Human SIR2 deacetylates p53 and antagonizes PML/p53-induced cellular senescence

Translating the Histone Code

2001 • 9,488 citations

The language of covalent histone modifications

2000 • 8,260 citations

A biomarker that identifies senescent human cells in culture and in aging skin in vivo.

1995 • 6,950 citations

Surfing the p53 network

2000 • 6,487 citations

Lanthanum Chloride Inhibits LPS Mediated Expressions of Pro-Inflammatory Cytokines and Adhesion Molecules in HUVECs: Involvement of NF-κB-Jmjd3 Signaling

2017 • 5,610 citations

Oncogenic ras Provokes Premature Cell Senescence Associated with Accumulation of p53 and p16INK4a

1997 • 4,870 citations

Transcriptional silencing and longevity protein Sir2 is an NAD-dependent histone deacetylase

2000 • 3,355 citations

hSIR2SIRT1 Functions as an NAD-Dependent p53 Deacetylase

2001 • 2,550 citations

Activation of p53 Sequence-Specific DNA Binding by Acetylation of the p53 C-Terminal Domain

1997 • 2,510 citations

The SIR2/3/4 complex and SIR2 alone promote longevity in Saccharomyces cerevisiae by two different mechanisms

1999 • 2,199 citations

Advanced mammalian gene transfer: high titre retroviral vectors with multiple drug selection markers and a complementary helper-free packaging cell line

1990 • 2,129 citations

Negative Control of p53 by Sir2α Promotes Cell Survival under Stress

2001 • 2,042 citations

Increased dosage of a sir-2 gene extends lifespan in Caenorhabditis elegans

2001 • 1,892 citations

The CBP co-activator is a histone acetyltransferase

1996 • 1,773 citations

Requirement of NAD and SIR2 for Life-Span Extension by Calorie Restriction in Saccharomyces cerevisiae

2000 • 1,756 citations

Atmospheric carbon dioxide concentrations over the past 60 million years

2000 • 1,734 citations

p53 mutant mice that display early ageing-associated phenotypes

2002 • 1,428 citations

Phylogenetic Classification of Prokaryotic and Eukaryotic Sir2-like Proteins

2000 • 1,360 citations

Genetic pathways that regulate ageing in model organisms

2000 • 1,341 citations

Retinoblastoma protein recruits histone deacetylase to repress transcription

1998 • 1,231 citations

DNA damage activates p53 through a phosphorylation–acetylation cascade

1998 • 1,194 citations

Post‐translational modifications and activation of p53 by genotoxic stresses

2001 • 1,076 citations

Deconstructing a Disease: RAR, Its Fusion Partners, and Their Roles in the Pathogenesis of Acute Promyelocytic Leukemia

1999 • 1,042 citations

DNA methyltransferase Dnmt1 associates with histone deacetylase activity

2000 • 960 citations

The silencing protein SIR2 and its homologs are NAD-dependent protein deacetylases

2000 • 946 citations

Cellular senescence as a tumor-suppressor mechanism

2001 • 847 citations

PML regulates p53 acetylation and premature senescence induced by oncogenic Ras

2000 • 826 citations

Pml Is Critical for Nd10 Formation and Recruits the Pml-Interacting Protein Daxx to This Nuclear Structure When Modified by Sumo-1

1999 • 809 citations

Deacetylation of p53 modulates its effect on cell growth and apoptosis

2000 • 794 citations

Characterization of Five Human cDNAs with Homology to the Yeast SIR2 Gene: Sir2-like Proteins (Sirtuins) Metabolize NAD and May Have Protein ADP-Ribosyltransferase Activity

1999 • 781 citations

p53 Sites Acetylated In Vitro by PCAF and p300 Are Acetylated In Vivo in Response to DNA Damage

1999 • 764 citations

Sir2 links chromatin silencing, metabolism, and aging

2000 • 725 citations

Regulation and function of the p53 tumor suppressor protein

2001 • 716 citations

Acetylation of p53 Activates Transcription through Recruitment of Coactivators/Histone Acetyltransferases

2001 • 704 citations

A phylogenetically conserved NAD ⁺ -dependent protein deacetylase activity in the Sir2 protein family

2000 • 703 citations

Conjugation with the ubiquitin-related modifier SUMO-1 regulates the partitioning of PML within the nucleus

1998 • 676 citations

Recruitment of p300/CBP in p53-Dependent Signal Pathways

1997 • 671 citations

The SIR2 gene family, conserved from bacteria to humans, functions in silencing, cell cycle progression, and chromosome stability.

