Treatment of hematologic malignancies and solid tumors by inhibiting IGF receptor signaling

Activating Mutations in the Epidermal Growth Factor Receptor Underlying Responsiveness of Non–Small-Cell Lung Cancer to Gefitinib

2004 • 11,185 citations

EGFR Mutations in Lung Cancer: Correlation with Clinical Response to Gefitinib Therapy

2004 • 9,201 citations

EGF receptor gene mutations are common in lung cancers from “never smokers” and are associated with sensitivity of tumors to gefitinib and erlotinib

2004 • 4,293 citations

Effects of a selective inhibitor of the Abl tyrosine kinase on the growth of Bcr–Abl positive cells

1996 • 3,649 citations

Activity of a Specific Inhibitor of the BCR-ABL Tyrosine Kinase in the Blast Crisis of Chronic Myeloid Leukemia and Acute Lymphoblastic Leukemia with the Philadelphia Chromosome

2001 • 2,749 citations

Insulin-like growth factors and neoplasia

2004 • 1,452 citations

The insulin-like growth factor system and cancer

2003 • 1,099 citations

Molecular sequelae of proteasome inhibition in human multiple myeloma cells

2002 • 759 citations

Insulin-like Growth Factor (IGF)-binding Protein-3 Induces Apoptosis and Mediates the Effects of Transforming Growth Factor-β1 on Programmed Cell Death through a p53- and IGF-independent Mechanism

1997 • 725 citations

Inhibition of the insulin-like growth factor receptor-1 tyrosine kinase activity as a therapeutic strategy for multiple myeloma, other hematologic malignancies, and solid tumors

2004 • 621 citations

Structure and function of the type 1 insulin-like growth factor receptor

2000 • 602 citations

Structural biology of insulin and IGF1 receptors: implications for drug design

2002 • 577 citations

In vivo antitumor activity of NVP-AEW541—A novel, potent, and selective inhibitor of the IGF-IR kinase

2004 • 544 citations

Effect of a null mutation of the insulin-like growth factor I receptor gene on growth and transformation of mouse embryo fibroblasts.

1994 • 527 citations

Insulin-like growth factor binding protein 1 stimulates cell migration and binds to the alpha 5 beta 1 integrin by means of its Arg-Gly-Asp sequence.

1993 • 515 citations

Insulin/Insulin-like Growth Factor I Hybrid Receptors Have Different Biological Characteristics Depending on the Insulin Receptor Isoform Involved

2002 • 492 citations

Activation of NF-κB and upregulation of intracellular anti-apoptotic proteins via the IGF-1/Akt signaling in human multiple myeloma cells: therapeutic implications

2002 • 467 citations

Biological effects in vitro of monoclonal antibodies to human epidermal growth factor receptors.

1983 • 456 citations

Monoclonal antibodies to receptors for insulin and somatomedin-C.

1983 • 423 citations

Overexpression of the human insulinlike growth factor I receptor promotes ligand-dependent neoplastic transformation.

1990 • 404 citations

The insulin-like growth factor I receptor protects tumor cells from apoptosis in vivo.

1995 • 385 citations

Circulating insulin-like growth factor-I levels regulate colon cancer growth and metastasis.

2002 • 374 citations

Cyclolignans as Inhibitors of the Insulin-Like Growth Factor-1 Receptor and Malignant Cell Growth

2004 • 364 citations

Combination Therapy Enhances the Inhibition of Tumor Growth with the Fully Human Anti–Type 1 Insulin-Like Growth Factor Receptor Monoclonal Antibody CP-751,871

2005 • 363 citations

M6P/IGF2R gene is mutated in human hepatocellular carcinomas with loss of heterozygosity

1995 • 352 citations

A fully human monoclonal antibody to the insulin-like growth factor I receptor blocks ligand-dependent signaling and inhibits human tumor growth in vivo.

2003 • 352 citations

Insulin-Like Growth Factor (IGF) Binding Protein from Human Decidua Inhibits the Binding and Biological Action of IGF-I in Cultured Choriocarcinoma Cells**

1988 • 347 citations

Insulin-like growth factor-I receptor overexpression mediates cellular radioresistance and local breast cancer recurrence after lumpectomy and radiation.

1997 • 343 citations

Blockade of the type I somatomedin receptor inhibits growth of human breast cancer cells in athymic mice.

1989 • 334 citations

Elevated insulin receptor content in human breast cancer.

