MEMBRANE-ASSOCIATED GUANYLATE KINASES REGULATE ADHESION AND PLASTICITY AT CELL JUNCTIONS

A synaptic model of memory: long-term potentiation in the hippocampus

1993 • 11,303 citations

Long‐lasting potentiation of synaptic transmission in the dentate area of the anaesthetized rabbit following stimulation of the perforant path

1973 • 7,118 citations

Excitatory Amino Acids as a Final Common Pathway for Neurologic Disorders

1994 • 2,668 citations

Occludin: a novel integral membrane protein localizing at tight junctions.

1993 • 2,466 citations

Structure and Regulation of Voltage-Gated Ca²⁺ Channels

2000 • 2,264 citations

Claudin-1 and -2: Novel Integral Membrane Proteins Localizing at Tight Junctions with No Sequence Similarity to Occludin

1998 • 2,005 citations

Domain Interaction Between NMDA Receptor Subunits and the Postsynaptic Density Protein PSD-95

1995 • 1,861 citations

Size-selective loosening of the blood-brain barrier in claudin-5–deficient mice

2003 • 1,705 citations

Homosynaptic long-term depression in area CA1 of hippocampus and effects of N-methyl-D-aspartate receptor blockade.

1992 • 1,675 citations

PEST sequences and regulation by proteolysis

1996 • 1,606 citations

Interaction of Nitric Oxide Synthase with the Postsynaptic Density Protein PSD-95 and α1-Syntrophin Mediated by PDZ Domains

1996 • 1,589 citations

Identification of ZO-1: a high molecular weight polypeptide associated with the tight junction (zonula occludens) in a variety of epithelia.

1986 • 1,588 citations

Claudin-based tight junctions are crucial for the mammalian epidermal barrier

2002 • 1,412 citations

Recognition of Unique Carboxyl-Terminal Motifs by Distinct PDZ Domains

1997 • 1,371 citations

Activation of postsynaptically silent synapses during pairing-induced LTP in CA1 region of hippocampal slice

1995 • 1,342 citations

The Tight Junction Protein ZO-1 Establishes a Link between the Transmembrane Protein Occludin and the Actin Cytoskeleton

1998 • 1,331 citations

PSD-95 Involvement in Maturation of Excitatory Synapses

2000 • 1,238 citations

Fatty acylation of proteins: new insights into membrane targeting of myristoylated and palmitoylated proteins

1999 • 1,236 citations

Evidence for silent synapses: Implications for the expression of LTP

1995 • 1,212 citations

PDZ Domains and the Organization of Supramolecular Complexes

2001 • 1,203 citations

The rat brain postsynaptic density fraction contains a homolog of the drosophila discs-large tumor suppressor protein

1992 • 1,180 citations

Neuroligin Expressed in Nonneuronal Cells Triggers Presynaptic Development in Contacting Axons

2000 • 1,176 citations

Enhanced long-term potentiation and impaired learning in mice with mutant postsynaptic density-95 protein

1998 • 1,147 citations

Crystal Structures of a Complexed and Peptide-Free Membrane Protein–Binding Domain: Molecular Basis of Peptide Recognition by PDZ

1996 • 1,127 citations

Complex Phenotype of Mice Lacking Occludin, a Component of Tight Junction Strands

2000 • 1,118 citations

Paracellin-1, a Renal Tight Junction Protein Required for Paracellular Mg ²⁺ Resorption

1999 • 1,107 citations

Direct Binding of Three Tight Junction-Associated Maguks, Zo-1, Zo-2, and Zo-3, with the Cooh Termini of Claudins

1999 • 1,094 citations

Tight junction proteins

2002 • 1,091 citations

A decade of CDK5

2001 • 1,027 citations

Clustering of Shaker-type K+ channels by interaction with a family of membrane-associated guanylate kinases

1995 • 994 citations

Treatment of Ischemic Brain Damage by Perturbing NMDA Receptor- PSD-95 Protein Interactions

2002 • 964 citations

Direct association of occludin with ZO-1 and its possible involvement in the localization of occludin at tight junctions.

