The Role of the Insulin‐like Growth Factor‐I Receptor in Cancer

Mice carrying null mutations of the genes encoding insulin-like growth factor I (Igf-1) and type 1 IGF receptor (Igf1r)

1993 • 2,880 citations

Role of insulin-like growth factors in embryonic and postnatal growth

1993 • 2,349 citations

Insulin-Like Growth Factors I and II. Peptide, Messenger Ribonucleic Acid and Gene Structures, Serum, and Tissue Concentrations*

1989 • 1,796 citations

The insulin signaling system.

1994 • 1,733 citations

Molecular and Cellular Aspects of the Insulin-Like Growth Factor I Receptor

1995 • 1,361 citations

Insulin-like Growth Factor Binding Proteins

1993 • 754 citations

Insulin-like growth factors and cancer

1992 • 622 citations

Growth factors and the regulation of bone remodeling.

1988 • 614 citations

Binding of the Wilms' Tumor Locus Zinc Finger Protein to the EGR-1 Consensus Sequence

1990 • 588 citations

Simian virus 40 large tumor antigen is unable to transform mouse embryonic fibroblasts lacking type 1 insulin-like growth factor receptor.

1993 • 554 citations

Overexpression of the human insulinlike growth factor I receptor promotes ligand-dependent neoplastic transformation.

1990 • 404 citations

Increased expression of the insulin-like growth factor I receptor gene, IGF1R, in Wilms tumor is correlated with modulation of IGF1R promoter activity by the WT1 Wilms tumor gene product.

1993 • 268 citations

Inhibition of growth of prostatic cancer cell lines by peptide analogues of insulin-like growth factor 1.

1993 • 240 citations

Dominant negative inhibition of tumorigenesis in vivo by human insulin-like growth factor I receptor mutant.

1994 • 195 citations

Insulin-like growth factor II in human adrenal pheochromocytomas and Wilms tumors: expression at the mRNA and protein level.

1987 • 191 citations

Inhibition of cellular proliferation by peptide analogues of insulin-like growth factor 1.

1992 • 183 citations

Insulin-like Growth Factors in Health and Disease

1992 • 164 citations

Transcriptional repression of the insulin-like growth factor I receptor (IGF-I-R) gene by the tumor suppressor WT1 involves binding to sequences both upstream and downstream of the IGF-I-R gene transcription start site.

1994 • 154 citations

The type I insulin-like growth factor receptor is a motility receptor in human melanoma cells

1989 • 151 citations

The role of the IGF‐I receptor in the growth and transformation of mammalian cells

1994 • 151 citations

Human osteosarcoma cell lines are dependent on insulin-like growth factor I for in vitro growth.

1994 • 125 citations

The growth-stimulatory effect of simian virus 40 T antigen requires the interaction of insulinlike growth factor 1 with its receptor.

1992 • 99 citations

Structural and functional analysis of the insulin-like growth factor I receptor gene promoter.

1992 • 98 citations

The protooncogene c-myb increases the expression of insulin-like growth factor 1 and insulin-like growth factor 1 receptor messenger RNAs by a transcriptional mechanism.

1991 • 64 citations

Structural and functional analysis of the insulin-like growth factor I receptor gene promoter

1992 • 47 citations

Detection of type 1 insulinlike growth factor (IGF) receptors in Wilms' tumors.

1988 • 41 citations

Effects of insulin-like growth factor receptor inhibition on human melanomas in culture and in athymic mice.

1993 • 39 citations