid Wall Thickening

1999 • 216 citations

Efficacy of antithrombotic therapy in chronic heart failure: The HELAS study

2006 • 216 citations

Non-insulin-dependent diabetes and its metabolic control are important predictors of stroke in elderly subjects.

1994 • 215 citations

Factors Associated With Closures of Emergency Departments in the United States

2011 • 214 citations

The Unchanging Incidence and Case-Fatality of Stroke in the 1990s

2006 • 214 citations

Metabolic Syndrome and the Risk of Stroke in Middle-Aged Men

2006 • 214 citations

Factor V Leiden: The Copenhagen City Heart Study and 2 meta-analyses

2002 • 213 citations

Hydroxyurea therapy lowers transcranial Doppler flow velocities in children with sickle cell anemia

2007 • 213 citations

Antihypertensive Treatment and Secondary Prevention of Cardiovascular Disease Events Among Persons Without Hypertension

2011 • 212 citations

Oral contraception and risk of a cerebral thromboembolic attack: results of a case-control study.

1993 • 211 citations

Baseline Characteristics and Early Blood Pressure Control in the CONVINCE Trial

2001 • 210 citations

The Impact of Screening, Brief Intervention, and Referral for Treatment on Emergency Department Patients' Alcohol Use

2007 • 210 citations

Sequence variants on chromosome 9p21.3 confer risk for atherosclerotic stroke

2009 • 210 citations

COL4A1 Mutations as a Monogenic Cause of Cerebral Small Vessel Disease

2010 • 210 citations

Salt intake and stroke: a possible direct effect.

1992 • 209 citations

Cerebral Venous Thrombosis: Analysis of a Multicenter Cohort From the United States

2008 • 209 citations

Associations of lipoprotein cholesterols, apolipoproteins A-I and B, and triglycerides with carotid atherosclerosis and coronary heart disease. The Atherosclerosis Risk in Communities (ARIC) Study.

1994 • 208 citations

The Association Between Lipid Levels and the Risks of Incident Myocardial Infarction, Stroke, and Total Mortality: The Cardiovascular Health Study

2004 • 207 citations

Plasma Homocysteine as a Risk Factor for Vascular Disease

1998 • 207 citations

Cocaine-Induced Cerebral Vasoconstriction Detected in Humans With Magnetic Resonance Angiography

1998 • 207 citations

Aspirin for Primary Prevention of Cardiovascular Events in People With Diabetes

2010 • 206 citations

Systematic Review: The Value of the Periodic Health Evaluation

2007 • 205 citations

Migraine Headache in Middle Age and Late-Life Brain Infarcts

2009 • 205 citations

Alcohol Consumption and Risk of Stroke Among Middle-Aged Men: The JPHC Study Cohort I

2004 • 204 citations

Ischaemia-induced (symptomatic) migraine attacks may be more frequent than migraine-induced ischaemic insults

1993 • 204 citations

Dose-Response Relationship Between Cigarette Smoking and Risk of Ischemic Stroke in Young Women

2008 • 203 citations

Preventive Care in the Emergency Department, Part II: Clinical Preventive Services—An Emergency Medicine Evidence‐based Review*

2000 • 203 citations

Hospital Treatment of Patients With Ischemic Stroke or Transient Ischemic Attack Using the “Get With The Guidelines” Program

2008 • 202 citations

Greater Rupture Risk for Familial as Compared to Sporadic Unruptured Intracranial Aneurysms

2009 • 202 citations

Physical Activity and Stroke Incidence in Women and Men: The NHANES I Epidemiologic Follow-up Study

1996 • 201 citations

Clinical carotid endarterectomy decision making

2001 • 201 citations

Stroke and Use of Low-Dose Oral Contraceptives in Young Women

1998 • 201 citations

Inflammation and Atherothrombosis

2006 • 200 citations

Risks for Stroke, Bleeding, and Death in Patients With Atrial Fibrillation Receiving Dabigatran or Warfarin in Relation to the CHADS_2 Score: A Subgroup Analysis of the RE-LY Trial

2011 • 200 citations

Association Between Influenza Vaccination and Reduced Risk of Brain Infarction

2002 • 199 citations

Early-Life Origins of Adult Disease: National Longitudinal Population-Based Study of the United States

2011 • 198 citations

Folate, Vitamin B 6 , and B 12 Intakes in Relation to Risk of Stroke Among Men

2003 • 198 citations

Aortic Arch Plaques and Risk of Recurrent Stroke and Death

2009 • 198 citations

Dietary Flavonoids and Risk of Stroke in Women

2012 • 197 citations

Dietary Protein Sources and the Risk of Stroke in Men and Women

2011 • 196 citations

Risk of Hospitalized Stroke in Men Enrolled in the Honolulu Heart Program and the Framingham Study

2002 • 196 citations

Poor Prognosis in Warfarin-Associated Intracranial Hemorrhage Despite Anticoagulation Reversal

2012 • 196 citations

Sporadic and Familial Cerebral Amyloid Angiopathies

2002 • 196 citations

Dietary fat intake and risk of stroke in male US healthcare professionals: 14 year prospective cohort study

2003 • 195 citations

Inherited Thrombophilic Disorders in Young Adults With Ischemic Stroke and Patent Foramen Ovale

2003 • 193 citations

Neurological complications of drug abuse: pathophysiological mechanisms

2000 • 192 citations

Aspirin Is Beneficial in Hypertensive Patients With Chronic Kidney Disease

2010 • 192 citations

Alcohol consumption as a risk factor for atrial fibrillation: a systematic review and meta-analysis

2010 • 191 citations

Stroke and Cocaine or Amphetamine Use

1998 • 190 citations

Postmenopausal Hormone Therapy and Stroke

2008 • 190 citations

Transfusion management of sickle cell disease

1993 • 189 citations

Declining stroke rates in Californian children with sickle cell disease

2004 • 189 citations

Parental Occurrence of Stroke and Risk of Stroke in Their Children

2010 • 188 citations

Heritability of Ischemic Stroke in Relation to Age, Vascular Risk Factors, and Subtypes of Incident Stroke in Population-Based Studies

2004 • 188 citations

Cannabis Use, Ischemic Stroke, and Multifocal Intracranial Vasoconstriction

2011 • 188 citations

Patent Foramen Ovale in Young Adults with Unexplained Stroke

2005 • 188 citations

Changing Physician Behavior to Improve Disease Prevention

1994 • 187 citations

Risk factors of stroke incidence and mortality. A 12-year follow-up of the Oslo Study.

1993 • 187 citations

Pharmacotherapy for mild hypertension

2012 • 187 citations

Association Between Lipoprotein-Associated Phospholipase A2 and Cardiovascular Disease: A Systematic Review

2007 • 187 citations

Treatment of Fabry Disease: Outcome of a Comparative Trial with Agalsidase Alfa or Beta at a Dose of 0.2 mg/kg

2007 • 186 citations

Smoking and the Risk of Hemorrhagic Stroke in Men

2003 • 186 citations

New Oral Anticoagulants and the Risk of Intracranial Hemorrhage

2013 • 186 citations

Health Supervision for Children with Sickle Cell Disease

2002 • 185 citations

Five-Year Follow-Up After Intracoronary Gamma Radiation Therapy for In-Stent Restenosis

2004 • 185 citations

Nonsurgical Management of Obesity in Adults

2008 • 183 citations

Meta-Analysis of Multiple Primary Prevention Trials of Cardiovascular Events Using Aspirin

2011 • 182 citations

The Use of Auto-Titrating Continuous Positive Airway Pressure for Treatment of Adult Obstructive Sleep Apnea

2002 • 182 citations

Moderate Alcohol Consumption Reduces Risk of Ischemic Stroke

2005 • 182 citations

Brain-Immune Interactions and Ischemic Stroke

2012 • 182 citations

Risk factors for a first thrombotic event in antiphospholipid antibody carriers: a prospective multicentre follow-up study

2011 • 181 citations

Common infections and the risk of stroke

2010 • 180 citations

Major Risk Factors for Intracerebral Hemorrhage in the Young Are Modifiable

2005 • 179 citations

Cerebral cavernous malformations: from CCM genes to endothelial cell homeostasis

2013 • 177 citations

ACC/AHA 2004 guideline update for coronary artery bypass graft surgery

2004 • 177 citations

Effect of Oral Contraceptives on Haemostasis Variables

1997 • 176 citations

Metabolic Syndrome Compared With Type 2 Diabetes Mellitus as a Risk Factor for Stroke

