Reversal of Behavioral and Metabolic Abnormalities, and Insulin Resistance Syndrome, by Dietary Restriction in Mice Deficient in Brain-Derived Neurotrophic Factor

Oxidative Stress, Caloric Restriction, and Aging

1996 • 3,136 citations

Extended Longevity in Mice Lacking the Insulin Receptor in Adipose Tissue

2003 • 1,328 citations

Loss of Huntingtin-Mediated BDNF Gene Transcription in Huntington's Disease

2001 • 1,293 citations

Leptin enters the brain by a saturable system independent of insulin

1996 • 1,210 citations

Evidence that brain‐derived neurotrophic factor is required for basal neurogenesis and mediates, in part, the enhancement of neurogenesis by dietary restriction in the hippocampus of adult mice

2002 • 932 citations

A high-fat, refined sugar diet reduces hippocampal brain-derived neurotrophic factor, neuronal plasticity, and learning

2002 • 853 citations

Hypothalamic insulin signaling is required for inhibition of glucose production

2002 • 852 citations

Brain-derived neurotrophic factor-deficient mice develop aggressiveness and hyperphagia in conjunction with brain serotonergic abnormalities

1999 • 825 citations

BDNF regulates eating behavior and locomotor activity in mice

2000 • 788 citations

Insulin in the Brain: A Hormonal Regulator of Energy Balance*

1992 • 784 citations

Conditional Deletion Of Brain-Derived Neurotrophic Factor in the Postnatal Brain Leads to Obesity and Hyperactivity

2001 • 738 citations

From Acquisition to Consolidation: On the Role of Brain-Derived Neurotrophic Factor Signaling in Hippocampal-Dependent Learning

2002 • 667 citations

Long-Term Environmental Enrichment Leads to Regional Increases in Neurotrophin Levels in Rat Brain

2000 • 538 citations

Neurotrophins are required for nerve growth during development

2001 • 519 citations

Learning Deficit in BDNF Mutant Mice

1997 • 470 citations

Brain-derived neurotrophic factor promotes the survival and sprouting of serotonergic axons in rat brain

1995 • 470 citations

Dietary restriction enhances neurotrophin expression and neurogenesis in the hippocampus of adult mice

2002 • 449 citations

Modification of Brain Aging and Neurodegenerative Disorders by Genes, Diet, and Behavior

2002 • 436 citations

Dietary restriction reduces insulin-like growth factor I levels, which modulates apoptosis, cell proliferation, and tumor progression in p53-deficient mice.

1997 • 432 citations

Dietary restriction normalizes glucose metabolism and BDNF levels, slows disease progression, and increases survival in huntingtin mutant mice

2003 • 417 citations

Food restriction reduces brain damage and improves behavioral outcome following excitotoxic and metabolic insults

1999 • 415 citations

Leptin Enhances NMDA Receptor Function and Modulates Hippocampal Synaptic Plasticity

2001 • 396 citations

Dietary restriction and 2‐deoxyglucose administration improve behavioral outcome and reduce degeneration of dopaminergic neurons in models of Parkinson's disease

1999 • 385 citations

Neurotrophins Induce Formation of Functional Excitatory and Inhibitory Synapses between Cultured Hippocampal Neurons

1998 • 365 citations

Exercise-induced regulation of brain-derived neurotrophic factor (BDNF) transcripts in the rat hippocampus

1998 • 360 citations

Dietary restriction and 2-deoxyglucose administration reduce focal ischemic brain damage and improve behavioral outcome: Evidence for a preconditioning mechanism

1999 • 354 citations

Dietary Restriction Benefits Learning and Motor Performance of Aged Mice

1987 • 341 citations

Brain-derived neurotrophic factor in Huntington disease

2000 • 326 citations

Effects of intermittent feeding upon body weight and lifespan in inbred mice: interaction of genotype and age

1990 • 266 citations

Neurotrophins and activity-dependent plasticity of cortical interneurons

1997 • 225 citations

Brain‐derived neurotrophic factor mediates an excitoprotective effect of dietary restriction in mice

2001 • 183 citations

Current concepts in insulin resistance, type 2 diabetes mellitus, and the metabolic syndrome

2002 • 169 citations

Diabetes mellitus in Huntington disease

1985 • 168 citations

Brain‐derived neurotrophic factor (BDNF) regulates glucose and energy metabolism in diabetic mice

2002 • 120 citations

Pharmacology of appetite suppression

2000 • 119 citations

Neuroendocrine mechanisms regulating food intake and body weight

2000 • 105 citations

Caloric intake and aging: mechanisms in rodents and a study in nonhuman primates

1999 • 98 citations

Central Leptin Gene Therapy Blocks High-Fat Diet-Induced Weight Gain, Hyperleptinemia, and Hyperinsulinemia

2002 • 96 citations

Leptin: a possible link between food intake, energy expenditure, and reproductive function

2000 • 95 citations

Dose-Dependent Effects of Central Leptin Gene Therapy on Genes That Regulate Body Weight and Appetite in the Hypothalamus

2001 • 74 citations

Physiologic Effects of Lowering Caloric Intake in Nonhuman Primates and Nonobese Humans

2001 • 51 citations

Target‐derived BDNF (brain‐derived neurotrophic factor) is essential for the survival of developing neurons in the isthmo‐optic nucleus

2001 • 34 citations

Disease model: hyperinsulinemia and insulin resistance

2001 • 31 citations

Recombinant human insulin-like growth factor-I: a therapeutic challenge for diabetes mellitus

1994 • 24 citations

Altered c-fos expression in autonomic regulatory centers of genetically obese (ob/ob) mouse brain

1998 • 19 citations

Regulation of brain-derived neurotrophic factor messenger RNA levels in avian hypothalamic slice cultures

2000 • 13 citations

Introduction

2001 • 12 citations