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Plants with traditional uses and activities, relevant to the management of Alzheimer's disease and other cognitive disorders

Data up to Jan 2025

Published2003
Citations398
References248

Total Citations Per Year

Abstract

References (248)

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An evaluation of the antioxidant and antiviral action of extracts of rosemary and provençal herbs

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Anti-oxidant effect of Withania somnifera glycowithanolides in chronic footshock stress-induced perturbations of oxidative free radical scavenging enzymes and lipid peroxidation in rat frontal cortex and striatum

2001 • 289 citations

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Eating soya improves human memory

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Pharmacological evaluation of novel Alzheimer's disease therapeutics: acetylcholinesterase inhibitors related to galanthamine.

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Magnolol and honokiol isolated from magnolia officinalis protect rat heart mitochondria against lipid peroxidation

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The Ginkgo biloba Extract (EGb 761) Protects and Rescues Hippocampal Cells Against Nitric Oxide‐Induced Toxicity

2000 • 222 citations

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1983 • 221 citations

Nicotine Inhibits Amyloid Formation by the β-Peptide

1996 • 218 citations

Systemic administration of defined extracts from Withania somnifera (Indian ginseng) and Shilajit differentially affects cholinergic but not glutamatergic and GABAergic markers in rat brain

1997 • 216 citations

CNS acetylcholine receptor activity in European medicinal plants traditionally used to improve failing memory

2000 • 207 citations

Galantamine: a randomized, double‐blind, dose comparison in patients with Alzheimer's disease

2001 • 204 citations

Pharmacology of nicotine and its therapeutic use in smoking cessation and neurodegenerative disorders

1996 • 204 citations

Inhibition of Acetylcholinesterase Activity by Monoterpenoids with a p-Menthane Skeleton

1997 • 201 citations

Relation between nicotine intake and Alzheimer's disease.

1991 • 199 citations

Scavenging effects of salvia miltiorrhiza on free radicals and its protection for myocardial mitochondrial membranes from ischemia-reperfusion injury.

1996 • 199 citations

The influence of smoking on the risk of Alzheimer’s disease

1999 • 197 citations

Effect of thyme oil and thymol dietary supplementation on the antioxidant status and fatty acid composition of the ageing rat brain

2000 • 186 citations

Antioxidative activity of extracts from selected species of the family Lamiaceae in sunflower oil

1997 • 184 citations

A New Antioxidative 1,3-Benzodioxole fromMelissa officinalis

1998 • 183 citations

The Ginkgo biloba extract EGb 761 rescues the PC12 neuronal cells from β-amyloid-induced cell death by inhibiting the formation of β-amyloid-derived diffusible neurotoxic ligands

2001 • 181 citations

Rivastigmine

1998 • 179 citations

Galantamine: Effect on nicotinic receptor binding, acetylcholinesterase inhibition, and learning

2001 • 177 citations

Antioxidative constituents ofRosmarinus officinalis andSalvia officinalis

1992 • 175 citations

Effect of ashwagandha on lipid peroxidation in stress-induced animals

1998 • 168 citations

A 26-Week Analysis of a Double-Blind, Placebo-Controlled Trial of the Ginkgo biloba Extract EGb 761<sup>®</sup> in Dementia

2000 • 164 citations

Effect of Bacopa monniera Linn. (Brāhmi) extract on avoidance responses in rat

1982 • 162 citations

Crocin suppresses tumor necrosis factor-α-induced cell death of neuronally differentiated PC-12 cells

2001 • 162 citations

The pharmacology of galanthamine and its analogues

1995 • 158 citations

In-vitro activity of S. lavandulaefolia (Spanish sage) relevant to treatment of Alzheimer's disease

2001 • 157 citations

A new class of COX-2 inhibitor, rutaecarpine from Evodia rutaecarpa

1999 • 153 citations

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1996 • 152 citations

Huperzine A attenuates amyloid β‐peptide fragment 25‐35‐induced apoptosis in rat cortical neurons via inhibiting reactive oxygen species formation and caspase‐3 activation

2001 • 151 citations

Effect of some Indian herbs on macrophage functions in ochratoxin A treated mice

1997 • 147 citations

Immunomodulatory and CNS effects of sitoindosides IX and X, two new glycowithanolides from Withania somnifera

1989 • 146 citations

Triterpene antioxidants fromGanoderma lucidum

1999 • 141 citations

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1987 • 141 citations

Novel Anticholinesterase and Antiamnesic Activities of Dehydroevodiamine, a Constituent ofEvodia rutaecarpa

1996 • 138 citations

Mechanism of inhibition of cholinesterases by huperzine A

1992 • 135 citations

Neuroprotective role of curcumin fromCurcuma longa on ethanol-induced brain damage

