Nitric Oxide Modulates Pro- and Anti-inflammatory Cytokines in Lipopolysaccharide-Activated Macrophages

Nitric oxide: physiology, pathophysiology, and pharmacology.

1991 • 15,563 citations

Nitric oxide release accounts for the biological activity of endothelium-derived relaxing factor

1987 • 10,774 citations

An endotoxin-induced serum factor that causes necrosis of tumors.

1975 • 4,522 citations

IL-10 acts on the antigen-presenting cell to inhibit cytokine production by Th1 cells.

1991 • 1,880 citations

Cachectin and tumour necrosis factor as two sides of the same biological coin

1986 • 1,659 citations

Resistance to Endotoxin Shock and Reduced Dissemination of Gram-Negative Bacteria in CD14-Deficient Mice

1996 • 760 citations

DNA binding and IκB inhibition of the cloned p65 subunit of NF-κB, a rel-related polypeptide

1991 • 604 citations

Gram‐negative endotoxin: an extraordinary lipid with profound effects on eukaryotic signal transduction ¹

1991 • 519 citations

Adenosine receptor agonists differentially regulate IL-10, TNF-alpha, and nitric oxide production in RAW 264.7 macrophages and in endotoxemic mice.

1996 • 517 citations

Interferon‐γ and tumor necrosis factor induce the L‐arginine‐dependent cytotoxic effector mechanism in murine macrophages^*

1988 • 511 citations

Biological significance of endogenous methylarginines that inhibit nitric oxide synthases

1999 • 456 citations

Nitric oxide in septic shock

1999 • 452 citations

Interleukin 10 inhibits macrophage microbicidal activity by blocking the endogenous production of tumor necrosis factor alpha required as a costimulatory factor for interferon gamma-induced activation.

1992 • 352 citations

Cytokines, sepsis and immunomodulation

1993 • 219 citations

VITAMIN A AND RETINOIDS: FROM NUTRITION TO PHARMACOTHERAPY IN DERMATOLOGY AND ONCOLOGY

1983 • 218 citations

LPS/IFN‐γ cytotoxicity in oligodendroglial cells: role of nitric oxide and protection by the anti‐inflammatory cytokine IL‐10

2001 • 163 citations

Cytokines Induce Both Necrosis and Apoptosis via a Common Bcl-2-Inhibitable Pathway in Rat Insulin-Producing Cells*

2000 • 163 citations

Nitric oxide up‐regulates the release of inflammatory mediators by mouse macrophages

1995 • 145 citations

Analysis of lipopolysaccharide binding by CD14.

1993 • 143 citations

Exogenous and endogenous nitric oxide attenuates tumor necrosis factor synthesis in the murine macrophage cell line RAW 264.7.

1995 • 108 citations

Macrophage activation by T cells: cognate and non-cognate signals

1993 • 92 citations

EFFECT OF GENETIC DISRUPTION OF POLY (ADP-RIBOSE) SYNTHETASE ON DELAYED PRODUCTION OF INFLAMMATORY MEDIATORS AND DELAYED NECROSIS DURING MYOCARDIAL ISCHEMIA-REPERFUSION INJURY

2000 • 87 citations

Induction of macrophage nitric oxide production by interferon‐γ and tumor necrosis factor‐α is enhanced by interleukin‐10

1993 • 83 citations

Intrarenal haemodynamics and renal dysfunction in endotoxaemia: effects of nitric oxide synthase inhibition

1997 • 77 citations

PRE-EXPOSURE TO HYPOXIA OR SEPTIC STIMULI DIFFERENTIALLY REGULATES ENDOTOXIN RELEASE OF TUMOR NECROSIS FACTOR, INTERLEUKIN-6, INTERLEUKIN-1, PROSTAGLANDIN E2, NITRIC OXIDE, AND SUPEROXIDE BY MACROPHAGES

1994 • 69 citations

Role of endothelium-formed nitric oxide on vascular responses

1990 • 66 citations

Nitric Oxide Modulates Interleukin-1 β and Tumor Necrosis Factor- α Synthesis by Alveolar Macrophages in Pulmonary Tuberculosis

2000 • 63 citations

Therapeutic concentrations of propofol protects mouse macrophages from nitric oxide-induced cell death and apoptosis

2002 • 55 citations

Nitric oxide induces osteoblast apoptosis through the de novo synthesis of Bax protein

2002 • 52 citations

Mechanisms of reprogrammed macrophage endotoxin signal transduction after lipopolysaccharide pretreatment*

1995 • 50 citations

Nitric oxide inhibits LPS-induced tumor necrosis factor synthesis in vitro and in vivo

1996 • 42 citations

Detoxification of plasma containing lipopolysaccharide by adsorption

1990 • 40 citations

Heart failure in pediatric septic shock: Utilizing inotropic support

2001 • 38 citations

Exhaled Nitric Oxide (NO), NO Synthase Activity, and Regulation of Nuclear Factor (NF)- κ B

1999 • 33 citations

Effects of retinoids on the production of tumour necrosis factor-alpha and nitric oxide by lipopolysaccharide-stimulated rat Kupffer cellsin vitro: evidence for participation of retinoid X receptor signalling pathway

1997 • 32 citations

Differential effects of interleukin-4 and interleukin-10 on nitric oxide production by murine macrophages

1999 • 28 citations

Management of septic shock

1995 • 20 citations

Induction of cytochrome P450 1A1 in human hepatoma HepG2 cells by 6-nitrochrysene

2000 • 14 citations