1990 • 332 citations

Insulin-like growth factor receptor expression and function in human breast cancer.

1990 • 321 citations

Insulin-Like Growth Factor I (IGF-I)-Binding Protein Complex Is a Better Mitogen than Free IGF-I*

1989 • 318 citations

Rat glioblastoma cells expressing an antisense RNA to the insulin-like growth factor-1 (IGF-1) receptor are nontumorigenic and induce regression of wild-type tumors.

1994 • 310 citations

Tissue-Specific Expression of Two Alternatively Spliced Insulin Receptor mRNAs in Man

1989 • 308 citations

An anti-insulin-like growth factor I receptor antibody that is a potent inhibitor of cancer cell proliferation.

2003 • 306 citations

A functional insulin-like growth factor I receptor is required for the mitogenic and transforming activities of the epidermal growth factor receptor.

1994 • 282 citations

A dominant negative mutant of the insulin-like growth factor-I receptor inhibits the adhesion, invasion, and metastasis of breast cancer.

1998 • 274 citations

Monoclonal antibody to the type I insulin-like growth factor (IGF-I) receptor blocks IGF-I receptor-mediated DNA synthesis: clarification of the mitogenic mechanisms of IGF-I and insulin in human skin fibroblasts.

1986 • 269 citations

Insulin and insulin-like growth factor-I (IGF-I) receptor overexpression in breast cancers leads to insulin/IGF-I hybrid receptor overexpression: evidence for a second mechanism of IGF-I signaling.

1999 • 254 citations

Role of tyrosine kinase activity in signal transduction by the insulin-like growth factor-I (IGF-I) receptor. Characterization of kinase-deficient IGF-I receptors and the action of an IGF-I-mimetic antibody (alpha IR-3).

1993 • 247 citations

Expression of insulin-like growth factor-1 receptor in human colorectal cancer

1999 • 238 citations

The Efficacy of Small Interfering RNAs Targeted to the Type 1 Insulin-like Growth Factor Receptor (IGF1R) Is Influenced by Secondary Structure in the IGF1R Transcript

2003 • 238 citations

Insulin-like growth factor II stimulates cell proliferation through the insulin receptor

1997 • 234 citations

Growth inhibition of human melanoma cells in nude mice by antisense strategies to the type 1 insulin-like growth factor receptor.

1994 • 234 citations

Growth inhibition of human breast cancer cells in vitro with an antibody against the type I somatomedin receptor.

1989 • 233 citations

Functional Polymorphism in the Parental Imprinting of the Human IGF2R Gene

1993 • 228 citations

Insulin-like growth factor I receptor-mediated circuit in Ewing's sarcoma/peripheral neuroectodermal tumor: a possible therapeutic target.

1996 • 225 citations

A recombinant humanized anti‐insulin‐like growth factor receptor type I antibody (h7C10) enhances the antitumor activity of vinorelbine and anti‐epidermal growth factor receptor therapy against human cancer xenografts

2004 • 218 citations

A Novel Autocrine Loop Involving IGF-II and the Insulin Receptor Isoform-A Stimulates Growth of Thyroid Cancer

2002 • 216 citations

Results of a Pilot Study Involving the Use of an Antisense Oligodeoxynucleotide Directed Against the Insulin-Like Growth Factor Type I Receptor in Malignant Astrocytomas

2001 • 214 citations

Loss of the gene encoding mannose 6-phosphate/insulin-like growth factor II receptor is an early event in liver carcinogenesis

1997 • 210 citations

M6P/IGF2 receptor: a candidate breast tumor suppressor gene.

1996 • 205 citations

Insulin receptor expression and function in human breast cancer cell lines.

1992 • 202 citations

Reduced circulating insulin-like growth factor I levels delay the onset of chemically and genetically induced mammary tumors.

2003 • 195 citations

A chimeric humanized single-chain antibody against the type I insulin-like growth factor (IGF) receptor renders breast cancer cells refractory to the mitogenic effects of IGF-I.

2003 • 189 citations

Distribution and Characterization of Insulin and Insulin-like Growth Factor I Receptors in Normal Human Ovary*

1985 • 182 citations

A Fully Human Recombinant IgG-like Bispecific Antibody to Both the Epidermal Growth Factor Receptor and the Insulin-like Growth Factor Receptor for Enhanced Antitumor Activity

2005 • 182 citations

Blockage of insulin-like growth factor-I receptor inhibits the growth of Ewing's sarcoma in athymic mice.

