G-protein–coupled receptor signaling in Syk-deficient neutrophils and mast cells

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International union of pharmacology. XXII. Nomenclature for chemokine receptors.

2000 • 1,771 citations

Granules of the Human Neutrophilic Polymorphonuclear Leukocyte

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β-Arrestin-Dependent Formation of β ₂ Adrenergic Receptor-Src Protein Kinase Complexes

1999 • 1,427 citations

A role for Pyk2 and Src in linking G-protein-coupled receptors with MAP kinase activation

1996 • 971 citations

Perinatal lethality and blocked B-cell development in mice lacking the tyrosine kinase Syk

1995 • 726 citations

Neutrophil and B Cell Expansion in Mice That Lack the Murine IL-8 Receptor Homolog

1994 • 666 citations

Chemokines in pathology and medicine

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Syk tyrosine kinase required for mouse viability and B-cell development

1995 • 632 citations

Essential role for ZAP-70 in both positive and negative selection of thymocytes

1995 • 554 citations

Human Severe Combined Immunodeficiency Due to a Defect in ZAP-70, a T Cell Tyrosine Kinase

1994 • 516 citations

A Critical Role for Syk in Signal Transduction and Phagocytosis Mediated by Fcγ Receptors on Macrophages

1997 • 495 citations

ZAP-70 Deficiency in an Autosomal Recessive form of Severe Combined Immunodeficiency

1994 • 495 citations

Inflammation: Basic Principles and Clinical Correlates

1993 • 473 citations

The Fc receptor γ-chain and the tyrosine kinase Syk are essential for activation of mouse platelets by collagen

1997 • 456 citations

Ras-dependent Mitogen-activated Protein Kinase Activation by G Protein-coupled Receptors

1997 • 454 citations

Lipopolysaccharide (LPS)-induced Macrophage Activation and Signal Transduction in the Absence of Src-Family Kinases Hck, Fgr, and Lyn

1997 • 439 citations

Syk Is Required for Integrin Signaling in Neutrophils

2002 • 419 citations

Coordinate interactions of Csk, Src, and Syk kinases with αIIbβ3 initiate integrin signaling to the cytoskeleton

2002 • 400 citations

The Syk Protein Tyrosine Kinase Is Essential for Fcγ Receptor Signaling in Macrophages and Neutrophils

1998 • 378 citations

Inhibition of mast cell Fc epsilon R1-mediated signaling and effector function by the Syk-selective inhibitor, piceatannol.

1994 • 346 citations

The C5a chemoattractant receptor mediates mucosal defence to infection

1996 • 345 citations

The Syk tyrosine kinase suppresses malignant growth of human breast cancer cells

2000 • 309 citations

Kinase Pathways in Chemoattractant-Induced Degranulation of Neutrophils: The Role of p38 Mitogen-Activated Protein Kinase Activated by Src Family Kinases

2000 • 295 citations

Phosphoinositide 3-Kinase γ Is an Essential Amplifier of Mast Cell Function

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Critical role for the tyrosine kinase Syk in signalling through the high affinity IgE receptor of mast cells.

1996 • 292 citations

Tyrosine kinases in activation of the MAP kinase cascade by G-protein-coupled receptors

1996 • 275 citations

Adhesion-Dependent Degranulation of Neutrophils Requires the Src Family Kinases Fgr and Hck

1999 • 231 citations

Leukotriene B4

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Piceatannol (3,4,3′,5′-tetrahydroxy-trans-stilbene) is a naturally occurring protein-tyrosine kinase inhibitor

1989 • 203 citations

Regulation of antigen receptor signal transduction by protein tyrosine kinases

1996 • 179 citations

Regulation of the pp72syk protein tyrosine kinase by platelet integrin alpha IIbbeta 3

1997 • 170 citations

Syk Expression and Novel Function in a Wide Variety of Tissues

2001 • 170 citations

Genetic and Pharmacological Analyses of Syk Function in IIbβ3 Signaling in Platelets

1999 • 161 citations

A Requirement for Syk in the Activation of the Microtubule-associated Protein Kinase/Phospholipase A2 Pathway by FcεR1 Is Not Shared by a G Protein-coupled Receptor

1995 • 142 citations

Use of Potato Disc and Brine Shrimp Bioassays to Detect Activity and Isolate Piceatannol as the Antileukemic Principle from the Seeds of Euphorbia lagascae

1984 • 140 citations

Signal transduction involved in MCP-1–mediated monocytic transendothelial migration

2001 • 137 citations

Differential Requirements for ZAP-70 in TCR Signaling and T Cell Development

1998 • 122 citations

Regulation of Capacitative Ca2+ Influx in Human Neutrophil Granulocytes

1997 • 115 citations

A continuous, spectroscopic analysis of the kinetics of elastase secretion by neutrophils. The dependence of secretion upon receptor occupancy.

1982 • 108 citations

Signal transduction pathways involved in soluble fractalkine–induced monocytic cell adhesion

2001 • 92 citations

β-Chemokine Receptor CCR5 Signals through SHP1, SHP2, and Syk

2000 • 88 citations

Inhibition of β2 Integrin Receptor and Syk Kinase Signaling in Monocytes by the Src Family Kinase Fgr

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Biologically Active constituents of Melaleuca leucadendron: Inhibitors of Induced Histamine Release from Rat Mast Cells.

1991 • 77 citations

Genetic Evidence for a Tyrosine Kinase Cascade Preceding the Mitogen-activated Protein Kinase Cascade in Vertebrate G Protein Signaling

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Normal Ligand Binding and Signaling by CD47 (Integrin-associated Protein) Requires a Long Range Disulfide Bond between the Extracellular and Membrane-spanning Domains

2001 • 66 citations

Syk expression in endothelial cells and their morphologic defects in embryonic Syk-deficient mice

2001 • 61 citations

Purification of a 72-kDa Protein-Tyrosine Kinase from Rat Liver and Its Identification as Syk: Involvement of Syk in Signaling Events of Hepatocytes

2000 • 45 citations

Gsα Repression of Adipogenesis via Syk

1999 • 38 citations

Gi-Mediated Activation of the Syk Kinase by the Receptor Mimetic Basic Secretagogues of Mast Cells: Role in Mediating Arachidonic Acid/Metabolites Release

2001 • 37 citations

Piceatannol is an effective inhibitor of IgE-mediated secretion from human basophils but is neither selective for this receptor nor acts on syk kinase at concentrations where mediator release inhibition occurs

2001 • 31 citations

A New Look at Syk in αβ and γδ T Cell Development Using Chimeric Mice with a Low Competitive Hematopoietic Environment

2000 • 26 citations