Essential Functional Interactions of SAGA, a Saccharomyces cerevisiae Complex of Spt, Ada, and Gcn5 Proteins, With the Snf/Swi and Srb/Mediator Complexes

Quantitative Monitoring of Gene Expression Patterns with a Complementary DNA Microarray

1995 • 9,575 citations

A system of shuttle vectors and yeast host strains designed for efficient manipulation of DNA in Saccharomyces cerevisiae.

1989 • 8,705 citations

[12] One-step gene disruption in yeast

1983 • 3,302 citations

New yeast-Escherichia coli shuttle vectors constructed with in vitro mutagenized yeast genes lacking six-base pair restriction sites

1988 • 2,903 citations

A positive selection for mutants lacking orotidine-5′-phosphate decarboxylase activity in yeast: 5-fluoro-orotic acid resistance

1984 • 2,401 citations

Multifunctional yeast high-copy-number shuttle vectors

1992 • 1,656 citations

Tetrahymena Histone Acetyltransferase A: A Homolog to Yeast Gcn5p Linking Histone Acetylation to Gene Activation

1996 • 1,567 citations

Accessing Genetic Information with High-Density DNA Arrays

1996 • 1,511 citations

A p300/CBP-associated factor that competes with the adenoviral oncoprotein E1A

1996 • 1,457 citations

A multiprotein mediator of transcriptional activation and its interaction with the C-terminal repeat domain of RNA polymerase II

1994 • 1,064 citations

Yeast Gcn5 functions in two multisubunit complexes to acetylate nucleosomal histones: characterization of an Ada complex and the SAGA (Spt/Ada) complex.

1997 • 1,053 citations

Construction of a set of convenient saccharomyces cerevisiae strains that are isogenic to S288C

1995 • 945 citations

Solubilization and Purification of Enzymatically Active Glutathione S-Transferase (pGEX) Fusion Proteins

1993 • 891 citations

Stimulation of GAL4 Derivative Binding to Nucleosomal DNA by the Yeast SWI/SNF Complex

1994 • 853 citations

Nucleosome disruption and enhancement of activator binding by a human SW1/SNF complex

1994 • 766 citations

The TAFII250 Subunit of TFIID Has Histone Acetyltransferase Activity

1996 • 705 citations

Characterization of the yeast SWI1, SWI2, and SWI3 genes, which encode a global activator of transcription

1992 • 596 citations

Facilitated binding of TATA-binding protein to nucleosomal DNA

1994 • 593 citations

An RNA polymerase II holoenzyme responsive to activators

1994 • 586 citations

GENES AFFECTING THE REGULATION OF SUC2 GENE EXPRESSION BY GLUCOSE REPRESSION IN SACCHAROMYCES CEREVISIAE

1984 • 567 citations

Evidence that SNF2/SWI2 and SNF5 activate transcription in yeast by altering chromatin structure.

1992 • 535 citations

Special HATs for special occasions: linking histone acetylation to chromatin assembly and gene activation

1996 • 525 citations

Ste5 tethers multiple protein kinases in the MAP kinase cascade required for mating in S. cerevisiae

1994 • 499 citations

Transcription-linked acetylation by Gcn5p of histones H3 and H4 at specific lysines

1997 • 480 citations

A multisubunit complex associated with the RNA polymerase II CTD and TATA-binding protein in yeast

1993 • 465 citations

Ethidium bromide provides a simple tool for identifying genuine DNA-independent protein associations.

1992 • 461 citations

Genetic isolation of ADA2: A potential transcriptional adaptor required for function of certain acidic activation domains

1992 • 446 citations

Repression and activation by multiprotein complexes that alter chromatin structure.

1996 • 444 citations

Five SWI/SNF gene products are components of a large multisubunit complex required for transcriptional enhancement.

1994 • 410 citations

A multisubunit complex containing the SWI1/ADR6,SWI2/SNF2, SWI3, SNF5, and SNF6 gene products isolated fromyeast.

1994 • 396 citations

The SWI-SNF complex: a chromatin remodeling machine?