1994 • 949 citations

A Single Gene Product, Claudin-1 or -2, Reconstitutes Tight Junction Strands and Recruits Occludin in Fibroblasts

1998 • 923 citations

The discs-large tumor suppressor gene of Drosophila encodes a guanylate kinase homolog localized at septate junctions

1991 • 902 citations

Specific Coupling of NMDA Receptor Activation to Nitric Oxide Neurotoxicity by PSD-95 Protein

1999 • 821 citations

Mechanism and role of PDZ domains in signaling complex assembly

2001 • 819 citations

PIP₂and Proteins: Interactions, Organization, and Information Flow

2002 • 815 citations

Two Binding Orientations for Peptides to the Src SH3 Domain: Development of a General Model for SH3-Ligand Interactions

1994 • 800 citations

The diversity of Rab proteins in vesicle transport

1997 • 762 citations

Direct interactions between PSD-95 and stargazin control synaptic AMPA receptor number

2002 • 729 citations

Unusual spectral energy distribution of a galaxy previously reported to be at redshift 6.68

2000 • 683 citations

Calcium channel β-subunit binds to a conserved motif in the I–II cytoplasmic linker of the α1-subunit

1994 • 659 citations

SynGAP: a Synaptic RasGAP that Associates with the PSD-95/SAP90 Protein Family

1998 • 617 citations

Palmitoylation of Intracellular Signaling Proteins: Regulation and Function

2004 • 579 citations

A Synaptic Ras-GTPase Activating Protein (p135 SynGAP) Inhibited by CaM Kinase II

1998 • 578 citations

MODULAR PEPTIDE RECOGNITION DOMAINS IN EUKARYOTIC SIGNALING

1997 • 558 citations

Ubiquitination Regulates PSD-95 Degradation and AMPA Receptor Surface Expression

2003 • 548 citations

Synaptic Strength Regulated by Palmitate Cycling on PSD-95

2002 • 547 citations

Postsynaptic Density 95 controls AMPA Receptor Incorporation during Long-Term Potentiation and Experience-Driven Synaptic Plasticity

2004 • 533 citations

Unexpected Modes of PDZ Domain Scaffolding Revealed by Structure of nNOS-Syntrophin Complex

1999 • 530 citations

A Synthetic Peptide Corresponding to the Extracellular Domain of Occludin Perturbs the Tight Junction Permeability Barrier

1997 • 527 citations

PDZ domains in synapse assembly and signalling

2000 • 525 citations

PSD-95 Assembles a Ternary Complex with theN-Methyl-d-aspartic Acid Receptor and a Bivalent Neuronal NO Synthase PDZ Domain

1999 • 525 citations

Structural determinants of peptide-binding orientation and of sequence specificity in SH3 domains

1994 • 519 citations

Epithelial Cell Polarity and Cell Junctions inDrosophila

2001 • 516 citations

GKAP, a Novel Synaptic Protein That Interacts with the Guanylate Kinase-like Domain of the PSD-95/SAP90 Family of Channel Clustering Molecules

1997 • 503 citations

The role of ARF and Rab GTPases in membrane transport

1999 • 496 citations

Direct interaction of two polarity complexes implicated in epithelial tight junction assembly

2003 • 476 citations

PDZ Proteins Organize Synaptic Signaling Pathways

1998 • 474 citations

Protein Interactions at the Tight Junction

1999 • 470 citations

Interaction of Junctional Adhesion Molecule with the Tight Junction Components ZO-1, Cingulin, and Occludin

2000 • 469 citations

Subunit structure of dihydropyridine-sensitive calcium channels from skeletal muscle.

1987 • 468 citations

The tight junction protein ZO-1 is homologous to the Drosophila discs-large tumor suppressor protein of septate junctions.

