The C. elegans vulval induction gene lin-2 encodes a member of the MAGUK family of cell junction proteins.

THE GENETICS OF CAENORHABDITIS ELEGANS

1974 • 14,589 citations

The Protein Kinase Family: Conserved Features and Deduced Phylogeny of the Catalytic Domains

1988 • 5,115 citations

The embryonic cell lineage of the nematode Caenorhabditis elegans

1983 • 4,070 citations

Post-embryonic cell lineages of the nematode, Caenorhabditis elegans

1977 • 3,432 citations

Efficient gene transfer in C.elegans: extrachromosomal maintenance and integration of transforming sequences.

1991 • 3,108 citations

The Nematode Caenorhabditis elegans

1988 • 2,868 citations

Domain Interaction Between NMDA Receptor Subunits and the Postsynaptic Density Protein PSD-95

1995 • 1,861 citations

Identification of ZO-1: a high molecular weight polypeptide associated with the tight junction (zonula occludens) in a variety of epithelia.

1986 • 1,588 citations

2.2 Mb of contiguous nucleotide sequence from chromosome III of C. elegans

1994 • 1,472 citations

Identification of a Ten-Amino Acid Proline-Rich SH3 Binding Site

1993 • 1,205 citations

The rat brain postsynaptic density fraction contains a homolog of the drosophila discs-large tumor suppressor protein

1992 • 1,180 citations

Direct association of occludin with ZO-1 and its possible involvement in the localization of occludin at tight junctions.

1994 • 949 citations

The discs-large tumor suppressor gene of Drosophila encodes a guanylate kinase homolog localized at septate junctions

1991 • 902 citations

FAP-1: A Protein Tyrosine Phosphatase That Associates with Fas

1995 • 702 citations

THE DNA OF CAENORHABDITIS ELEGANS

1974 • 583 citations

Identification of a Protein that Binds to the SH3 Region of Abl and Is Similar to Bcr and GAP-rho

1992 • 553 citations

IDENTIFICATION AND CHARACTERIZATION OF 22 GENES THAT AFFECT THE VULVAL CELL LINEAGES OF THE NEMATODE CAENORHABDITIS ELEGANS

1985 • 531 citations

Identification of a 160-kDa polypeptide that binds to the tight junction protein ZO-1.

1991 • 520 citations

Alterations in cell lineage following laser ablation of cells in the somatic gonad of Caenorhabditis elegans

1981 • 494 citations

The tight junction protein ZO-1 is homologous to the Drosophila discs-large tumor suppressor protein of septate junctions.

1993 • 467 citations

Molecular characterization and tissue distribution of ZO-2, a tight junction protein homologous to ZO-1 and the Drosophila discs-large tumor suppressor protein

1994 • 452 citations

Kanamycin-resistant vectors that are analogues of plasmids pUC8, pUC9, pEMBL8 and pEMBL9

1986 • 444 citations

Genome linking with yeast artificial chromosomes

1988 • 438 citations

The let-23 gene necessary for Caenorhabditis elegans vulval induction encodes a tyrosine kinase of the EGF receptor subfamily

1990 • 420 citations

Integrative transformation of Caenorhabditis elegans

1986 • 417 citations

SAP90, a rat presynaptic protein related to the product of the Drosophila tumor suppressor gene dlg-A.

1993 • 415 citations

ISOLATION AND GENETIC CHARACTERIZATION OF CELL-LINEAGE MUTANTS OF THE NEMATODE CAENORHABDITIS ELEGANS

1980 • 413 citations

Caenorhabditis elegans ras gene let-60 acts as a switch in the pathway of vulval induction

1990 • 412 citations

Pattern formation during vulval development in C. elegans

1986 • 411 citations

let-60, a gene that specifies cell fates during C. elegans vulval induction, encodes a ras protein

1990 • 397 citations

The gene lin-3 encodes an inductive signal for vulval development in C. elegans

1992 • 392 citations

Molecular characterization and spatial distribution of SAP97, a novel presynaptic protein homologous to SAP90 and the Drosophila discs-large tumor suppressor protein

1995 • 388 citations

Muscle cell attachment in Caenorhabditis elegans.

1991 • 371 citations

Cloning and characterization of hdlg: the human homologue of the Drosophila discs large tumor suppressor binds to protein 4.1.

1994 • 365 citations

Rational scanning mutagenesis of a protein kinase identifies functional regions involved in catalysis and substrate interactions

1991 • 334 citations

Structural Framework for the Protein Kinase Family

1992 • 333 citations

Complex cellular and subcellular regulation of notch expression during embryonic and imaginal development of Drosophila: implications for notch function.

