Characterization of and Functional Antigen Presentation by Central Nervous System Mononuclear Cells from Mice Infected with Theiler’s Murine Encephalomyelitis Virus

CD28/B7 SYSTEM OF T CELL COSTIMULATION

1996 • 2,726 citations

B7-1 and B7-2 costimulatory molecules activate differentially the Th1/Th2 developmental pathways: Application to autoimmune disease therapy

1995 • 1,695 citations

Perivascular Microglial Cells of the CNS Are Bone Marrow-Derived and Present Antigen in Vivo

1988 • 1,451 citations

The B7 and CD28 receptor families

1994 • 1,342 citations

Immunohistochemical localization of macrophages and microglia in the adult and developing mouse brain

1985 • 881 citations

Astrocytes present myelin basic protein to encephalitogenic T-cell lines

1984 • 773 citations

Comparative analysis of B7-1 and B7-2 costimulatory ligands: expression and function.

1994 • 681 citations

Isolation and direct characterization of resident microglial cells from the normal and inflamed central nervous system.

1991 • 675 citations

Cervical lymphatics, the blood-brain barrier and the immunoreactivity of the brain: a new view

1992 • 653 citations

Antigen presentation and tumor cytotoxicity by interferon‐γ‐treated microglial cells

1987 • 648 citations

Normal adult ramified microglia separated from other central nervous system macrophages by flow cytometric sorting. Phenotypic differences defined and direct ex vivo antigen presentation to myelin basic protein-reactive CD4+ T cells compared.

1995 • 622 citations

Receptor-Mediated Antigen Uptake and its Effect on Antigen Presentation to Class II-Restricted T Lymphocytes

1990 • 605 citations

Persistent infection with Theiler's virus leads to CNS autoimmunity via epitope spreading

1997 • 558 citations

Functional evidence for epitope spreading in the relapsing pathology of experimental autoimmune encephalomyelitis.

1995 • 522 citations

Expression of costimulatory molecules B7-1 (CD80), B7-2 (CD86), and interleukin 12 cytokine in multiple sclerosis lesions.

1995 • 473 citations

Epidemiologic evidence for multiple sclerosis as an infection

1993 • 467 citations

Multiple Sclerosis: Distribution of T Cell Subsets Within Active Chronic Lesions

1983 • 417 citations

Blockade of CD28/B7-1 interaction prevents epitope spreading and clinical relapses of murine EAE

1995 • 326 citations

Immunoregulatory molecules and IL 2 receptors identified in multiple sclerosis brain.

1986 • 316 citations

Expression and functional significance of an additional ligand for CTLA-4.

1993 • 262 citations

Persistent infection of oligodendrocytes in Theiler's virus-induced encephalomyelitis

1983 • 243 citations

Theiler's Virus-Induced Demyelination: Prevention by Immunosuppression

1976 • 242 citations

The ups and downs of T cell costimulation

1994 • 240 citations

Induction of active and adoptive relapsing experimental autoimmune encephalomyelitis (EAE) using an encephalitogenic epitope of proteolipid protein

1992 • 231 citations

Brain macrophages: questions of origin and interrelationship

1988 • 220 citations

The Costimulatory Molecule B7 is Expressed on Human Microglia in Culture and in Multiple Sclerosis Acute Lesions

1995 • 205 citations

The predominant virus antigen burden is present in macrophages in Theiler's murine encephalomyelitis virus-induced demyelinating disease

1995 • 184 citations

Monocytes/macrophages isolated from the mouse central nervous system contain infectious Theiler's murine encephalomyelitis virus (TMEV)

1990 • 179 citations

Multiple sclerosis: relevance of Class I and Class II MHC-expressing cells to lesion development

1987 • 169 citations

B7/BB‐1 antigen expression on adult human microglia studied in vitro and in situ

1994 • 167 citations

Immune regulation by brain cells in the central nervous system: microglia but not astrocytes present myelin basic protein to encephalitogenic T cells under in vivo-mimicking conditions.

1992 • 160 citations

Evolution of the T‐Cell Repertoire during the Course of Experimental Immune‐Mediated Demyelinating Diseases

1995 • 158 citations

The Effect of L3T4 T Cell Depletion on the Pathogenesis of Theiler's Murine Encephalomyelitis Virus Infection in CBA Mice

1987 • 155 citations

IFN-gamma-activated primary murine astrocytes express B7 costimulatory molecules and prime naive antigen-specific T cells.

1997 • 153 citations

Genetic analysis of susceptibility to Theiler's virus-induced demyelinating disease in mice.

1984 • 148 citations

Ultrastructural immunohistochemical localization of virus in acute and chronic demyelinating Theiler's virus infection.

