Synthetic Lethal Interactions Suggest a Role for the Saccharomyces cerevisiae Rtf1 Protein in Transcription Elongation

A system of shuttle vectors and yeast host strains designed for efficient manipulation of DNA in Saccharomyces cerevisiae.

1989 • 8,705 citations

Current Protocols in Molecular Biology

2001 • 2,451 citations

Methods in Yeast Genetics: A Laboratory Course Manual

1990 • 1,922 citations

Methods in Yeast Genetics — A Laboratory Course Manual

1991 • 1,257 citations

A Saccharomyces cerevisiae genomic plasmid bank based on a centromere-containing shuttle vector

1987 • 1,181 citations

Construction of a set of convenient saccharomyces cerevisiae strains that are isogenic to S288C

1995 • 945 citations

Transcriptional regulation

1991 • 893 citations

Methods in yeast genetics, laboratory manual

1987 • 733 citations

DSIF, a novel transcription elongation factor that regulates RNA polymerase II processivity, is composed of human Spt4 and Spt5 homologs

1998 • 718 citations

Molecular Genetics of the RNA Polymerase II General Transcriptional Machinery

1998 • 557 citations

Purification of P-TEFb, a Transcription Factor Required for the Transition into Productive Elongation

1995 • 544 citations

The chromatin-specific transcription elongation factor FACT comprises human SPT16 and SSRP1 proteins

1999 • 533 citations

[14] Genetic applications of yeast transformation with linear and gapped plasmids

1983 • 503 citations

Reversible Phosphorylation of the C-terminal Domain of RNA Polymerase II

1996 • 498 citations

Elongator, a Multisubunit Component of a Novel RNA Polymerase II Holoenzyme for Transcriptional Elongation

1999 • 482 citations

A multisubunit complex associated with the RNA polymerase II CTD and TATA-binding protein in yeast

1993 • 465 citations

Evidence that Spt4, Spt5, and Spt6 control transcription elongation by RNA polymerase II in Saccharomyces cerevisiae

1998 • 460 citations

A Novel Histone Acetyltransferase Is an Integral Subunit of Elongating RNA Polymerase II Holoenzyme

1999 • 453 citations

Repression and activation by multiprotein complexes that alter chromatin structure.

1996 • 444 citations

BASIC MECHANISMS OF TRANSCRIPT ELONGATION AND ITS REGULATION

1997 • 441 citations

Temporal Regulation of RNA Polymerase II by Srb10 and Kin28 Cyclin-Dependent Kinases

1998 • 400 citations

Characterization of the CHD family of proteins

1997 • 389 citations

Characterization of the Imitation Switch subfamily of ATP-dependent chromatin-remodeling factors in Saccharomyces cerevisiae

1999 • 386 citations

Evidence That Spt6p Controls Chromatin Structure by a Direct Interaction with Histones

1996 • 352 citations

Phosphorylation of RNA polymerase II C-terminal domain and transcriptional elongation

1994 • 325 citations

The nonphosphorylated form of RNA polymerase II preferentially associates with the preinitiation complex.

1991 • 319 citations

Requirement of RSF and FACT for Transcription of Chromatin Templates in Vitro

1998 • 298 citations

Role of chromatin structure in the regulation of transcription by RNA polymerase II

1993 • 298 citations

Messenger RNA synthesis in mammalian cells is catalyzed by the phosphorylated form of RNA polymerase II.

1987 • 288 citations

Essential Functional Interactions of SAGA, a Saccharomyces cerevisiae Complex of Spt, Ada, and Gcn5 Proteins, With the Snf/Swi and Srb/Mediator Complexes

1997 • 277 citations

ROLE OF CHROMATIN STRUCTURE IN THE REGULATION OF TRANSCRIPTION BY RNA POLYMERASE II

1994 • 276 citations

A Review of Phenotypes in Saccharomyces cerevisiae

1997 • 270 citations

Contact with a component of the polymerase II holoenzyme suffices for gene activation

1995 • 262 citations

Enhanced processivity of RNA polymerase II triggered by Tat-induced phosphorylation of its carboxy-terminal domain

1996 • 255 citations

6-Azauracil inhibition of GTP biosynthesis in Saccharomyces cerevisiae

1992 • 254 citations

Yeast global transcriptional regulators Sin4 and Rgr1 are components of mediator complex/RNA polymerase II holoenzyme.

1995 • 247 citations

Transcriptional elongation by RNA polymerase II is stimulated by transactivators

1994 • 243 citations

The transition of RNA polymerase II from initiation to elongation is associated with phosphorylation of the carboxyl-terminal domain of subunit IIa

1989 • 236 citations

Activator-dependent regulation of transcriptional pausing on nucleosomal templates.

