Degradation of BACE by the ubiquitin‐proteasome pathway

Alzheimer's Disease: Genes, Proteins, and Therapy

2001 • 5,919 citations

Alzheimer's disease: Initial report of the purification and characterization of a novel cerebrovascular amyloid protein

1984 • 5,166 citations

β-Secretase Cleavage of Alzheimer's Amyloid Precursor Protein by the Transmembrane Aspartic Protease BACE

1999 • 3,692 citations

Inhibition of Proteasome Activities and Subunit-Specific Amino-Terminal Threonine Modification by Lactacystin

1995 • 1,601 citations

Purification and cloning of amyloid precursor protein β-secretase from human brain

1999 • 1,589 citations

Themes and variations on ubiquitylation

2001 • 1,475 citations

Membrane-anchored aspartyl protease with Alzheimer's disease β-secretase activity

1999 • 1,440 citations

Degradation of CFTR by the ubiquitin-proteasome pathway

1995 • 1,285 citations

Identification of a Novel Aspartic Protease (Asp 2) as β-Secretase

1999 • 1,072 citations

BACE1 is the major β-secretase for generation of Aβ peptides by neurons

2001 • 1,032 citations

Mice deficient in BACE1, the Alzheimer's β-secretase, have normal phenotype and abolished β-amyloid generation

2001 • 988 citations

Multiple proteolytic systems, including the proteasome, contribute to CFTR processing

1995 • 885 citations

Degradation of oxidized proteins in mammalian cells

1997 • 845 citations

Impaired Proteasome Function in Alzheimer's Disease

2000 • 795 citations

Human aspartic protease memapsin 2 cleaves the β-secretase site of β-amyloid precursor protein

2000 • 777 citations

BACE knockout mice are healthy despite lacking the primary beta-secretase activity in brain: implications for Alzheimer's disease therapeutics

2001 • 706 citations

Increased expression of the amyloid precursor β‐secretase in Alzheimer's disease

2002 • 559 citations

Frameshift Mutants of β Amyloid Precursor Protein and Ubiquitin-B in Alzheimer's and Down Patients

1998 • 558 citations

Presenilins are required for γ-secretase cleavage of β-APP and transmembrane cleavage of Notch-1

2000 • 407 citations

Maturation and Endosomal Targeting of β-Site Amyloid Precursor Protein-cleaving Enzyme

2000 • 404 citations

BACE2, a β-secretase homolog, cleaves at the β site and within the amyloid-β region of the amyloid-β precursor protein

2000 • 389 citations

Alzheimer Disease: Mechanistic Understanding Predicts Novel Therapies

2004 • 384 citations

Involvement of the Ubiquitin-Proteasome System in the Early Stages of Wallerian Degeneration

2003 • 320 citations

Phosphorylation Regulates Intracellular Trafficking of β-Secretase

2001 • 275 citations

A Furin-like Convertase Mediates Propeptide Cleavage of BACE, the Alzheimer's β-Secretase

2000 • 268 citations

Maturation and Pro-peptide Cleavage of β-Secretase

2000 • 247 citations

Are Ubiquitination Pathways Central to Parkinson's Disease?

2003 • 232 citations

Characterization of Alzheimer's β-Secretase Protein BACE

2000 • 229 citations

Defective ubiquitination of cerebral proteins in Alzheimer's disease

2000 • 216 citations

Transcriptional Regulation of BACE1, the β-Amyloid Precursor Protein β-Secretase, by Sp1

2003 • 215 citations

The Ubiquitin Pathway for the Degradation of Intracellular Proteins

1986 • 213 citations

Presenilin-1 mutations in Alzheimer's disease

2000 • 152 citations

Mutant ubiquitin expressed in Alzheimer's disease causes neuronal death¹

2001 • 122 citations

The C‐terminal fragment of the Alzheimer's disease amyloid protein precursor is degraded by a proteasome‐dependent mechanism distinct from γ‐secretase

2001 • 120 citations

Expression of human β‐secretase in the mouse brain increases the steady‐state level of β‐amyloid

2002 • 120 citations

Characterization of the Glycosylation Profiles of Alzheimer's β-Secretase Protein Asp-2 Expressed in a Variety of Cell Lines

2001 • 94 citations

The proteasome: a protein‐destroying machine

1998 • 93 citations

A Distinct ER/IC γ-Secretase Competes with the Proteasome for Cleavage of APP

1999 • 73 citations

Proteasome‐mediated degradation of the C‐terminus of the Alzheimer's disease β‐amyloid protein precursor: Effect of C‐terminal truncation on production of β‐amyloid protein

2003 • 64 citations

Specific Increase in Amyloid β-Protein 42 Secretion Ratio by Calpain Inhibition

1997 • 60 citations

Functional characterization of the 5′ flanking region of the BACE gene: identification of a 91 bp fragment involved in basal level of BACE promoter expression

2004 • 56 citations

Amyloid β secretase gene (BACE) is neither mutated in nor associated with early-onset Alzheimer's disease

2001 • 46 citations

Mutations in the open reading frame of the β-site APP cleaving enzyme (BACE) locus are not a common cause of Alzheimer's disease

2001 • 41 citations

Inhibiting Amyloid Precursor Protein C-terminal Cleavage Promotes an Interaction with Presenilin 1

2000 • 38 citations

Alzheimer’s Disease

1999 • 33 citations