Does my mouse have Alzheimer's disease?

Alzheimer's disease: Initial report of the purification and characterization of a novel cerebrovascular amyloid protein

1984 • 5,166 citations

Amyloid plaque core protein in Alzheimer disease and Down syndrome.

1985 • 4,276 citations

Correlative Memory Deficits, Aβ Elevation, and Amyloid Plaques in Transgenic Mice

1996 • 4,118 citations

Immunization with amyloid-β attenuates Alzheimer-disease-like pathology in the PDAPP mouse

1999 • 3,112 citations

Alzheimer-type neuropathology in transgenic mice overexpressing V717F β-amyloid precursor protein

1995 • 2,456 citations

Peripherally administered antibodies against amyloid β-peptide enter the central nervous system and reduce pathology in a mouse model of Alzheimer disease

2000 • 1,954 citations

Genetic enhancement of learning and memory in mice

1999 • 1,831 citations

Enhanced Neurofibrillary Degeneration in Transgenic Mice Expressing Mutant Tau and APP

2001 • 1,543 citations

Aβ peptide vaccination prevents memory loss in an animal model of Alzheimer's disease

2000 • 1,498 citations

Formation of Neurofibrillary Tangles in P301L Tau Transgenic Mice Induced by Aβ42 Fibrils

2001 • 1,469 citations

Familial Alzheimer's Disease–Linked Presenilin 1 Variants Elevate Aβ1–42/1–40 Ratio In Vitro and In Vivo

1996 • 1,467 citations

Increased amyloid-β42(43) in brains of mice expressing mutant presenilin 1

1996 • 1,439 citations

Two amyloid precursor protein transgenic mouse models with Alzheimer disease-like pathology

1997 • 1,438 citations

Aβ peptide immunization reduces behavioural impairment and plaques in a model of Alzheimer's disease

2000 • 1,433 citations

Treatment with a Copper-Zinc Chelator Markedly and Rapidly Inhibits β-Amyloid Accumulation in Alzheimer's Disease Transgenic Mice

2001 • 1,418 citations

Amyloid, the presenilins and Alzheimer's disease

1997 • 1,370 citations

Behavioral phenotypes of inbred mouse strains: implications and recommendations for molecular studies

1997 • 1,362 citations

Accelerated Alzheimer-type phenotype in transgenic mice carrying both mutant amyloid precursor protein and presenilin 1 transgenes

1998 • 1,336 citations

Neurofibrillary tangles, amyotrophy and progressive motor disturbance in mice expressing mutant (P301L) tau protein

2000 • 1,311 citations

Peripheral anti-Aβ antibody alters CNS and plasma Aβ clearance and decreases brain Aβ burden in a mouse model of Alzheimer's disease

2001 • 1,264 citations

Mutant presenilins of Alzheimer's disease increase production of 42-residue amyloid β-protein in both transfected cells and transgenic mice

1997 • 1,259 citations

Plaque-independent disruption of neural circuits in Alzheimer’s disease mouse models

1999 • 1,118 citations

Attention and executive deficits in Alzheimer's disease: A critical review

1999 • 1,110 citations

Accelerated Amyloid Deposition in the Brains of Transgenic Mice Coexpressing Mutant Presenilin 1 and Amyloid Precursor Proteins

1997 • 1,015 citations

Age-Dependent Changes in Brain, CSF, and Plasma Amyloid β Protein in the Tg2576 Transgenic Mouse Model of Alzheimer's Disease

2001 • 990 citations

Tau in Alzheimer's disease

1998 • 936 citations

Early-onset Amyloid Deposition and Cognitive Deficits in Transgenic Mice Expressing a Double Mutant Form of Amyloid Precursor Protein 695

2001 • 924 citations

Impaired synaptic plasticity and learning in aged amyloid precursor protein transgenic mice

1999 • 918 citations

Apolipoprotein E isoform-dependent amyloid deposition and neuritic degeneration in a mouse model of Alzheimer's disease

2000 • 896 citations

Ibuprofen Suppresses Plaque Pathology and Inflammation in a Mouse Model for Alzheimer's Disease

2000 • 880 citations

Functional gamma‐secretase inhibitors reduce beta‐amyloid peptide levels in brain

2001 • 876 citations

Immunization reverses memory deficits without reducing brain Aβ burden in Alzheimer's disease model