1999 • 135 citations

The efficacy of EGb 761 in patients with senile dementia of the alzheimer type, a double‐blind, placebo‐controlled study on different levels of investigation

1994 • 132 citations

A systematic review and meta-analysis of Hypericum perforatum in depression: a comprehensive clinical review

2001 • 131 citations

Ginkgo Biloba Extract (EGb 761) Independently Improves Changes in Passive Avoidance Learning and Brain Membrane Fluidity in the Aging Mouse

2007 • 128 citations

Antiinflammatory activity and chemical composition of extracts of Verbena officinalis

2000 • 128 citations

Phytochemical Dictionary

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Protection from phenytoin-induced cognitive deficit by Bacopa monniera, a reputed Indian nootropic plant

2000 • 121 citations

Effects of Hypericum perforatum L. and Hypericum calycinum L. extracts on the central nervous system in mice

1996 • 120 citations

Antidepressant effects of Banxia Houpu decoction, a traditional Chinese medicinal empirical formula

2000 • 117 citations

Long term effect of herbal drug Withania somnifera on adjuvant induced arthritis in rats.

1988 • 116 citations

Topical anti-inflammatory activity of some Asian medicinal plants used in dermatological disorders

2001 • 115 citations

Effects of glycowithanolides from Withania somnifera on an animal model of Alzheimer's disease and perturbed central cholinergic markers of cognition in rats

1995 • 112 citations

Inhibition of acetylcholinesterases by pulegone-1,2-epoxide

1985 • 111 citations

Effects of lobeline, a nicotinic receptor agonist, on learning and memory

1993 • 109 citations

Medicinal Plants and Alzheimer's Disease: Integrating Ethnobotanical and Contemporary Scientific Evidence

1998 • 108 citations

The effects of acute doses of standardized Ginkgo biloba extract on memory and psychomotor performance in volunteers

1999 • 106 citations

Dendrite extension by methanol extract of Ashwagandha (roots of Withania somnifera) in SK-N-SH cells

2000 • 106 citations

Age-related increase of oxidative stress-induced apoptosis in micePrevention by Ginkgo biloba extract (EGb761)

2001 • 104 citations

Salvianolic acid L, a potent phenolic antioxidant from Salvia officinalis

2001 • 104 citations

Anti-inflammatory and analgesic effects of magnolol

1992 • 103 citations

Modification of arachidonic metabolism by flavonoids

1987 • 103 citations

Effects of four non-cholinergic cognitive enhancers in comparison with tacrine and galanthamine on scopolamine-induced amnesia in rats

1992 • 103 citations

Neuroprotective Effects of Withania somnifera Dunn. in Hippocampal Sub‐regions of Female Albino Rat

2001 • 101 citations

Radical scavenging activity and antioxidant properties of tannins fromGuiera senegalensis (Combretaceae)

1998 • 101 citations

Studies on the activities of tannins and related compounds from medicinal plants and drugs. VII. Effects of extracts of leaves of Artemisia species, and caffeic acid and chlorogenic acid on lipid metabolic injury in rats fed peroxidized oil.

1985 • 100 citations

Soy Phytoestrogens Improve Radial Arm Maze Performance in Ovariectomized Retired Breeder Rats and Do Not Attenuate Benefits of 17β-Estradiol Treatment

2000 • 99 citations

Chapter 34 The cholinergic system in Alzheimer disease

1990 • 98 citations

Proof of efficacy of the Ginkgo biloba special extract EGb 761 in outpatients suffering from mild to moderate primary degenerative dementia of the Alzheimer type or multi-infarct dementia

1997 • 96 citations

The triterpene celastrol as a very potent inhibitor of lipid peroxidation in mitochondria

1990 • 95 citations

Effect of St. John's wort on free radical production

2001 • 93 citations

Enhanced maze performance and reduced oxidative stress by combined extracts of zingiber officinale and ginkgo biloba in the aged rat

2002 • 91 citations

Retracted:Nootropic‐like effect of ashwagandha (Withania somnifera L.) in mice

2001 • 89 citations

Antioxidative Phenolic Glycosides from Sage (Salvia officinalis)

1999 • 89 citations

The ameliorating effects of the cognitive-enhancing Chinese herbs on scopolamine-induced amnesia in rats

2000 • 89 citations

Dementia in Ayurveda

1999 • 87 citations

The use of substituent constants in the study of structure-activity relationships in cholinesterase inhibitors

1966 • 87 citations

Neurotropic Action of the Hydroalcoholic Extract ofMelissa officinalisin the Mouse

