Cloning and Characterization of a Protein Kinase A Anchoring Protein (AKAP)-related Protein That Interacts with and Regulates Sphingosine Kinase 1 Activity

Mammalian MAP kinase signalling cascades

2001 • 5,041 citations

Current Protocols in Molecular Biology

1989 • 1,916 citations

Suppression of ceramide-mediated programmed cell death by sphingosine-1-phosphate

1996 • 1,493 citations

Edg-1, the G protein–coupled receptor for sphingosine-1-phosphate, is essential for vascular maturation

2000 • 1,138 citations

Vascular Endothelial Cell Adherens Junction Assembly and Morphogenesis Induced by Sphingosine-1-Phosphate

1999 • 999 citations

Sphingosine-1-phosphate as second messenger in cell proliferation induced by PDGF and FCS mitogens

1993 • 879 citations

Sphingosine 1-phosphate promotes endothelial cell barrier integrity by Edg-dependent cytoskeletal rearrangement

2001 • 830 citations

Ceramide in the eukaryotic stress response

2000 • 729 citations

Sphingosine 1-phosphate signalling in mammalian cells

2000 • 698 citations

Molecular Cloning and Functional Characterization of a Novel Mammalian Sphingosine Kinase Type 2 Isoform

2000 • 654 citations

Sphingolipids—The Enigmatic Lipid Class: Biochemistry, Physiology, and Pathophysiology

1997 • 640 citations

Structural basis for the recognition of regulatory subunits by the catalytic subunit of protein phosphatase 1

1997 • 625 citations

Lysosphingolipids Inhibit Protein Kinase C: Implications for the Sphingolipidoses

1987 • 593 citations

Oocyte apoptosis is suppressed by disruption of the acid sphingomyelinase gene or by sphingosine -1-phosphate therapy

2000 • 581 citations

Lysophospholipids--Receptor Revelations

2001 • 539 citations

Molecular Cloning and Functional Characterization of Murine Sphingosine Kinase

1998 • 528 citations

Sphingosine Kinase Expression Increases Intracellular Sphingosine-1-Phosphate and Promotes Cell Growth and Survival

1999 • 516 citations

Diversity of cellular receptors and functions for the lysophospholipid growth factors lysophosphatidic acid and sphingosine 1‐phosphate

1998 • 516 citations

Regulation of NMDA Receptors by an Associated Phosphatase-Kinase Signaling Complex

1999 • 497 citations

Sphingosine 1-phosphate signalling in mammalian cells

2000 • 458 citations

Role of the Sphingosine-1-Phosphate Receptor EDG-1 in PDGF-Induced Cell Motility

2001 • 421 citations

A sphingosine-1-phosphate receptor regulates cell migration during vertebrate heart development

2000 • 401 citations

An oncogenic role of sphingosine kinase

2000 • 394 citations

Sphingosine 1-Phosphate Stimulates Cell Migration through a Gi-coupled Cell Surface Receptor

1999 • 371 citations

Apoptosis-associated signaling pathways are required for chemotherapy-mediated female germ cell destruction

1997 • 354 citations

Inhibitory Regulation of Rac Activation, Membrane Ruffling, and Cell Migration by the G Protein-Coupled Sphingosine-1-Phosphate Receptor EDG5 but Not EDG1 or EDG3

2000 • 328 citations

Sphingosine Kinase Interacts with TRAF2 and Dissects Tumor Necrosis Factor-α Signaling

2002 • 291 citations

Involvement of Sphingosine 1-Phosphate in Nerve Growth Factor-Mediated Neuronal Survival and Differentiation

1997 • 278 citations

Sphingosine‐1‐phosphate: signaling inside and out

2000 • 275 citations

Sphingosine-1-phosphate, a putative second messenger, mobilizes calcium from internal stores via an inositol trisphosphate-independent pathway.

1994 • 273 citations

Activation of Sphingosine Kinase by Tumor Necrosis Factor-α Inhibits Apoptosis in Human Endothelial Cells

1999 • 270 citations

Sphingosine 1-Phosphate Inhibits Activation of Caspases that Cleave Poly(ADP-ribose) Polymerase and Lamins during Fas- and Ceramide-mediated Apoptosis in Jurkat T Lymphocytes

1998 • 265 citations

Characterization of a Novel Giant Scaffolding Protein, CG-NAP, That Anchors Multiple Signaling Enzymes to Centrosome and the Golgi Apparatus

1999 • 239 citations

A-kinase anchoring proteins: protein kinase A and beyond

2000 • 228 citations

AKAP signaling complexes at the cytoskeleton

2001 • 223 citations

Purification and Characterization of Rat Kidney Sphingosine Kinase

1998 • 221 citations

Sphingosine kinase-mediated Ca2+ signalling by G-protein-coupled receptors

1998 • 208 citations

Functions of a new family of sphingosine-1-phosphate receptors

2000 • 194 citations

Sphingosine kinase expression regulates apoptosis and caspase activation in PC12 cells

2001 • 193 citations

Expression of a Catalytically Inactive Sphingosine Kinase Mutant Blocks Agonist-induced Sphingosine Kinase Activation

2000 • 186 citations

The Balance between Sphingosine and Sphingosine-1-Phosphate Is Decisive for Mast Cell Activation after Fc∈ Receptor I Triggering

1999 • 175 citations

FcγRI Coupling to Phospholipase D Initiates Sphingosine Kinase-mediated Calcium Mobilization and Vesicular Trafficking

1998 • 172 citations

EDG‐1 links the PDGF receptor to Src and focal adhesion kinase activation leading to lamellipodia formation and cell migration

2001 • 167 citations

Isolation and Molecular Characterization of AKAP110, a Novel, Sperm-Specific Protein Kinase A-Anchoring Protein

1999 • 163 citations

Sphingosine kinases: A novel family of lipid kinases

2002 • 158 citations

Sphingosine enhances apoptosis of radiation-resistant prostate cancer cells.

2000 • 156 citations

Sphingosine kinase: a mediator of vital cellular functions

2001 • 151 citations

Ceramide as a second messenger: sticky solutions to sticky problems

2000 • 147 citations

Localization of a Novel Human A-Kinase-Anchoring Protein, hAKAP220, during Spermatogenesis

2000 • 115 citations

1Alpha,25-dihydroxyvitamin D3 inhibits programmed cell death in HL-60 cells by activation of sphingosine kinase.

1998 • 107 citations

Effect of acidic phospholipids on sphingosine kinase

1996 • 99 citations

Stimulation of intracellular sphingosine-1-phosphate production by G-protein-coupled sphingosine-1-phosphate receptors

2001 • 95 citations

Prediction of the Coding Sequences of Unidentified Human Genes. XIX. The complete Sequences of 100 New cDNA Clones from Brain Which Code for Large Proteins in vitro

2000 • 88 citations

Protein kinase C-dependent regulation of human erythroleukemia (HEL) cell sphingosine kinase activity

1996 • 78 citations

Platelet‐derived growth factor‐induced activation of sphingosine kinase requires phosphorylation of the PDGF receptor tyrosine residue responsible for binding of PLCγ

1999 • 77 citations

Involvement of Sphingosine Kinase in TNF-α-stimulated Tetrahydrobiopterin Biosynthesis in C6 Glioma Cells

2002 • 75 citations

Role of sphingosine kinase in Ca²⁺ signalling by epidermal growth factor receptor

1999 • 70 citations

Stimulation of nuclear sphingosine kinase activity by platelet‐derived growth factor

2001 • 62 citations

Sphingosine kinase-mediated calcium signaling by muscarinic acetylcholine receptors

2001 • 61 citations