The Genetics of Aging

Central nervous system control of food intake

2000 • 6,305 citations

Introduction to Quantitative Genetics

1962 • 3,615 citations

A C. elegans mutant that lives twice as long as wild type

1993 • 3,250 citations

Oxidative Stress, Caloric Restriction, and Aging

1996 • 3,136 citations

Mechanism of activation of protein kinase B by insulin and IGF-1.

1996 • 2,965 citations

Characterization of a 3-phosphoinositide-dependent protein kinase which phosphorylates and activates protein kinase Bα

1997 • 2,747 citations

Role of Brain Insulin Receptor in Control of Body Weight and Reproduction

2000 • 2,178 citations

daf-2 , an Insulin Receptor-Like Gene That Regulates Longevity and Diapause in Caenorhabditis elegans

1997 • 2,174 citations

The Fork head transcription factor DAF-16 transduces insulin-like metabolic and longevity signals in C. elegans

1997 • 1,905 citations

Increased dosage of a sir-2 gene extends lifespan in Caenorhabditis elegans

2001 • 1,892 citations

Why do we age?

2000 • 1,696 citations

The p66shc adaptor protein controls oxidative stress response and life span in mammals

1999 • 1,688 citations

A Mutant Drosophila Insulin Receptor Homolog That Extends Life-Span and Impairs Neuroendocrine Function

2001 • 1,583 citations

Gene Expression Profile of Aging and Its Retardation by Caloric Restriction

1999 • 1,483 citations

Extension of Life-Span by Loss of CHICO, a Drosophila Insulin Receptor Substrate Protein

2001 • 1,398 citations

Genetic pathways that regulate ageing in model organisms

2000 • 1,341 citations

Loss of Insulin Signaling in Hepatocytes Leads to Severe Insulin Resistance and Progressive Hepatic Dysfunction

2000 • 1,213 citations

An evolutionarily conserved function of the Drosophila insulin receptor and insulin-like peptides in growth control

2001 • 1,206 citations

Tissue-Specific Knockout of the Insulin Receptor in Pancreatic β Cells Creates an Insulin Secretory Defect Similar to that in Type 2 Diabetes

1999 • 1,151 citations

Genetic associations with human longevity at the APOE and ACE loci

1994 • 1,079 citations

Gene-expression profile of the ageing brain in mice

2000 • 1,057 citations

Neurodegeneration, myocardial injury, and perinatal death in mitochondrial superoxide dismutase-deficient mice.

1996 • 1,020 citations

The genetics of caloric restriction in Caenorhabditis elegans

1998 • 918 citations

Neurobiology of the Caenorhabditis elegans Genome

1998 • 912 citations

Extension of Life-Span with Superoxide Dismutase/Catalase Mimetics

2000 • 909 citations

A phosphatidylinositol-3-OH kinase family member regulating longevity and diapause in Caenorhabditis elegans

1996 • 870 citations

Regulation of Longevity and Stress Resistance by Sch9 in Yeast

2001 • 858 citations

Extension of Drosophila lifespan by overexpression of human SOD1 in motorneurons

1998 • 852 citations

Thermotolerance and extended life-span conferred by single-gene mutations and induced by thermal stress.

1995 • 847 citations

Extended Life-Span and Stress Resistance in the Drosophila Mutant methuselah

1998 • 815 citations

The heritability of human longevity: A population-based study of 2872 Danish twin pairs born 1870–1900

1996 • 813 citations

Negative Regulation of the Forkhead Transcription Factor FKHR by Akt

1999 • 763 citations

Thedaf‐2gene network for longevity regulates oxidative stress resistance and Mn‐superoxide dismutase gene expression inCaenorhabditis elegans

1999 • 721 citations

Aging and resistance to oxidative damage in Caenorhabditis elegans.