2006 • 176 citations

Counseling and Interventions to Prevent Tobacco Use and Tobacco-Caused Disease in Adults and Pregnant Women: U.S. Preventive Services Task Force Reaffirmation Recommendation Statement

2009 • 176 citations

Pulmonary, Gonadal, and Central Nervous System Status after Bone Marrow Transplantation for Sickle Cell Disease

2009 • 176 citations

The Current State of Niacin in Cardiovascular Disease Prevention

2012 • 175 citations

Statins and Intracerebral Hemorrhage

2011 • 175 citations

Chlamydia pneumoniae but Not Cytomegalovirus Antibodies Are Associated With Future Risk of Stroke and Cardiovascular Disease

1999 • 174 citations

Promotion and Prescribing of Hormone Therapy After Report of Harm by the Women’s Health Initiative

2004 • 174 citations

Risk of atrial fibrillation and stroke in rheumatoid arthritis: Danish nationwide cohort study

2012 • 174 citations

Apixaban versus aspirin in patients with atrial fibrillation and previous stroke or transient ischaemic attack: a predefined subgroup analysis from AVERROES, a randomised trial

2012 • 174 citations

Knowledge of stroke risk factors and warning signs among Michigan adults

2002 • 173 citations

Effect of short-term treatment with azithromycin on recurrent ischaemic events in patients with acute coronary syndrome in the Azithromycin in Acute Coronary Syndrome (AZACS) trial: a randomised controlled trial

2003 • 173 citations

Carotid Revascularization Using Endarterectomy or Stenting Systems (CaRESS) phase I clinical trial: 1-year results

2007 • 173 citations

Relation Between the Metabolic Syndrome and Ischemic Stroke or Transient Ischemic Attack

2005 • 172 citations

Lipoprotein (a) and Stroke

2007 • 172 citations

Lack of Evidence of an Association between Mitral-Valve Prolapse and Stroke in Young Patients

1999 • 171 citations

Aspirin for the Primary Prevention of Stroke and Other Major Vascular Events

2000 • 171 citations

Hydroxyurea for sickle cell disease in children and for prevention of cerebrovascular events: the Belgian experience

2004 • 170 citations

Patterns of Alcohol Intake and Risk of Stroke in Middle-aged British Men

1996 • 169 citations

Red Meat Consumption and Risk of Stroke

2012 • 169 citations

Effect of Aspirin on Mortality in the Primary Prevention of Cardiovascular Disease

2011 • 169 citations

Risk of Stroke in Women Exposed to Low-Dose Oral Contraceptives

2004 • 169 citations

Snoring, sleep apnea syndrome, and stroke.

1992 • 168 citations

Management of Patients With Atrial Fibrillation (Compilation of 2006 ACCF/AHA/ESC and 2011 ACCF/AHA/HRS Recommendations)

2013 • 167 citations

Recommendations for the Management of Patients With Unruptured Intracranial Aneurysms

2000 • 166 citations

Mitral Annular Calcification, Aortic Valve Sclerosis, and Incident Stroke in Adults Free of Clinical Cardiovascular Disease

2005 • 166 citations

Rosuvastatin in the Prevention of Stroke Among Men and Women With Elevated Levels of C-Reactive Protein

2009 • 165 citations

Methamphetamine-related stroke: four cases

1999 • 165 citations

Common variants at 6p21.1 are associated with large artery atherosclerotic stroke

2012 • 164 citations

Recent Heavy Drinking of Alcohol and Embolic Stroke

1999 • 164 citations

Race-Ethnicity and Determinants of Carotid Atherosclerosis in a Multiethnic Population

1997 • 164 citations

Increasing US Emergency Department Visit Rates and Subsequent Hospital Admissions for Atrial Fibrillation from 1993 to 2004

2007 • 163 citations

Moderate alcohol consumption increases insulin sensitivity and ADIPOQ expression in postmenopausal women: a randomised, crossover trial

2008 • 163 citations

Influence of Metabolic Syndrome and General Obesity on the Risk of Ischemic Stroke

2006 • 163 citations

The Incidence of Stroke after Myocardial Infarction: A Meta-Analysis

2006 • 162 citations

Effect of hypertension on anticoagulated patients with atrial fibrillation

2007 • 162 citations

Smoking and Risk of Hemorrhagic Stroke in Women

2003 • 162 citations

Ischaemic stroke and combined oral contraceptives: results of an international, multicentre, case-control study. WHO Collaborative Study of Cardiovascular Disease and Steroid Hormone Contraception.

1996 • 161 citations

Infectious Burden and Risk of Stroke

2009 • 161 citations

POTASSIUM INTAKE, STROKE, AND CARDIOVASCULAR DISEASE: A META-ANALYSIS OF PROSPECTIVE STUDIES

2011 • 160 citations

Modeling of Risk Factors for Ischemic Stroke

1997 • 160 citations

Preadmission antithrombotic treatment and stroke severity in patients with atrial fibrillation and acute ischaemic stroke: an observational study

2006 • 160 citations

Ethnic differences in stroke mortality between non-Hispanic whites, Hispanic whites, and blacks. The National Longitudinal Mortality Study.

1994 • 159 citations

Frequency of Left Ventricular Thrombus in Patients With Anterior Wall Acute Myocardial Infarction Treated With Percutaneous Coronary Intervention and Dual Antiplatelet Therapy

2010 • 159 citations

Cardiovascular Risk Assessment Based on US Cohort Studies

2001 • 159 citations

Inherited Thrombophilia in Ischemic Stroke and Its Pathogenic Subtypes

2001 • 158 citations

An Evidence-Based Alcohol Screening, Brief Intervention and Referral to Treatment (SBIRT) Curriculum for Emergency Department (ED) Providers Improves Skills and Utilization

2007 • 157 citations

Migraine frequency and risk of cardiovascular disease in women

2009 • 157 citations

Interventions to improve use of continuous positive airway pressure for obstructive sleep apnoea

2004 • 156 citations

Application of Framingham risk estimates to ethnic minorities in United Kingdom and implications for primary prevention of heart disease in general practice: cross sectional population based study

2002 • 155 citations

A comparison of prevalence estimates for selected health indicators and chronic diseases or conditions from the Behavioral Risk Factor Surveillance System, the National Health Interview Survey, and the National Health and Nutrition Examination Survey, 2007–2008

2012 • 155 citations

Comparisons of high-dose and combination nicotine replacement therapy, varenicline, and bupropion for smoking cessation: A systematic review and multiple treatment meta-analysis

2012 • 154 citations

MR Imaging of Carotid Plaque Composition During Lipid-Lowering Therapy

2011 • 154 citations

Incidence and Risk Factors for Stroke in American Indians

2008 • 154 citations

Impact of Mitral Annular Calcification on Cardiovascular Events in a Multiethnic Community

2008 • 153 citations

Cholesterol and the Risk of Ischemic Stroke

2003 • 153 citations

High-Density Lipoprotein Cholesterol and Risk of Ischemic Stroke Mortality

1997 • 152 citations

Smoking and Elevated Blood Pressure Are the Most Important Risk Factors for Subarachnoid Hemorrhage in the Asia-Pacific Region

2005 • 151 citations

Patent Foramen Ovale and Migraine

2008 • 150 citations

Cigarette Smoking and Stroke in a Cohort of U.S. Male Physicians

1994 • 150 citations

Fibromuscular dysplasia

2000 • 149 citations

Efficacy of Homocysteine-Lowering Therapy With Folic Acid in Stroke Prevention

2010 • 149 citations

Aspirin for primary prevention of cardiovascular events in patients with diabetes: A meta-analysis

2009 • 149 citations

Pressure modification for improving usage of continuous positive airway pressure machines in adults with obstructive sleep apnoea

2009 • 148 citations

Recommendations on the Risk of Ischaemic Stroke Associated With Use of Combined Oral Contraceptives and Hormone Replacement Therapy in Women With Migraine

2000 • 148 citations

G6PD deficiency, absence of α-thalassemia, and hemolytic rate at baseline are significant independent risk factors for abnormally high cerebral velocities in patients with sickle cell anemia

2008 • 147 citations

Factors Explaining Excess Stroke Prevalence in the US Stroke Belt

2009 • 147 citations

Oral contraception and stroke. Evidence from the Royal College of General Practitioners' Oral Contraception Study.

