Cytosolic phospholipase A₂mediates neuronal apoptosis induced by soluble oligomers of the amyloid‐β peptide

Alzheimer's Disease Is a Synaptic Failure

2002 • 4,102 citations

Common Structure of Soluble Amyloid Oligomers Implies Common Mechanism of Pathogenesis

2003 • 3,943 citations

Prostaglandins and Leukotrienes: Advances in Eicosanoid Biology

2001 • 3,629 citations

Diffusible, nonfibrillar ligands derived from Aβ _1–42 are potent central nervous system neurotoxins

1998 • 3,404 citations

cPLA2 is phosphorylated and activated by MAP kinase

1993 • 1,858 citations

High-Level Neuronal Expression of Aβ_1–42in Wild-Type Human Amyloid Protein Precursor Transgenic Mice: Synaptotoxicity without Plaque Formation

2000 • 1,793 citations

Soluble pool of A? amyloid as a determinant of severity of neurodegeneration in Alzheimer's disease

1999 • 1,787 citations

A novel arachidonic acid-selective cytosolic PLA2 contains a Ca2+-dependent translocation domain with homology to PKC and GAP

1991 • 1,709 citations

Soluble Amyloid β Peptide Concentration as a Predictor of Synaptic Change in Alzheimer's Disease

1999 • 1,505 citations

The 'Arctic' APP mutation (E693G) causes Alzheimer's disease by enhanced Aβ protofibril formation

2001 • 1,126 citations

Plaque-independent disruption of neural circuits in Alzheimer’s disease mouse models

1999 • 1,118 citations

Targeting small Aβ oligomers: the solution to an Alzheimer's disease conundrum?

2001 • 975 citations

Properties and Regulation of Cytosolic Phospholipase A2

1997 • 814 citations

Gene expression profiling of 12633 genes in Alzheimer hippocampal CA1: Transcription and neurotrophic factor down‐regulation and up‐regulation of apoptotic and pro‐inflammatory signaling

2002 • 516 citations

Calcium-mediated Translocation of Cytosolic Phospholipase A2 to the Nuclear Envelope and Endoplasmic Reticulum

1995 • 469 citations

A calcium-dependent mechanism for associating a soluble arachidonoyl-hydrolyzing phospholipase A2 with membrane in the macrophage cell line RAW 264.7.

1990 • 447 citations

DNA damage and apoptosis in Alzheimer's disease: colocalization with c- Jun immunoreactivity, relationship to brain area, and effect of postmortem delay

1996 • 400 citations

Phospholipase A2 in the central nervous system

2004 • 386 citations

Brain membrane phospholipid alterations in Alzheimer's disease.

2001 • 284 citations

Aggregated Amyloid-β Protein Induces Cortical Neuronal Apoptosis and Concomitant “Apoptotic” Pattern of Gene Induction

1997 • 261 citations

Disease and anatomic specificity of ethanolamine plasmalogen deficiency in Alzheimer's disease brain

1995 • 230 citations

Serine 727 Phosphorylation and Activation of Cytosolic Phospholipase A2 by MNK1-related Protein Kinases

2000 • 228 citations

Cytosolic Phospholipase A2(cPLA2) Immunoreactivity Is Elevated in Alzheimer's Disease Brain

1996 • 211 citations

Selective neuronal degeneration induced by soluble oligomeric amyloid beta‐protein

2002 • 205 citations

Neural membrane phospholipids in alzheimer disease

1995 • 156 citations

Long-term potentiation in the hippocampus induced by platelet-activating factor

1993 • 150 citations

Cytoplasmic phospholipase A2 translocates to membrane fraction in human neutrophils activated by stimuli that phosphorylate mitogen-activated protein kinase.

1994 • 149 citations

A Novel Action of Alzheimer's Amyloid β-Protein (Aβ): Oligomeric Aβ Promotes Lipid Release

2001 • 146 citations

Cytosolic phospholipase A2 is induced in reactive glia following different forms of neurodegeneration

1999 • 145 citations

Dopamine D₂ Receptors Potentiate Arachidonate Release via Activation of Cytosolic, Arachidonate‐Specific Phospholipase A₂

1995 • 134 citations

The Nonfibrillar Amyloid β‐Peptide Induces Apoptotic Neuronal Cell Death

1999 • 120 citations

Apoptotic Neuronal Cell Death Induced by the Non-fibrillar Amyloid-β Peptide Proceeds through an Early Reactive Oxygen Species-dependent Cytoskeleton Perturbation

2003 • 106 citations

Involvement of phospholipase A2 in neurodegeneration

1997 • 87 citations

Molecular basis of Alzheimer's disease

2000 • 86 citations

Phospholipase A₂ mediates ischemic injury in the hippocampus: a regional difference of neuronal vulnerability

2001 • 82 citations

The Calcium Binding Loops of the Cytosolic Phospholipase A₂C2 Domain Specify Targeting to Golgi and ER in Live Cells

2003 • 73 citations

Selective Inhibition of Cytosolic Phospholipase A2 in Activated Human Monocytes

1997 • 61 citations

Cytosolic phospholipase A2 (cPLA2) and lipid mediator release in the brain

1996 • 42 citations

Inhibition of the MEK1/ERK pathway reduces arachidonic acid release independently of cPLA2 phosphorylation and translocation.

2002 • 41 citations

Elevated Activities of Lipases and Lysophospholipase in Alzheimer's Disease

1990 • 27 citations

Alzheimer's Disease: Membrane‐Associated Metabolic Changes^a

1994 • 20 citations

N‐terminal and C‐terminal plasma membrane anchoring modulate differently agonist‐induced activation of cytosolic phospholipase A₂

1999 • 12 citations