1993 • 720 citations

Phosphorylation of the Transcription Factor Forkhead Family Member FKHR by Protein Kinase B

1999 • 719 citations

Two Pleiotropic Classes of daf-2 Mutation Affect Larval Arrest, Adult Behavior, Reproduction and Longevity in Caenorhabditis elegans

1998 • 691 citations

Caenorhabditis elegans Akt/PKB transduces insulin receptor-like signals from AGE-1 PI3 kinase to the DAF-16 transcription factor

1998 • 680 citations

A mutation in succinate dehydrogenase cytochrome b causes oxidative stress and ageing in nematodes

1998 • 676 citations

Regulation of C. elegans Life-Span by Insulinlike Signaling in the Nervous System

2000 • 661 citations

Regulation of DAF-2 receptor signaling by human insulin and ins-1, a member of the unusually large and diverse C. elegans insulin gene family

2001 • 637 citations

Assessment of Growth Parameters and Life Span of GHR/BP Gene-Disrupted Mice¹

2000 • 613 citations

Longevity, senescence, and the genome

1992 • 609 citations

Food and metabolic signalling defects in a Caenorhabditis elegans serotonin-synthesis mutant

2000 • 606 citations

Genes that regulate both development and longevity in Caenorhabditis elegans.

1995 • 579 citations

Regulation of lifespan by sensory perception in Caenorhabditis elegans

1999 • 554 citations

Phosphorylation of Serine 256 by Protein Kinase B Disrupts Transactivation by FKHR and Mediates Effects of Insulin on Insulin-like Growth Factor-binding Protein-1 Promoter Activity through a Conserved Insulin Response Sequence

1999 • 542 citations

Control of C. elegans Larval Development by Neuronal Expression of a TGF-β Homolog

1996 • 516 citations

Genetics of Aging

1997 • 493 citations

Extended Life-Span Conferred by Cotransporter Gene Mutations in Drosophila

2000 • 488 citations

Insulin Stimulates Phosphorylation of the Forkhead Transcription Factor FKHR on Serine 253 through a Wortmannin-sensitive Pathway

1999 • 470 citations

The age-1 and daf-2 genes function in a common pathway to control the lifespan of Caenorhabditis elegans.

1995 • 442 citations

The C. elegans PTEN Homolog, DAF-18, Acts in the Insulin Receptor-like Metabolic Signaling Pathway

1998 • 440 citations

A method for the isolation of longevity mutants in the nematode Caenorhabditis elegans and initial results

1983 • 427 citations

A PDK1 homolog is necessary and sufficient to transduce AGE-1 PI3 kinase signals that regulate diapause in Caenorhabditis elegans

1999 • 421 citations

Control of Larval Development by Chemosensory Neurons in Caenorhabditis elegans

1991 • 400 citations

daf-2, daf-16 and daf-23: genetically interacting genes controlling Dauer formation in Caenorhabditis elegans.

1994 • 375 citations

Hormones and the Physiological Architecture of Life History Evolution

1995 • 370 citations

The daf-4 gene encodes a bone morphogenetic protein receptor controlling C. elegans dauer larva development

1993 • 368 citations

Inhibition of transcription of the phosphoenolpyruvate carboxykinase gene by insulin

1983 • 366 citations

Genotype-Environment Interaction for Quantitative Trait Loci Affecting Life Span in Drosophila melanogaster

2000 • 352 citations

Genes Control the Cessation of a Woman’s Reproductive Life: A Twin Study of Hysterectomy and Age at Menopause¹

1998 • 350 citations

An Insulin-like Signaling Pathway Affects Both Longevity and Reproduction in Caenorhabditis elegans

1998 • 347 citations

Regulation of Glucose-6-phosphatase Gene Expression by Protein Kinase Bα and the Forkhead Transcription Factor FKHR

2000 • 339 citations

Overexpression of thioredoxin in transgenic mice attenuates focal ischemic brain damage

1999 • 337 citations

A Transmembrane Guanylyl Cyclase (DAF-11) and Hsp90 (DAF-21) Regulate a Common Set of Chemosensory Behaviors in Caenorhabditis elegans

2000 • 332 citations

Age and growth estimates of bowhead whales (Balaena mysticetus) via aspartic acid racemization

1999 • 317 citations

Chemosensory Neurons Function in Parallel to Mediate a Pheromone Response in C. elegans

1996 • 311 citations

Selection on stress resistance increases longevity in Drosophila melanogaster

1992 • 304 citations

daf-1, a C. elegans gene controlling dauer larva development, encodes a novel receptor protein kinase

1990 • 293 citations

Genetic and environmental conditions that increase longevity in Caenorhabditis elegans decrease metabolic rate

1999 • 280 citations

Regulation of Phosphoenolpyruvate Carboxykinase and Insulin-like Growth Factor-binding Protein-1 Gene Expression by Insulin

2000 • 277 citations

CLK-1 controls respiration, behavior and aging in the nematode Caenorhabditis elegans

1999 • 274 citations

Chance, development, and aging

2001 • 274 citations

Evidence for parallel processing of sensory information controlling dauer formation in Caenorhabditis elegans.