1994 • 146 citations

Maintained intentional weight loss reduces cardiovascular outcomes: results from the Sibutramine Cardiovascular OUTcomes (SCOUT) trial

2011 • 145 citations

Utilities for major stroke: Results from a survey of preferences among persons at increased risk for stroke

1998 • 145 citations

Antiphospholipid Antibodies and Stroke in Young Women

2002 • 144 citations

Total Homocyst(e)ine Concentration and the Likelihood of Nonfatal Stroke

1998 • 144 citations

Intensive statin therapy compared with moderate dosing for prevention of cardiovascular events: a meta-analysis of &gt;40 000 patients

2011 • 144 citations

Malaria Surveillance—United States, 2013

2016 • 142 citations

Stroke in Young Women Who Use Cocaine or Amphetamines

1998 • 142 citations

Total and HDL cholesterol and risk of stroke. EUROSTROKE: a collaborative study among research centres in Europe

2002 • 141 citations

Prevalence of cerebral aneurysms in patients with fibromuscular dysplasia: a reassessment

1998 • 141 citations

Low-Density Lipoprotein Cholesterol Concentrations and Death Due to Intraparenchymal Hemorrhage

2009 • 141 citations

Low serum cholesterol and haemorrhagic stroke in men: Korea Medical Insurance Corporation Study

2001 • 141 citations

Hospital Admissions for Acute Myocardial Infarction, Angina, Stroke, and Asthma After Implementation of Arizona's Comprehensive Statewide Smoking Ban

2010 • 141 citations

Efficacy of statins for primary prevention in people at low cardiovascular risk: a meta-analysis

2011 • 140 citations

Plasma Concentration of Lipoprotein(a) and the Risk of Future Stroke

1995 • 140 citations

Epidemic of illicit drug use, mechanisms of action/addiction and stroke as a health hazard

2011 • 139 citations

Interventions to Increase Recommendation and Delivery of Screening for Breast, Cervical, and Colorectal Cancers by Healthcare Providers

2008 • 139 citations

Cerebrovascular disease related to COL4A1 mutations in HANAC syndrome

2009 • 139 citations

Association between genetic variant on chromosome 12p13 and stroke survival and recurrence: a one year prospective study in Taiwan

2012 • 138 citations

Low Total Serum Cholesterol and Intracerebral Hemorrhagic Stroke: Is the Association Confined to Elderly Men?

1996 • 138 citations

Inhibition of Plasminogen Activation by Lipoprotein(a)

2003 • 138 citations

Risk Factor Associations With the Presence of a Lipid Core in Carotid Plaque of Asymptomatic Individuals Using High-Resolution MRI

2008 • 138 citations

Trends in ATP-III-Defined High Blood Cholesterol Prevalence, Awareness, Treatment and Control Among U.S. Adults

2007 • 137 citations

Genetic predictors for stroke in children with sickle cell anemia

2011 • 136 citations

Morphology of the Patent Foramen Ovale in Asymptomatic Versus Symptomatic (Stroke or Transient Ischemic Attack) Patients

2008 • 136 citations

Impaired Glucose Tolerance Increases Stroke Risk in Nondiabetic Patients With Transient Ischemic Attack or Minor Ischemic Stroke

2006 • 136 citations

Lipid management in the prevention of stroke: a meta-analysis of fibrates for stroke prevention

2013 • 136 citations

Passive Smoking and Risk of Peripheral Arterial Disease and Ischemic Stroke in Chinese Women Who Never Smoked

2008 • 136 citations

Influenza Vaccination Is Associated With a Reduced Risk of Stroke

2005 • 136 citations

Deaths: leading causes for 2007.

2011 • 135 citations

Cerebrovascular Complications of Methamphetamine Abuse

2009 • 135 citations

Circadian Variation of Paroxysmal Atrial Fibrillation

1997 • 135 citations

Animal Protein, Animal Fat, and Cholesterol Intakes and Risk of Cerebral Infarction Mortality in the Adult Health Study

2004 • 134 citations

Antithrombotic therapy in patients treated with oral anticoagulation undergoing coronary artery stenting. An expert consensus document with focus on atrial fibrillation

2008 • 133 citations

Carotid artery stenting has increased rates of postprocedure stroke, death, and resource utilization than does carotid endarterectomy in the United States, 2005

2008 • 132 citations

Papillary fibroelastoma: increasing recognition of a surgical disease

1999 • 131 citations

Net Clinical Benefit of Adding Clopidogrel to Aspirin Therapy in Patients With Atrial Fibrillation for Whom Vitamin K Antagonists Are Unsuitable

2011 • 131 citations

Blood pressure is linked to salt intake and modulated by the angiotensinogen gene in normotensive and hypertensive elderly subjects

2001 • 131 citations

High-Density Lipoprotein Cholesterol and Risk of Stroke in Japanese Men and Women

2003 • 131 citations

Diabetes, Fasting Glucose Levels, and Risk of Ischemic Stroke and Vascular Events

2008 • 130 citations

Inclusion of Stroke in Cardiovascular Risk Prediction Instruments

2012 • 129 citations

Components of the Metabolic Syndrome and Risk for First-Ever Acute Ischemic Nonembolic Stroke in Elderly Subjects

2005 • 129 citations

Ischemic Stroke in Young Women

2004 • 128 citations

Meta‐analysis of complications in aortic valve replacement: Comparison of Medtronic‐Corevalve, Edwards‐Sapien and surgical aortic valve replacement in 8,536 patients

2012 • 128 citations

Abdominal obesity in the United States: prevalence and attributable risk of hypertension

1999 • 128 citations

Trend of Stroke Hospitalization, United States, 1988–1997

2001 • 127 citations

Increased incidence of nonfatal cardiovascular events in stroke patients with sleep apnoea: effect of CPAP treatment

2011 • 127 citations

Clinicopathologic Study and DNA Analysis of 37 Cardiac Myxomas

2003 • 127 citations

Aortic atheroma morphology and the risk of ischemic stroke in a multiethnic population

2000 • 126 citations

High-Dose B Vitamin Supplementation and Progression of Subclinical Atherosclerosis

2009 • 125 citations

Cost-effectiveness of dabigatran etexilate for the prevention of stroke and systemic embolism in UK patients with atrial fibrillation

2012 • 125 citations

Triggers of Ischemic Stroke

2010 • 125 citations

Cardiogenic and Aortogenic Brain Embolism

2008 • 124 citations

Exploring the relationship between alcohol consumption and non‐fatal or fatal stroke: a systematic review

2001 • 124 citations

Alcohol Drinking and Cardiovascular Risk in a Population With High Mean Alcohol Consumption

2008 • 124 citations

Relative Risks for Stroke by Age, Sex, and Population Based on Follow-Up of 18 European Populations in the MORGAM Project

2009 • 124 citations

Intracerebral haemorrhage and drug abuse in young adults

2000 • 122 citations

Alcohol Consumption, Blood Pressure, and the Risk of Stroke

2011 • 122 citations

Anticardiolipin Antibodies and Risk of Ischemic Stroke and Transient Ischemic Attack

2004 • 121 citations

Platelet-leukocyte interaction and platelet activation in migraine: a link to ischemic stroke?

2004 • 121 citations

A stroke prediction score in the elderly

2002 • 120 citations

Randomised evaluation of alternative electrosurgical modalities to treat bladder outflow obstruction in men with benign prostatic hyperplasia

2005 • 120 citations

Ischemic stroke risk and passive exposure to spouses' cigarette smoking. Melbourne Stroke Risk Factor Study (MERFS) Group.

