Resveratrol—A boon for treating Alzheimer's disease?

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2001 • 1,892 citations

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2004 • 1,877 citations

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2004 • 1,847 citations

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2005 • 1,772 citations

HIGH ABSORPTION BUT VERY LOW BIOAVAILABILITY OF ORAL RESVERATROL IN HUMANS

2004 • 1,673 citations

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2006 • 1,505 citations

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2004 • 1,478 citations

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2003 • 1,467 citations

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2000 • 1,360 citations

Extended Longevity in Mice Lacking the Insulin Receptor in Adipose Tissue

2003 • 1,328 citations

Evolutionarily Conserved and Nonconserved Cellular Localizations and Functions of Human SIRT Proteins

2005 • 1,305 citations

Bioavailability and bioefficacy of polyphenols in humans. II. Review of 93 intervention studies

2005 • 1,297 citations

The inflammatory response system of brain: implications for therapy of Alzheimer and other neurodegenerative diseases

1995 • 1,290 citations

ABAD Directly Links Aß to Mitochondrial Toxicity in Alzheimer's Disease

2004 • 1,232 citations

Calorie Restriction Promotes Mitochondrial Biogenesis by Inducing the Expression of eNOS

2005 • 1,075 citations

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2004 • 1,052 citations

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2005 • 1,020 citations

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2005 • 1,005 citations

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2001 • 964 citations

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2002 • 912 citations

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2005 • 859 citations

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2004 • 845 citations

Human SIR2 deacetylates p53 and antagonizes PML/p53-induced cellular senescence

2002 • 842 citations

Properties and Regulation of Cytosolic Phospholipase A2

1997 • 814 citations

Characterization of Five Human cDNAs with Homology to the Yeast SIR2 Gene: Sir2-like Proteins (Sirtuins) Metabolize NAD and May Have Protein ADP-Ribosyltransferase Activity

1999 • 781 citations

Substrate-specific Activation of Sirtuins by Resveratrol

2005 • 736 citations

Sir2 links chromatin silencing, metabolism, and aging

2000 • 725 citations

SIRT1 Protects against Microglia-dependent Amyloid-β Toxicity through Inhibiting NF-κB Signaling

2005 • 718 citations

Resveratrol Promotes Clearance of Alzheimer's Disease Amyloid-β Peptides

2005 • 716 citations

The physiology and pathophysiology of nitric oxide in the brain

2005 • 700 citations

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2005 • 691 citations

Resveratrol as an anti-inflammatory and anti-aging agent: Mechanisms and clinical implications

2005 • 668 citations

Lipopolysaccharide-Induced Inflammation Exacerbates Tau Pathology by a Cyclin-Dependent Kinase 5-Mediated Pathway in a Transgenic Model of Alzheimer's Disease

2005 • 654 citations

FOXO transcription factors directly activate bim gene expression and promote apoptosis in sympathetic neurons

2003 • 635 citations

Metabolism and bioavailability oftrans-resveratrol

2005 • 635 citations

ApoE genotype accounts for the vast majority of AD risk and AD pathology

2004 • 572 citations

Toward a unified theory of caloric restriction and longevity regulation

2005 • 568 citations

Mitochondrial targeting and a novel transmembrane arrest of Alzheimer's amyloid precursor protein impairs mitochondrial function in neuronal cells

2003 • 547 citations

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2005 • 538 citations

Identification of a Class of Small Molecule Inhibitors of the Sirtuin Family of NAD-dependent Deacetylases by Phenotypic Screening

2001 • 524 citations

Resveratrol protects against global cerebral ischemic injury in gerbils

2002 • 515 citations

Sirtuins: Sir2-related NAD-dependent protein deacetylases.

2004 • 515 citations

Resveratrol rescues mutant polyglutamine cytotoxicity in nematode and mammalian neurons

2005 • 513 citations

Resveratrol: from grapevines to mammalian biology

2003 • 508 citations

Insulin, insulin-degrading enzyme and amyloid-β peptide in Alzheimer's disease: review and hypothesis

2005 • 496 citations

Plants used in Chinese and Indian traditional medicine for improvement of memory and cognitive function

2003 • 433 citations

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2005 • 402 citations

Plants with traditional uses and activities, relevant to the management of Alzheimer's disease and other cognitive disorders

2003 • 398 citations

Protective effect of resveratrol on β-amyloid-induced oxidative PC12 cell death

2003 • 374 citations

Oxidative Stress Increases Expression and Activity of BACE in NT2 Neurons

2002 • 363 citations

Protective effect of resveratrol against oxidative stress in middle cerebral artery occlusion model of stroke in rats

2002 • 355 citations

A novel VNTR enhancer within the SIRT3 gene, a human homologue of SIR2, is associated with survival at oldest ages

2004 • 350 citations

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1999 • 338 citations

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2001 • 337 citations

Chronic treatment with trans resveratrol prevents intracerebroventricular streptozotocin induced cognitive impairment and oxidative stress in rats

2002 • 325 citations

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2005 • 322 citations

β‐Site APP cleaving enzyme up‐regulation induced by 4‐hydroxynonenal is mediated by stress‐activated protein kinases pathways