1995 • 379 citations

Genetic analysis of the mitotic transmission of minichromosomes

1985 • 310 citations

Two distinct yeast transcriptional activators require the function of the GCN5 protein to promote normal levels of transcription.

1992 • 302 citations

Vectors for the inducible overexpression of glutathione S‐transferase fusion proteins in yeast

1993 • 284 citations

FUS3 phosphorylates multiple components of the mating signal transduction cascade: evidence for STE12 and FAR1.

1993 • 274 citations

Contact with a component of the polymerase II holoenzyme suffices for gene activation

1995 • 262 citations

Intragenic and extragenic suppressors of mutations in the heptapeptide repeat domain of Saccharomyces cerevisiae RNA polymerase II.

1989 • 250 citations

Yeast global transcriptional regulators Sin4 and Rgr1 are components of mediator complex/RNA polymerase II holoenzyme.

1995 • 247 citations

Amino acid substitutions in the structured domains of histones H3 and H4 partially relieve the requirement of the yeast SWI/SNF complex for transcription.

1995 • 245 citations

Association of an activator with an RNA polymerase II holoenzyme.

1995 • 237 citations

Inhibition of in Vivo and in Vitro Transcription by Monoclonal Antibodies Prepared against Wheat Germ RNA Polymerase II That React with the Heptapeptide Repeat of Eukaryotic RNA Polymerase II

1989 • 228 citations

A SUPPRESSOR OF snf1 MUTATIONS CAUSES CONSTITUTIVE HIGH-LEVEL INVERTASE SYNTHESIS IN YEAST

1984 • 228 citations

SPT3 interacts with TFIID to allow normal transcription in Saccharomyces cerevisiae.

1992 • 217 citations

Histone acetyltransferase activity and interaction with ADA2 are critical for GCN5 function invivo

1997 • 208 citations

GENETICS OF TRANSCRIPTIONAL REGULATION IN YEAST: Connections to the RNA Polymerase II CTD

1997 • 202 citations

TheKIN28Gene is Required both for RNA Polymerase II Mediated Transcription and Phosphorylation of the Rpb1p CTD

1995 • 185 citations

Characterization of Physical Interactions of the Putative Transcriptional Adaptor, ADA2, with Acidic Activation Domains and TATA-binding Protein

1995 • 184 citations

ADA3, a Putative Transcriptional Adaptor, Consists of Two Separable Domains and Interacts with ADA2 and GCN5 in a Trimeric Complex

1995 • 175 citations

YEAST TRANSCRIPTIONAL REGULATORY MECHANISMS

1995 • 173 citations

A novel transcription factor reveals a functional link between the RNA polymerase II CTD and TFIID

1992 • 170 citations

GAL4 Interacts with TATA-Binding Protein and Coactivators

1995 • 164 citations

Involvement of the SIN4 global transcriptional regulator in the chromatin structure of Saccharomyces cerevisiae.

1992 • 162 citations

TFG3/TAF30/ANC1, a Component of the Yeast SWI/SNF Complex That Is Similar to the Leukemogenic Proteins ENL and AF-9

1996 • 158 citations

A Negative Regulator of HO Transcription, SIN1 (SPT2), Is a Nonspecific DNA-Binding Protein Related to HMG1

1991 • 157 citations

Cdc73p and Paf1p Are Found in a Novel RNA Polymerase II-Containing Complex Distinct from the Srbp-Containing Holoenzyme

1997 • 153 citations

GAL11P: A yeast mutation that potentiates the effect of weak GAL4-derived activators

1990 • 149 citations

Cloning by function: an alternative approach for identifying yeast homologs of genes from other organisms.

1990 • 149 citations

Histone acetylation in chromatin and chromosomes

1995 • 149 citations

Paf1p, an RNA Polymerase II-Associated Factor inSaccharomyces cerevisiae, May Have both Positive and Negative Roles in Transcription

1996 • 148 citations

Transcriptional coactivators in yeast and beyond

1995 • 146 citations

Ty-mediated gene expression of the LYS2 and HIS4 genes of Saccharomyces cerevisiae is controlled by the same SPT genes.

