Substrate-specific Activation of Sirtuins by Resveratrol

Small molecule activators of sirtuins extend Saccharomyces cerevisiae lifespan

2003 • 3,673 citations

Transcriptional silencing and longevity protein Sir2 is an NAD-dependent histone deacetylase

2000 • 3,355 citations

hSIR2SIRT1 Functions as an NAD-Dependent p53 Deacetylase

2001 • 2,550 citations

Modulation of NF-κB-dependent transcription and cell survival by the SIRT1 deacetylase

2004 • 2,531 citations

A positive selection for mutants lacking orotidine-5′-phosphate decarboxylase activity in yeast: 5-fluoro-orotic acid resistance

1984 • 2,401 citations

The SIR2/3/4 complex and SIR2 alone promote longevity in Saccharomyces cerevisiae by two different mechanisms

1999 • 2,199 citations

Negative Control of p53 by Sir2α Promotes Cell Survival under Stress

2001 • 2,042 citations

Sirt1 promotes fat mobilization in white adipocytes by repressing PPAR-γ

2004 • 1,896 citations

Increased dosage of a sir-2 gene extends lifespan in Caenorhabditis elegans

2001 • 1,892 citations

Sirtuin activators mimic caloric restriction and delay ageing in metazoans

2004 • 1,847 citations

Requirement of NAD and SIR2 for Life-Span Extension by Calorie Restriction in Saccharomyces cerevisiae

2000 • 1,756 citations

The Sir2 Family of Protein Deacetylases

2004 • 1,478 citations

Extrachromosomal rDNA Circles— A Cause of Aging in Yeast

1997 • 1,477 citations

Rates of Behavior and Aging Specified by Mitochondrial Function During Development

2002 • 1,058 citations

Increased Nuclear NAD Biosynthesis and SIRT1 Activation Prevent Axonal Degeneration

2004 • 1,052 citations

Calorie restriction extends Saccharomyces cerevisiae lifespan by increasing respiration

2002 • 1,051 citations

Inhibition of Silencing and Accelerated Aging by Nicotinamide, a Putative Negative Regulator of Yeast Sir2 and Human SIRT1

2002 • 971 citations

The silencing protein SIR2 and its homologs are NAD-dependent protein deacetylases

2000 • 946 citations

A systematic RNAi screen identifies a critical role for mitochondria in C. elegans longevity

2002 • 944 citations

Extension of Life-Span with Superoxide Dismutase/Catalase Mimetics

2000 • 909 citations

Four Genes Responsible for a Position Effect on Expression From HML and HMR in Saccharomyces cerevisiae

1987 • 709 citations

Modifiers of position effect are shared between telomeric and silent mating-type loci in S. cerevisiae

1991 • 700 citations

Components of the Ku-dependent non-homologous end-joining pathway are involved in telomeric length maintenance and telomeric silencing

1998 • 636 citations

Calorie restriction extends yeast life span by lowering the level of NADH

2004 • 629 citations

An unusual form of transcriptional silencing in yeast ribosomal DNA.

1997 • 590 citations

A new role for a yeast transcriptional silencer gene, SIR2, in regulation of recombination in ribosomal DNA

1989 • 550 citations

Silent information regulator 2 family of NAD- dependent histone/protein deacetylases generates a unique product, 1- O- acetyl-ADP-ribose

2000 • 541 citations

Determination of Life-Span in Caenorhabditis elegans by Four Clock Genes

1996 • 529 citations

Identification of a Class of Small Molecule Inhibitors of the Sirtuin Family of NAD-dependent Deacetylases by Phenotypic Screening

2001 • 524 citations

Relocalization of Telomeric Ku and SIR Proteins in Response to DNA Strand Breaks in Yeast

1999 • 458 citations

Inhibition of mitochondrial proton F0F1‐ATPase/ATP synthase by polyphenolic phytochemicals

2000 • 439 citations

Sir2-Independent Life Span Extension by Calorie Restriction in Yeast

2004 • 434 citations

Elimination of Replication Block Protein Fob1 Extends the Life Span of Yeast Mother Cells

1999 • 398 citations

Cancer Chemopreventive Activity of Resveratrol

2002 • 386 citations

Transcriptional silencing of Ty1 elements in the RDN1 locus of yeast.

