Inverse Relation between Disease Severity and Expression of the Streptococcal Cysteine Protease, SpeB, among Clonal M1T1 Isolates Recovered from Invasive Group A Streptococcal Infection Cases

Severe Group A Streptococcal Infections Associated with a Toxic Shock-like Syndrome and Scarlet Fever Toxin A

1989 • 1,236 citations

Invasive Group A Streptococcal Infections in Ontario, Canada

1996 • 725 citations

Invasive Group A Streptococcus Infections

1992 • 710 citations

Defining the Group A Streptococcal Toxic Shock Syndrome

1993 • 610 citations

Sourcebook of bacterial protein toxins

1991 • 537 citations

The Changing Epidemiology of Invasive Group A Streptococcal Infections and the Emergence of Streptococcal Toxic Shock-like Syndrome

1993 • 394 citations

Role of Superantigens in Human Disease

1993 • 347 citations

Bacterial pyrogenic exotoxins as superantigens

1995 • 281 citations

Genetic Relatedness and Superantigen Expression in Group A Streptococcus Serotype M1 Isolates from Patients with Severe and Nonsevere Invasive Diseases

2000 • 274 citations

A Response Regulator That Represses Transcription of Several Virulence Operons in the Group A Streptococcus

1999 • 273 citations

Identification of csrR/csrS, a genetic locus that regulates hyaluronic acid capsule synthesis in group A Streptococcus

1998 • 273 citations

A role for Trigger Factor and an Rgg-like regulator in the transcription, secretion and processing of the cysteine proteinase ofStreptococcus pyogenes

1998 • 262 citations

Cleavage of interleukin 1 beta (IL-1 beta) precursor to produce active IL-1 beta by a conserved extracellular cysteine protease from Streptococcus pyogenes.

1993 • 254 citations

Severe Invasive Group A Streptococcal Infections In Ontario, Canada: 1987-1991

1993 • 251 citations

A Two-Component Regulatory System, CsrR-CsrS, Represses Expression of Three Streptococcus pyogenes Virulence Factors, Hyaluronic Acid Capsule, Streptolysin S, and Pyrogenic Exotoxin B

1999 • 233 citations

A conserved Streptococcus pyogenes extracellular cysteine protease cleaves human fibronectin and degrades vitronectin

1993 • 225 citations

Streptococcal Cysteine Proteinase Releases Biologically Active Fragments of Streptococcal Surface Proteins

1995 • 219 citations

Molecular analysis of the role of the group A streptococcal cysteine protease, hyaluronic acid capsule, and M protein in a murine model of human invasive soft-tissue infection.

1998 • 213 citations

Identification and Characterization of Novel Superantigens from Streptococcus pyogenes

1999 • 195 citations

Association of phenotypic and genotypic characteristics of invasive Streptococcus pyogenes isolates with clinical components of streptococcal toxic shock syndrome

1993 • 195 citations

Streptococcal cysteine proteinase releases kinins: a virulence mechanism.

1996 • 192 citations

Plasma from patients with severe invasive group A streptococcal infections treated with normal polyspecific IgG inhibits streptococcal superantigen-induced T cell proliferation and cytokine production.

1996 • 184 citations

Inactivation of Streptococcus pyogenes extracellular cysteine protease significantly decreases mouse lethality of serotype M3 and M49 strains.

1997 • 181 citations

A novel superantigen isolated from pathogenic strains of Streptococcus pyogenes with aminoterminal homology to staphylococcal enterotoxins B and C.

1993 • 157 citations

Extracellular Cysteine Protease Produced by Streptococcus pyogenes Participates in the Pathogenesis of Invasive Skin Infection and Dissemination in Mice

1999 • 151 citations

Risk Factors in the Pathogenesis of Invasive Group A Streptococcal Infections: Role of Protective Humoral Immunity

1999 • 142 citations

Protein GRAB of Streptococcus pyogenes Regulates Proteolysis at the Bacterial Surface by Binding α2-Macroglobulin

1999 • 139 citations

Genetic Inactivation of an Extracellular Cysteine Protease (SpeB) Expressed byStreptococcus pyogenesDecreases Resistance to Phagocytosis and Dissemination to Organs

1998 • 132 citations

Geographic and Temporal Distribution and Molecular Characterization of Two Highly Pathogenic Clones ofStreptococcus pyogenesExpressing Allelic Variants of Pyrogenic Exotoxin A (Scarlet Fever Toxin)

1993 • 129 citations

Role of Streptococcal Pyrogenic Exotoxin B in the Mouse Model of Group A Streptococcal Infection

1998 • 124 citations

Vaccination with streptococcal extracellular cysteine protease (interleukin-1β convertase) protects mice against challenge with heterologous group A streptococci

1994 • 123 citations

Genetic and Phenotypic Diversity among Isolates of Streptococcus pyogenes from Invasive Infections

1996 • 114 citations

Activation of a 66-kilodalton human endothelial cell matrix metalloprotease by Streptococcus pyogenes extracellular cysteine protease

1996 • 111 citations

A secreted streptococcal cysteine protease can cleave a surface-expressed M1 protein and alter the immunoglobulin binding properties

1998 • 88 citations

Genetic Diversity in T1M1 Group A Streptococci in Relation to Clinical Outcome of Infection

1992 • 75 citations

Identification of pel , a Streptococcus pyogenes Locus That Affects both Surface and Secreted Proteins

1999 • 74 citations

Peptic Digestion of Streptococcal M Protein II. Extraction of M Antigen from Group A Streptococci With Pepsin

1974 • 66 citations

Proteolytically active streptococcal pyrogenic exotoxin B cleaves monocytic cell urokinase receptor and releases an active fragment of the receptor from the cell surface.

1994 • 50 citations

Absence of SpeB Production in Virulent Large Capsular Forms of Group A Streptococcal Strain 64

2000 • 50 citations

Role of superantigens in the pathogenesis of infectious diseases and their sequelae

1992 • 47 citations

Association of type II immunoglobulin G-binding protein expression and survival of group A streptococci in human blood

1993 • 38 citations

Role of emm and mrp Genes in the Virulence of Group A Streptococcal Isolate 64/14 in a Mouse Model of Skin Infection

1998 • 32 citations

Properties of IgG-Binding Proteins Expressed by Streptococcus pyogenes Isolates Are Predictive of Invasive Potential

1996 • 28 citations

Comparison of pathogenic factors expressed by group A Streptococci isolated from patients with streptococcal toxic shock syndrome and scarlet fever

1999 • 27 citations

Streptococcal Pyrogenic Exotoxin A, Streptolysin O, Exoenzymes, Serotype and Biotype Profiles of Streptococcus pyogenes Isolates from Patients with Toxic Shock Syndrome and other Severe Infections

1997 • 14 citations