1991 • 86 citations

857-860Anti-inflammatory Effect of Magnolol, Isolated fromMagnolia officinalis, on A23187-induced Pleurisy in Mice

1995 • 86 citations

Antioxidant activity of quinones extracted from tanshen (Salvia miltiorrhiza Bunge)

1992 • 86 citations

Memory Effects of Standardized Extracts ofPanax ginseng(G115),Ginkgo biloba(GK 501) and their Combination Gincosan® (PHL-00701)

1993 • 84 citations

Arisugacins, selective acetylcholinesterase inhibitors of microbial origin

1997 • 80 citations

Nicotinic Receptors and Neurodegenerative Dementing Diseases

1995 • 79 citations

Comparative Evaluation of Melissa officinalis L., Tilia europaea L., Passiflora edulis Sims. and Hypericum perforatum L. in the Elevated Plus Maze Anxiety Test

2001 • 79 citations

Nicotinic systems in central nervous systems disease: degenerative disorders and beyond

2000 • 77 citations

Influences of Ginkgo biloba on cyclosporin a induced lipid peroxidation in human liver microsomes in comparison to vitamin E, glutathione and N-acetylcysteine

1991 • 76 citations

Effect of Withania somnifera glycowithanolides on iron-induced hepatotoxicity in rats

2000 • 76 citations

Influence of an Indian medicine (Ashwagandha) on acute-phase reactants in inflammation.

1981 • 76 citations

[Anti-cholinesterase activity of huperzine A].

1986 • 75 citations

MAGNOLOL ATTENUATES PEROXIDATIVE DAMAGE AND IMPROVES SURVIVAL OF RATS WITH SEPSIS

2000 • 75 citations

The Anxiolytic Effect of Two Oriental Herbal Drugs in Japan Attributed to Honokiol from Magnolia Bark

2000 • 74 citations

Pharmacological effects of Withania somnifera root extract on GABAA receptor complex.

1991 • 73 citations

Antioxidative components of tanshen (Salvia miltiorhiza Bung)

1990 • 72 citations

Compounds from Danshen. Part 4. Structure-activity relationship of miltirone, an active central benzodiazepine receptor ligand isolated from Salvia miltiorrhiza Bunge (Danshen)

1991 • 71 citations

Lobeline inhibits nicotine-evoked [3H]dopamine overflow from rat striatal slices and nicotine-evoked 86Rb+ efflux from thalamic synaptosomes

2000 • 69 citations

Effect of Centella asiatica fresh leaf aqueous extract on learning and memory and biogenic amine turnover in albino rats

1992 • 68 citations

[Antioxidative effect of three water-soluble components isolated from Salvia miltiorrhiza in vitro].

1992 • 67 citations

(+)-.ALPHA.-Viniferin, a Stilbene Trimer from Caragana chamlague, Inhibits Acetylcholinesterase.

2002 • 67 citations

Hypericum Extract and Hyperforin: Memory-Enhancing Properties in Rodents

2001 • 66 citations

Efficacy and tolerability of rivastigmine in patients with dementia of the Alzheimer type

1998 • 65 citations

New Anti-inflammatory Treatment Strategy in Alzheimer’s Disease

2000 • 63 citations

Antinociceptive and Anti-Inflammatory Activities of Limonin Isolated from the Fruits ofEvodia rutaecarpavar.bodinieri

1998 • 63 citations

Antiamnesic and cholinomimetic side-effects of the cholinesterase inhibitors, physostigmine, tacrine and NIK-247 in rats

1993 • 62 citations

Salvianolic Acid B Protects the Memory Functions against Transient Cerebral Ischemia in Mice

2000 • 61 citations

Huperzine A attenuates cognitive deficits and hippocampal neuronal damage after transient global ischemia in gerbils

2001 • 60 citations

Potencies and stereoselectivities of enantiomers of huperzine A for inhibition of rat cortical acetylcholinesterase

1991 • 60 citations

The association between smoking and Alzheimer’s disease: effects of study design and bias

2001 • 60 citations

Isolation and Structural Elucidation of Two New Glycosides from Sage (Salvia officinalis L.)

1999 • 59 citations

In vitro and in vivo protective effect of honokiol on rat liver from peroxidative injury

1997 • 59 citations

Inhibition of Prostaglandin E2 and Leukotriene C4 in Mouse Peritoneal Macrophages and Thromboxane B2 Production in Human Platelets by Flavonoids from Stachys chrysantha and Stachys candida.

2000 • 59 citations

Mono- and sesquiterpenoids from Hydrocotyle and Centella species

1982 • 58 citations

Crocin Improves the Ethanol-induced Impairment of Learning Behaviors of Mice in Passive Avoidance Tasks.

