Opposing effects of Ctk1 kinase and Fcp1 phosphatase at Ser 2 of the RNA polymerase II C-terminal domain
Data up to Jan 2025
Total Citations Per Year
Abstract
References (61)
Guide to Yeast Genetics and Molecular Biology
1993 • 2,377 citations
Different phosphorylated forms of RNA polymerase II and associated mRNA processing factors during transcription
2000 • 1,049 citations
Guide to yeast genetics and molecular biology
1992 • 1,032 citations
RNA POLYMERASE II
1991 • 729 citations
Transcription elongation factor P-TEFb is required for HIV-1 Tat transactivation in vitro
1997 • 692 citations
P-TEFb, a Cyclin-Dependent Kinase Controlling Elongation by RNA Polymerase II
2000 • 671 citations
Guide to Yeast Genetics and Molecular Biology
1991 • 607 citations
5′-Capping enzymes are targeted to pre-mRNA by binding to the phosphorylated carboxy-terminal domain of RNA polymerase II
1997 • 540 citations
Reversible Phosphorylation of the C-terminal Domain of RNA Polymerase II
1996 • 498 citations
mRNA capping enzyme is recruited to the transcription complex by phosphorylation of the RNA polymerase II carboxy-terminal domain
1997 • 467 citations
A kinase–cyclin pair in the RNA polymerase II holoenzyme
1995 • 418 citations
Temporal Regulation of RNA Polymerase II by Srb10 and Kin28 Cyclin-Dependent Kinases
1998 • 400 citations
Dynamic association of capping enzymes with transcribing RNA polymerase II
2000 • 384 citations
TFIIH is negatively regulated by cdk8-containing mediator complexes
2000 • 381 citations
Distinct Roles for CTD Ser-2 and Ser-5 Phosphorylation in the Recruitment and Allosteric Activation of Mammalian mRNA Capping Enzyme
1999 • 329 citations
Transcription-dependent redistribution of the large subunit of RNA polymerase II to discrete nuclear domains.
1995 • 328 citations
Phosphorylation of RNA polymerase II C-terminal domain and transcriptional elongation
1994 • 325 citations
A hyperphosphorylated form of the large subunit of RNA polymerase II is associated with splicing complexes and the nuclear matrix.
1996 • 324 citations
Tails of RNA polymerase II
1990 • 320 citations
Negative regulation of Gcn4 and Msn2 transcription factors by Srb10 cyclin-dependent kinase
2001 • 308 citations
Messenger RNA synthesis in mammalian cells is catalyzed by the phosphorylated form of RNA polymerase II.
1987 • 288 citations
Tat Modifies the Activity of CDK9 To Phosphorylate Serine 5 of the RNA Polymerase II Carboxyl-Terminal Domain during Human Immunodeficiency Virus Type 1 Transcription
2000 • 260 citations
Construction and analysis of yeast RNA polymerase II CTD deletion and substitution mutations.
1995 • 239 citations
The transition of RNA polymerase II from initiation to elongation is associated with phosphorylation of the carboxyl-terminal domain of subunit IIa
1989 • 236 citations
NAT, a Human Complex Containing Srb Polypeptides that Functions as a Negative Regulator of Activated Transcription
1998 • 235 citations
Growth-related Changes in Phosphorylation of Yeast RNA Polymerase II
1998 • 225 citations
KIN28 Encodes a C-Terminal Domain Kinase That Controls mRNA Transcription in Saccharomyces cerevisiae but Lacks Cyclin-Dependent Kinase-Activating Kinase (CAK) Activity
1995 • 208 citations
Kin28, the TFIIH-Associated Carboxy-Terminal Domain Kinase, Facilitates the Recruitment of mRNA Processing Machinery to RNA Polymerase II
2000 • 200 citations
An Unusual Eukaryotic Protein Phosphatase Required for Transcription by RNA Polymerase II and CTD Dephosphorylation in S. cerevisiae
1999 • 198 citations
A protein phosphatase functions to recycle RNA polymerase II
1999 • 195 citations
Locus-specific variation in phosphorylation state of RNA polymerase II in vivo: correlations with gene activity and transcript processing.
1993 • 175 citations
CTD kinase large subunit is encoded by CTK1, a gene required for normal growth of Saccharomyces cerevisiae.
1991 • 170 citations
Purification of eukaryotic RNA polymerase II by immunoaffinity chromatography. Elution of active enzyme with protein stabilizing agents from a polyol-responsive monoclonal antibody.
