Roles of PI3K in Neutrophil Function

PHOSPHOINOSITIDE KINASES

1998 • 1,321 citations

Central Role for G Protein-Coupled Phosphoinositide 3-Kinase γ in Inflammation

2000 • 1,209 citations

Function of PI3Kγ in Thymocyte Development, T Cell Activation, and Neutrophil Migration

2000 • 1,031 citations

Polarization of Chemoattractant Receptor Signaling During Neutrophil Chemotaxis

2000 • 892 citations

Roles of PLC-β2 and -β3 and PI3Kγ in Chemoattractant-Mediated Signal Transduction

2000 • 825 citations

Spatial and Temporal Regulation of 3-Phosphoinositides by PI 3-Kinase and PTEN Mediates Chemotaxis

2002 • 755 citations

The superoxide-generating NADPH oxidase: structural aspects and activation mechanism

2002 • 753 citations

Structure and function of phosphoinositide 3-kinases

1998 • 666 citations

The PX domains of p47phox and p40phox bind to lipid products of PI(3)K

2001 • 600 citations

Distinct roles of class I and class III phosphatidylinositol 3-kinases in phagosome formation and maturation

2001 • 531 citations

A PtdInsP3- and Rho GTPase-mediated positive feedback loop regulates neutrophil polarity

2002 • 522 citations

PtdIns(3)P regulates the neutrophil oxidase complex by binding to the PX domain of p40phox

2001 • 402 citations

Temporal and Spatial Regulation of Chemotaxis

2002 • 335 citations

Binding of the PX domain of p47phox to phosphatidylinositol 3,4-bisphosphate and phosphatidic acid is masked by an intramolecular interaction

2002 • 308 citations

Leukocytes navigate by compass: roles of PI3Kγ and its lipid products

2000 • 298 citations

Identification of ARAP3, a Novel PI3K Effector Regulating Both Arf and Rho GTPases, by Selective Capture on Phosphoinositide Affinity Matrices

2002 • 293 citations

The Crystal Structure of the PX Domain from p40phox Bound to Phosphatidylinositol 3-Phosphate

2001 • 273 citations

Roles of PI3Ks in leukocyte chemotaxis and phagocytosis

2002 • 252 citations

Location, Location, Location: Membrane Targeting Directed by PX Domains

2001 • 237 citations

Neutrophils lacking phosphoinositide 3-kinase γ show loss of directionality duringN-formyl-Met-Leu-Phe-induced chemotaxis

2002 • 235 citations

Role of Phosphatidylinositol 3′ Kinase and a Downstream Pleckstrin Homology Domain–Containing Protein in Controlling Chemotaxis inDictyostelium

2001 • 231 citations

Dynamics of a Chemoattractant Receptor in Living Neutrophils during Chemotaxis

1999 • 230 citations

Involvement of phosphatidylinositol 3-kinase in Fc gamma receptor signaling.

1994 • 212 citations

Phosphoinositide 3-kinase in immunological systems

2002 • 206 citations

Phosphatidylinositol 3-phosphate is generated in phagosomal membranes

2001 • 178 citations

Solution structure of the PX domain, a target of the SH3 domain.

2001 • 165 citations

Lipid phosphatases in the immune system

2000 • 135 citations

Cell polarity: A chemical compass

2002 • 134 citations

Phox Homology Domains Specifically Bind Phosphatidylinositol Phosphates

2001 • 125 citations

Localization of p21-activated kinase 1 (PAK1) to pseudopodia, membrane ruffles, and phagocytic cups in activated human neutrophils

1999 • 105 citations

Roles of phospholipid signaling in chemoattractant-induced responses

2000 • 105 citations

Role of Src kinases and Syk in Fcgamma receptor-mediated phagocytosis and phagosome-lysosome fusion.

2001 • 101 citations

Disruption of Dictyostelium PI3K genes reduces [32P]phosphatidylinositol 3,4 bisphosphate and [32P]phosphatidylinositol trisphosphate levels, alters F-actin distribution and impairs pinocytosis

1998 • 91 citations

Establishing Direction during Chemotaxis in Eukaryotic Cells

2002 • 88 citations

Autosomal recessive chronic granulomatous disease caused by defects in NCF-1, the gene encoding the phagocyte p47-phox: mutations not arising in theNCF-1 pseudogenes

2001 • 84 citations

Role of Src kinases and Syk in Fcγ receptor-mediated phagocytosis and phagosome-lysosome fusion

2001 • 83 citations

Rab7 regulates phagosome maturation in Dictyostelium

2001 • 83 citations

Potential role of membrane internalization and vesicle fusion in adhesion of neutrophils in response to lipopolysaccharide and TNF.

1996 • 82 citations

Rab5a GTPase regulates fusion between pathogen-containing phagosomes and cytoplasmic organelles in human neutrophils

2002 • 82 citations

Hematologically Important Mutations: Leukocyte Adhesion Deficiency

2001 • 80 citations

Role of Phosphoinositide 3-Kinase in Monocyte Recruitment under Flow Conditions

2001 • 65 citations

Regulation of Phosphatidylinositol 3-Kinase Activity and Phosphatidylinositol 3,4,5-Trisphosphate Accumulation by Neutrophil Priming Agents

2002 • 65 citations

Phosphatidylinositol 3‐Kinase and the Control of Endosome Dynamics: New Players Defined by Structural Motifs

2001 • 60 citations

Phosphoinositide 3-kinase modulation of β3-integrin represents an endogenous “braking” mechanism during neutrophil transmatrix migration

2001 • 49 citations

Priming of human neutrophil superoxide generation by tumour necrosis factor‐α is signalled by enhanced phosphatidylinositol 3,4,5‐trisphosphate but not inositol 1,4,5‐trisphosphate accumulation

1998 • 43 citations

The p47phox PX Domain

2002 • 19 citations

Roles of phosphatidylinositol 3‐kinase and phospholipase D in temporal activation of superoxide production in FMLP‐stimulated human neutrophils

2001 • 15 citations