1982 • 139 citations

Role of macrophages during Theiler's virus infection

1997 • 130 citations

Class II-restricted T cell responses in Theiler's murine encephalomyelitis virus-induced demyelinating disease. VI. Potentiation of demyelination with and characterization of an immunopathologic CD4+ T cell line specific for an immunodominant VP2 epitope.

1994 • 128 citations

Presentation of proteolipid protein epitopes and B7-1-dependent activation of encephalitogenic T cells by IFN-gamma-activated SJL/J astrocytes.

1998 • 116 citations

Expression of Ia molecules by astrocytes during acute experimental allergic encephalomyelitis in the Lewis rat

1985 • 115 citations

Class II-restricted T cell responses in Theiler's murine encephalomyelitis virus (TMEV)-induced demyelinating disease

1990 • 113 citations

Chronic neurologic disease in Theiler's virus infection of SJL/J mice

1976 • 108 citations

Susceptibility of inbred mice to chronic central nervous system infection by Theiler's murine encephalomyelitis virus

1979 • 100 citations

The blood-brain barrier regulates the expression of a macrophage sialic acid-binding receptor on microglia

1992 • 93 citations

Presentation of Proteolipid Protein Epitopes and B7-1-Dependent Activation of Encephalitogenic T Cells by IFN-γ-Activated SJL/J Astrocytes

1998 • 91 citations

Inhibition of Theiler's virus-mediated demyelination by peripheral immune tolerance induction.

1995 • 82 citations

Class II-restricted T cell responses in Theiler's murine encephalomyelitis virus (TMEV)-induced demyelinating disease. I. Cross-specificity among TMEV substrains and related picornaviruses, but not myelin proteins.

1987 • 81 citations

Anergy in vivo: down-regulation of antigen-specific CD4⁺ T_h1 but not T_h2 cytokine responses

1994 • 79 citations

Mouse resident microglia: Isolation and characterization of immunoregulatory properties with naïve CD4⁺and CD8⁺T‐cells

1998 • 78 citations

Microglial cells qualify as the stimulators of unprimed CD4+ and CD8+ T lymphocytes in the central nervous system

1994 • 74 citations

Monoclonal anti-I-A antibody reverses chronic paralysis and demyelination in Theiler's virus-infected mice: critical importance of timing of treatment

1987 • 70 citations

Flow cytometric and functional analyses of central nervous system-infiltrating cells in SJL/J mice with Theiler's virus-induced demyelinating disease. Evidence for a CD4+ T cell-mediated pathology.

1996 • 68 citations

Contrasting effects of immunosuppression on Theiler's virus infection in mice

1977 • 64 citations

Central Nervous System Immunity in Mice Infected with Theiler's Virus. I. Local Neutralizing Antibody Response

1978 • 64 citations

Transfer of experimental allergic encephalomyelitis to bone marrow chimeras. Endothelial cells are not a restricting element.

1987 • 63 citations

A possible immunodominant epitope recognized by murine T lymphocytes immune to different myoglobins.

1982 • 61 citations

Mouse resident microglia: Isolation and characterization of immunoregulatory properties with na�ve CD4+ and CD8+ T-cells

1998 • 60 citations

In vivo antigen presentation by both brain parenchymal cells and hematopoietically derived cells during the induction of experimental autoimmune encephalomyelitis.

1993 • 52 citations

Theiler's virus replication in brain macrophages cultured in vitro

1992 • 52 citations

Class II-restricted T cell responses in Theiler's murine encephalomyelitis virus-induced demyelinating disease. IV. Identification of an immunodominant T cell determinant on the N-terminal end of the VP2 capsid protein in susceptible SJL/J mice.

1991 • 49 citations

The Theiler's murine encephalomyelitis virus (TMEV) model for multiple sclerosis shows a strong influence of the murine equivalents of HLA-A, B, and C

1987 • 47 citations

Demonstration of α, β, and γ Interferon in Active Chronic Multiple Sclerosis Lesionsa

1988 • 39 citations

Theiler's virus in brain cell cultures: Lysis of neurons and oligodendrocytes and persistence in astrocytes and macrophages

1986 • 34 citations

Susceptibility to Theiler's virus-induced demyelinating disease correlates with astrocyte class II induction and antigen presentation.

1992 • 25 citations

Uncoupled relationship between demyelination and primary infection of myelinating cells in Theiler's virus encephalomyelitis

1982 • 19 citations

Relationship between host age and persistence of Theiler's virus in the central nervous system of mice

1984 • 13 citations

Immunocytochemical localization of MAG, MBP and P0 protein in acute and relapsing demyelinating lesions of Theiler's virus infection

1985 • 12 citations