1995 • 57 citations

Anti-inflammatory and analgesic activity of Indian Hypericum perforatum L.

2001 • 56 citations

Galanthamine

1996 • 56 citations

Honokiol and magnolol increase the number of [3H] muscimol binding sites three-fold in rat forebrain membranes in vitro using a filtration assay, by allosterically increasing the affinities of low-affinity sites.

1999 • 56 citations

Effect of flavonoids on arachidonic acid metabolism.

1986 • 56 citations

Phenylpropanoids fromBallota nigra L. inhibitin vitro LDL peroxidation

2000 • 55 citations

Effects of transdermal nicotine on attention and memory in healthy elderly non-smokers

2001 • 55 citations

Acute Hepatitis After Tetrahydroaminoacridine Administration for Alzheimerʼs Disease

1990 • 52 citations

Beneficial effects of thyme oil on age-related changes in the phospholipid C20 and C22 polyunsaturated fatty acid composition of various rat tissues

1999 • 52 citations

A psycho-neuropharmacological profile of Centella asiatica extract.

1990 • 51 citations

Inhibition of Acetylcholinesterase Activity by Essential Oil fromCitrus paradisi

2001 • 51 citations

The in vitro effect of dandelions antioxidants on microsomal lipid peroxidation

2000 • 50 citations

The tradition of medicinal plants in Zagori, Epirus (northwestern Greece)

1992 • 50 citations

Über die chemische Zusammensetzung von Melissenölen

1982 • 49 citations

Magnolol, a potent antioxidant from Magnolia officinalis, attenuates intimal thickening and MCP-1 expression after balloon injury of the aorta in cholesterol-fed rabbits

2001 • 48 citations

WITHANIA SOMNIFERA ROOT EXTRACT IN THE REGULATION OF LEAD-INDUCED OXIDATIVE DAMAGE IN MALE MOUSE

2000 • 48 citations

Honokiol and Magnolol Increased Hippocampal Acetylcholine Release in Freely-Moving Rats

2000 • 47 citations

Ameliorative Effects of Chronic Treatment Using DX-9386, a Traditional Chinese Prescription, on Learning Performance and Lipid Peroxide Content in Senescence Accelerated Mouse.

1994 • 47 citations

Acute and chronic studies with the anticholinesterase huperzine a: Effect on central nervous system cholinergic parameters

1991 • 45 citations

A Reference Guide to Medicinal Plants

1990 • 45 citations

Enhancements of choline acetyltransferase activity and nerve growth factor secretion by Polygalae radix-extract containing active ingredients in Kami-untan-to

1997 • 44 citations

Effect of dibenzo[a,c]cyclooctene lignans isolated from Fructus schizandrae on lipid peroxidation and antioxidative enzyme activity

1991 • 43 citations

Antioxidant effect ofSalvia miltiorrhiza

1997 • 43 citations

Low-Dose Estrogen Replacement Therapy for Alzheimer Disease in Women

1994 • 42 citations

Radix Salviae miltiorrhizae treatment results in decreased lipid peroxidation in reperfusion injury.

1996 • 42 citations

Pharmacological Studies on Leaves ofWithania somnifera

1986 • 41 citations

Review: on the chemistry of oxidative stress.

1993 • 41 citations

Protective effects of salvianolic acid A against impairment of memory induced by cerebral ischemia-reperfusion in mice.

1997 • 41 citations

Beneficial Effects of Biota, a Traditional Chinese Herbal Medicine, on Learning Impairment Induced by Basal Forebrain-Lesion in Mice.

1995 • 41 citations

Cirsiliol and caffeic acid ethyl ester, isolated from Salvia guaranitica, are competitive ligands for the central benzodiazepine receptors

1996 • 41 citations

Nicotine and its interaction with β-amyloid protein: a short review

2001 • 41 citations

Magnolol protects cortical neuronal cells from chemical hypoxia in rats

1998 • 39 citations

Effect of Polygala tenuifolia root extract on the tumor necrosis factor-α secretion from mouse astrocytes

1998 • 39 citations

Actions of the soy phytoestrogen genistein in models of human chronic disease: potential involvement of transforming growth factor β

2001 • 39 citations

Application of the elevated plus-maze test in mice for evaluation of the content of Honokiol in water extracts of magnolia

1999 • 38 citations

Differential inhibition of acetylcholinesterase molecular forms in normal and Alzheimer disease brain

1992 • 38 citations

Review of rivastigmine and its clinical applications in Alzheimer’s disease and related disorders

2001 • 37 citations

Galantamine: A New Alzheimer Drug with a Past Life

2001 • 37 citations

Effect of huperzine A on working memory in reserpine- or yohimbine-treated monkeys

2001 • 37 citations

Peroxyl Radical Scavenging Activities of Hamamelitannin in Chemical and Biological Systems

1995 • 35 citations

Beneficial Effects of S-113m, a Novel Herbal Prescription, on Learning Impairment Model in Mice.