1993 • 467 citations

Targeting of PKA to Glutamate Receptors through a MAGUK-AKAP Complex

2000 • 463 citations

The tight junction protein ZO-1 and an interacting transcription factor regulate ErbB-2 expression

2000 • 437 citations

SAP102, a Novel Postsynaptic Protein That Interacts with NMDA Receptor Complexes In Vivo

1996 • 422 citations

Dlg protein is required for junction structure, cell polarity, and proliferation control in Drosophila epithelia.

1996 • 422 citations

SAP90, a rat presynaptic protein related to the product of the Drosophila tumor suppressor gene dlg-A.

1993 • 415 citations

Structure of a complex between a voltage-gated calcium channel β-subunit and an α-subunit domain

2004 • 413 citations

Regulation of Synapse Structure and Function by the Drosophila Tumor Suppressor Gene dlg

1996 • 411 citations

The ZO-1–associated Y-box factor ZONAB regulates epithelial cell proliferation and cell density

2003 • 400 citations

Heterogeneity in the Molecular Composition of Excitatory Postsynaptic Sites during Development of Hippocampal Neurons in Culture

1998 • 396 citations

Molecular characterization and spatial distribution of SAP97, a novel presynaptic protein homologous to SAP90 and the Drosophila discs-large tumor suppressor protein

1995 • 388 citations

The cell polarity protein ASIP/PAR-3 directly associates with junctional adhesion molecule (JAM)

2001 • 387 citations

Impaired metabolic modulation of α-adrenergic vasoconstriction in dystrophin-deficient skeletal muscle

1998 • 373 citations

The LIN-2/LIN-7/LIN-10 Complex Mediates Basolateral Membrane Localization of the C. elegans EGF Receptor LET-23 in Vulval Epithelial Cells

1998 • 366 citations

Cloning and characterization of hdlg: the human homologue of the Drosophila discs large tumor suppressor binds to protein 4.1.

1994 • 365 citations

Interaction of ion channels and receptors with PDZ domain proteins

1997 • 362 citations

Interactions between the crumbs, lethal giant larvae and bazooka pathways in epithelial polarization

2002 • 359 citations

SAPAPs

1997 • 356 citations

Segregation of receptor and ligand regulates activation of epithelial growth factor receptor

2003 • 355 citations

Claudin-based barrier in simple and stratified cellular sheets

2002 • 355 citations

The Maguk protein, Pals1, functions as an adapter, linking mammalian homologues of Crumbs and Discs Lost

2002 • 353 citations

The junction-associated protein, zonula occludens-1, localizes to the nucleus before the maturation and during the remodeling of cell-cell contacts.

1996 • 353 citations

Nuclear translocation and transcription regulation by the membrane-associated guanylate kinase CASK/LIN-2

2000 • 350 citations

Direct Interaction of CASK/LIN-2 and Syndecan Heparan Sulfate Proteoglycan and Their Overlapping Distribution in Neuronal Synapses

1998 • 342 citations

Protein palmitoylation: a regulator of neuronal development and function

2002 • 334 citations

Postsynaptic Density-95 Mimics and Occludes Hippocampal Long-Term Potentiation and Enhances Long-Term Depression

2003 • 333 citations

Signalling functions of protein palmitoylation

1998 • 328 citations

Synaptic Targeting of the Postsynaptic Density Protein PSD-95 Mediated by Lipid and Protein Motifs

1999 • 327 citations

Cloning and Characterization of Postsynaptic Density 93, a Nitric Oxide Synthase Interacting Protein

1996 • 327 citations

Association of Neuronal Calcium Channels with Modular Adaptor Proteins

1999 • 315 citations

Exploiting the Basis of Proline Recognition by SH3 and WW Domains: Design of N-Substituted Inhibitors

1998 • 309 citations

The drosophila tumor suppressor gene dlg is required for normal synaptic bouton structure