1996 • 205 citations

The Saccharomyces cerevisiae DNA Polymerase α Catalytic Subunit Interacts with Cdc68/Spt16 and with Pob3, a Protein Similar to an HMG1-Like Protein

1997 • 204 citations

An Unusual Eukaryotic Protein Phosphatase Required for Transcription by RNA Polymerase II and CTD Dephosphorylation in S. cerevisiae

1999 • 198 citations

A protein phosphatase functions to recycle RNA polymerase II

1999 • 195 citations

The HIV transactivator TAT binds to the CDK-activating kinase and activates the phosphorylation of the carboxy-terminal domain of RNA polymerase II

1997 • 193 citations

The Transcriptional Elongation Inhibitor 5,6-Dichloro-1-β-D-ribofuranosylbenzimidazole Inhibits Transcription Factor IIH-associated Protein Kinase

1995 • 178 citations

SPT4, SPT5 and SPT6 interactions: effects on transcription and viability in Saccharomyces cerevisiae.

1992 • 176 citations

Mutations in SPT16/CDC68 suppress cis- and trans-acting mutations that affect promoter function in Saccharomyces cerevisiae.

1991 • 171 citations

CTD kinase large subunit is encoded by CTK1, a gene required for normal growth of Saccharomyces cerevisiae.

1991 • 170 citations

An Activator Binding Module of Yeast RNA Polymerase II Holoenzyme

1999 • 162 citations

Cloning by function: an alternative approach for identifying yeast homologs of genes from other organisms.

1990 • 149 citations

An essential component of a C-terminal domain phosphatase that interacts with transcription factor IIF in Saccharomyces cerevisiae

1997 • 145 citations

Mutations that suppress the deletion of an upstream activating sequence in yeast: involvement of a protein kinase and histone H3 in repressing transcription in vivo.

1993 • 144 citations

The Yeast Carboxyl-Terminal Repeat Domain Kinase CTDK-I Is a Divergent Cyclin–Cyclin-Dependent Kinase Complex

1995 • 140 citations

Spt16 and Pob3 of Saccharomyces cerevisiae Form an Essential, Abundant Heterodimer That Is Nuclear, Chromatin-Associated, and Copurifies with DNA Polymerase α

1999 • 132 citations

CDC68, a yeast gene that affects regulation of cell proliferation and transcription, encodes a protein with a highly acidic carboxyl terminus.

1991 • 129 citations

The interaction of RNA polymerase II with the adenovirus-2 major late promoter is precluded by phosphorylation of the C-terminal domain of subunit IIa.

1992 • 128 citations

Dynamic localization of the nuclear import receptor and its interactions with transport factors.

1996 • 127 citations

CHD1 interacts with SSRP1 and depends on both its chromodomain and its ATPase/helicase-like domain for proper association with chromatin

1999 • 126 citations

A protein kinase that phosphorylates the C-terminal repeat domain of the largest subunit of RNA polymerase II.

1989 • 123 citations

The Activity of COOH-terminal Domain Phosphatase Is Regulated by a Docking Site on RNA Polymerase II and by the General Transcription Factors IIF and IIB

1995 • 121 citations

Mechanisms of heritable gene repression during development of Drosophila

1993 • 113 citations

Purification of a Tat-associated kinase reveals a TFIIH complex that modulates HIV-1 transcription

1997 • 111 citations

Mutations in the Second Largest Subunit of RNA Polymerase II Cause 6-Azauracil Sensitivity in Yeast and Increased Transcriptional Arrest in Vitro

1996 • 97 citations

Modulation of RNA Polymerase II Elongation Efficiency by C-terminal Heptapeptide Repeat Domain Kinase I

1997 • 97 citations

Structure and molecular analysis of RGR1, a gene required for glucose repression of Saccharomyces cerevisiae.

1990 • 87 citations

Activator-Specific Requirement of Yeast Mediator Proteins for RNA Polymerase II Transcriptional Activation

1999 • 87 citations

Characterization of the CP Complex, an Abundant Dimer of Cdc68 and Pob3 Proteins That Regulates Yeast Transcriptional Activation and Chromatin Repression

1998 • 85 citations

The Kin28 Protein Kinase is Associated with a Cyclin in Saccharomyces cerevisiae

1993 • 77 citations

Identification of RTF1, a Novel Gene Important for TATA Site Selection by TATA Box-Binding Protein in Saccharomyces cerevisiae

1997 • 71 citations

TFIIH Functions in Regulating Transcriptional Elongation by RNA Polymerase II in Xenopus Oocytes

1996 • 61 citations

Equivalent mutations in the two repeats of yeast TATA-binding protein confer distinct TATA recognition specificities.

1994 • 28 citations

Unusual charge configurations in transcription factors of the basic RNA polymerase II initiation complex.

1993 • 21 citations

Equivalent Mutations in the Two Repeats of Yeast TATA-Binding Protein Confer Distinct TATA Recognition Specificities

1994 • 10 citations