1995 • 34 citations

Anti-aging Effect of DX-9386 in Senescence Accelerated Mouse.

1994 • 33 citations

Pharmacological treatment of cognitive dysfunction in dementia disorders

1996 • 33 citations

Constituents of the Essential Oil fromMelissa officinalis

1991 • 33 citations

Effects of DX-9386, a Traditional Chinese Preparation, on Passive and Active Avoidance Performances in Mice.

1994 • 33 citations

Is Smoking Associated with the Risk of Developing Alzheimer's Disease? Results from Three Canadian Data Sets

2000 • 31 citations

Beneficial Effects of DX-9386, a Traditional Chinese Prescription, on Memory Disorder Produced by Lesioning the Amygdala in Mice.

1994 • 28 citations

MOLECULAR FORMS OF ACETYLCHOLINESTERASE IN ALZHEIMERʼS DISEASE

1986 • 27 citations

Effect of Ginkgo biloba extract (EGb761) on glucose metabolism-related markers in streptozotocin-damaged rat brain

2001 • 26 citations

Increased Feline Cerebral Blood Flow Induced by Dehydroevodiamine Hydrochloride from Evodia rutaecarpa

1994 • 26 citations

Old Chinese herbal medicine used for fever yields possible new Alzheimer disease therapy

1997 • 24 citations

Cholinergic Dysfunction in Alzheimer Disease: Cause or Effect?

1986 • 23 citations

Effects of Hypericum perforatum (St. John’s wort) on Passive Avoidance in the Rat: Evaluation of Potential Neurochemical Mechanisms Underlying its Antidepressant Activity

2001 • 23 citations

Automatic Memory Processes in Patients with Dementia-Alzheimer's Type (DAT)

1990 • 23 citations

Effect of radix salviae miltiorrhizae on EAA and IAA during cerebral ischemia in gerbils: a microdialysis study.

1994 • 23 citations

An investigation into the antioxidant activity of Allium nutans L.

1999 • 22 citations

Pharmacologic Management of Alzheimer’s Disease

1998 • 22 citations

Inhibition of Leukocyte Eicosanoid Generation and Radical Scavenging Activity by Gnaphalin, a Lipophilic Flavonol Isolated from Helichrysum picardii

1999 • 22 citations

Episodic and semantic memory in early versus late onset Alzheimer's disease*1

1991 • 19 citations

A Review of Terrestrial Plants and Marine Organisms Having Antiinflammatory Activity

1995 • 18 citations

Effect of radix Salviae miltiorrhizae on nitric oxide in cerebral ischemic-reperfusion injury.

1996 • 17 citations

Alzheimer's Disease: An Overview for the Pharmacist

1997 • 16 citations

[Antioxidative effect of Chinese drugs].

1992 • 13 citations

Isolation and identification of the major insecticidal compound of poleo (Lippia stoechadifolia)

1985 • 12 citations

Jekka's Complete Herb Book

1994 • 12 citations

Inhibitory Effect of Interleukin-1α-Induced Apoptosis byPolygala Tenuifoliain Hep G2 Cells

2000 • 10 citations

Withania somnifera(Ashwagandha), a Rejuvenating Herbal Drug Which Controls Alpha-2-Macroglobulin Synthesis During Inflammation

1985 • 9 citations

The effect of radix Salviae Miltiorrhizae (RSM) on substance P in cerebral ischemia--animal experiment.

1991 • 9 citations

Biota (Po‐Tzu‐Jen), a traditional Chinese medicine, ameliorates the memory acquisition disorder induced by amygdala lesion in mice

1992 • 9 citations

Lemonbalm

1998 • 6 citations

The effect of radix Salviae Miltiorrhizae Composita on peroxidation of low density lipoprotein due to copper dichloride.

1994 • 6 citations

Pharmacokinetics of galanthamine in humans and corresponding cholinesterase inhibition

1990 • 5 citations

Update on cholinergic enhancement therapy for Alzheimer disease.

1987 • 4 citations

Nootropic effect of dangshen, radix cadonopsis pilosulae

1990 • 4 citations

Role of free radicals in biological systems

1993 • 3 citations

PROTECTIVE EFFECT OF RADIX SALVIAE MILTIORRHIZAE COMPOSITA ON CEREBRAL ISCHEMIA

1995 • 2 citations

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