2005 • 316 citations

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2000 • 302 citations

Bioavailability oftrans-resveratrol from red wine in humans

2005 • 302 citations

Neuroprotective effects of resveratrol against β‐amyloid‐induced neurotoxicity in rat hippocampal neurons: involvement of protein kinase C

2004 • 291 citations

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2005 • 289 citations

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2005 • 280 citations

Variability of the SIRT3 gene, human silent information regulator Sir2 homologue, and survivorship in the elderly

2003 • 277 citations

Bioactivity and metabolism oftrans-resveratrol orally administered to Wistar rats

2005 • 236 citations

MicroReview: Small molecules that regulate lifespan: evidence for xenohormesis

2004 • 234 citations

Partial neuroprotection of in vivo excitotoxic brain damage by chronic administration of the red wine antioxidant agent, trans-resveratrol in rats

2000 • 233 citations

Caloric restriction in humans: Potential pitfalls and health concerns

2005 • 231 citations

Immunotherapeutic Approaches to Alzheimer's Disease

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Linking chromatin function with metabolic networks: Sir2 family of NAD+-dependent deacetylases

2003 • 208 citations

Potential Mechanism by Which Resveratrol, a Red Wine Constituent, Protects Neurons

2003 • 185 citations

Red Wine Ingredient Resveratrol Protects from β-Amyloid Neurotoxicity

2003 • 176 citations

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2004 • 174 citations

A blend of polyphenolic compounds explains the stimulatory effect of red wine on human endothelial NO synthase

2005 • 173 citations

Resveratrol reduction of infarct size in Long-Evans rats subjected to focal cerebral ischemia

2001 • 171 citations

Essential Role of E2-25K/Hip-2 in Mediating Amyloid-β Neurotoxicity

2003 • 155 citations

Amyloid peptide attenuates the proteasome activity in neuronal cells

2005 • 154 citations

Protective effect of trans-resveratrol against kainic acid-induced seizures and oxidative stress in rats

2002 • 153 citations

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2005 • 150 citations

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2005 • 145 citations

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2004 • 145 citations

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2004 • 143 citations

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2004 • 142 citations

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2003 • 118 citations

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2004 • 98 citations

Crosstalk between p53 and FOXO Transcription Factors

2004 • 89 citations

Mechanisms of Soluble β-Amyloid Impairment of Endothelial Function

2004 • 88 citations

Sirtuin 1 (SIRT1) sequence variation is not associated with exceptional human longevity

2005 • 80 citations

Resveratrol inhibits interleukin-6 production in cortical mixed glial cells under hypoxia/hypoglycemia followed by reoxygenation

2001 • 74 citations

Effects of resveratrol on acoustic trauma

2003 • 69 citations

BCL11A-dependent recruitment of SIRT1 to a promoter template in mammalian cells results in histone deacetylation and transcriptional repression

2004 • 68 citations

Alternative therapies for traditional disease states: menopause.

2002 • 66 citations

Trans-resveratrol, a red wine ingredient, inhibits voltage-activated potassium currents in rat hippocampal neurons

2005 • 60 citations

Bioavailability of Dietary Supplements and Impact of Physiologic State: Infants, Children and Adolescents

2001 • 60 citations

Red wine micronutrients as protective agents in Alzheimer-like induced insult

2003 • 59 citations

Inhibition of human liver and duodenum sulfotransferases by drugs and dietary chemicals: a review of the literature

2004 • 54 citations

FoxO-dependent and -independent mechanisms mediate SirT1 effects on IGFBP-1 gene expression

2005 • 53 citations

N-acteyl cysteine alleviates oxidative damage to central nervous system of ApoE-deficient mice following folate and vitamin E-deficiency

2005 • 53 citations

The proteasome in Alzheimer's disease and Parkinson's disease: lessons from ubiquitin B+1

2005 • 52 citations

Alzheimer's disease: the pharmacological pathway

2003 • 51 citations

Alzheimer’s disease: Channeling APP to non-amyloidogenic processing

2005 • 50 citations

Natural antioxidants and neurodegenerative diseases

2004 • 50 citations

Resveratrol-induced limitation of dysfunction of mitochondria isolated from rat brain in an anoxia-reoxygenation model

2002 • 44 citations

Dehydroepiandrosterone reduces expression and activity of BACE in NT2 neurons exposed to oxidative stress

2003 • 44 citations

Androgens, ApoE, and Alzheimer's Disease

2004 • 43 citations

Apoptosis is secondary to non-apoptotic axonal degeneration in neurons exposed to Aβ in distal axons

2005 • 42 citations

Proteasome-mediated effects on amyloid precursor protein processing at the γ-secretase site

2005 • 40 citations

Neuroprotective effects of lipoxygenase inhibitors against ischemic injury in rat hippocampal slice cultures

2001 • 38 citations

Alcoholic Beverages and Coronary Heart Disease

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Billion-dollar market blossoms as botanicals take root

1999 • 34 citations

Nitric oxide alters arachidonic acid turnover in brain cortex synaptoneurosomes

2005 • 28 citations