1990 • 163 citations
The Ess1 prolyl isomerase is linked to chromatin remodeling complexes and the general transcription machinery
2000 • 163 citations
Phospho-Carboxyl-Terminal Domain Binding and the Role of a Prolyl Isomerase in Pre-mRNA 3′-End Formation
1999 • 147 citations
An essential component of a C-terminal domain phosphatase that interacts with transcription factor IIF in Saccharomyces cerevisiae
1997 • 145 citations
FCP1, the RAP74-Interacting Subunit of a Human Protein Phosphatase That Dephosphorylates the Carboxyl-terminal Domain of RNA Polymerase IIO
1998 • 144 citations
GAL4 Is Regulated by the RNA Polymerase II Holoenzyme–Associated Cyclin-Dependent Protein Kinase SRB10/CDK8
1999 • 142 citations
The Yeast Carboxyl-Terminal Repeat Domain Kinase CTDK-I Is a Divergent Cyclin–Cyclin-Dependent Kinase Complex
1995 • 140 citations
Purification and characterization of a phosphatase from HeLa cells which dephosphorylates the C-terminal domain of RNA polymerase II
1994 • 137 citations
Phosphorylation-dependent prolyl isomerization: a novel signaling regulatory mechanism
1999 • 134 citations
Synthetic Lethal Interactions Suggest a Role for the Saccharomyces cerevisiae Rtf1 Protein in Transcription Elongation
2000 • 131 citations
Functional Relationships of Srb10-Srb11 Kinase, Carboxy-Terminal Domain Kinase CTDK-I, and Transcriptional Corepressor Ssn6-Tup1
1998 • 126 citations
Mutations in a Peptidylprolyl-cis/trans-isomerase Gene Lead to a Defect in 3′-End Formation of a Pre-mRNA inSaccharomyces cerevisiae
1999 • 102 citations
Ubiquitination of RNA polymerase II large subunit signaled by phosphorylation of carboxyl-terminal domain
1999 • 99 citations
Phosphorylation of the RNA Polymerase II Carboxy-Terminal Domain by the Bur1 Cyclin-Dependent Kinase
2001 • 98 citations
Modulation of RNA Polymerase II Elongation Efficiency by C-terminal Heptapeptide Repeat Domain Kinase I
1997 • 97 citations
Purification and Characterization of an RNA Polymerase II Phosphatase from Yeast
1996 • 76 citations
BUR1andBUR2Encode a Divergent Cyclin-Dependent Kinase–Cyclin Complex Important for Transcription In Vivo
2000 • 74 citations
A Motif Shared by TFIIF and TFIIB Mediates Their Interaction with the RNA Polymerase II Carboxy-Terminal Domain Phosphatase Fcp1p in Saccharomyces cerevisiae
2000 • 69 citations
Yeast Carboxyl-terminal Domain Kinase I Positively and Negatively Regulates RNA Polymerase II Carboxyl-terminal Domain Phosphorylation
1999 • 68 citations
Involvement of yeast carboxy-terminal domain kinase I (CTDK-I) in transcription elongation in vivo
2001 • 54 citations
Regulated phosphorylation of the RNA polymerase II C-terminal domain (CTD)
1999 • 54 citations
Regulation of Carboxyl-terminal Domain Phosphatase by HIV-1 Tat Protein
1998 • 48 citations
Suppression Analysis Reveals a Functional Difference Between the Serines in Positions Two and Five in the Consensus Sequence of the C-Terminal Domain of Yeast RNA Polymerase II
1996 • 47 citations
Phosphorylation of RNA Polymerase II CTD Fragments Results in Tight Binding to the WW Domain from the Yeast Prolyl Isomerase Ess1
2001 • 43 citations
Heat shock of HeLa cells inactivates a nuclear protein phosphatase specific for dephosphorylation of the C-terminal domain of RNA polymerase II
1999 • 34 citations
The Essential Interaction between Yeast mRNA Capping Enzyme Subunits Is Not Required for Triphosphatase Function In Vivo
2000 • 31 citations
The Sensitivity of RNA Polymerase II in Elongation Complexes to C-terminal Domain Phosphatase
2000 • 29 citations
C-terminal Domain Phosphatase Sensitivity of RNA Polymerase II in Early Elongation Complexes on the HIV-1 and Adenovirus 2 Major Late Templates
2000 • 26 citations
Regulated phosphorylation of the RNA polymerase II C-terminal domain (CTD)
1999 • 3 citations