1998 • 181 citations

Insulin-like growth factor-1 receptor in uveal melanoma: a predictor for metastatic disease and a potential therapeutic target.

2002 • 177 citations

Correlation between apoptosis, tumorigenesis, and levels of insulin-like growth factor I receptors.

1995 • 172 citations

A Dominant Negative Type I Insulin-like Growth Factor Receptor Inhibits Metastasis of Human Cancer Cells

2004 • 166 citations

Characterization of an anti-p185HER2 monoclonal antibody that stimulates receptor function and inhibits tumor cell growth.

1991 • 163 citations

Reduced growth of human breast cancer xenografts in hosts homozygous for the lit mutation.

1996 • 160 citations

In IGF-I receptor-deficient leiomyosarcoma cells autocrine IGF-II induces cell invasion and protection from apoptosis via the insulin receptor isoform A

2002 • 156 citations

An antibody to the receptor for insulin-like growth factor I inhibits the growth of MCF-7 cells in tissue culture

1987 • 155 citations

Substrate Competitive Inhibitors of IGF-1 Receptor Kinase

2000 • 153 citations

Insulin-like Growth Factor Binding Protein-3 Induces Apoptosis in MCF7 Breast Cancer Cells

1997 • 152 citations

The type I insulin-like growth factor receptor is a motility receptor in human melanoma cells

1989 • 151 citations

Essential role of tyrosine residues 1131, 1135, and 1136 of the insulin-like growth factor-I (IGF-I) receptor in IGF-I action.

1994 • 145 citations

Growth factor receptors as therapeutic targets: strategies to inhibit the insulin-like growth factor I receptor

2003 • 144 citations

Inhibition of insulin-like growth factor I receptor increases the antitumor activity of doxorubicin and vincristine against Ewing's sarcoma cells.

2001 • 141 citations

Antitumor activity of the growth hormone receptor antagonist pegvisomant against human meningiomas in nude mice

2001 • 133 citations

Downregulation of the type 1 insulin-like growth factor receptor in mouse melanoma cells is associated with enhanced radiosensitivity and impaired activation of Atm kinase

2001 • 129 citations

Simultaneous Blockade of Both the Epidermal Growth Factor Receptor and the Insulin-like Growth Factor Receptor Signaling Pathways in Cancer Cells with a Fully Human Recombinant Bispecific Antibody

2004 • 129 citations

Regulation of breast cancer cell motility by insulin receptor substrate-2 (IRS-2) in metastatic variants of human breast cancer cell lines

2001 • 128 citations

Growth inhibition of MCF-7 breast cancer cells by stable expression of an insulin-like growth factor I receptor antisense ribonucleic acid.

1995 • 126 citations

Development of New Insulin-like Growth Factor-1 Receptor Kinase Inhibitors Using Catechol Mimics

2003 • 122 citations

Structure and function of the insulin-like growth factor I receptor

1998 • 122 citations

Insulin-like growth factor-II overexpression in MCF-7 cells induces phenotypic changes associated with malignant progression.

1992 • 120 citations

Activation of ErbB-2 via a hierarchical interaction between ErbB-2 and type I insulin-like growth factor receptor in mammary tumor cells

2001 • 120 citations

Growth-promoting effects of insulin-like growth factor-1 (IGF-1) on hematopoietic cells: overexpression of introduced IGF-1 receptor abrogates interleukin-3 dependency of murine factor-dependent cells by a ligand-dependent mechanism

1991 • 112 citations

Expression of insulin-like growth factor 1 receptor in primary breast cancer: Immunohistochemical analysis

2004 • 111 citations

The Role of Erlotinib (Tarceva, OSI 774) in the Treatment of Non-Small Cell Lung Cancer

2004 • 109 citations

Insulin-Like Growth Factor-Binding Protein 3 Induces Caspase-Dependent Apoptosis through a Death Receptor-Mediated Pathway in MCF-7 Human Breast Cancer Cells

2004 • 108 citations

Regulation of Insulin-Like Growth Factor-Binding Protein (IGFBP) Expression by Breast Cancer Cells: Use of IGFBP-1 as as Inhibitor of Insulin-like Growth Factor Action

1992 • 107 citations

M6P/IGF2R is mutated in squamous cell carcinoma of the lung

2000 • 106 citations

Effectiveness of insulin-like growth factor I receptor antisense strategy against Ewing's sarcoma cells

2002 • 105 citations

Inhibition of tumor growth by a dominant negative mutant of the insulin-like growth factor I receptor with a bystander effect.

