Transmembrane kit ligand cleavage does not require a signal in the cytoplasmic domain and occurs at a site dependent on spacing from the membrane.

Stem cell factor is encoded at the SI locus of the mouse and is the ligand for the c-kit tyrosine kinase receptor

1990 • 1,448 citations

The proto-oncogene c-kit encoding a transmembrane tyrosine kinase receptor maps to the mouse W locus

1988 • 1,390 citations

The dominant-white spotting (W) locus of the mouse encodes the c-kit proto-oncogene

1988 • 1,336 citations

The hematopoietic growth factor KL is encoded by the SI locus and is the ligand of the c-kit receptor, the gene product of the W locus

1990 • 1,208 citations

Hereditary Anemias of the Mouse: A Review for Geneticists

1979 • 1,141 citations

Molecular cloning of mast cell growth factor, a hematopoietin that is active in both membrane bound and soluble forms

1990 • 870 citations

Identification, purification, and biological characterization of hematopoietic stem cell factor from buffalo rat liver-conditioned medium

1990 • 837 citations

Primary structure and functional expression of rat and human stem cell factor DNAs

1990 • 779 citations

The kit ligand: A cell surface molecule altered in steel mutant fibroblasts

1990 • 777 citations

Transmembrane form of the kit ligand growth factor is determined by alternative splicing and is missing in the SId mutant

1991 • 740 citations

Beta-amyloid precursor protein cleavage by a membrane-bound protease.

1992 • 726 citations

MEMBRANE-ANCHORED GROWTH FACTORS

1993 • 676 citations

Mast cell growth factor maps near the steel locus on mouse chromosome 10 and is deleted in a number of steel alleles

1990 • 632 citations

Molecular cloning of a ligand for the flt3flk-2 tyrosine kinase receptor: A proliferative factor for primitive hematopoietic cells

1993 • 546 citations

Embryonic expression of a haematopoietic growth factor encoded by the SI locus and the ligand for c-kit

1990 • 521 citations

Expression of c-kit gene products in known cellular targets of W mutations in normal and W mutant mice--evidence for an impaired c-kit kinase in mutant mice.

1989 • 495 citations

The TGF-α precursor expressed on the cell surface binds to the EGF receptor on adjacent cells, leading to signal transduction

1989 • 482 citations

Transmembrane TGF-α precursors activate EGF/TGF-α receptors

1989 • 432 citations

A nonsecretable cell surface mutant of tumor necrosis factor (TNF) kills by cell-to-cell contact

1990 • 409 citations

Embryonic RNA expression patterns of the c-kit receptor and its cognate ligand suggest multiple functional roles in mouse development.

1991 • 346 citations

Differential expression and processing of two cell associated forms of the kit-ligand: KL-1 and KL-2.

1992 • 320 citations

Steel-Dickie mutation encodes a c-kit ligand lacking transmembrane and cytoplasmic domains.

1991 • 300 citations

Membrane proteins with soluble counterparts: role of proteolysis in the release of transmembrane proteins

1991 • 287 citations

The c-kit receptor ligand functions as a mast cell chemoattractant

1992 • 281 citations

Cell-cell adhesion mediated by binding of membrane-anchored transforming growth factor alpha to epidermal growth factor receptors promotes cell proliferation.

1990 • 262 citations

Altered Metabolism of Mast-Cell Growth Factor (c-kit Ligand) in Cutaneous Mastocytosis

1993 • 261 citations

The c-kit receptor ligand functions as a mast cell chemoattractant

1992 • 217 citations

Developmental abnormalities in Steel17H mice result from a splicing defect in the steel factor cytoplasmic tail.

1992 • 134 citations

Multiple signals activate cleavage of the membrane transforming growth factor-alpha precursor.

1991 • 129 citations

The cytoplasmic carboxy-terminal amino acid specifies cleavage of membrane TGFα into soluble growth factor

1992 • 126 citations

Cleavage of membrane-anchored growth factors involves distinct protease activities regulated through common mechanisms.

1992 • 116 citations

Identification and mutation of primary and secondary proteolytic cleavage sites in murine stem cell factor cDNA yields biologically active, cell-associated protein.

1994 • 89 citations

Alzheimer disease and the prion disorders amyloid beta-protein and prion protein amyloidoses.

1993 • 62 citations

Isolation of large T antigen-producing mouse cell lines capable of supporting replication of polyomavirus-plasmid recombinants.

1984 • 47 citations

Mouse mutants provide new insights into the role of extracellular matrix in cell migration and differentiation

1989 • 47 citations

Canine stem cell factor (c-kit ligand) supports the survival of hematopoietic progenitors in long-term canine marrow culture.

1992 • 45 citations

Post-translational processing of membrane-associated recombinant human stem cell factor expressed in Chinese hamster ovary cells

1992 • 38 citations

Proteolytic processing of a plasma membrane-bound precursor to human macrophage colony-stimulating factor (CSF-1) is accelerated by phorbol ester.

1991 • 38 citations

Adhesion of mouse mast cells to fibroblasts: Adverse effects of steel (SI) mutation

1991 • 37 citations

Hemopoietic growth factors and receptors: bound and free.

1991 • 34 citations

Isolation of Large T Antigen-Producing Mouse Cell Lines Capable of Supporting Replication of Polyomavirus-Plasmid Recombinants

1984 • 14 citations

Hemopoietic growth factors and receptors: bound and free.

1991 • 11 citations