Activation of type II calcium/calmodulin-dependent protein kinase by Ca2+/calmodulin is inhibited by autophosphorylation of threonine within the calmodulin-binding domain.

A simplification of the protein assay method of Lowry et al. which is more generally applicable

1977 • 8,485 citations

PROTEIN SERINE/THREONINE KINASES

1987 • 1,457 citations

Regulation of brain Type II Ca2+/calmodulin-dependent protein kinase by autophosphorylation: A Ca2+-triggered molecular switch

1986 • 856 citations

[1] Assays of protein kinase

1983 • 832 citations

Regional distribution of type II Ca2+/calmodulin-dependent protein kinase in rat brain

1985 • 625 citations

Structural similarities between the Ca2+-dependent regulatory proteins of 3':5'-cyclic nucleotide phosphodiesterase and actomyosin ATPase.

1976 • 517 citations

Purification and characterization of a calmodulin-dependent protein kinase that is highly concentrated in brain.

1983 • 481 citations

Expression of 5-aminolaevulinate synthase and cytochrome P-450 mRNAs in chicken embryo hepatocytes in vivo and in culture. Effect of porphyrinogenic drugs and haem

1989 • 411 citations

Adenosine 3':5'-monophosphate-regulated phosphoprotein system of neuronal membranes. I. Solubilization, purification, and some properties of an endogenous phosphoprotein.

1977 • 411 citations

The relationship between calmodulin binding and phosphorylation of smooth muscle myosin kinase by the catalytic subunit of 3‘:5‘ cAMP-dependent protein kinase.

1981 • 388 citations

Purification and characterization of a calmodulin-dependent kinase from rat brain cytosol able to phosphorylate tubulin and microtubule-associated proteins.

1983 • 343 citations

Calmodulin binding domains: characterization of a phosphorylation and calmodulin binding site from myosin light chain kinase

1986 • 319 citations

Distinct forebrain and cerebellar isozymes of type II Ca2+/calmodulin-dependent protein kinase associate differently with the postsynaptic density fraction.

1985 • 305 citations

Ca2+/calmodulin-dependent protein kinase II. Isozymic forms from rat forebrain and cerebellum.

1985 • 301 citations

Autophosphorylation reversibly regulates the Ca2+/calmodulin-dependence of Ca2+/calmodulin-dependent protein kinase II.

1986 • 293 citations

Molecular cloning of a brain-specific calcium/calmodulin-dependent protein kinase.

1987 • 287 citations

Sequences of autophosphorylation sites in neuronal type II CaM kinase that control Ca2+-independent activity

1988 • 283 citations

Glycogen synthase from rabbit skeletal muscle. Amino acid sequence at the sites phosphorylated by glycogen synthase kinase-3, and extension of the N-terminal sequence containing the site phosphorylated by phosphorylase kinase.

1980 • 279 citations

Reversible generation of a Ca2+-independent form of Ca2+(calmodulin)-dependent protein kinase II by an autophosphorylation mechanism.

1986 • 270 citations

A calcium/calmodulin-dependent protein kinase from mammalian brain that phosphorylates Synapsin I: partial purification and characterization

1983 • 265 citations

Calcium/calmodulin-dependent protein kinase II. Characterization of distinct calmodulin binding and inhibitory domains.

1988 • 256 citations

Deduced primary structure of the beta subunit of brain type II Ca2+/calmodulin-dependent protein kinase determined by molecular cloning.

1987 • 253 citations

Substrate specificity of a multifunctional calmodulin-dependent protein kinase.

1985 • 243 citations

Activation of the multifunctional Ca2+/calmodulin-dependent protein kinase by autophosphorylation: ATP modulates production of an autonomous enzyme.

1986 • 207 citations

Ca2+/calmodulin-dependent protein kinase II. Identification of a regulatory autophosphorylation site adjacent to the inhibitory and calmodulin-binding domains.

1988 • 193 citations

Glycogen Synthase from Rabbit Skeletal Muscle

1980 • 191 citations

Functional Analysis of a Complementary DNA for the 50-Kilodalton Subunit of Calmodulin Kinase II

1987 • 179 citations

Ca2+/calmodulin-dependent protein kinase II: identification of threonine-286 as the autophosphorylation site in the alpha subunit associated with the generation of Ca2+-independent activity.

1988 • 175 citations

Autophosphorylation of Ca2+/calmodulin-dependent protein kinase II. Effects on total and Ca2+-independent activities and kinetic parameters.

1987 • 174 citations

Distinct autophosphorylation sites sequentially produce autonomy and inhibition of the multifunctional Ca2+/calmodulin-dependent protein kinase

1989 • 164 citations

Identification of protein phosphatase 1 in synaptic junctions: dephosphorylation of endogenous calmodulin-dependent kinase II and synapse-enriched phosphoproteins

1985 • 162 citations

The catalytic subunits of protein phosphatase‐1 and protein phosphatase 2A are distinct gene products

1984 • 160 citations

Regulatory interactions of the calmodulin-binding, inhibitory, and autophosphorylation domains of Ca2+/calmodulin-dependent protein kinase II.

1988 • 159 citations

Domain organization of chicken gizzard myosin light chain kinase deduced from a cloned cDNA

1986 • 148 citations

Sequence of the sites phosphorylated by protein kinase C in the smooth muscle myosin light chain.

1987 • 142 citations

Amino acid sequences at the two sites on glycogen synthetase phosphorylated by cyclic AMP‐dependent protein kinase and their dephosphorylation by protein phosphatase‐III

1977 • 111 citations

Amino acid sequence of the phosphorylation site of rat liver 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase.

1984 • 94 citations

Mapping of calmodulin-binding domain of Ca2+/calmodulin-dependent protein kinase II from rat brain

1988 • 59 citations

Regulation of Ca2+/calmodulin-dependent protein kinase II by Ca2+/calmodulin-independent autophosphorylation.

1988 • 49 citations