1998 • 104 citations

The growth-stimulatory effect of simian virus 40 T antigen requires the interaction of insulinlike growth factor 1 with its receptor.

1992 • 99 citations

Regulation of Vascular Endothelial Growth Factor Expression by Insulin-Like Growth Factor I in Thyroid Carcinomas

2003 • 98 citations

Insulin-like growth factor-1 and its receptor mediate the autocrine proliferation of human ovarian carcinoma cell lines.

1993 • 98 citations

Antiproliferative action of tumor necrosis factor-alpha on MCF-7 breastcancer cells is associated with increased insulin-like growth factor binding protein-3 accumulation.

1998 • 96 citations

Insulinlike Growth Factor I: A Potent Mitogen for Human Osteogenic Sarcoma

1990 • 90 citations

Antibody to type I insulinlike growth factor receptor inhibits growth of Wilms' tumor in culture and in athymic mice.

1989 • 88 citations

Single-chain antibodies against human insulin-like growth factor I receptor: expression, purification, and effect on tumor growth

2000 • 87 citations

ASPB10 insulin induction of increased mitogenic responses and phenotypic changes in human breast epithelial cells: Evidence for enhanced interactions with the insulin-like growth factor-I receptor

1997 • 85 citations

Redundancy of autocrine loops in human osteosarcoma cells

1999 • 83 citations

The insulin-like growth factor 1 receptor is required for the proliferation of hemopoietic cells.

1992 • 82 citations

Activation of the IGF-IR system contributes to malignant growth of human and mouse medulloblastomas

2001 • 79 citations

Recombinant insulin‐like growth factor binding protein‐1 inhibits IGF‐I, serum, and estrogen‐dependent growth of MCF‐7 human breast cancer cells

1993 • 78 citations

The Role of the Insulin‐like Growth Factor‐I Receptor in Cancer

1995 • 78 citations

Insulin-like growth factor I receptors in normal and neoplastic human endometrium.

1990 • 77 citations

Vital factors in liver cancer

1996 • 75 citations

Regulation of Apo2L/Tumor Necrosis Factor-Related Apoptosis-Inducing Ligand-Induced Apoptosis in Thyroid Carcinoma Cells

2002 • 73 citations

A phase I trial of a Bcl-2 antisense (G3139) and weekly docetaxel in patients with advanced breast cancer and other solid tumors

2004 • 71 citations

Mechanisms of regulation of cell adhesion and motility by insulin receptor substrate-1 in prostate cancer cells

2001 • 70 citations

Insulin-like growth factor receptors and binding proteins

1996 • 68 citations

Differential roles of IRS-1 and SHC signaling pathways in breast cancer cells

1997 • 67 citations

Expression of Insulin-Like Growth Factor-1 Receptor (IGF-1R) and p27^Kip1in Melanocyte Tumors: A Potential Regulatory Role of IGF-1 Pathway in Distribution of p27^Kip1between Different Cyclins

2000 • 66 citations

Affinity for the insulin-like growth factor-II (IGF-II) receptor inhibits autocrine IGF-II activity in MCF-7 breast cancer cells.

1996 • 66 citations

Insulin-like growth factor binding protein-3 (IGFBP-3) potentiates paclitaxel-induced apoptosis in human breast cancer cells

2000 • 66 citations

Inhibition of in vivo breast cancer growth by antisense oligodeoxynucleotides to type I insulin-like growth factor receptor mRNA involves inactivation of ErbBs, PI-3K/Akt and p42/p44 MAPK signaling pathways but not modulation of progesterone receptor activity

2004 • 65 citations

Inhibition of hamster mesothelioma tumorigenesis by an antisense expression plasmid to the insulin-like growth factor-1 receptor.

1996 • 65 citations

Loss of heterozygosity at the mannose 6-phosphate insulin-like growth factor 2 receptor gene correlates with poor differentiation in early breast carcinomas

1997 • 64 citations

A randomized trial of tamoxifen alone or combined with octreotide in the treatment of women with metastatic breast carcinoma

1999 • 63 citations

Expression of the insulin-like growth factor I receptor C terminus as a myristylated protein leads to induction of apoptosis in tumor cells.