1999 • 119 citations

Lipoprotein(a) and Incident Ischemic Stroke

2006 • 118 citations

Stroke in Women

1999 • 118 citations

Improving Blood Pressure Control Through a Clinical Pharmacist Outreach Program in Patients With Diabetes Mellitus in 2 High-Performing Health Systems

2012 • 118 citations

Prevalence of Sleep Apnea Syndrome in Lone Atrial Fibrillation

2004 • 118 citations

Black-white differences in stroke incidence in a national sample. The contribution of hypertension and diabetes mellitus

1990 • 118 citations

Hyperinsulinemia and the Risk of Stroke in Healthy Middle-Aged Men

1998 • 117 citations

Medical Treatment for Stroke Prevention

1994 • 117 citations

Impact of influenza vaccination on major cause-specific mortality

2006 • 117 citations

Stroke prevention

2000 • 116 citations

Evaluation of lipoprotein(a) as a prothrombotic factor: progress from bench to bedside

2003 • 116 citations

Migraine and risk of haemorrhagic stroke in women: prospective cohort study

2010 • 115 citations

Efficacy and Safety of Dabigatran vs. Warfarin in Patients With Atrial Fibrillation - Sub-Analysis in Japanese Population in RE-LY Trial -

2011 • 115 citations

Homocysteine-Lowering Vitamin B Treatment Decreases Cardiovascular Events in Hemodialysis Patients

2006 • 115 citations

Prospective Study of Serum Homocysteine and Risk of Ischemic Stroke Among Patients With Preexisting Coronary Heart Disease

2003 • 115 citations

Weekly alcohol consumption, cigarette smoking, and the risk of ischemic stroke

1989 • 113 citations

Heparin-induced thrombocytopenia: in vitro studies on the interaction of dabigatran, rivaroxaban, and low-sulfated heparin, with platelet factor 4 and anti-PF4/heparin antibodies

2011 • 113 citations

The Anglo-Scandinavian Cardiac Outcomes Trial: blood pressure-lowering limb: effects in patients with type II diabetes

2008 • 113 citations

Cholesterol Predicts Stroke Mortality in the Women’s Pooling Project

2002 • 113 citations

Prothrombotic conditions, oral contraceptives, and the risk of ischemic stroke

2005 • 112 citations

Heart and tumors: location, metastasis, clinical manifestations, diagnostic approaches and therapeutic considerations

2008 • 112 citations

Population-Based Study of the Relationship Between Patent Foramen Ovale and Cerebrovascular Ischemic Events

2006 • 112 citations

Perindopril-Based Blood Pressure–Lowering Reduces Major Vascular Events in Patients With Atrial Fibrillation and Prior Stroke or Transient Ischemic Attack

2005 • 112 citations

Prothrombin 20210A Mutation

2004 • 111 citations

Effects of Habitual Alcohol Intake on Ambulatory Blood Pressure, Heart Rate, and Its Variability Among Japanese Men

2008 • 111 citations

Illicit drug‐associated ischemic stroke in the Baltimore‐Washington Young Stroke Study

1998 • 110 citations

Hospitalization for Infection and Risk of Acute Ischemic Stroke

2011 • 110 citations

Sex Differences in Heritability of Ischemic Stroke

2007 • 109 citations

Prothrombotic abnormalities in childhood ischaemic stroke

2005 • 109 citations

Influenza Vaccination as Secondary Prevention for Cardiovascular Disease

2006 • 108 citations

Cost-Effectiveness of Dabigatran Compared With Warfarin for Stroke Prevention in Patients With Atrial Fibrillation and Prior Stroke or Transient Ischemic Attack

2012 • 108 citations

Intracerebral Hemorrhage in Cocaine Users

2010 • 108 citations

Determinants of black-white differences in the risk of cerebral infarction. The National Health and Nutrition Examination Survey Epidemiologic Follow-up Study

1995 • 107 citations

Risk of Stroke and Cardiovascular Events After Ischemic Stroke or Transient Ischemic Attack in Patients With Type 2 Diabetes or Metabolic Syndrome

2011 • 107 citations

Incidence of early left ventricular thrombus after acute anterior wall myocardial infarction in the primary coronary intervention era

2009 • 107 citations

Association of Khat Chewing With Increased Risk of Stroke and Death in Patients Presenting With Acute Coronary Syndrome

2010 • 107 citations

Antibiotic Therapy After Acute Myocardial Infarction

2003 • 107 citations

Alcohol Intake, Type of Beverage, and the Risk of Cerebral Infarction in Young Women

2001 • 107 citations

Prenatal Influences on Stroke Mortality in England and Wales

2003 • 107 citations

Prevention of cardiovascular events with calcium channel blocker-based combination therapies in patients with hypertension

2011 • 107 citations

The Safety of Dedicated-Team Catheter-Based Diagnostic Cerebral Angiography in the Era of Advanced Noninvasive Imaging

2009 • 106 citations

Yield of Transesophageal Echocardiography for Nonbacterial Thrombotic Endocarditis and Other Cardiac Sources of Embolism in Cancer Patients With Cerebral Ischemia

2006 • 106 citations

Surgical results: A justification of the surgeon selection process for the ACAS trial

1996 • 106 citations

Percutaneous Device Closure of Patent Foramen Ovale for Secondary Stroke Prevention

2009 • 106 citations

Haemorrhagic stroke, overall stroke risk, and combined oral contraceptives: results of an international, multicentre, case-control study. WHO Collaborative Study of Cardiovascular Disease and Steroid Hormone Contraception.

1996 • 105 citations

Race- and Sex-Specific Associations of Obesity Measures With Ischemic Stroke Incidence in the Atherosclerosis Risk in Communities (ARIC) Study

2010 • 104 citations

Enzyme replacement reverses abnormal cerebrovascular responses in Fabry disease

2002 • 104 citations

Status of Cardiovascular Health Among Adult Americans in the 50 States and the District of Columbia, 2009

2012 • 104 citations

Beneficial Postprandial Effect of a Small Amount of Alcohol on Diabetes and Cardiovascular Risk Factors: Modification by Insulin Resistance

2005 • 103 citations

Improving Global Vascular Risk Prediction With Behavioral and Anthropometric Factors

2009 • 103 citations

Effect of Raloxifene on Stroke and Venous Thromboembolism According to Subgroups in Postmenopausal Women at Increased Risk of Coronary Heart Disease

2008 • 103 citations

Cigarette Smoking, Systolic Blood Pressure, and Cardiovascular Diseases in the Asia-Pacific Region

2008 • 103 citations

Delivery of Optimized Anticoagulant Therapy: Consensus Statement from the Anticoagulation Forum

2008 • 102 citations

Aspirin for the Primary Prevention of Cardiovascular Events

2009 • 102 citations

Efficacy of folic acid supplementation in cardiovascular disease prevention: An updated meta-analysis of randomized controlled trials

2012 • 102 citations

Alpha Thalassemia is Associated With Decreased Risk of Abnormal Transcranial Doppler Ultrasonography in Children With Sickle Cell Anemia

2003 • 102 citations

Lack of Association Between Migraine Headache and Patent Foramen Ovale

2010 • 102 citations

Neurological Aspects of Substance Abuse

2004 • 101 citations

Trends in the Prevalence, Awareness, Treatment, and Control of Cardiovascular Disease Risk Factors among Noninstitutionalized Patients with a History of Myocardial Infarction and Stroke

2006 • 101 citations

Effect of Smoking on Cerebrovascular Reactivity

1996 • 100 citations

Stroke Prevention

1995 • 100 citations

Combined oral contraceptives, smoking, and cardiovascular risk

1998 • 100 citations

Advancing Evidence-Based Care For Diabetes: Lessons From The Veterans Health Administration

2007 • 100 citations

Beta-blockers for hypertension

2012 • 99 citations

Cohort Study of Exposure to Environmental Tobacco Smoke and Risk of First Ischemic Stroke and Transient Ischemic Attack

2004 • 99 citations

Lower prevalence of silent brain infarcts in the physically active

2011 • 98 citations

Is Ischemic Stroke Risk Related to Folate Status or Other Nutrients Correlated With Folate Intake?

