An analysis of in vivo hprt mutant frequency in circulating T-lymphocytes in the normal human population: a comparison of four datasets

Practical Statistics for Medical Research.

1992 • 12,008 citations

MUTATIONS OF BACTERIA FROM VIRUS SENSITIVITY TO VIRUS RESISTANCE

1943 • 3,852 citations

Practical statistics for medical research

1992 • 1,728 citations

T-cell cloning to detect the mutant 6-thioguanine-resistant lymphocytes present in human peripheral blood.

1982 • 386 citations

Working paper no. 3 Somatic mutant frequency, mutation rates and mutational spectra in the human population in vivo

1994 • 234 citations

Refinement of a T-lymphocyte cloning assay to quantify the in vivo thioguanine-resistant mutant frequency in humans

1987 • 178 citations

Biological and chemical monitoring of occupational exposure to ethylene oxide

1991 • 148 citations

A further assessment of factors influencing measurements of thioguanine-resistant mutant frequency in circulating T-lymphocytes

1988 • 142 citations

Mutation frequency in human lymphocytes increases with age

1984 • 138 citations

Somatic gene mutations in vivo as indicated by the 6-thioguanine-resistant T-lymphocytes in human blood

1985 • 134 citations

Use of the clonal assay for the measurement of frequencies of HPRT mutants in T-lymphocytes from five control populations

1991 • 99 citations

Analysis of Mutations Occurring at the Human hprt Locus

1993 • 84 citations

Measurement of HPRT mutant frequencies in T-lymphocytes from healthy human populations

1993 • 81 citations

Detection of somatic mutations in man: evaluation of the microtitre cloning assay for T-lymphocytes

1986 • 80 citations

In vivo mutant frequency rises among breast cancer patients after exposure to high doses of γ-radiation

1985 • 77 citations

In vivo hprt mutant frequencies in T-cells of normal human newborns

1990 • 77 citations

Mutagenicity monitoring in humans by autoradiographic assay for mutant T lymphocytes

1988 • 76 citations

Molecular analyses of in vivo hprt mutations in human T-lymphocytes III. Longitudinal study of hprt gene structural alterations and T-cell clonal origins

1989 • 76 citations

Possible association between mutant frequency in peripheral lymphocytes and domestic radon concentrations

1991 • 74 citations

Factors influencing mutation at the hprt locus in T-lymphocytes: women treated for breast cancer.

1991 • 72 citations

Molecular analyses of in vivo hprt mutations in human T-lymphocytes I. Studies of low frequency ‘spontaneous’ mutants by Southern blots

1987 • 71 citations

HPRT and glycophorin A mutations in foundry workers: relationship to PAH exposure and to PAH-DNA adducts

1993 • 68 citations

Molecular analyses of in vivo hypoxanthine‐guanine phosphoribosyltransferase mutations in human T‐lymphocytes: II. Demonstration of a clonal amplification of hprt mutant T‐lymphocytes in vivo

1988 • 64 citations

Molecular analysis of in vivo hprt mutations in human T lymphocytes. V. Effects of total body irradiation secondary to radioimmunoglobulin therapy (RIT)

1990 • 63 citations

Longitudinal study of the in vivo hprt mutant frequency in human T‐lymphocytes as determined by a cell cloning assay

1989 • 62 citations

Genotoxic effects of radiotherapy and chemotherapy on the circulating lymphocytes of breast cancer patients. III: Measurements of mutant frequency to 6-thioguanine resistance

1990 • 61 citations

In vivo ionizing irradiations produce deletions in the hprt gene of human T-lymphocytes

1991 • 57 citations

Measurement of in vivo HGPRT-deficient mutant cell frequency using a modified method for cloning human peripheral blood T-lymphocytes

1988 • 53 citations

Exposure of nuclear medicine patients to ionizing radiation is associated with rises in HPRT− mutant frequency in peripheral T-lymphocytes

1987 • 48 citations

Mutant Frequency of Radiotherapy Technicians Appears to Be Associated With Recent Dose of Ionizing Radiation

1989 • 46 citations

Thioguanine-resistant mutant frequency in T-lymphocytes from a healthy human population

1992 • 43 citations

In vivo somatic mutation in the lymphocytes of Hodgkin's disease patients

1991 • 42 citations

Elevated hprt mutant frequency in circulating T-lymphocytes of xeroderma pigmentosum patients

1992 • 41 citations

Factors influencing mutation at the hprt locus in T‐lymphocytes: Studies in normal women and women with benign and malignant breast masses

1992 • 36 citations

New Trends in Genetic Risk Assessment

1989 • 33 citations

HPRT somatic mutation data.

1990 • 29 citations

Measurement of Mutant Frequency to 6-Thioguanine Resistance in Circulating T-lymphocytes for Human Population Monitoring

1989 • 24 citations

Use of t cell cloning to detect in vivo mutations induced by cyclophosphamide

1988 • 17 citations

Radionuclide angiography with technetium-99m in vivo labeled erythrocytes does not lead to induction of mutations in the HPRT gene of human T-lymphocytes.

1991 • 14 citations