1994 • 301 citations

PSD‐95 regulates synaptic transmission and plasticity in rat cerebral cortex

2003 • 296 citations

Dlg, Scribble and Lgl in cell polarity, cell proliferation and cancer

2003 • 294 citations

N-Terminal Palmitoylation of PSD-95 Regulates Association with Cell Membranes and Interaction with K+ Channel Kv1.4

1998 • 292 citations

Dual Palmitoylation of Psd-95 Mediates Its Vesiculotubular Sorting, Postsynaptic Targeting, and Ion Channel Clustering

2000 • 272 citations

Regulation of DLG Localization at Synapses by CaMKII-Dependent Phosphorylation

1999 • 270 citations

LET-23 Receptor Localization by the Cell Junction Protein LIN-7 during C. elegans Vulval Induction

1996 • 268 citations

Structural Analysis of the Voltage-Dependent Calcium Channel β Subunit Functional Core and Its Complex with the α1 Interaction Domain

2004 • 267 citations

The junctional adhesion molecule (JAM) family members JAM-2 and JAM-3 associate with the cell polarity protein PAR-3: a possible role for JAMs in endothelial cell polarity

2003 • 262 citations

SAP90 Binds and Clusters Kainate Receptors Causing Incomplete Desensitization

1998 • 261 citations

Synapse-Associated Protein 97 Selectively Associates with a Subset of AMPA Receptors Early in their Biosynthetic Pathway

2001 • 259 citations

Impairment of AMPA Receptor Function in Cerebellar Granule Cells of Ataxic Mutant MouseStargazer

1999 • 253 citations

Ca2+ channel regulation by a conserved β subunit domain

1994 • 252 citations

Establishment and Characterization of Cultured Epithelial Cells Lacking Expression of ZO-1

2004 • 246 citations

Structure of the SH3-Guanylate Kinase Module from PSD-95 Suggests a Mechanism for Regulated Assembly of MAGUK Scaffolding Proteins

2001 • 244 citations

The Roles of Claudin Superfamily Proteins in Paracellular Transport

2001 • 240 citations

Drosophila Stardust interacts with Crumbs to control polarity of epithelia but not neuroblasts

2001 • 233 citations

Hrs, a FYVE finger protein localized to early endosomes, is implicated in vesicular traffic and required for ventral folding morphogenesis

1999 • 232 citations

Concentration-dependent effects of cytochalasin D on tight junctions and actin filaments in MDCK epithelial cells

1994 • 232 citations

PEST sequences and regulation by proteolysis

1996 • 227 citations

Cyclin-Dependent Kinase 5 Phosphorylates the N-Terminal Domain of the Postsynaptic Density Protein PSD-95 in Neurons

2004 • 227 citations

Inhibition of calcium/calmodulin-dependent protein kinase in drosophila disrupts behavioral plasticity

1993 • 213 citations

crumbs and stardust Act in a Genetic Pathway That Controls the Organization of Epithelia in Drosophila melanogaster

1993 • 210 citations

Localization of Postsynaptic Density-93 to Dendritic Microtubules and Interaction with Microtubule-Associated Protein 1A

1998 • 204 citations

The C. elegans vulval induction gene lin-2 encodes a member of the MAGUK family of cell junction proteins.

1996 • 204 citations

MAGI-1, a Membrane-associated Guanylate Kinase with a Unique Arrangement of Protein-Protein Interaction Domains

1997 • 196 citations

Synapse-Associated Protein-97 Isoform-Specific Regulation of Surface AMPA Receptors and Synaptic Function in Cultured Neurons

2003 • 188 citations

A Novel Claudin 16 Mutation Associated with Childhood Hypercalciuria Abolishes Binding to ZO-1 and Results in Lysosomal Mistargeting

2003 • 188 citations

JAM4, a Junctional Cell Adhesion Molecule Interacting with a Tight Junction Protein, MAGI-1

2003 • 184 citations

Calcium/Calmodulin-Dependent Protein Kinase II

1990 • 182 citations

PSD-95 and SAP97 Exhibit Distinct Mechanisms for Regulating K+ Channel Surface Expression and Clustering

2000 • 178 citations

Activation of type II calcium/calmodulin-dependent protein kinase by Ca2+/calmodulin is inhibited by autophosphorylation of threonine within the calmodulin-binding domain.