2008 • 98 citations

Association of Passive Smoking by Husbands with Prevalence of Stroke among Chinese Women Nonsmokers

2005 • 97 citations

Moderate to high intensity conditioning leisure time physical activity and high cardiorespiratory fitness are associated with reduced plasma fibrinogen in Eastern Finnish men

1993 • 97 citations

Multistate improvement in process and outcomes of carotid endarterectomy

2004 • 96 citations

High-Density Lipoprotein Cholesterol

2007 • 96 citations

CADASIL: hereditary disease of arteries causing brain infarcts and dementia

1999 • 95 citations

Tobacco Control Interventions in the Emergency Department: A Joint Statement of Emergency Medicine Organizations

2006 • 95 citations

Cannabis-Related Stroke: Case Series and Review of Literature

2011 • 94 citations

Glucose levels are associated with cardiovascular disease and death in an international cohort of normal glycaemic and dysglycaemic men and women: the EpiDREAM cohort study

2011 • 94 citations

Cerebral embolization during cardiac surgery: impact of aortic atheroma burden

2003 • 94 citations

Progression Rate and Ipsilateral Neurological Events in Asymptomatic Carotid Stenosis

2011 • 93 citations

Lipoprotein-Associated Phospholipase A 2 and High-Sensitivity C-Reactive Protein Improve the Stratification of Ischemic Stroke Risk in the Atherosclerosis Risk in Communities (ARIC) Study

2008 • 93 citations

Cholesterol-Lowering Interventions and Stroke

2010 • 93 citations

Alcohol Drinking and Risk of Hemorrhagic Stroke

2002 • 93 citations

Lipid-Related Markers and Cardiovascular Disease Prediction

2012 • 93 citations

Confirmation of an Association Between the TNF(−308) Promoter Polymorphism and Stroke Risk in Children With Sickle Cell Anemia

2007 • 93 citations

Increased incidence of and impaired prognosis after acute myocardial infarction among patients with seropositive rheumatoid arthritis

2006 • 93 citations

The Metabolic Syndrome Predicts Incident Stroke

2008 • 92 citations

Snoring, daytime sleepiness and stroke: a case–control study of first‐ever stroke

2003 • 92 citations

Evaluation of a comprehensive transcranial doppler screening program for children with sickle cell anemia

2007 • 92 citations

Serum total cholesterol levels and risk of mortality from stroke and coronary heart disease in Japanese: The JACC study

2006 • 92 citations

Subarachnoid Hemorrhage and Family History

1995 • 91 citations

Empirically supported substance abuse treatment approaches: A survey of treatment providers' perspectives and practices

2007 • 91 citations

Spontaneous Intracerebral Hemorrhage Related to Methamphetamine Abuse

2004 • 91 citations

Screening for Carotid Artery Stenosis: U.S. Preventive Services Task Force Recommendation Statement

2007 • 91 citations

Hydroxyurea therapy lowers TCD velocities in children with sickle cell disease

2006 • 91 citations

Comparative effectiveness of antihypertensive medication for primary prevention of cardiovascular disease: systematic review and multiple treatments meta-analysis

2012 • 91 citations

Folate, Vitamin B 12 , and Risk of Ischemic and Hemorrhagic Stroke

2005 • 89 citations

Cerebral Ischemic Events After Diagnosis of Mitral Valve Prolapse

2003 • 89 citations

Racial Differences in Risks for First Cardiovascular Events and Noncardiovascular Death

2012 • 89 citations

Oral Contraceptives and the Absolute Risk of Venous Thromboembolism in Women With Single or Multiple Thrombophilic Defects

2007 • 89 citations

Alcohol consumption and risk for stroke among Chinese men

2007 • 88 citations

Alcohol drinking and risk of hospitalization for ischemic stroke

2001 • 88 citations

Risk Factors for Stroke in Blacks: A Critical Review

1999 • 88 citations

Evidence-based medication and revascularization: powerful tools in the management of patients with diabetes and coronary artery disease: a report from the Euro Heart Survey on diabetes and the heart

2008 • 88 citations

Risk of Stroke and Myocardial Infarction After Reduction or Cessation of Cigarette Smoking

2008 • 88 citations

A study of inbreeding and kinship in intracranial aneurysms in the Saguenay Lac‐Saint‐Jean region (Quebec, Canada)

1996 • 88 citations

Carotid endarterectomy was performed with lower stroke and death rates than carotid artery stenting in the United States in 2003 and 2004

2007 • 87 citations

Definitions of Risk

2001 • 86 citations

Low Birth Weight as a Risk Factor for Hypertension

2003 • 86 citations

Early differentiation of cardioembolic from atherothrombotic cerebral infarction: a multivariate analysis

1999 • 86 citations

Sleep-disordered breathing and chronic atrial fibrillation

2008 • 86 citations

Proinsulin and Insulin Concentrations in Relation to Carotid Wall Thickness

1998 • 86 citations

The Pathogenesis of Venous Thromboembolism: Evidence for Multiple Interrelated Causes

2006 • 86 citations

Risk of Ischemic Stroke Among Users of the Oral Contraceptive Pill

2003 • 85 citations

Long-term follow-up of pediatric sickle cell disease patients with abnormal high velocities on transcranial Doppler

2005 • 83 citations

Alcohol Consumption and Platelet Activation and Aggregation Among Women and Men: The Framingham Offspring Study

2005 • 83 citations

A multicenter validation study of Doppler ultrasound versus angiography

1991 • 83 citations

Infectious Burden and Carotid Plaque Thickness

2010 • 82 citations

Causal Relationship of Susceptibility Genes to Ischemic Stroke: Comparison to Ischemic Heart Disease and Biochemical Determinants

2010 • 82 citations

Failure to Validate Association between 12p13 Variants and Ischemic Stroke

2010 • 81 citations

Should Patients with Venous Thromboembolism Be Screened for Thrombophilia?

2008 • 81 citations

Correlation of bruits over the carotid artery with angiographically demonstrated lesions

1971 • 81 citations

Relationship of Alcohol Consumption and Type of Alcoholic Beverage Consumed With Plasma Lipid Levels: Differences Between Whites and African Americans of the ARIC Study

2007 • 81 citations

Influence of severity of anemia on clinical findings in infants with sickle cell anemia: Analyses from the BABY HUG study

2011 • 80 citations

Epidemiology of Stroke in Young Adults: Race/Ethnic Differences

2005 • 80 citations

Stroke Prevention by Cilostazol in Patients with Atherothrombosis: Meta-analysis of Placebo-controlled Randomized Trials

2009 • 80 citations

Alcohol consumption and the risk of incident atrial fibrillation among people with cardiovascular disease

2012 • 79 citations

Lipoprotein(a) and Asymptomatic Carotid Artery Disease

1995 • 79 citations

Process evaluation of a tailored multifaceted approach to changing family physician practice patterns improving preventive care.

2001 • 79 citations

Dietary Potassium Intake and Risk of Stroke

2011 • 78 citations

Elevated plasma YKL‐40 levels and ischemic stroke in the general population

2010 • 78 citations

Meta-Analysis of Factor V Leiden and Ischemic Stroke in Young Adults

2010 • 78 citations

Effects of High-Dose Atorvastatin on Cerebrovascular Events in Patients With Stable Coronary Disease in the TNT (Treating to New Targets) Study

2006 • 77 citations

Lipoprotein(a) Is Associated Differentially With Carotid Stenosis, Occlusion, and Total Plaque Area

2008 • 77 citations

High Salt Intake and Stroke: Meta‐analysis of the Epidemiologic Evidence

2012 • 77 citations

Magnetic resonance angiography‐defined intracranial vasculopathy is associated with silent cerebral infarcts and glucose‐6‐phosphate dehydrogenase mutation in children with sickle cell anaemia

2012 • 76 citations

The effect of long-term homocysteine-lowering on carotid intima-media thickness and flow-mediated vasodilation in stroke patients: a randomized controlled trial and meta-analysis

2008 • 75 citations

Association between change in plasma triglyceride levels and risk of stroke and carotid atherosclerosis

2010 • 75 citations

Constructing the Prediction Model for the Risk of Stroke in a Chinese Population

2010 • 74 citations

Antiplatelet therapy and the effects of B vitamins in patients with previous stroke or transient ischaemic attack: a post-hoc subanalysis of VITATOPS, a randomised, placebo-controlled trial

2012 • 74 citations

Nocturnal Oxygen Desaturation and Disordered Sleep as a Potential Factor in Executive Dysfunction in Sickle Cell Anemia

2011 • 74 citations

Effect of Antihypertensive Therapy on Incident Stroke in Cohorts With Prehypertensive Blood Pressure Levels

2011 • 73 citations

Left Atrial Appendage Occlusion — Closure or Just the Beginning?

