Reactivation of Formyl Peptide Receptors Triggers the Neutrophil NADPH-oxidase but Not a Transient Rise in Intracellular Calcium

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Roles of PLC-β2 and -β3 and PI3Kγ in Chemoattractant-Mediated Signal Transduction

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Respiratory burst in human neutrophils

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Separation of Leucocytes: Improved Cell Purity by Fine Adjustments of Gradient Medium Density and Osmolality

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The NADPH oxidase of human polymorphonuclear leukocytes. Evidence for regulation by multiple signals.

1984 • 222 citations

The Synthetic Peptide Trp-Lys-Tyr-Met-Val-Met-NH2 Specifically Activates Neutrophils through FPRL1/Lipoxin A4 Receptors and Is an Agonist for the Orphan Monocyte-expressed Chemoattractant Receptor FPRL2

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Characterization of fMet-Leu-Phe receptor-mediated Ca2+ influx across the plasma membrane of human neutrophils.

1986 • 157 citations

Subcellular localization and translocation of the receptor for N-formylmethionyl-leucyl-phenylalanine in human neutrophils

1994 • 146 citations

Receptor-cytoskeleton interactions and membrane traffic may regulate chemoattractant-induced superoxide production in human granulocytes.

1986 • 144 citations

The synthetic chemoattractant Trp-Lys-Tyr-Met-Val-DMet activates neutrophils preferentially through the lipoxin A4 receptor

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Regulation of human neutrophil granule protein expression

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N-Formylpeptides Induce Two Distinct Concentration Optima for Mouse Neutrophil Chemotaxis by Differential Interaction with Two N-Formylpeptide Receptor (Fpr) Subtypes

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Structure and Function of Leukocyte Chemoattractant Receptors

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G-Protein-coupled receptors in HL-60 human leukemia cells

1996 • 99 citations

Lipopolysaccharide-Induced Gelatinase Granule Mobilization Primes Neutrophils for Activation by Galectin-3 and Formylmethionyl-Leu-Phe

2001 • 97 citations

Activation of MEKK by Formyl-methionyl-leucyl-phenylalanine in Human Neutrophils

1996 • 88 citations

Lipopolysaccharide-Induced Granule Mobilization and Priming of the Neutrophil Response toHelicobacter pyloriPeptide Hp(2-20), Which Activates Formyl Peptide Receptor-Like 1

2002 • 77 citations

Chemoattractant-induced respiratory burst: increases in cytosolic Ca2+ concentrations are essential and synergize with a kinetically distinct second signal

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Monokines Mediate Decreased Hepatic Glucocorticoid Binding in Endotoxemia

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Regulation of chemoattractant receptor interaction with transducing proteins by organizational control in the plasma membrane of human neutrophils.

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Modeling Activation and Desensitization of G-Protein Coupled Receptors Provides Insight into Ligand Efficacy

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NADPH-oxidase activation in murine neutrophils via formyl peptide receptors

2003 • 56 citations

Cytoskeletal regulation of chemotactic receptors: Molecular complexation of N‐formyl peptide receptors with G proteins and actin

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Differential Phosphorylation Paradigms Dictate Desensitization and Internalization of the N-Formyl Peptide Receptor

1999 • 51 citations

Function and Regulation of Chemoattractant Receptors

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Neutrophil control of formylmethionyl-leucyl-phenylalanine induced mobilization of secretory vesicles and NADPH-oxidase activation: Effect of an association of the ligand-receptor complex to the cytoskeleton

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Correlation of messenger RNA levels with protein defects in specific granule deficiency

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Human Complement 5a (C5a) Anaphylatoxin Receptor (CD88) Phosphorylation Sites and Their Specific Role in Receptor Phosphorylation and Attenuation of G Protein-mediated Responses

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Potential drug targets: small GTPases that regulate leukocyte function

1999 • 36 citations

A single amino acid substitution (N297A) in the conserved NPXXY sequence of the human N-formyl peptide receptor results in inhibition of desensitization and endocytosis, and a dose-dependent shift in p42/44 mitogen-activated protein kinase activation and chemotaxis

2000 • 36 citations

Remodeling of the plasma membrane after stimulation of neutrophils with f-Met-Leu-Phe and dihydrocytochalasin B: identification of membrane subdomains containing NADPH oxidase activity

1994 • 33 citations

Real-time Analysis of G Protein-coupled Receptor Reconstitution in a Solubilized System

2001 • 32 citations

Desensitization of Formyl Peptide Receptors Is Abolished in Calcium Ionophore-Primed Neutrophils: An Association of the Ligand-Receptor Complex to the Cytoskeleton Is Not Required for a Rapid Termination of the NADPH-Oxidase Response

1998 • 31 citations

Activation and priming of neutrophil nicotinamide adenine dinucleotide phosphate oxidase and phospholipase A2 are dissociated by inhibitors of the kinases p42ERK2and p38SAPK and by methyl arachidonyl fluorophosphonate, the dual inhibitor of cytosolic and calcium-independent phospholipase A2

2001 • 30 citations

Arrestin Variants Display Differential Binding Characteristics for the Phosphorylated N-Formyl Peptide Receptor Carboxyl Terminus

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Universality of receptor channel responses

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Possible role of RAC-GTPASE-activating protein in the termination of superoxide production in phagocytic cells

1999 • 11 citations

Deficient homologous desensitization of formyl peptide receptors stably expressed in undifferentiated HL-60 cells

2000 • 7 citations

The Uncoupled State of the Human Formyl Peptide Receptor

1999 • 5 citations