1990 • 171 citations

Inactivation of Ca2+/calmodulin-dependent protein kinase II by basal autophosphorylation.

1993 • 163 citations

Tight junction assembly during mouse blastocyst formation is regulated by late expression of ZO-1 α+ isoform

1997 • 160 citations

GAKIN, a Novel Kinesin-like Protein Associates with the Human Homologue of the Drosophila Discs Large Tumor Suppressor in T Lymphocytes

2000 • 150 citations

Identification of an Intramolecular Interaction between the SH3 and Guanylate Kinase Domains of PSD-95

1999 • 150 citations

Solution structure of the extended neuronal nitric oxide synthase PDZ domain complexed with an associated peptide.

1999 • 148 citations

Molecular identification of a major palmitoylated erythrocyte membrane protein containing the src homology 3 motif.

1991 • 148 citations

A Novel and Conserved Protein-Protein Interaction Domain of Mammalian Lin-2/CASK Binds and Recruits SAP97 to the Lateral Surface of Epithelia

2002 • 144 citations

Craniofacial Dysmorphogenesis Including Cleft Palate in Mice with an Insertional Mutation in the discs large Gene

2001 • 140 citations

Interaction of Two Actin-binding Proteins, Synaptopodin and α-Actinin-4, with the Tight Junction Protein MAGI-1

2002 • 138 citations

Transcriptional Modification by a CASK-Interacting Nucleosome Assembly Protein

2004 • 138 citations

Organizing a functional junctional complex requires specific domains of the Drosophila MAGUK Discs large

1997 • 136 citations

Electron microscopic immunocytochemical detection of PSD‐95, PSD‐93, SAP‐102, and SAP‐97 at postsynaptic, presynaptic, and nonsynaptic sites of adult and neonatal rat visual cortex

2001 • 135 citations

Postsynaptic Targeting of Alternative Postsynaptic Density-95 Isoforms by Distinct Mechanisms

2002 • 126 citations

Energetic Determinants of Internal Motif Recognition by PDZ Domains

2001 • 126 citations

Involvement of the Junctional Adhesion Molecule-1 (JAM1) Homodimer Interface in Regulation of Epithelial Barrier Function

2004 • 126 citations

Modelling of a voltage‐dependent Ca²⁺ channel β subunit as a basis for understanding its functional properties

1999 • 124 citations

An Intramolecular Interaction between Src Homology 3 Domain and Guanylate Kinase-Like Domain Required for Channel Clustering by Postsynaptic Density-95/SAP90

2000 • 124 citations

Human Homologue of the Drosophila Discs Large Tumor Suppressor Binds to p56 Tyrosine Kinase and Shaker Type Kv1.3 Potassium Channel in T Lymphocytes

1997 • 124 citations

Endosomal Localization and Receptor Dynamics Determine Tyrosine Phosphorylation of Hepatocyte Growth Factor-Regulated Tyrosine Kinase Substrate

2000 • 121 citations

Hrs-2 is an ATPase implicated in calcium-regulated secretion

1997 • 120 citations

Two independent domains of hDlg are sufficient for subcellular targeting: the PDZ1-2 conformational unit and an alternatively spliced domain.