2009 • 73 citations

Body Mass Index and Risk of Stroke and Myocardial Infarction in a Relatively Lean Population

2010 • 72 citations

Homocysteine or Renal Impairment

2008 • 71 citations

The onset of symptomatic atrial fibrillation and paroxysmal supraventricular tachycardia is characterized by different circadian rhythms

1993 • 71 citations

Patent Foramen Ovale, Ischemic Stroke and Migraine: Systematic Review and Stratified Meta-Analysis of Association Studies

2012 • 71 citations

A family study of anticardiolipin antibodies and associated clinical conditions

1995 • 70 citations

Discontinuing prophylactic transfusions increases the risk of silent brain infarction in children with sickle cell disease: data from STOP II

2011 • 70 citations

A Correlation of Neck Bruits and Arteriosclerotic Carotid Arteries

1973 • 69 citations

The new American Heart Association 2020 goal: achieving ideal cardiovascular health

2011 • 69 citations

High Proinsulin Levels Precede First-Ever Stroke in a Nondiabetic Population

2000 • 69 citations

Prehypertension, Racial Prevalence and Its Association With Risk Factors: Analysis of the REasons for Geographic And Racial Differences in Stroke (REGARDS) Study

2010 • 69 citations

Cardiorespiratory fitness and coronary heart disease risk factor association in women

1995 • 68 citations

Sustained Inhibition of Whole-Blood Clot Procoagulant Activity by Inhibition of Thrombus-Associated Factor Xa

1996 • 68 citations

National Survey of Preventive Health Services in US Emergency Departments

2010 • 68 citations

Use of oral contraceptives and hormone replacement therapy in the WHO MONICA project

2003 • 67 citations

Burden of atherosclerosis and risk of venous thromboembolism in patients with migraine

2008 • 67 citations

Angiotensin-converting enzyme inhibitors or angiotensin receptor blockers are beneficial in normotensive atherosclerotic patients: a collaborative meta-analysis of randomized trials

2011 • 67 citations

Temporal Trends in the Incidence and Case Fatality of Stroke in Children and Adolescents

2006 • 67 citations

Why is environmental tobacco smoke more strongly associated with coronary heart disease than expected? A review of potential biases and experimental data.

1999 • 66 citations

Prevalence of Atrial Fibrillation and Antithrombotic Prophylaxis in Emergency Department Patients

2002 • 66 citations

Atheroembolism in cardiac surgery

2003 • 65 citations

Risk factors profile and clinical outcome of ischemic stroke patients admitted in a Department of Internal Medicine and classified by TOAST classification.

2006 • 65 citations

A critical assessment of transcranial doppler screening rates in a large pediatric sickle cell center: Opportunities to improve healthcare quality

2008 • 65 citations

Inherited prothrombotic risk factors and cerebral venous thrombosis

1998 • 64 citations

Effects of Statins on Progression of Carotid Atherosclerosis as Measured By Carotid Intimal—Medial Thickness: A Meta-Analysis of Randomized Controlled Trials

2010 • 64 citations

Implications of Obstructive Sleep Apnea for Atrial Fibrillation and Sudden Cardiac Death

2008 • 64 citations

Impact of lower achieved blood pressure on outcomes in hypertensive patients

2012 • 63 citations

The effectiveness of personalized coronary heart disease and stroke risk communication

2011 • 63 citations

Cocaine-Induced Erythrocytosis and Increase in von Willebrand Factor

1999 • 62 citations

Value of Risk Stratification to Increase the Predictive Validity of HbA1c in Screening for Undiagnosed Diabetes in the US Population

2008 • 62 citations

Reduction in Incident Stroke Risk With Vigorous Physical Activity

2009 • 61 citations

Patent Foramen Ovale, Subclinical Cerebrovascular Disease, and Ischemic Stroke in a Population-Based Cohort

2013 • 60 citations

Percutaneous Device Closure of Patent Foramen Ovale for Secondary Stroke Prevention

2009 • 60 citations

Transcranial Doppler ultrasonography in adults with sickle cell disease

2006 • 60 citations

Genetics of blood pressure, hypertensive complications, and antihypertensive drug responses

2003 • 60 citations

Prevalence of Abnormal Glucose Metabolism and Insulin Resistance Among Subtypes of Ischemic Stroke in Japanese Patients

2009 • 60 citations

The metabolic syndrome predicts cardiovascular events in subjects with normal fasting glucose: Results of a 15 years follow-up in a Mediterranean population

2007 • 59 citations

Aspirin effect on the incidence of major adverse cardiovascular events in patients with diabetes mellitus: a systematic review and meta-analysis

2011 • 59 citations

Carotid bruit for detection of hemodynamically significant carotid stenosis: the Northern Manhattan Study

2009 • 59 citations

Influenza Vaccination and Major Adverse Vascular Events in High-Risk Patients

2012 • 58 citations

Elevated lipoprotein (a), small apolipoprotein (a), and the risk of arterial ischemic stroke in North American children

2013 • 58 citations

Reduced Poststroke Mortality in Patients With Stroke and Atrial Fibrillation Treated With Anticoagulants

2006 • 58 citations

Enhancing the Effectiveness of Community Stroke Risk Screening: A Randomized Controlled Trial

2010 • 58 citations

Synergistic Effect of Apolipoprotein E Polymorphisms and Cigarette Smoking on Risk of Ischemic Stroke in Young Adults

2004 • 58 citations

Anticardiolipin Antibodies and Mortality in Patients with Ischemic Stroke: A Prospective Follow-Up Study

2002 • 58 citations

Diabetes and Glucose Intolerance as Risk Factors for Stroke

1999 • 57 citations

Cerebral ischemic attacks as a complication of aortic and mitral valve prolapse.

1985 • 57 citations

Associations of plasma homocysteine and the methylenetetrahydrofolate reductase C677T polymorphism with carotid intima media thickness among South Asian, Chinese and European Canadians

2004 • 57 citations

Elevated blood flow velocity in the anterior cerebral artery and stroke risk in sickle cell disease: extended analysis from the STOP trial

2006 • 57 citations

Results from the Estonian postmenopausal hormone therapy trial [ISRCTN35338757]

2006 • 57 citations

The impact of standardized stroke orders on adherence to best practices

2005 • 57 citations

Sleep-disordered breathing and stroke.

2003 • 56 citations

Enzyme replacement therapy in Anderson-Fabry's disease: beneficial clinical effect on vital organ function

2002 • 56 citations

Impaired Glucose Tolerance and the Likelihood of Nonfatal Stroke and Myocardial Infarction

1998 • 56 citations

Lipoprotein-associated phospholipase A2 (Lp-PLA2): a review of its role and significance as a cardiovascular biomarker

2012 • 56 citations

Cigarette Smoking Among Spouses

2005 • 56 citations

Impact of Nativity and Race on “Stroke Belt” Mortality

1999 • 55 citations

Contemporary Results of Carotid Endarterectomy for Asymptomatic Carotid Stenosis

2010 • 55 citations

Impaired glucose tolerance is a risk factor for stroke in a Japanese sample—the Funagata study

2008 • 55 citations

Effect of a Pharmacist‐Managed Hypertension Program on Health System Costs: An Evaluation of the Study of Cardiovascular Risk Intervention by Pharmacists—Hypertension (<scp>SCRIP</scp>‐<scp>HTN</scp>)

2012 • 54 citations

A Randomized Trial of a Multicomponent Cessation Strategy for Emergency Department Smokers

2011 • 54 citations

Alcohol Consumption and Risk of Stroke in Women

2012 • 53 citations

Risks for cardiovascular disease, stroke, ischaemic heart disease, and diabetes mellitus associated with the metabolic syndrome using the new harmonised definition: Findings from nationally representative longitudinal data from an Asian population

2010 • 53 citations

Cannabis-Related Myocardial Infarction and Cardioembolic Stroke

2010 • 52 citations

The Metabolic Syndrome and Cardiovascular Disease: Part 2

2008 • 52 citations

Serum lipoprotein(a) levels and apolipoprotein(a) isoform size and risk for first-ever acute ischaemic nonembolic stroke in elderly individuals

2005 • 52 citations

Association of Sleep-Disordered Breathing and Ventricular Arrhythmias in Patients Without Heart Failure

2008 • 51 citations

Increased number of circulating endothelial cells and plasma markers of endothelial damage in chronic cocaine users

2011 • 51 citations

Multifaceted implementation of stroke prevention guidelines in primary care: cluster-randomised evaluation of clinical and cost effectiveness

2007 • 51 citations

Risk factors for cryptogenic ischaemic stroke

2002 • 51 citations

Patients Living in Impoverished Areas Have More Severe Ischemic Strokes

2012 • 51 citations

Measures of Adiposity and Future Risk of Ischemic Stroke and Coronary Heart Disease in Older Men and Women

2010 • 51 citations

Rare Bleeding Disorders in Children: Identification and Primary Care Management

2013 • 51 citations

Cardiovascular Disease Risk of Abdominal Obesity vs. Metabolic Abnormalities

2010 • 51 citations

Effect of folic acid supplementation on the progression of carotid intima-media thickness: A meta-analysis of randomized controlled trials

2011 • 50 citations

Screening for Type 2 diabetes in the accident and emergency department

2005 • 49 citations

ACE D/I polymorphism, migraine, and cardiovascular disease in women

2009 • 49 citations

Does achieving an intensive versus usual blood pressure level prevent stroke?