2002 • 858 citations

The cell biology of β-amyloid precursor protein and presenilin in Alzheimer's disease

1998 • 845 citations

Behavioral phenotyping of transgenic and knockout mice: experimental design and evaluation of general health, sensory functions, motor abilities, and specific behavioral tests1Published on the World Wide Web on 2 December 1998.1

1999 • 751 citations

Cell Biology of the Amyloid beta-Protein Precursor and the Mechanism of Alzheimer's Disease

1994 • 749 citations

A learning deficit related to age and β-amyloid plaques in a mouse model of Alzheimer's disease

2000 • 733 citations

The Pathogenesis of Senile Plaques

1997 • 717 citations

The Relationship between Aβ and Memory in the Tg2576 Mouse Model of Alzheimer's Disease

2002 • 699 citations

Unusual spectral energy distribution of a galaxy previously reported to be at redshift 6.68

2000 • 683 citations

Early Phenotypic Changes in Transgenic Mice That Overexpress Different Mutants of Amyloid Precursor Protein in Brain

1999 • 664 citations

APPSW Transgenic Mice Develop Age-related Aβ Deposits and Neuropil Abnormalities, but no Neuronal Loss in CA1

1997 • 640 citations

Amyloid precursor protein processing and Aβ ₄₂ deposition in a transgenic mouse model of Alzheimer disease

1997 • 624 citations

Microglial response to amyloid plaques in APPsw transgenic mice.

1998 • 580 citations

MUTANT GENES IN FAMILIAL ALZHEIMER'S DISEASE AND TRANSGENIC MODELS

1998 • 576 citations

A Proposed Test Battery and Constellations of Specific Behavioral Paradigms to Investigate the Behavioral Phenotypes of Transgenic and Knockout Mice

1997 • 553 citations

A Cholesterol-Lowering Drug Reduces β-Amyloid Pathology in a Transgenic Mouse Model of Alzheimer's Disease

2001 • 516 citations

Aβ Deposition Is Associated with Neuropil Changes, but not with Overt Neuronal Loss in the Human Amyloid Precursor Protein V717F (PDAPP) Transgenic Mouse

1997 • 502 citations

Secreted form of amyloid β protein precursor is involved in the growth regulation of fibroblasts

1989 • 477 citations

Amyloid β Protein Enhances the Survival of Hippocampal Neurons in Vitro

1989 • 470 citations

Apolipoprotein E is essential for amyloid deposition in the APP ^V717F transgenic mouse model of Alzheimer's disease

1999 • 467 citations

Apolipoprotein E and Alzheimer's Disease

1996 • 457 citations

Secreted Forms of β-Amyloid Precursor Protein Protect Hippocampal Neurons against Amyloid β-Peptide-Induced Oxidative Injury

1994 • 445 citations

A heparin-binding domain in the amyloid protein precursor of Alzheimer's disease is involved in the regulation of neurite outgrowth

1994 • 393 citations

Neuronal overexpression of mutant amyloid precursor protein results in prominent deposition of cerebrovascular amyloid

1999 • 392 citations

Formation of β-amyloid protein deposits in brains of transgenic mice

1991 • 385 citations

Comparison of neurodegenerative pathology in transgenic mice overexpressing V717F beta-amyloid precursor protein and Alzheimer's disease.

1996 • 373 citations

Transgenic mice with Alzheimer presenilin 1 mutations show accelerated neurodegeneration without amyloid plaque formation

1999 • 369 citations

Behavioral changes in transgenic mice expressing both amyloid precursor protein and presenilin-1 mutations: lack of association with amyloid deposits.

1999 • 355 citations

Microglial Activation and β-Amyloid Deposit Reduction Caused by a Nitric Oxide-Releasing Nonsteroidal Anti-Inflammatory Drug in Amyloid Precursor Protein Plus Presenilin-1 Transgenic Mice

2002 • 344 citations

Expression of human apolipoprotein E reduces amyloid-β deposition in a mouse model of Alzheimer's disease

1999 • 342 citations

Age-related learning deficits in transgenic mice expressing the 751-amino acid isoform of human beta-amyloid precursor protein.