1996 • 118 citations

PSD-93 Knock-Out Mice Reveal That Neuronal MAGUKs Are Not Required for Development or Function of Parallel Fiber Synapses in Cerebellum

2001 • 118 citations

Cell polarity: the ups and downs of the Par6/aPKC complex

2003 • 116 citations

Small Synthetic Peptides Homologous to Segments of the First External Loop of Occludin Impair Tight Junction Resealing

1999 • 112 citations

Regulation of the Ca2+/CaM-Responsive Pool of CaMKII by Scaffold-Dependent Autophosphorylation

2003 • 109 citations

hCASK and hDlg Associate in Epithelia, and Their Src Homology 3 and Guanylate Kinase Domains Participate in Both Intramolecular and Intermolecular Interactions

2000 • 109 citations

Skeletal muscle contractions stimulate cGMP formation and attenuate vascular smooth muscle myosin phosphorylation via nitric oxide

1998 • 101 citations

Intramolecular interactions regulate SAP97 binding to GKAP

2000 • 101 citations

Interaction of transmembrane AMPA receptor regulatory proteins with multiple membrane associated guanylate kinases

2003 • 100 citations

Critical residues in an SH3 domain from Sem-5 suggest a mechanism for proline-rich peptide recognition

1994 • 97 citations

Differentiation of the epithelial apical junctional complex during mouse preimplantation development: a role for rab13 in the early maturation of the tight junction

2000 • 93 citations

Ion Channel Clustering by Membrane-associated Guanylate Kinases

2000 • 91 citations

Identification of critical amino acids involved in α₁‐β interaction in voltage‐dependent Ca²⁺ channels

1996 • 91 citations

Interaction of NE-dlg/SAP102, a Neuronal and Endocrine Tissue-specific Membrane-associated Guanylate Kinase Protein, with Calmodulin and PSD-95/SAP90

1999 • 88 citations

Membrane-associated guanylate kinase-like properties of β-subunits required for modulation of voltage-dependent Ca ²⁺ channels

2004 • 84 citations

The Voltage-dependent Calcium Channel β Subunit Contains Two Stable Interacting Domains

2003 • 83 citations

The maternal effect of lethal(1)discs-large-1: A recessive oncogene of Drosophila melanogaster

1988 • 80 citations

The tetrameric L27 domain complex as an organization platform for supramolecular assemblies

2004 • 77 citations

Nucleotide bindind by the synapse associated protein SAP90

1995 • 73 citations

Calcium Channel Function Regulated by the SH3-GK Module in β Subunits

2004 • 70 citations

Murine CASK Is Disrupted in a Sex-Linked Cleft Palate Mouse Mutant

1998 • 68 citations

Solution structure and ligand–binding site of the carboxy–terminal SH3 domain of GRB2

1994 • 66 citations

Kinetic and Thermodynamic Characterizations of Yeast Guanylate Kinase

1996 • 63 citations

Synaptic Localization and Presynaptic Function of Calcium Channel β4-Subunits in Cultured Hippocampal Neurons

2000 • 62 citations

Sorting out Genes that Regulate Epithelial and Neuronal Polarity

1998 • 60 citations

L27, a novel heterodimerization domain in receptor targeting proteins Lin-2 and Lin-7

2000 • 59 citations

Functional analysis of the guanylate kinase‐like domain in the synapse‐associated protein SAP97

1998 • 53 citations

Stability and peptide binding affinity of an SH3 domain from the Caenorhabditis elegans signaling protein Sem‐5

1994 • 53 citations

Human Homologue of the Drosophila Discs Large Tumor Suppressor Protein Forms an Oligomer in Solution

2000 • 45 citations

Functional Analysis of the Nucleotide Binding Domain of Membrane-associated Guanylate Kinases

2003 • 43 citations

Acidic motif responsible for plasma membrane association of the voltage‐dependent calcium channel β1b subunit

2000 • 41 citations

Molecular Cloning and Chromosomal Mapping of the Mouse Gene Encoding Cyclin-Dependent Kinase 5 Regulatory Subunit p35

1996 • 39 citations

Structural Basis for Nucleotide-dependent Regulation of Membrane-associated Guanylate Kinase-like Domains

2002 • 36 citations

Synaptic glutamate receptor clustering in mice lacking the SH3 and GK domains of SAP97

2002 • 29 citations