Association of PI 3-K with tyrosine phosphorylated Vav is essential for its activity in neutrophil-like maturation of myeloid cells

Induction of differentiation of the human promyelocytic leukemia cell line (HL-60) by retinoic acid.

1980 • 1,997 citations

Synthesis and Function of 3-Phosphorylated Inositol Lipids

2001 • 1,527 citations

Role of Substrates and Products of PI 3-kinase in Regulating Activation of Rac-Related Guanosine Triphosphatases by Vav

1998 • 798 citations

PHOSPHOINOSITIDE LIPIDS AS SIGNALING MOLECULES: Common Themes for Signal Transduction, Cytoskeletal Regulation, and Membrane Trafficking

1998 • 515 citations

Regulatory and Signaling Properties of the Vav Family

2000 • 513 citations

The nuclear matrix: Three-dimensional architecture and protein composition

1982 • 445 citations

VAV proteins as signal integrators for multi-subunit immune-recognition receptors

2002 • 321 citations

Accelerated degradation of PML-retinoic acid receptor alpha (PML-RARA) oncoprotein by all-trans-retinoic acid in acute promyelocytic leukemia: possible role of the proteasome pathway.

1996 • 223 citations

Vav proteins, adaptors and cell signaling

2001 • 212 citations

Evidence for a molecular complex consisting of Fyb/SLAP, SLP-76, Nck, VASP and WASP that links the actin cytoskeleton to Fcγ receptor signalling during phagocytosis

2001 • 198 citations

Control of Intramolecular Interactions between the Pleckstrin Homology and Dbl Homology Domains of Vav and Sos1 Regulates Rac Binding

2000 • 185 citations

Tyrosine Phosphorylation Mediates Both Activation and Downmodulation of the Biological Activity of Vav

2000 • 170 citations

Vav3 Modulates B Cell Receptor Responses by Regulating Phosphoinositide 3-Kinase Activation

2002 • 143 citations

Pleckstrin Homology Domains Interact with Filamentous Actin

1999 • 133 citations

Association of PI-3 Kinase with PAK1 Leads to Actin Phosphorylation and Cytoskeletal Reorganization

2002 • 123 citations

Vav Is Necessary for Prolactin-stimulated Proliferation and Is Translocated into the Nucleus of a T-cell Line

1995 • 111 citations

Conformational Switch and Role of Phosphorylation in PAK Activation

2001 • 104 citations

Pleiotropic defects in TCR signaling in a Vav-1-null Jurkat T-cell line

2002 • 96 citations

p95^vavAssociates with the Nuclear Protein Ku-70

1996 • 79 citations

Vav1 Is a Component of Transcriptionally Active Complexes

2002 • 76 citations

Phosphoinositide 3-kinase activity is essential for all-trans-retinoic acid-induced granulocytic differentiation of HL-60 cells.

1999 • 75 citations

The Binding of Ku Antigen to Homeodomain Proteins Promotes Their Phosphorylation by DNA-dependent Protein Kinase

2001 • 63 citations

Nuclear translocation of protein kinase C‐α and ‐ζ isoforms in HL‐60 cells induced to differentiate along the granulocytic lineage by all‐trans retinoic acid

1996 • 61 citations

Phosphatidylinositol 3-Kinase in HL-60 Nuclei Is Bound to the Nuclear Matrix and Increases During Granulocytic Differentiation

1998 • 56 citations

Role of the vav Proto-oncogene Product (Vav) in Erythropoietin-mediated Cell Proliferation and Phosphatidylinositol 3-Kinase Activity

1997 • 55 citations

Protein composition of nuclear matrix preparations from hela cells: An immunochemical approach

1986 • 55 citations

Nuclear association of tyrosine‐phosphorylated Vav to phospholipase C‐γ1 and phosphoinositide 3‐kinase during granulocytic differentiation of HL‐60 cells

1998 • 52 citations

Regulation of Vav proteins by intramolecular events

2002 • 49 citations

Intranuclear Translocation of Phospholipase C β2 during HL-60 Myeloid Differentiation

1997 • 48 citations

Rac and Phosphatidylinositol 3-Kinase Regulate the Protein Kinase B in FcεRI Signaling in RBL 2H3 Mast Cells

2001 • 43 citations

Vav Binding to Heterogeneous Nuclear Ribonucleoprotein (hnRNP) C

1998 • 37 citations

New insights into the mechanisms of nuclear segmentation in human neutrophils

1999 • 37 citations

Requirement of tyrosine-phosphorylated Vav for morphological differentiation of all-trans-retinoic acid-treated HL-60 cells.

2001 • 25 citations

B-cell development and antigen receptor signalling

2002 • 14 citations

Vav and SLP-76 recruitment by cross-linking of FcγRIIa1 in promyelocytic HL-60 cells

1999 • 11 citations

Biochemical analysis of regulation of Vav, a guanine-nucleotide exchange factor for Rho family of GTPases

2000 • 8 citations