2011 • 49 citations

Tobacco Control Interventions in the Emergency Department: A Joint Statement of Emergency Medicine Organizations

2006 • 49 citations

Evaluating Rivaroxaban for Nonvalvular Atrial Fibrillation — Regulatory Considerations

2011 • 49 citations

Cost-effectiveness of varenicline compared with nicotine patches for smoking cessation—results from four European countries

2009 • 48 citations

Migraine, Migraine Features, and Cardiovascular Disease

2010 • 48 citations

Combination Antiplatelet Therapy for Secondary Stroke Prevention: Enhanced Efficacy or Double Trouble?

2009 • 48 citations

MANAGEMENT OF THROMBOSIS IN ANTIPHOSPHOLIPID ANTIBODY SYNDROME

2001 • 47 citations

Can peak systolic velocities be used for prediction of stroke in sickle cell anemia?

2004 • 47 citations

Population-Wide Sodium Reduction: The Bumpy Road from Evidence to Policy

2012 • 47 citations

Folate Intake and Risk of Stroke Among Women

2004 • 47 citations

Relationship Between Insulin and Carotid Atherosclerosis in the General Population

1997 • 47 citations

Changes in the Use of Carotid Revascularization Among the Medicare Population

2008 • 46 citations

The Influence of Oseltamivir Treatment on the Risk of Stroke after Influenza Infection

2008 • 46 citations

Influences of Gender and Age on Relationships Between Alcohol Drinking and Atherosclerotic Risk Factors

2008 • 46 citations

Metabolic syndrome (MetS) predicts cardio and cerebrovascular events in a twenty years follow-up. A prospective study

2012 • 46 citations

Differences in intracerebral hemorrhage between Mexican Americans and non-Hispanic whites

2006 • 46 citations

Cerebrovascular disease and sleep

2004 • 46 citations

Burden of Risk Alleles for Hypertension Increases Risk of Intracerebral Hemorrhage

2012 • 45 citations

Health promotion practices of emergency physicians

2000 • 45 citations

Sleep-disordered breathing and stroke

2003 • 45 citations

Cervical carotid artery disease in sickle cell anemia: clinical and radiological features

2011 • 45 citations

Heavy alcohol intake and intracerebral hemorrhage

2012 • 45 citations

High reticulocyte count is an independent risk factor for cerebrovascular disease in children with sickle cell anemia

2010 • 44 citations

Two Self-management Interventions to Improve Hypertension Control

2020 • 44 citations

Alcohol consumption and cerebral blood flow among older adults

2008 • 43 citations

The Risk of Intracerebral Haemorrhage with Smoking

1999 • 43 citations

Migraine and cardiovascular disease in women and the role of aspirin: Subgroup analyses in the Women’s Health Study

2011 • 43 citations

Secondary Prevention of Atherothrombotic Events After Ischemic Stroke

2009 • 43 citations

Low-Dose Aspirin for Primary Prevention of Cardiovascular Events in Patients With Diabetes: A Meta-Analysis

2010 • 43 citations

Pediatric Stroke Initiatives and Preliminary Studies: What Is Known and What Is Needed?

2006 • 42 citations

Prognosis in Patients with Atrial Fibrillation and CHA2DS2‐VASc Score = 0 in a Community‐Based Cohort Study

2012 • 42 citations

Recurrent stroke and vascular events in elderly patients with anticardiolipin antibodies: a prospective study

2001 • 42 citations

Correlations between plasma homocysteine and folate concentrations and carotid atherosclerosis in high-risk individuals: baseline data from the Homocysteine and Atherosclerosis Reduction Trial (HART)

2008 • 41 citations

Synergism between smoking and vital exhaustion in the risk of Ischemic stroke: evidence from the ARIC study

2004 • 41 citations

A Prospective Study of Fasting Plasma Glucose and Risk of Stroke in Asymptomatic Men

2011 • 41 citations

Population-Based Study of the Relationship Between Atherosclerotic Aortic Debris and Cerebrovascular Ischemic Events

2006 • 41 citations

A Simple Index Using Age, Hemoglobin, and Aspartate Transaminase Predicts Increased Intracerebral Blood Velocity as Measured by Transcranial Doppler Scanning in Children With Sickle Cell Anemia

2008 • 41 citations

Patient-Specific Decision-Making for Warfarin Therapy in Nonvalvular Atrial Fibrillation

2008 • 41 citations

Potassium prevents death from strokes in hypertensive rats without lowering blood pressure.

1984 • 41 citations

Kaiser Permanente’s Performance Improvement System, Part 1: From Benchmarking to Executing on Strategic Priorities

2010 • 40 citations

Alcohol consumption and risk of cardiovascular disease among hypertensive women

2010 • 40 citations

Effect of Aspirin Dose on Mortality and Cardiovascular Events in People with Diabetes: A Meta-Analysis

2011 • 40 citations

Treatment of asymptomatic carotid artery disease: Similar early outcomes after carotid stenting for high-risk patients and endarterectomy for standard-risk patients

2006 • 39 citations

Effect of low doses of ethanol on platelet function in long-life abstainers and moderate-wine drinkers

2003 • 39 citations

Adherence to transcranial Doppler screening guidelines among children with sickle cell disease

2012 • 39 citations

Multifaceted support to improve preventive cardiovascular care: a nationwide, controlled trial in general practice.

2003 • 39 citations

Migraine and hypercoagulable states in ischemic stroke

2011 • 38 citations

A revised definition of the metabolic syndrome predicts coronary artery disease and ischemic stroke after adjusting for low density lipoprotein cholesterol in a 13-year cohort study of Japanese: The Suita Study

2011 • 38 citations

Risk factors for subclinical carotid atherosclerosis in healthy men

2002 • 38 citations

Combination therapy for hypertension in the elderly: a sub-analysis of the Combination Therapy of Hypertension to Prevent Cardiovascular Events (COPE) Trial

2012 • 37 citations

Obesity as a risk factor for cerebrovascular disease

2004 • 36 citations

Body Mass Index and Risk of Total and Type-Specific Stroke in Chinese Adults: Results from a Longitudinal Study in China

2012 • 36 citations

A framework for health promoting emergency departments

2002 • 36 citations

Plasma glial fibrillary acidic protein levels in children with sickle cell disease

2011 • 36 citations

The Value of Adjuvant Treatment in Young Women with Breast Cancer

2002 • 35 citations

Genetic Predisposition to Stroke in Relatives of Hypertensives

2000 • 35 citations

A cluster randomised controlled trial of vascular risk factor management in general practice

2012 • 35 citations

Treatment of hypertension in the emergency department

2011 • 35 citations

Utility of Routine Testing for Patients With Asymptomatic Severe Blood Pressure Elevation in the Emergency Department

2007 • 34 citations

The family history of patients with primary or secondary antiphospholipid syndrome (APS)

2000 • 34 citations

Systematic review of alcohol screening tools for use in the emergency department

2010 • 34 citations

The Emergency Department Action in Smoking Cessation (EDASC) Trial: Impact on Delivery of Smoking Cessation Counseling

2012 • 33 citations

Higher lipoprotein (a) levels in atherothrombotic than lacunar ischemic cerebrovascular disease

2002 • 33 citations

Subclinical Hypertensive Heart Disease in Black Patients With Elevated Blood Pressure in an Inner-City Emergency Department