1997 • 376 citations

Identification of a small molecule inhibitor of Sir2p

2001 • 337 citations

MEC1-Dependent Redistribution of the Sir3 Silencing Protein from Telomeres to DNA Double-Strand Breaks

1999 • 332 citations

Cloning and characterization of four SIR genes of Saccharomyces cerevisiae.

1986 • 305 citations

Effects of stilbenes on arachidonate metabolism in leukocytes

1985 • 275 citations

A Fluorogenic Histone Deacetylase Assay Well Suited for High-Throughput Activity Screening

2003 • 264 citations

Effects of resveratrol on the rat brain respiratory chain.

1999 • 256 citations

Extension of Life-Span in Caenorhabditis elegans by a Diet Lacking Coenzyme Q

2002 • 247 citations

MicroReview: Small molecules that regulate lifespan: evidence for xenohormesis

2004 • 234 citations

Substrate Specificity and Kinetic Mechanism of the Sir2 Family of NAD⁺-Dependent Histone/Protein Deacetylases

2004 • 208 citations

Resveratrol acts as a natural profungicide and induces self‐intoxication by a specific laccase

2002 • 171 citations

Effect of vitamin E on lifespan and reproduction in Caenorhabditis elegans

1988 • 167 citations

Effects of Mutations in DNA Repair Genes on Formation of Ribosomal DNA Circles and Life Span in Saccharomyces cerevisiae

1999 • 153 citations

Inhibitors of Sir2: Evaluation of Splitomicin Analogues

2004 • 151 citations

High Osmolarity Extends Life Span in Saccharomyces cerevisiae by a Mechanism Related to Calorie Restriction

2002 • 138 citations

Piceatannol, a Stilbene Phytochemical, Inhibits Mitochondrial F0F1-ATPase Activity by Targeting the F1 Complex

1999 • 100 citations

Inhibition sites in F1-ATPase from bovine heart mitochondria

2005 • 96 citations

Diversity in the Sir2 family of protein deacetylases

2004 • 95 citations

N-Acetylcysteine slows down ageing and increases the life span of Drosophila melanogaster

1997 • 91 citations

Large-scale identification in yeast of conserved ageing genes

2004 • 78 citations

Identification of Selective Inhibitors of NAD+-dependent Deacetylases Using Phenotypic Screens in Yeast

2003 • 72 citations

Pleiotropic effects of resveratrol

2003 • 68 citations

Saccharomyces cerevisiae SSD1-V Confers Longevity by a Sir2p-Independent Mechanism

2004 • 56 citations

Mutations inSaccharomyces cerevisiaeGeneSIR2Can Have Differential Effects on In Vivo Silencing Phenotypes and In Vitro Histone Deacetylation Activity

2002 • 52 citations

SIR2 and aging – the exception that proves the rule

2001 • 50 citations

Quantitative Assays for Characterization of the Sir2 Family of NAD+-Dependent Deacetylases

2003 • 42 citations

Intracellular targeting and functional analysis of single-chain Fv fragments in mammalian cells

2004 • 32 citations

Prolongation of life in an experimental model of aging in Drosophila melanogaster.

1999 • 25 citations

Effect of butylated hydroxytoluene on the life span of Drosophila bipectinata

1983 • 25 citations

Society for biomolecular screening

1996 • 11 citations

Saccharomyces cerevisiae SSD1-V Confers Longevity by a Sir2p-Independent Mechanism

2004 • 10 citations

Effect of Sodium Selenite on Antioxidative Enzymes of Banana Fruitfly

1989 • 7 citations

Life Span Studies in <i>Zaprionus paravittiger</i>with Sodium Hypophosphite Feeding

1986 • 7 citations