Mechanisms of Soluble β-Amyloid Impairment of Endothelial Function

Activation of nitric oxide synthase in endothelial cells by Akt-dependent phosphorylation

1999 • 3,529 citations

Regulation of endothelium-derived nitric oxide production by the protein kinase Akt

1999 • 2,577 citations

NITRIC OXIDE: A Physiologic Messenger Molecule

1994 • 2,299 citations

RAGE mediates amyloid-β peptide transport across the blood-brain barrier and accumulation in brain

2003 • 1,289 citations

Alzheimer Disease as a Vascular Disorder

2002 • 834 citations

β-Amyloid-mediated vasoactivity and vascular endothelial damage

1996 • 686 citations

Amyloid β protein forms ion channels: implications for Alzheimer's disease pathophysiology

2001 • 617 citations

Coordinated Control of Endothelial Nitric-oxide Synthase Phosphorylation by Protein Kinase C and the cAMP-dependent Protein Kinase

2001 • 547 citations

Post-translational control of endothelial nitric oxide synthase: why isn't calcium/calmodulin enough?

2001 • 495 citations

Signal transduction of eNOS activation

1999 • 444 citations

SOD1 rescues cerebral endothelial dysfunction in mice overexpressing amyloid precursor protein

1999 • 393 citations

Leptin Effect on Endothelial Nitric Oxide Is Mediated Through Akt–Endothelial Nitric Oxide Synthase Phosphorylation Pathway

2002 • 332 citations

Detection of single amyloid β-protein aggregates in the cerebrospinal fluid of Alzheimer's patients by fluorescence correlation spectroscopy

1998 • 323 citations

Cerebral vessels in ageing and Alzheimer's disease

1996 • 323 citations

The Role of Oxidative Stress in Alzheimer Disease

1999 • 299 citations

Role of Ca2+ signaling in the regulation of endothelial permeability

2002 • 292 citations

Ca ²⁺ -Independent Activation of the Endothelial Nitric Oxide Synthase in Response to Tyrosine Phosphatase Inhibitors and Fluid Shear Stress

1998 • 267 citations

Compensatory Phosphorylation and Protein-Protein Interactions Revealed by Loss of Function and Gain of Function Mutants of Multiple Serine Phosphorylation Sites in Endothelial Nitric-oxide Synthase

2003 • 241 citations

Aβ1–40-related reduction in functional hyperemia in mouse neocortex during somatosensory activation

2000 • 237 citations

Fresh and globular amyloid β protein (1–42) induces rapid cellular degeneration: evidence for AβP channel‐mediated cellular toxicity

2000 • 221 citations

Molecular control of nitric oxide synthases in the cardiovascular system

1999 • 195 citations

Inhibition of Endothelial Nitric Oxide Synthase Activity by Protein Kinase C

1995 • 188 citations

Peripheral markers in testing pathophysiological hypotheses and diagnosing Alzheimer's disease

1998 • 167 citations

The Dual-Specificity Phosphatase MKP-1 Limits the Cardiac Hypertrophic Response In Vitro and In Vivo

2001 • 163 citations

Pharmacological analysis of intracellular Ca2+ signalling: problems and pitfalls

1998 • 160 citations

Fresh and nonfibrillar amyloid β protein(1–40) induces rapid cellular degeneration in aged human fibroblasts: evidence for AβP‐channel‐mediated cellular toxicity

2000 • 148 citations

The conformation of Alzheimer's β peptide determines the rate of amyloid formation and its resistance to proteolysis

1996 • 118 citations

Cellular hypertrophy in mesenteric resistance vessels from renal hypertensive rats.

1988 • 76 citations

Cardiovascular factors in Alzheimer's disease

1998 • 75 citations

Intravascular infusions of soluble β-amyloid compromise the blood–brain barrier, activate CNS glial cells and induce peripheral hemorrhage

1999 • 67 citations

Intercellular signal modulation: A pivotal role for protein kinase C

1997 • 65 citations

β‐Amyloid inhibits NOS activity by subtracting NADPH availability

2002 • 39 citations

Physiological levels of β-amyloid peptide stimulate protein kinase C in PC12 cells

1997 • 36 citations

Peripheral markers in testing pathophysiological hypotheses and diagnosing Alzheimer's disease

1998 • 35 citations

Biphasic modulation of protein kinase C and enhanced cell toxicity by amyloid beta peptide and anoxia in neuronal cultures

2001 • 32 citations