Mouse resident microglia: Isolation and characterization of immunoregulatory properties with na�ve CD4+ and CD8+ T-cells

CD28/B7 SYSTEM OF T CELL COSTIMULATION

1996 • 2,726 citations

HISTOCHEMISTRY, THEORETICAL AND APPLIED

1969 • 1,640 citations

Localization of the glial fibrillary acidic protein in astrocytes by immunofluorescence

1972 • 1,456 citations

Perivascular Microglial Cells of the CNS Are Bone Marrow-Derived and Present Antigen in Vivo

1988 • 1,451 citations

Characterization of ameboid microglia isolated from developing mammalian brain

1986 • 1,287 citations

Functional plasticity of microglia: A review

1988 • 931 citations

Immunohistochemical localization of macrophages and microglia in the adult and developing mouse brain

1985 • 881 citations

Macrophages and microglia in the nervous system

1988 • 742 citations

Isolation and direct characterization of resident microglial cells from the normal and inflamed central nervous system.

1991 • 675 citations

Inducible expression of H–2 and Ia antigens on brain cells

1984 • 656 citations

Antigen presentation and tumor cytotoxicity by interferon‐γ‐treated microglial cells

1987 • 648 citations

Selective development of CD4+ T cells in transgenic mice expressing a class II MHC-restricted antigen receptor

1989 • 646 citations

CD14: Cell surface receptor and differentiation marker

1993 • 600 citations

New perspectives of C1328-137-mediated T cell costimulation

1995 • 526 citations

Expression of costimulatory molecules B7-1 (CD80), B7-2 (CD86), and interleukin 12 cytokine in multiple sclerosis lesions.

1995 • 473 citations

Brain macrophages: evaluation of microglia and their functions

1992 • 443 citations

Brain microglia constitutively express β-2 integrins

1990 • 423 citations

Molecular Biology and Function of CD4 and CD8

1989 • 388 citations

Monokine production by microglial cell clones

1989 • 366 citations

Authentic T helper CD4 (W3/25) antigen on rat peritoneal macrophages.

1985 • 353 citations

Bone marrow derived elements and resident microglia in brain inflammation

1993 • 352 citations

MHC antigen expression on bulk isolated macrophage-microglia from newborn mouse brain: induction of Ia antigen expression by γ-interferon

1987 • 346 citations

Modulation of CD4 antigen on macrophages and microglia in rat brain.

1987 • 229 citations

Comparison of phenotypic and functional properties of immediately ex vivo and cultured human adult microglia

1996 • 217 citations

The Costimulatory Molecule B7 is Expressed on Human Microglia in Culture and in Multiple Sclerosis Acute Lesions

1995 • 205 citations

Human microglial cells have phenotypic and functional characteristics in common with both macrophages and dendritic antigen-presenting cells

1994 • 203 citations

Infection of brain microglial cells by human immunodeficiency virus type 1 is CD4 dependent

1991 • 184 citations

Inflammatory cytokines in the brain: Does the CNS shape immune responses?

1994 • 180 citations

TNF-alpha- and IFN-gamma-mediated signal transduction pathways: effects on glial cell gene expression and function.

1995 • 172 citations

Microglial progenitors with a high proliferative potential in the embryonic and adult mouse brain.

1991 • 169 citations

B7/BB‐1 antigen expression on adult human microglia studied in vitro and in situ

1994 • 167 citations

Microglial release of nitric oxide by the synergistic action of β-amyloid and IFN-γ

1995 • 165 citations

Activation of naive, memory and effector T cells

1994 • 141 citations

Absence of donor-type major histocompatibility complex class I antigen-bearing microglia in the rat central nervous system of radiation bone marrow chimeras

1987 • 123 citations

Interactions of the nervous and immune systems in development, normal brain homeostasis, and disease ¹

1995 • 121 citations

Analysis of B7-1 and B7-2 costimulatory ligands in cultured mouse microglia: upregulation by interferon-γ and lipopolysaccharide and downregulation by interleukin-10, prostaglandin E2 and cyclic AMP-elevating agents

1997 • 110 citations

Resident macrophages (ramified microglia) of the adult brown Norway rat central nervous system are constitutively major histocompatibility complex class II positive.

1993 • 100 citations

Mouse microglial cell lines differing in constitutive and interferon-γ-inducible antigen-presenting activities for naive and memory CD4+ and CD8+ T cells

1995 • 92 citations

Transformation of mouse bone marrow cells by transfection with a human oncogene related to c‐myc is associated with the endogenous production of macrophage colony stimulating factor 1

1985 • 89 citations

Expression and synthesis of murine immune response-associated (Ia) antigens by brain cells.

1981 • 85 citations

Production of macrophage colony-stimulating factor by astrocytes and brain macrophages

1992 • 84 citations

CNS antigen presentation

1995 • 82 citations

Microglial cells qualify as the stimulators of unprimed CD4+ and CD8+ T lymphocytes in the central nervous system

1994 • 74 citations

Production of granulocyte/macrophage colony-stimulating factor by cultured astrocytes

1990 • 70 citations

Macrophages, microglial cells, and HLA-DR antigens in fetal and infant brain.

1991 • 70 citations

Immunobiology of Microglial Cellsa

1988 • 64 citations

Microglia Present Myelin Antigens to T Cells after Phagocytosis of Oligodendrocytes

1993 • 60 citations

Production of interleukin-5 by mouse astrocytes and microglia in culture

1993 • 58 citations

Isolation and Flow Cytometric Characterization of Newborn Mouse Brain-Derived Microglia Maintained In Vitro

1991 • 51 citations

Functional dichotomy of mouse microglia developed in vitro: Differential effects of macrophage and granulocyte/macrophage colony-stimulating factor on cytokine secretion and antitoxoplasmic activity

1993 • 50 citations

Biology of the mononuclear phagocyte system of the central nervous system and HIV infection

1994 • 48 citations

Tissue digestion with dispase substantially reduces lymphocyte and macrophage cell-surface antigen expression

1996 • 45 citations

Human microglia activate lymphoproliferative responses to recall viral antigens

1996 • 31 citations

Use of the Pannell-Milstein roller bottle apparatus to produce high concentrations of the CSF-1, the mouse macrophage growth factor

1995 • 19 citations

Phenotypes and alloantigen-presenting activity of individual clones of microglia derived from the mouse brain

1992 • 16 citations

A Subset of Splenic Macrophages Process and Present Native Antigen to Naive Antigen-Specific CD4+T-Cells from Mice Transgenic for an αβ T-Cell Receptor

1995 • 15 citations

Mouse splenic macrophage cell lines with different antigen-presenting activities for CD4+ helper T cell subsets and allogeneic CD8+ T cells

1992 • 15 citations

Alloantigen presentation to naive CD8+ T cells by mouse microglia: Evidence for a distinct phenotype based on expression of surface-associated and soluble costimulatory molecules

1996 • 11 citations

Mouse macrophages contain a truncated CD4 transcript

1992 • 7 citations