2012 • 33 citations

Abdominal and gynoid adiposity and the risk of stroke

2011 • 33 citations

Efficacy of Intensive Control of Glucose in Stroke Prevention: A Meta-Analysis of Data from 59197 Participants in 9 Randomized Controlled Trials

2013 • 33 citations

Intensive Blood Pressure Treatment Does Not Improve Cardiovascular Outcomes in Centrally Obese Hypertensive Individuals With Diabetes

2012 • 32 citations

Effectiveness of Stroke Education in the Emergency Department Waiting Room

2010 • 32 citations

Stroke Incidence in Older US Hispanics

2012 • 31 citations

Familial moyamoya disease in caucasians

2000 • 31 citations

Impact of Metabolic Syndrome Independent of Insulin Resistance on the Development of Cardiovascular Disease

2012 • 31 citations

Genetic Variant on Chromosome 12p13 Does Not Show Association to Ischemic Stroke in 3 Swedish Case-Control Studies

2010 • 30 citations

Knowledge Translation of the American College of Emergency Physicians Clinical Policy on Hypertension

2007 • 30 citations

Plasma interleukin-1β concentration is associated with stroke in sickle cell disease

2009 • 30 citations

The Reply

2008 • 30 citations

Society of Vascular Surgery Vascular Registry® comparison of carotid artery stenting outcomes for atherosclerotic vs nonatherosclerotic carotid artery disease

2010 • 29 citations

Transcranial Doppler in Adult Patients with Sickle Cell Disease

2005 • 29 citations

Assessment of Multiple Health Risks in a Single Obstructive Sleep Apnea Population

2012 • 28 citations

A Cost-Effectiveness Analysis of Carotid Artery Stenting Compared With Endarterectomy

2010 • 28 citations

Pharmacogenetic Effect of the Stromelysin (MMP3) Polymorphism on Stroke Risk in Relation to Antihypertensive Treatment

2010 • 28 citations

Improving delivery of preventive health care with the comprehensive annotated reminder tool (CART).

2001 • 28 citations

Trends in the Hospitalization of Ischemic Stroke in the United States, 1998–2007

2011 • 28 citations

Transesophageal echocardiography for the evaluation and management of patients with cerebral ischemia

1999 • 28 citations

Lipoprotein(a) associated with coronary artery disease in older women: age and gender analysis

2000 • 28 citations

Cardiac causes of stroke

2000 • 27 citations

Antihypertensive pharmacogenetic effect of fibrinogen-beta variant −455G&gt;A on cardiovascular disease, end-stage renal disease, and mortality: the GenHAT study

2009 • 27 citations

Economic Evaluation of Carotid Artery Stenting Versus Carotid Endarterectomy for the Treatment of Carotid Artery Stenosis

2007 • 26 citations

Meta-analysis of the cardiovascular benefits of intensive lipid lowering with statins

2010 • 26 citations

Heavy Drinking Is Associated with Poor Blood Pressure Control in the REasons for Geographic and Racial Differences in Stroke (REGARDS) Study

2011 • 25 citations

Warfarin after anterior myocardial infarction in current era of dual antiplatelet therapy: a randomized feasibility trial

2010 • 25 citations

Multicenter Survey of Emergency Physician Management and Referral for Hyperglycemia

2008 • 24 citations

Trends in comorbid sickle cell disease among stroke patients

2011 • 24 citations

Anatomical Variants of the Circle of Willis and Brain Lesions in Migraineurs

2011 • 24 citations

Racial residential segregation and stroke mortality in Atlanta.

2011 • 24 citations

Improving Female Preventive Health Care Delivery Through Practice Change: An Every Woman Matters Study

2005 • 23 citations

Asymptomatic carotid stenosis: What we can learn from the next generation of randomized clinical trials

2014 • 23 citations

Quality Improvement Initiatives Improve Hypertension Care Among Veterans

2009 • 22 citations

Exercise Reduces Age-dependent Decrease in Platelet Protein Kinase C Activity and Translocation

1995 • 22 citations

Management of patients with refractory migraine and PFO: Is MIST I Relevant?

2008 • 21 citations

Lifestyle Factors and Antihypertensive Treatment on the Risks of Ischemic and Hemorrhagic Stroke

2012 • 21 citations

Short-term exposure of platelets to glucose impairs inhibition of platelet aggregation by cyclooxygenase inhibitors

2011 • 21 citations

Thrombophilic screening in young patients (&lt;40years) with idiopathic ischemic stroke: A controlled study

2010 • 21 citations

Impaired glucose tolerance as a risk factor for stroke in a cohort of non-institutionalised people aged 70 years

2006 • 21 citations

Quality of stroke prevention in general practice: relationship with practice organization

2005 • 20 citations

Organized Blood Pressure Control Programs to Prevent Stroke in Australia

2012 • 20 citations

Effects of an Intervention Brochure on Emergency Department Patients' Safe Alcohol Use and Knowledge

2008 • 20 citations

Antiarrhythmic efficacy and hemodynamic effects of cibenzoline in patients with nonsustained ventricular tachycardia and left ventricular dysfunction.

1987 • 19 citations

Comparison of definitions of metabolic syndrome in relation to risk for coronary artery disease and stroke.

2011 • 19 citations

Comparison of Frequencies of Patent Foramen Ovale and Thoracic Aortic Atherosclerosis in Patients With Cryptogenic Ischemic Stroke Undergoing Transesophageal Echocardiography

2011 • 18 citations

Aspirin Reduces Cerebrovascular Events in Type 2 Diabetic Patients With Poorly Controlled Blood Pressure

2012 • 18 citations

Association between 1425G/A SNP in PRKCH and ischemic stroke among Chinese and Japanese populations: A meta-analysis including 3686 cases and 4589 controls

2011 • 17 citations

Childhood and Adult Social Conditions and Risk of Stroke

2012 • 16 citations

Obesity Screening in the Pediatric Emergency Department

2012 • 16 citations

Age at intracranial aneurysm rupture among generations

2009 • 15 citations

Alcohol consumption and the risk of stroke among hypertensive and overweight men

2012 • 15 citations

Superior Sagittal Sinus and Cerebral Cortical Venous Thrombosis Caused by Congenital Protein C Deficiency. Case Report.

2000 • 15 citations

Implementation of a simple age‐based strategy in the prevention of cardiovascular disease: the Polypill approach

2011 • 14 citations

A possible advance in arterial gene therapy for aortic complications in the Marfan syndrome by local transfer of an antisense Mg-dependent hammerhead ribozyme.

2001 • 14 citations

Cardiovascular risk: its assessment in clinical practice.

2001 • 14 citations

New data about stenting versus endarterectomy for symptomatic carotid artery stenosis

2009 • 14 citations

Prevention of stroke in chronic andrecurrent atrial fibrillation

2001 • 12 citations

Emergency Department Management of Patients on Warfarin Therapy

2011 • 12 citations

Screening for type 2 diabetes with random finger‐prick glucose and bedside HbA1c in an Australian emergency department

2010 • 12 citations

Introduction

2008 • 12 citations

The relationship between metabolic syndrome (MetS) and spontaneous intracerebral hemorrhage (ICH)

2012 • 12 citations

Genetic Susceptibility to Cerebrovascular Accidents

2001 • 11 citations

Screening for Illicit Drug Use

1991 • 10 citations

Risk of Metabolic Syndrome for Stroke Is Not Greater than the Sum of its Components: Thai Epidemiologic Stroke (TES) Study

2012 • 9 citations

The state of nutritional epidemiology: why we are still unsure of what we should eat?

2013 • 9 citations

A Pilot Study to Assess the Feasibility of a Multicenter Cluster Randomized Trial for the Management of Asymptomatic Persons with a Thrombophilia

2009 • 8 citations

Monitoring central venous pressure: principles, procedures and problems.

1976 • 6 citations

The Hypertension Management Program: Identifying Opportunities for Improvement

2003 • 6 citations

Introduction

2008 • 5 citations

Benefits associated with achieving optimal risk factor levels for the primary prevention of cardiovascular disease in older men

2011 • 5 citations

Community Level Disadvantage and the Likelihood of First Ischemic Stroke

2012 • 5 citations

Deleted Work

1955 • 0 citations

Cited By (0)

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Guidelines for the primary prevention of stroke: a statement for healthcare professionals… (2014) – Stroke | Metascience Observatory Explorer