Vav Proteins in Neutrophils Are Required for FcγR-Mediated Signaling to Rac GTPases and Nicotinamide Adenine Dinucleotide Phosphate Oxidase Component p40(phox)

IgG Fc Receptors

2001 • 1,667 citations

Function of PI3Kγ in Thymocyte Development, T Cell Activation, and Neutrophil Migration

2000 • 1,031 citations

Identification of Two Distinct Mechanisms of Phagocytosis Controlled by Different Rho GTPases

1998 • 993 citations

FcR γ chain deletion results in pleiotrophic effector cell defects

1994 • 967 citations

Roles of PLC-β2 and -β3 and PI3Kγ in Chemoattractant-Mediated Signal Transduction

2000 • 825 citations

NADPH oxidase

2003 • 675 citations

Decreased Resistance to Bacterial Infection and Granulocyte Defects in IAP-Deficient Mice

1996 • 599 citations

Phagocytosis and innate immunity

2002 • 579 citations

Deficiency of the Hematopoietic Cell-Specific Rho Family GTPase Rac2 Is Characterized by Abnormalities in Neutrophil Function and Host Defense

1999 • 568 citations

The p47phox mouse knock-out model of chronic granulomatous disease.

1995 • 487 citations

Rho Family GTPases Bind to Phosphoinositide Kinases

1995 • 469 citations

PtdIns(3)P regulates the neutrophil oxidase complex by binding to the PX domain of p40phox

2001 • 402 citations

DIVERGENT ROLES FOR F<scp>c</scp>RECEPTORS AND COMPLEMENT IN VIVO

1998 • 376 citations

Deficiency of Src family kinases p59/61hck and p58c-fgr results in defective adhesion-dependent neutrophil functions.

1996 • 364 citations

Structural organization of the neutrophil NADPH oxidase: phosphorylation and translocation during priming and activation

2005 • 361 citations

Current molecular models for NADPH oxidase regulation by Rac GTPase

2002 • 335 citations

Vav-family proteins in T-cell signalling

2005 • 335 citations

Rac1 Deletion in Mouse Neutrophils Has Selective Effects on Neutrophil Functions

2003 • 312 citations

A Requirement for the Rho-Family GTP Exchange Factor Vav in Positive and Negative Selection of Thymocytes

1997 • 285 citations

Neutrophil priming: the cellular signals that say ‘amber’ but not ‘green’

1995 • 240 citations

Src-family kinases: rheostats of immune cell signaling

2004 • 233 citations

Vav1/2/3-null Mice Define an Essential Role for Vav Family Proteins in Lymphocyte Development and Activation but a Differential Requirement in MAPK Signaling in T and B Cells

2003 • 227 citations

Vav GEFs are required for β2 integrin-dependent functions of neutrophils

2004 • 220 citations

A Role for Mac-1 (CDIIb/CD18) in Immune Complex–stimulated Neutrophil Function In Vivo: Mac-1 Deficiency Abrogates Sustained Fcγ Receptor–dependent Neutrophil Adhesion and Complement-dependent Proteinuria in Acute Glomerulonephritis

1997 • 215 citations

Vav1 Transduces T Cell Receptor Signals to the Activation of Phospholipase C-γ1 via Phosphoinositide 3-Kinase-dependent and -independent Pathways

2002 • 214 citations

Cellular functions of the Rap1 GTP-binding protein: a pattern emerges

2002 • 211 citations

Src and Syk kinases: key regulators of phagocytic cell activation

2005 • 209 citations

Rac2 Is an Essential Regulator of Neutrophil Nicotinamide Adenine Dinucleotide Phosphate Oxidase Activation in Response to Specific Signaling Pathways

2001 • 202 citations

FcγRIII Mediates Neutrophil Recruitment to Immune Complexes

2001 • 201 citations

Rac1 is the small GTPase responsible for regulating the neutrophil chemotaxis compass

2004 • 198 citations

Rac GTPase interacts specifically with phosphatidylinositol 3-kinase

1996 • 186 citations

Comparison of the roles of mitogen-activated protein kinase kinase and phosphatidylinositol 3-kinase signal transduction in neutrophil effector function

1998 • 173 citations

P-Rex1 Regulates Neutrophil Function

2005 • 164 citations

Vav1 Regulates Phospholipase Cγ Activation and Calcium Responses in Mast Cells

2001 • 156 citations

Rac-1 dependent stimulation of the JNK/SAPK signaling pathway by Vav.

1996 • 152 citations

Local Phosphatidylinositol 3,4,5-Trisphosphate Accumulation Recruits Vav2 and Vav3 to Activate Rac1/Cdc42 and Initiate Neurite Outgrowth in Nerve Growth Factor-stimulated PC12 Cells

2005 • 146 citations

Vav3 Modulates B Cell Receptor Responses by Regulating Phosphoinositide 3-Kinase Activation

2002 • 143 citations

Regulation of neutrophil function by Rac GTPases

2003 • 136 citations

Rac2-Deficient Murine Macrophages Have Selective Defects in Superoxide Production and Phagocytosis of Opsonized Particles

2004 • 135 citations

The Respiratory Burst Oxidase and the Molecular Genetics of Chronic Granulomatous Disease

1993 • 130 citations

G-protein–coupled receptor signaling in Syk-deficient neutrophils and mast cells

2003 • 125 citations

Vav Regulates Activation of Rac but Not Cdc42 during FcγR-mediated Phagocytosis

2002 • 124 citations

p40 Is Phosphorylated on Threonine 154 and Serine 315 during Activation of the Phagocyte NADPH Oxidase

1998 • 109 citations

Mice lacking reduced nicotinamide adenine dinucleotide phosphate oxidase activity show increased susceptibility to early infection with Listeria monocytogenes.

1997 • 86 citations

The Hemopoietic Rho/Rac Guanine Nucleotide Exchange Factor Vav1 Regulates N-Formyl-Methionyl-Leucyl-Phenylalanine-Activated Neutrophil Functions

2003 • 86 citations

Fey receptors in phagocytes

1998 • 85 citations

Vav links antigen-receptor signaling to the actin cytoskeleton

1998 • 81 citations

SMC protein complexes and higher-order chromosome dynamics

1998 • 78 citations

Redundant and Alternative Roles for Activating Fc Receptors and Complement in an Antibody-Dependent Model of Autoimmune Vitiligo

2002 • 73 citations

p40phox: The last NADPH oxidase subunit

2005 • 62 citations

Continuous Translocation of Rac2 and the NADPH Oxidase Component p67 during Phagocytosis

2004 • 58 citations

Reactivation of Formyl Peptide Receptors Triggers the Neutrophil NADPH-oxidase but Not a Transient Rise in Intracellular Calcium

2003 • 56 citations

Roles of PI3K in Neutrophil Function

2004 • 55 citations

Vav proteins are required for B-lymphocyte responses to LPS

2005 • 49 citations

Rac2 Specificity in Macrophage Integrin Signaling

2003 • 47 citations

Association of PI 3-K with tyrosine phosphorylated Vav is essential for its activity in neutrophil-like maturation of myeloid cells

2003 • 37 citations

Phosphorylation of p40-phox during activation of neutrophil NADPH oxidase

1999 • 34 citations

PRAM-1 Is Required for Optimal Integrin-Dependent Neutrophil Function

2004 • 30 citations

Lineage-Specific Requirement for the PH Domain of Vav1 in the Activation of CD4+ but Not CD8+ T Cells

2005 • 28 citations