1998 • 60 citations

Insulin-like growth factor binding protein 1 expression inhibits insulin-like growth factor I action in MCF-7 breast cancer cells.

1994 • 59 citations

The role of the insulin-like growth factor I receptor in the transformation by simian virus 40 T antigen.

1994 • 58 citations

Proteinolytic activity against IGF-binding proteins involved in the paracrine interactions between prostate adenocarcinoma cells and osteoblasts.

1992 • 58 citations

The insulin‐like growth factor I receptor gene is the target for the 15q26 amplicon in breast cancer

1994 • 56 citations

Chemosensitization of human prostate cancer using antisense agents targeting the type 1 insulin‐like growth factor receptor

2003 • 56 citations

polyethylene glycol conjugated insulin-like growth factor binding protein-1 (IGFBP-1) inhibits growth of breast cancer in athymic mice

1997 • 56 citations

Inhibition of rat C6 glioblastoma tumor growth by expression of insulin-like growth factor I receptor antisense mRNA

1996 • 55 citations

Combination of Somatostatin Analog, Dexamethasone, and Standard Androgen Ablation Therapy in Stage D3 Prostate Cancer Patients with Bone Metastases

2004 • 54 citations

Growth regulation of human glioblastoma t98g cells by insulin‐like growth factor‐1 and its receptor

1994 • 53 citations

Regression of C6 rat brain tumors by cells expressing an antisense insulin-like growth factor I receptor RNA.

1996 • 51 citations

Inhibition of tumorigenesis and induction of apoptosis in human tumor cells by the stable expression of a myristylated COOH terminus of the insulin-like growth factor I receptor.

1998 • 51 citations

Effect of endocrine therapy on growth of T61 human breast cancer xenografts is directly correlated to a specific down-regulation of insulin-like growth factor II (IGF-II)

1993 • 48 citations

Inhibition of Cell Cycle Progression by Antisense Oligodeoxynucleotidesa

1992 • 48 citations

The insulin-like growth factor 1 receptor induces transformation and tumorigenicity of ovarian mesothelial cells and down-regulates their Fas-receptor expression.

1999 • 47 citations

Deletion of the M6P/IGF2r gene in primary hepatocellular carcinoma

1997 • 45 citations

Monoclonal antibody αIR-3 inhibits non-small cell lung cancer growth in vitro and in vivo

1996 • 45 citations

Insulin Stimulation of Aminoisobutyric Acid Transport in Human Skin Fibroblasts Is Mediated Through Both Insulin and Type I Insulin-Like Growth Factor Receptors*

1986 • 45 citations

Two New Monoclonal Antibodies against the α Subunit of the Human Insulin-like Growth Factor-I Receptor

1993 • 44 citations

Functional insulin receptors are overexpressed in thyroid tumors

1999 • 43 citations

Expression of the insulin-like growth factor-1 receptor and its anti-apoptotic effect in malignant melanoma: a potential therapeutic target

1998 • 42 citations

Expression of tyrosine kinases in human malignancies as potential targets for kinase-specific inhibitors

2004 • 41 citations

Effects of insulin-like growth factor receptor inhibition on human melanomas in culture and in athymic mice.

1993 • 39 citations

Insulin‐like growth factors modulate the growth inhibitory effects of retinoic acid on MCF‐7 breast cancer cells

1995 • 34 citations

Expression of the Insulin‐Like Growth Factor‐I Receptor and Proapoptotic Bax and Bak Proteins in Human Colorectal Cancer

2004 • 32 citations

Inhibition of Carcinoma Cell Growth and Metastasis by a Vesicular Stomatitis Virus G-Pseudotyped Retrovector Expressing Type I Insulin-Like Growth Factor Receptor Antisense

2001 • 30 citations

The Insulin-Like Growth Factor (IGF) Family and Breast Cancer

2003 • 25 citations

Evidence that Receptor Aggregation may Play a Role in Transmembrane Signaling through the Insulin-Like Growth Factor-I Receptor

1988 • 24 citations

IGFBPs and Breast Cancer

2003 • 12 citations

Pharmacokinetic profile of recombination human insulin-like growth factor binding protein-1 in athymic mice

1996 • 12 citations

The IGF Receptor as Anticancer Treatment Target

2004 • 11 citations

[Type I insulin-like growth factor receptor antisense strategies in experimental breast cancer].

2004 • 2 citations