A fully human monoclonal antibody to the insulin-like growth factor I receptor blocks ligand-dependent signaling and inhibits human tumor growth in vivo.

Antiapoptotic Signalling by the Insulin-Like Growth Factor I Receptor, Phosphatidylinositol 3-Kinase, and Akt

1997 • 1,051 citations

Insulin-Like Growth Factor-I Receptor Signaling and Resistance to Trastuzumab (Herceptin)

2001 • 868 citations

Structure and function of the type 1 insulin-like growth factor receptor

2000 • 602 citations

A Large Non-immunized Human Fab Fragment Phage Library That Permits Rapid Isolation and Kinetic Analysis of High Affinity Antibodies

1999 • 527 citations

Circulating insulin-like growth factor-I levels regulate colon cancer growth and metastasis.

2002 • 374 citations

Expression of the type 1 insulin-like growth factor receptor is up-regulated in primary prostate cancer and commonly persists in metastatic disease.

2002 • 371 citations

Insulin-like growth factor-I receptor overexpression mediates cellular radioresistance and local breast cancer recurrence after lumpectomy and radiation.

1997 • 343 citations

Blockade of the type I somatomedin receptor inhibits growth of human breast cancer cells in athymic mice.

1989 • 334 citations

Insulin-like growth factor receptor expression and function in human breast cancer.

1990 • 321 citations

Insulin-like growth factor physiology and cancer risk

2000 • 299 citations

Insulin and insulin-like growth factor-I (IGF-I) receptor overexpression in breast cancers leads to insulin/IGF-I hybrid receptor overexpression: evidence for a second mechanism of IGF-I signaling.

1999 • 254 citations

Role of tyrosine kinase activity in signal transduction by the insulin-like growth factor-I (IGF-I) receptor. Characterization of kinase-deficient IGF-I receptors and the action of an IGF-I-mimetic antibody (alpha IR-3).

1993 • 247 citations

The contradictions of the insulin-like growth factor 1 receptor

2000 • 236 citations

Growth inhibition of human breast cancer cells in vitro with an antibody against the type I somatomedin receptor.

1989 • 233 citations

In vivo progression of LAPC-9 and LNCaP prostate cancer models to androgen independence is associated with increased expression of insulin-like growth factor I (IGF-I) and IGF-I receptor (IGF-IR).

2001 • 230 citations

Dominant negative inhibition of tumorigenesis in vivo by human insulin-like growth factor I receptor mutant.

1994 • 195 citations

Insulin‐like growth factor (IGF)‐I rescues breast cancer cells from chemotherapy‐induced cell death – proliferative and anti‐apoptotic effects

1999 • 192 citations

A chimeric humanized single-chain antibody against the type I insulin-like growth factor (IGF) receptor renders breast cancer cells refractory to the mitogenic effects of IGF-I.

2003 • 189 citations

In vivo treatment with antibody against IGF-1 receptor suppresses growth of human rhabdomyosarcoma and down-regulates p34cdc2.

1994 • 186 citations

Inhibition of cellular proliferation by peptide analogues of insulin-like growth factor 1.

1992 • 183 citations

A soluble insulin-like growth factor I receptor that induces apoptosis of tumor cells in vivo and inhibits tumorigenesis.

1996 • 181 citations

Blockage of insulin-like growth factor-I receptor inhibits the growth of Ewing's sarcoma in athymic mice.

1998 • 181 citations

Insulin-like Growth Factor Expression in Human Cancer Cell Lines

1996 • 179 citations

Insulin-like growth factor-1 receptor in uveal melanoma: a predictor for metastatic disease and a potential therapeutic target.

2002 • 177 citations

Insulin-like growth factor I is a dual effector of multiple myeloma cell growth

2000 • 171 citations

Inhibition of human leukemia in an animal model with human antibodies directed against vascular endothelial growth factor receptor 2. Correlation between antibody affinity and biological activity

2003 • 160 citations

Specificity in ligand binding and intracellular signalling by insulin and insulin-like growth factor receptors

2001 • 157 citations

Human antibodies by design

1998 • 157 citations

Inhibition of insulin-like growth factor I receptor increases the antitumor activity of doxorubicin and vincristine against Ewing's sarcoma cells.

2001 • 141 citations

Selection of high affinity human neutralizing antibodies to VEGFR2 from a large antibody phage display library for antiangiogenesis therapy

2001 • 137 citations

Epidermal Growth Factor Receptor as a Therapeutic Target in Colorectal Cancer

2003 • 121 citations

Type 1 IGF receptor in human breast diseases

1992 • 120 citations

Growth Factor Receptors in Breast Cancer: Potential for Therapeutic Intervention

2003 • 116 citations

Expression of insulin-like growth factor I, its binding proteins, and its receptor in ovarian cancer.

1991 • 115 citations

Expression of an IGF‐I receptor dominant negative mutant induces apoptosis, inhibits tumorigenesis and enhances chemosensitivity in Ewing's sarcoma cells

2002 • 111 citations

Insulin-like growth factor II binding to the type I somatomedin receptor. Evidence for two high affinity binding sites.

1986 • 104 citations

The IGF system : molecular biology, physiology, and clinical applications

1999 • 99 citations

Insulin-like growth factors and breast cancer

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Insulin-like Growth Factor-I (IGF-I) Receptor Activation Rescues UV-damaged Cells through a p38 Signaling Pathway

2001 • 92 citations

Neutralizing anti-insulin-like growth factor receptor 1 antibodies inhibit receptor function and induce receptor degradation in tumor cells.

2002 • 92 citations

TCR-Like Human Antibodies Expressed on Human CTLs Mediate Antibody Affinity-Dependent Cytolytic Activity

2002 • 75 citations

Insulin-like Growth Factor I Receptor Antagonism Augments Response to Chemoradiation Therapy in Colon Cancer Cells

2000 • 69 citations

Varying patterns of expression of insulin-like growth factors I and II and their receptors in murine mammary adenocarcinomas of different metastasizing ability

1996 • 49 citations

JB3, an IGF-I Receptor Antagonist, Inhibits Early Renal Growth in Diabetic and Uninephrectomized Rats

2000 • 48 citations

High-affinity insulin binding to an atypical insulin-like growth factor-I receptor in human breast cancer cells.

1992 • 45 citations

The insulin-like growth factor system as a therapeutic target in colorectal cancer

2002 • 42 citations

Characterization of Ligand Binding of a Soluble Human Insulin-like Growth Factor I Receptor Variant Suggests a Ligand-induced Conformational Change

1997 • 40 citations

Effects of insulin-like growth factor receptor inhibition on human melanomas in culture and in athymic mice.

1993 • 39 citations

Antisense phosphorothioate oligodeoxynucleotide down-regulation of the insulin-like growth factor I receptor in ovarian cancer cells

1998 • 34 citations

IGF-I Receptor Function

1999 • 31 citations

Relaxation of Insulin-Like Growth Factor-ll Gene Imprinting in Human Gynecologic Tumors

1997 • 20 citations

Monoclonal antibody therapy

2001 • 16 citations