1984 • 137 citations

SNF11, a New Component of the Yeast SNF-SWI Complex That Interacts with a Conserved Region of SNF2

1995 • 125 citations

Molecular analysis of SNF2 and SNF5, genes required for expression of glucose-repressible genes in Saccharomyces cerevisiae.

1986 • 123 citations

A mutant nuclear protein with similarity to RNA binding proteins interferes with nuclear import in yeast.

1992 • 119 citations

Structural and Functional Analysis of Yeast Putative Adaptors

1996 • 119 citations

Essential role of Swp73p in the function of yeast Swi/Snf complex.

1996 • 119 citations

ADA3: a gene, identified by resistance to GAL4-VP16, with properties similar to and different from those of ADA2.

1993 • 118 citations

SSNGenes That Affect Transcriptional Repression inSaccharomyces cerevisiaeEncode SIN4, ROX3, and SRB Proteins Associated with RNA Polymerase II

1996 • 117 citations

Cloning and characterization of hTAFII18, hTAFII20 and hTAFII28: three subunits of the human transcription factor TFIID.

1995 • 114 citations

SPT20/ADA5 Encodes a Novel Protein Functionally Related to the TATA-Binding Protein and Important for Transcription in Saccharomyces cerevisiae

1996 • 114 citations

Identification of Native Complexes Containing the Yeast Coactivator/Repressor Proteins NGG1/ADA3 and ADA2

1997 • 113 citations

Yeast ADA2 protein binds to the VP16 protein activation domain and activates transcription.

1994 • 109 citations

Evidence that Spt3 Functionally Interacts with Mot1, TFIIA, and TATA-Binding Protein To Confer Promoter-Specific Transcriptional Control in Saccharomyces cerevisiae

1997 • 104 citations

ADA1, a Novel Component of the ADA/GCN5 Complex, Has Broader Effects than GCN5, ADA2, or ADA3

1997 • 104 citations

Three Genes Are Required for trans-Activation of Ty Transcription in Yeast

1987 • 102 citations

Genetic and physical interactions between yeast RGR1 and SIN4 in chromatin organization and transcriptional regulation.

1995 • 97 citations

ADA5/SPT20 Links the ADA and SPT Genes, Which Are Involved in Yeast Transcription

1996 • 96 citations

Analysis of the Yeast Transcription Factor TFIIA: Distinct Functional Regions and a Polymerase II-Specific Role in Basal and Activated Transcription

1995 • 95 citations

The Saccharomyces cerevisiae SPT7 gene encodes a very acidic protein important for transcription in vivo.

1995 • 92 citations

The Saccharomyces cerevisiae SPT8 gene encodes a very acidic protein that is functionally related to SPT3 and TATA-binding protein.

1994 • 91 citations

ADR1 Activation Domains Contact the Histone Acetyltransferase GCN5 and the Core Transcriptional Factor TFIIB

1996 • 87 citations

Structure and molecular analysis of RGR1, a gene required for glucose repression of Saccharomyces cerevisiae.

1990 • 87 citations

Epistasis analysis of suppressor mutations that allow HO expression in the absence of the yeast SW15 transcriptional activator.

1994 • 81 citations

TSF3, a global regulatory protein that silences transcription of yeast GAL genes, also mediates repression by alpha 2 repressor and is identical to SIN4.

1993 • 77 citations

Regulation of HIS4 expression by the Saccharomyces cerevisiae SIN4 transcriptional regulator.

1995 • 70 citations

Transcriptional Activation by Yeast PDR1p Is Inhibited by Its Association with NGG1p/ADA3p

1996 • 65 citations

Structure/Function Properties of the Yeast Dual Regulator Protein NGG1 That Are Required for Glucose Repression

1996 • 34 citations

The yeast GAL11 protein binds to the transcription factor IIE through GAL11 regions essential for its in vivo function.

1996 • 32 citations

TSF1 to TSF6, required for silencing the Saccharomyces cerevisiae GAL genes, are global regulatory genes.

1993 • 29 citations