Activated Leukocytes Oxidatively Damage DNA, RNA, and the Nucleotide Pool through Halide-Dependent Formation of Hydroxyl Radical

The cellular production of hydrogen peroxide

1972 • 1,526 citations

Formation of nitric oxide-derived inflammatory oxidants by myeloperoxidase in neutrophils

1998 • 1,494 citations

Cancer risk and oxidative DNA damage in man

1996 • 936 citations

Studies on the chlorinating activity of myeloperoxidase.

1976 • 918 citations

3-Chlorotyrosine, a specific marker of myeloperoxidase-catalyzed oxidation, is markedly elevated in low density lipoprotein isolated from human atherosclerotic intima.

1997 • 840 citations

Chlorination of Taurine by Human Neutrophils

1982 • 794 citations

Misreading of DNA templates containing 8-hydroxydeoxyguanosine at the modified base and at adjacent residues

1987 • 778 citations

Hyperoxia increases oxygen radical production in rat lungs and lung mitochondria.

1981 • 757 citations

Superoxide radicals as precursors of mitochondrial hydrogen peroxide

1974 • 627 citations

Myeloperoxidase-generated reactive nitrogen species convert LDL into an atherogenic form in vitro

1999 • 492 citations

Formation of Nitrating and Chlorinating Species by Reaction of Nitrite with Hypochlorous Acid

1996 • 440 citations

Human neutrophils employ chlorine gas as an oxidant during phagocytosis.

1996 • 258 citations

Spin trapping evidence for myeloperoxidase-dependent hydroxyl radical formation by human neutrophils and monocytes.

1992 • 233 citations

Free hydroxyl radicals are formed on reaction between the neutrophil‐derived species Superoxide anion and hypochlorous acid

1993 • 212 citations

Free-Radical Intermediates in the Metabolism of Toxic Chemicals

1982 • 197 citations

The Oxidation of Lipoproteins by Monocytes-Macrophages

1999 • 172 citations

Human Neutrophils Employ the Myeloperoxidase-Hydrogen Peroxide-Chloride System to Oxidize α-Amino Acids to a Family of Reactive Aldehydes

1998 • 170 citations

Damage to the bases in DNA induced by stimulated human neutrophils.

1989 • 139 citations

Role of oxidants in DNA damage. Hydroxyl radical mediates the synergistic DNA damaging effects of asbestos and cigarette smoke.

1987 • 130 citations

Eosinophils in the 1990s: New perspectives on their role in health and disease

1994 • 123 citations

Crystallographie study of a β-lactam inhibitor complex with elastase at 1.84 Å resolution

1987 • 103 citations

Parasite-associated morbidity: Liver fluke infection and bile duct cancer in Northeast Thailand

1994 • 73 citations

Identification of hydroxyl radical‐induced lesions in DNA base structure: Biomarkers with a putative link to cancer development

1993 • 65 citations

DNA damage induced by phorbol ester-stimulated neutrophils is augmented by extracellular cofactors. Role of histidine and metals.

1990 • 51 citations

Human genetic instability syndromes: single gene defects with increased risk of cancer

1993 • 50 citations

Effect of combinations of antioxidants on phagocyte-induced sister-chromatid exchanges

1989 • 29 citations

Metabolic activation of diethylstilbestrol by stimulated human leukocytes

1987 • 19 citations

The Respiratory Burst and Carcinogenesis

1988 • 19 citations

Rapid and sensitive detection of hydroxyl radicals formed by activated neutrophils in the presence of chelated iron: Hydroxylation of deoxyguanosine to 8-hydroxydeoxyguanosine

1992 • 16 citations