1991 • 297 citations

Molecular cloning of a brain-specific calcium/calmodulin-dependent protein kinase.

1987 • 287 citations

Localization of the sevenless protein, a putative receptor for positional information, in the eye imaginal disc of Drosophila

1987 • 279 citations

The multifunctional Ca2+/calmodulin-dependent protein kinases

1993 • 251 citations

The combined action of two intercellular signaling pathways specifies three cell fates during vulval induction in C. elegans

1989 • 249 citations

Multiple intercellular signalling systems control the development of the Caenorhabditis elegans vulva

1991 • 246 citations

Lateral inhibition during vulval induction in Caenorhabditis elegans

1988 • 218 citations

ZO-1, DlgA and PSD-95/SAP90: homologous proteins in tight, septate and synaptic cell junctions

1993 • 214 citations

A MAP kinase homolog, mpk-1, is involved in ras-mediated induction of vulval cell fates in Caenorhabditis elegans.

1994 • 212 citations

Different Levels of the C. elegans growth factor LIN-3 promote distinct vulval precursor fates

1995 • 200 citations

Limitation of the size of the vulval primordium of Caenorhabditis elegans by lin-15 expression in surrounding hypodermis

1990 • 198 citations

The let-60 locus controls the switch between vulval and nonvulval cell fates in Caenorhabditis elegans.

1990 • 192 citations

Molecular cloning of the lethal(1)discs large-1 oncogene of Drosophila

1989 • 176 citations

Multiple functions of let-23, a Caenorhabditis elegans receptor tyrosine kinase gene required for vulval induction.

1991 • 170 citations

Structure and function of the SH3 domain

1994 • 168 citations

In vitro binding studies suggest a membrane-associated complex between erythroid p55, protein 4.1, and glycophorin C.

1994 • 167 citations

lin-31, a Caenorhabditis elegans HNF-3/fork head transcription factor homolog, specifies three alternative cell fates in vulval development.

1993 • 167 citations

The recovery and preliminary characterization of X chromosome mutants affecting imaginal discs ofDrosophila melanogaster

1972 • 157 citations

Molecular identification of a major palmitoylated erythrocyte membrane protein containing the src homology 3 motif.

1991 • 148 citations

Receptor-mediated vectorial transcytosis of epidermal growth factor by Madin-Darby canine kidney cells.

1987 • 138 citations

Cell interactions coordinate the development of the C. elegans egg-laying system

1990 • 136 citations

Multifunctional Ca2+/calmodulin-dependent protein kinase

1993 • 130 citations

Sequential signalling during Caenorhabditis elegans vulval induction

1995 • 130 citations

Epidermal growth factor induces tyrosine phosphorylation and reorganization of the tight junction protein ZO-1 in A431 cells

1995 • 128 citations

The sevenless+ protein is expressed apically in cell membranes of developing Drosophila retina; it is not restricted to cell R7

1987 • 124 citations

Refined structure of the complex between guanylate kinase and its substrate GMP at 2·0 Å resolution

1992 • 123 citations

Targeting of the SF/HGF receptor to the basolateral domain of polarized epithelial cells.

1994 • 122 citations

MEK-2, a Caenorhabditis elegans MAP kinase kinase, functions in Ras-mediated vulval induction and other developmental events.

1995 • 107 citations

Increased Tyr phosphorylation of ZO-1 during modification of tight junctions between glomerular foot processes

1995 • 106 citations

The Caenorhabditis elegans gene mek-2 is required for vulval induction and encodes a protein similar to the protein kinase MEK.

1995 • 95 citations

Mosaic analysis of the let-23 gene function in vulval induction of Caenorhabditis elegans

1995 • 88 citations

The Caenorhabditis elegans gene lin-10 is broadly expressed while required specifically for the determination of vulval cell fates.

1990 • 71 citations

Regulation of type-II calmodulin kinase: Functional implications

1993 • 68 citations

Localization of DER and the pattern of cell divisions in wild-type and Ellipse eye imaginal discs

1992 • 67 citations

Signal transduction and cell fate specification during Caenorhabditis elegans vulval development

1994 • 51 citations

Epidermal growth factor-induced mitogenesis in kidney epithelial cells (LLC-PK1).

1988 • 46 citations

The Friedreich ataxia region: characterization of two novel genes and reduction of the critical region to 300 kb

1994 • 46 citations

Epithelial polarity and cell separation in the neoplastic l(1)dlg-1 mutant of Drosophila

1992 • 31 citations