Intraneuronal Aβ Causes the Onset of Early Alzheimer’s Disease-Related Cognitive Deficits in Transgenic Mice

The Mouse Brain in Stereotaxic Coordinates

2001 • 12,804 citations

Physical basis of cognitive alterations in alzheimer's disease: Synapse loss is the major correlate of cognitive impairment

1991 • 4,120 citations

Correlative Memory Deficits, Aβ Elevation, and Amyloid Plaques in Transgenic Mice

1996 • 4,118 citations

Triple-Transgenic Model of Alzheimer's Disease with Plaques and Tangles

2003 • 3,802 citations

mouse brain in stereotaxic coordinates

1997 • 3,077 citations

Neurofibrillary tangles but not senile plaques parallel duration and severity of Alzheimer's disease

1992 • 2,520 citations

The Role of the Amygdala in Fear and Anxiety

1992 • 2,216 citations

Aβ peptide vaccination prevents memory loss in an animal model of Alzheimer's disease

2000 • 1,498 citations

Aβ peptide immunization reduces behavioural impairment and plaques in a model of Alzheimer's disease

2000 • 1,433 citations

Attention and executive deficits in Alzheimer's disease: A critical review

1999 • 1,110 citations

Intraneuronal Aβ42 Accumulation in Human Brain

2000 • 955 citations

Mild Cognitive Impairment Can Be Distinguished From Alzheimer Disease and Normal Aging for Clinical Trials

2004 • 949 citations

Immunization reverses memory deficits without reducing brain Aβ burden in Alzheimer's disease model

2002 • 858 citations

Aβ Immunotherapy Leads to Clearance of Early, but Not Late, Hyperphosphorylated Tau Aggregates via the Proteasome

2004 • 760 citations

A learning deficit related to age and β-amyloid plaques in a mouse model of Alzheimer's disease

2000 • 733 citations

Unusual spectral energy distribution of a galaxy previously reported to be at redshift 6.68

2000 • 683 citations

Early Phenotypic Changes in Transgenic Mice That Overexpress Different Mutants of Amyloid Precursor Protein in Brain

1999 • 664 citations

NMDA receptors, place cells and hippocampal spatial memory

2004 • 591 citations

Amygdala modulation of hippocampal-dependent and caudate nucleus-dependent memory processes.

1994 • 544 citations

The Alzheimer's Aβ peptide induces neurodegeneration and apoptotic cell death in transgenic mice

1995 • 517 citations

Detection and Staging of Dementia in Alzheimer's Disease

1992 • 482 citations

Selective cytotoxicity of intracellular amyloid β peptide1–42 through p53 and Bax in cultured primary human neurons

2002 • 416 citations

Early Detection and Differential Diagnosis of Alzheimer’s Disease and Depression with Neuropsychological Tasks

2001 • 370 citations

Neuritic pathology and dementia in alzheimer's disease

1991 • 362 citations

Detecting Dementia: Novel Neuropsychological Markers of Preclinical Alzheimer’s Disease

2003 • 331 citations

Basolateral amygdala noradrenergic influence enables enhancement of memory consolidation induced by hippocampal glucocorticoid receptor activation

1999 • 291 citations

Amygdala Modulation of Multiple Memory Systems: Hippocampus and Caudate-Putamen

1998 • 285 citations

Hippocampus, amygdala, and memory deficits in rats

1990 • 281 citations

Synaptotrophic effects of human amyloid β protein precursors in the cortex of transgenic mice

1994 • 278 citations

Amygdala Modulation of Memory Consolidation: Interaction with Other Brain Systems

2002 • 273 citations

Intraneuronal Aβ-Amyloid Precedes Development of Amyloid Plaques in Down Syndrome

2001 • 271 citations

Image analysis of β-amyloid load in Alzheimer's disease and relation to dementia severity

1995 • 265 citations

Intraneuronal Aβ42 accumulation in Down syndrome brain

2002 • 251 citations

Heat Shock Protein 70 Participates in the Neuroprotective Response to Intracellularly Expressed β-Amyloid in Neurons

2004 • 232 citations

Intraneuronal Aβ-Amyloid Precedes Development of Amyloid Plaques in Down Syndrome

2001 • 230 citations

Homogeneity and heterogeneity in mild cognitive impairment and Alzheimer’s disease: a cross‐sectional and longitudinal study of 55 cases

2003 • 228 citations

Human neurons derived from a teratocarcinoma cell line express solely the 695-amino acid amyloid precursor protein and produce intracellular beta-amyloid or A4 peptides.

1993 • 223 citations

Chronic nicotine administration exacerbates tau pathology in a transgenic model of Alzheimer's disease

2005 • 201 citations

Clinical Correlates of Cortical and Nucleus Basalis Pathology in Alzheimer Dementia

1994 • 140 citations

Prediction of transition from cognitive impairment to senile dementia: a prospective, longitudinal study

2003 • 112 citations

Intracellular Accumulation of β-Amyloid in Cells Expressing the Swedish Mutant Amyloid Precursor Protein

1995 • 100 citations

Amyloid suppresses induction of genes critical for memory consolidation in APP + PS1 transgenic mice

2003 • 95 citations

Amyloid β-Peptide: The Inside Story

2004 • 71 citations

Distinct Mechanisms by Mutant Presenilin 1 and 2 Leading to Increased Intracellular Levels of Amyloid β-Protein 42 in Chinese Hamster Ovary Cells

2003 • 38 citations