1995 • 333 citations

The neuropsychology of preclinical Alzheimer's disease and mild cognitive impairment

2000 • 333 citations

Association of Microglia with Amyloid Plaques in Brains of APP23 Transgenic Mice

1999 • 332 citations

Introduction and expression of the 400 kilobase precursor amyloid protein gene in transgenic mice

1993 • 309 citations

Comparison of Neurodegenerative Pathology in Transgenic Mice Overexpressing V717F β-Amyloid Precursor Protein and Alzheimer’s Disease

1996 • 301 citations

Evidence for glial-mediated inflammation in aged APPSW transgenic mice

1999 • 295 citations

β-Amyloid-induced glial expression of both pro- and anti-inflammatory cytokines in cerebral cortex of aged transgenic Tg2576 mice with Alzheimer plaque pathology

2001 • 278 citations

Synaptotrophic effects of human amyloid β protein precursors in the cortex of transgenic mice

1994 • 278 citations

Behavioral profiles of inbred strains on novel olfactory, spatial and emotional tests for reference memory in mice

2002 • 275 citations

Alterations in synaptic transmission and long-term potentiation in hippocampal slices from young and aged PDAPP mice

1999 • 273 citations

Human and Murine ApoE Markedly Alters Aβ Metabolism before and after Plaque Formation in a Mouse Model of Alzheimer's Disease

2002 • 270 citations

Immunization with a Nontoxic/Nonfibrillar Amyloid-β Homologous Peptide Reduces Alzheimer's Disease-Associated Pathology in Transgenic Mice

2001 • 262 citations

Levels and Alternative Splicing of Amyloid β Protein Precursor (APP) Transcripts in Brains of APP Transgenic Mice and Humans with Alzheimer's Disease

1995 • 250 citations

Comparative Analysis of Amyloid-β Chemical Structure and Amyloid Plaque Morphology of Transgenic Mouse and Alzheimer's Disease Brains

2001 • 250 citations

Cognitive and neurobiologic markers of early Alzheimer disease

1996 • 242 citations

Cognitive and behavioral heterogeneity in Alzheimer's disease: seeking the neurobiological basis

2000 • 230 citations

Ibuprofen effects on Alzheimer pathology and open field activity in APPsw transgenic mice

2001 • 229 citations

Progressive and gender-dependent cognitive impairment in the APPSW transgenic mouse model for Alzheimer’s disease

1999 • 221 citations

Age-Related Impairment of Synaptic Transmission But Normal Long-Term Potentiation in Transgenic Mice that Overexpress the Human APP695SWE Mutant Form of Amyloid Precursor Protein

2001 • 214 citations

Behavioral tests of hippocampal function: simple paradigms complex problems

2001 • 209 citations

Amyloid-Associated Neuron Loss and Gliogenesis in the Neocortex of Amyloid Precursor Protein Transgenic Mice

2002 • 206 citations

Aβ-Induced Inflammatory Processes in Microglia Cells of APP23 Transgenic Mice

2001 • 199 citations

Reorganization of Cholinergic Terminals in the Cerebral Cortex and Hippocampus in Transgenic Mice Carrying Mutated Presenilin-1 and Amyloid Precursor Protein Transgenes

1999 • 196 citations

Cerebral Amyloid Induces Aberrant Axonal Sprouting and Ectopic Terminal Formation in Amyloid Precursor Protein Transgenic Mice

1999 • 189 citations

Enhancement of memory in cannabinoid CB1 receptor knock-out mice

1999 • 189 citations

Behavioral disturbances in transgenic mice overexpressing the V717F Β-amyloid precursor protein.

1999 • 185 citations

Abnormalities of neural circuitry in Alzheimer's disease

1998 • 179 citations

Amyloid beta-protein as a substrate interacts with extracellular matrix to promote neurite outgrowth.

1993 • 179 citations

Key Factors in Alzheimer's Disease: β‐amyloid Precursor Protein Processing, Metabolism and Intraneuronal Transport

2001 • 176 citations

Transgenic mouse models of Alzheimer's disease

2001 • 175 citations

Specific spatial learning deficits become severe with age in β-amyloid precursor protein transgenic mice that harbor diffuse β-amyloid deposits but do not form plaques

2001 • 162 citations

Adaptation of the circular platform spatial memory task for mice: use in detecting cognitive impairment in the APPSW transgenic mouse model for Alzheimer’s disease

1999 • 154 citations

Genetic Modification of the Phenotypes Produced by Amyloid Precursor Protein Overexpression in Transgenic Mice

1997 • 151 citations

Deposition of beta/A4 immunoreactivity and neuronal pathology in transgenic mice expressing the carboxyl-terminal fragment of the Alzheimer amyloid precursor in the brain.

