Engrailed-1 as a target of the Wnt-1 signalling pathway in vertebrate midbrain development

Sonic hedgehog, a member of a family of putative signaling molecules, is implicated in the regulation of CNS polarity

1993 • 2,146 citations

The Wnt-1 (int-1) proto-oncogene is required for development of a large region of the mouse brain

1990 • 1,531 citations

The mouse Fgf8 gene encodes a family of polypeptides and is expressed in regions that direct outgrowth and patterning in the developing embryo

1995 • 1,175 citations

Targeted disruption of the murine int-1 proto-oncogene resulting in severe abnormalities in midbrain and cerebellar development

1990 • 896 citations

Mouse Wnt genes exhibit discrete domains of expression in the early embryonic CNS and limb buds

1993 • 800 citations

Wnt-3a regulates somite and tailbud formation in the mouse embryo.

1994 • 784 citations

Midbrain development induced by FGF8 in the chick embryo

1996 • 734 citations

The midbrain-hindbrain phenotype of Wnt-1−Wnt-1− mice results from stepwise deletion of engrailed-expressing cells by 9.5 days postcoitum

1992 • 579 citations

Multiple developmental defects in Engrailed-1 mutant mice: an early mid-hindbrain deletion and patterning defects in forelimbs and sternum

1994 • 509 citations

Subtle Cerebellar Phenotype in Mice Homozygous for a Targeted Deletion of the En-2 Homeobox

1991 • 416 citations

Expression patterns of the homeo box-containing genes En-1 and En-2 and the proto-oncogene int-1 diverge during mouse development.

1988 • 393 citations

Two-tiered regulation of spatially patterned engrailed gene expression during Drosophila embryogenesis

1988 • 383 citations

Role of segment polarity genes in the definition and maintenance of cell states in the Drosophila embryo

1988 • 381 citations

Examining pattern formation in mouse, chicken and frog embryos with an En-specific antiserum

1991 • 325 citations

A role for FGF-8 in the initiation and maintenance of vertebrate limb bud outgrowth

1995 • 303 citations

Multiple modes of engrailed regulation in the progression towards cell fate determination

1991 • 248 citations

Boundaries and fields in early embryos

1992 • 239 citations

Dorsal-ventral patterning and differentiation of noggin-induced neural tissue in the absence of mesoderm

1995 • 215 citations

Pax-2 expression in the murine neural plate precedes and encompasses the expression domains of Wnt-1 and En-1

1995 • 151 citations

Pax-5 is expressed at the midbrain-hindbrain boundary during mouse development

1992 • 113 citations

Evidence for engrailed-Independent wingless Autoregulation in Drosophila

1995 • 94 citations

Development of midbrain and anterior hindbrain ocular motoneurons in normal and Wnt‐1 knockout mice

1995 • 59 citations