1995 • 601 citations

Histone acetylases and deacetylases in cell proliferation

1999 • 598 citations

The transcriptional role of PML and the nuclear body

2000 • 574 citations

Pml is essential for multiple apoptotic pathways

1998 • 564 citations

Role of SUMO-1–modified PML in nuclear body formation

2000 • 555 citations

p300/CBP-mediated p53 acetylation is commonly induced by p53-activating agents and inhibited by MDM2

2001 • 554 citations

Silent information regulator 2 family of NAD- dependent histone/protein deacetylases generates a unique product, 1- O- acetyl-ADP-ribose

2000 • 541 citations

The Human Histone Deacetylase Family

2001 • 541 citations

PML is induced by oncogenicrasand promotes premature senescence

2000 • 519 citations

Role of Promyelocytic Leukemia (Pml) Sumolation in Nuclear Body Formation, 11s Proteasome Recruitment, and as2O3-Induced Pml or Pml/Retinoic Acid Receptor α Degradation

2001 • 477 citations

PML protein isoforms and the RBCC/TRIM motif

2001 • 465 citations

Transcriptional Regulation by p53 through Intrinsic DNA/Chromatin Binding and Site-Directed Cofactor Recruitment

2001 • 437 citations

Arsenic-induced PML targeting onto nuclear bodies: Implications for the treatment of acute promyelocytic leukemia

1997 • 430 citations

Replicative Senescence: An Old Lives' Tale?

1996 • 429 citations

An Enzymatic Activity in the Yeast Sir2 Protein that Is Essential for Gene Silencing

1999 • 388 citations

PML induces a novel caspase-independent death process

1998 • 384 citations

BRCA1 regulates p53-dependent gene expression

1998 • 376 citations

Regulation of p53 activity in nuclear bodies by a specific PML isoform

2000 • 371 citations

Regulation of cellular senescence by p53

2001 • 361 citations

High-efficiency gene transfer and selection of human hematopoietic progenitor cells with a hybrid EBV/retroviral vector expressing the green fluorescence protein.

1998 • 357 citations

Functional significance of histone deacetylase diversity

2001 • 351 citations

Structure of the histone deacetylase SIRT2.

2001 • 349 citations

Nuclear bodies: multifaceted subdomains of the interchromatin space

1999 • 330 citations

Crystal Structure of a SIR2 Homolog–NAD Complex

2001 • 301 citations

PML, a growth suppressor disrupted in acute promyelocytic leukemia.

1994 • 296 citations

Chemistry of Gene Silencing: The Mechanism of NAD⁺-Dependent Deacetylation Reactions

2001 • 294 citations

The acetyltransferase activity of CBP stimulates transcription

1998 • 265 citations

Human Fibroblast Commitment to a Senescence-Like State in Response to Histone Deacetylase Inhibitors Is Cell Cycle Dependent

1996 • 265 citations

Coupling of histone deacetylation to NAD breakdown by the yeast silencing protein Sir2: Evidence for acetyl transfer from substrate to an NAD breakdown product

2000 • 245 citations

Acetylation of TAFI68, a subunit of TIF-IB/SL1, activates RNA polymerase I transcription

2001 • 200 citations

Cell cycle regulation of PML modification and ND10 composition

1999 • 190 citations

CREB-binding protein and p300/CBP-associated factor are transcriptional coactivators of the p53 tumor suppressor protein.

1997 • 183 citations

Structure, Organization, and Dynamics of Promyelocytic Leukemia Protein Nuclear Bodies

1998 • 174 citations

Modulation of CREB binding protein function by the promyelocytic (PML) oncoprotein suggests a role for nuclear bodies in hormone signaling

1999 • 173 citations

The Promyelocytic Leukemia Gene Product (PML) Forms Stable Complexes with the Retinoblastoma Protein

1998 • 166 citations

A cytosolic NAD-dependent deacetylase, Hst2p, can modulate nucleolar and telomeric silencing in yeast

2001 • 163 citations

Diverse and dynamic functions of the Sir silencing complex

1999 • 158 citations

The Growth Suppressor PML Represses Transcription by Functionally and Physically Interacting with Histone Deacetylases

2001 • 153 citations

The Transcription Coactivator Cbp Is a Dynamic Component of the Promyelocytic Leukemia Nuclear Body

2001 • 153 citations

SUMO: of branched proteins and nuclear bodies

2001 • 152 citations

Role of PML and PML-RARα in Mad-Mediated Transcriptional Repression

2001 • 143 citations

Identification of a nuclear domain with deacetylase activity

2000 • 138 citations

The PML nuclear bodies: actors or extras?

1999 • 131 citations

Characterization of a human gene with sequence homology to Saccharomyces cerevisiae SIR2

1999 • 130 citations

PML interaction with p53 and its role in apoptosis and replicative senescence

2001 • 123 citations

The Sir proteins of Saccharomyces cerevisiae: mediators of transcriptional silencing and much more

2000 • 99 citations

The Conserved Core of a HumanSIR2Homologue Functions in Yeast Silencing

1999 • 93 citations

PML, a Growth Suppressor Disrupted in Acute Promyelocytic Leukemia

1994 • 72 citations

Sir-Ku-itous Routes to Make Ends Meet

1999 • 70 citations

The nucleolus: Nucleolar space for RENT

1999 • 45 citations

Coupling of histone deacetylation to NAD breakdown by the yeast silencing protein Sir2: Evidence for acetyl transfer from substrate to an NAD breakdown product

2000 • 35 citations

Advanced mammalian gene transfer: high titre retroviral vectors with multiple drug selection markers and a complementary helper-free packaging cell line

1990 • 33 citations

Leukemia-associated AML1/ETO (8;21) chromosomal translocation protein increases the cellular representation of PML bodies

2000 • 19 citations

Targeting protein inactivation through an oligomerization chain reaction

2002 • 16 citations