1992 • 150 citations

Behavioral disturbances in transgenic mice overexpressing the V717F Β-amyloid precursor protein.

1999 • 149 citations

APP Transgenic Mice Tg2576 Accumulate Aβ Peptides That Are Distinct from the Chemically Modified and Insoluble Peptides Deposited in Alzheimer's Disease Senile Plaques

2001 • 149 citations

Scopolamine-induced deficits in a two-trial object recognition task in mice

1997 • 147 citations

Deposits of Amyloid β Protein in the Central Nervous System of Transgenic Mice

1991 • 140 citations

Neuroanatomical Abnormalities in Behaviorally Characterized APPV717F Transgenic Mice

2000 • 134 citations

Assessing Patterns of Agitation in Alzheimerʼs Disease Patients with the Cohen-Mansfield Agitation Inventory

1997 • 129 citations

Normal and Pathological Tau Proteins as Factors for Microtubule Assembly

1997 • 128 citations

Neuropsychological features of early Alzheimer's disease: preclinical and clinical stages

1996 • 121 citations

Memory systems analyses of mnemonic disorders in aging and age-related diseases

1996 • 117 citations

Neurofibrillary Pathology in Transgenic Mice Overexpressing V717F β-Amyloid Precursor Protein

2001 • 115 citations

Age-independent and age-related deficits in visuospatial learning, sleep–wake states, thermoregulation and motor activity in PDAPP mice

2002 • 111 citations

Transgenic mouse brain histopathology resembles early Alzheimer's disease

1994 • 110 citations

Genes, models and Alzheimer's disease

2001 • 108 citations

Maintained synaptophysin immunoreactivity in Tg2576 transgenic mice during aging: correlations with cognitive impairment

2002 • 105 citations

Gene targeting: technical confounds and potential solutions in behavioral brain research

2001 • 101 citations

Aβ amyloidosis induces the initial stage of tau accumulation in APPSw mice

2001 • 95 citations

Expression of APP in transgenic mice: a Comparison of neuron-specific promoters

1996 • 94 citations

Mutant Presenilin 2 Transgenic Mouse: Effect on an Age-Dependent Increase of Amyloid β-Protein 42 in the Brain

1998 • 93 citations

Transgenic mice for the amyloid precursor protein 695 isoform have impaired spatial memory

1991 • 91 citations

Impairments in learning and memory accompanied by neurodegeneration in mice transgenic for the carboxyl-terminus of the amyloid precursor protein

1999 • 88 citations

Transgenic mouse models of Alzheimer's disease

2001 • 84 citations

Expression of the human beta-amyloid precursor protein gene from a yeast artificial chromosome in transgenic mice.

1993 • 81 citations

Early Alzheimer disease-like histopathology increases in frequency with age in mice transgenic for beta-APP751.

1995 • 78 citations

In vivo synaptic transmission in young and aged amyloid precursor protein transgenic mice

2000 • 70 citations

Correction: Corrigendum: Introduction and expression of the 400 kilobase amyloid precursor protein gene in transgenic mice

1993 • 67 citations

Expression of APP in Brains of Transgenic Mice Containing the Entire Human APP Gene

1993 • 64 citations

Expression of the human beta-amyloid protein of Alzheimer's disease specifically in the brains of transgenic mice.

1991 • 64 citations

Early regional cerebral glucose hypometabolism in transgenic mice overexpressing the V717F β-amyloid precursor protein

1999 • 62 citations

Reduced corpus callosum, fornix and hippocampus in PDAPP transgenic mouse model of Alzheimer's disease

2001 • 61 citations

β-amyloid deposits in transgenic mice expressing human β-amyloid precursor protein have the same characteristics as those in Alzheimer's disease

2001 • 57 citations

Long-term memory in Alzheimer’s disease

1999 • 53 citations

Statistical aspects of quantitative image analysis of β-amyloid in the APPV717F transgenic mouse model of Alzheimer's disease

2001 • 15 citations

Deleted Work

1955 • 0 citations