1993 • 262 citations

Regulation of Interneuron Function in the C. elegans Thermoregulatory Pathway by the ttx-3 LIM Homeobox Gene

1997 • 262 citations

Genes Control the Cessation of a Woman's Reproductive Life: A Twin Study of Hysterectomy and Age at Menopause

1998 • 258 citations

Lessons from human progeroid syndromes

2000 • 257 citations

Overexpression of human copper,zinc-superoxide dismutase (SOD1) prevents postischemic injury

1998 • 254 citations

A cytosolic catalase is needed to extend adult lifespan in C. elegans daf-C and clk-1 mutants

1999 • 244 citations

Inheritance of human longevity in Iceland

2000 • 234 citations

The Effect of Genetic Factors for Longevity: A Comparison of Identical and Fraternal Twins in the Swedish Twin Registry

1998 • 228 citations

Ubiquitous overexpression of CuZn superoxide dismutase does not extendlife span in mice

2000 • 214 citations

A pheromone-induced developmental switch in Caenorhabditis elegans: Temperature-sensitive mutants reveal a wild-type temperature-dependent process.

1984 • 210 citations

Estimation of apolipoprotein E genotype-specific relative mortality risks from the distribution of genotypes in centenarians and middle-aged men: Apolipoprotein E gene is a ?frailty gene,? not a ?longevity gene?

2000 • 202 citations

The mosaic of brain glial hyperactivity during normal ageing and its attenuation by food restriction

1999 • 199 citations

PREMATURE OVARIAN FAILURE

1998 • 198 citations

The DAF-3 Smad protein antagonizes TGF-β-related receptor signaling in the Caenorhabditis elegansdauer pathway

1997 • 197 citations

A dietary source of coenzyme Q is essential for growth of long-lived Caenorhabditis elegans clk-1 mutants

2001 • 193 citations

Mice lacking cytosolic copper/zinc superoxide dismutase display a distinctive motor axonopathy

1999 • 186 citations

Mutations in the WRN Gene in Mice Accelerate Mortality in a p53-Null Background

2000 • 177 citations

DAF-16 recruits the CREB-binding protein coactivator complex to the insulin-like growth factor binding protein 1 promoter in HepG2 cells

2000 • 169 citations

The gerontogenes age‐1 and daf‐2 determine metabolic rate potential in aging Caenorhabditis elegans

1995 • 159 citations

Targets of TGF-β Signaling in Caenorhabditis elegans Dauer Formation

2000 • 155 citations

Body size parallels insulin-like growth factor I levels but not growth hormone secretory capacity

1984 • 153 citations

Targeted overexpression of Cu/Zn superoxide dismutase protects pancreatic beta-cells against oxidative stress

1997 • 150 citations

FKHR Binds the Insulin Response Element in the Insulin-Like Growth Factor Binding Protein-1 Promoter*

1999 • 146 citations

Apolipoprotein E4: an allele associated with many diseases

2000 • 145 citations

Specificity of TGFβ signaling is conferred by distinct type I receptors and their associated SMAD proteins in Caenorhabditis elegans

1999 • 139 citations

Exceptional Familial Clustering for Extreme Longevity in Humans

2000 • 127 citations

Kleemeier Award Lecture: Are There Genes for Aging?

1999 • 127 citations

Differential Longevity in Mouse Stocks Selected for Early Life Growth Trajectory

2000 • 124 citations

Does growth hormone prevent or accelerate aging?

1998 • 121 citations

Genetic control of size inDrosophila

2000 • 116 citations

Effects of growth hormone on hypothalamic catalase and Cu/Zn superoxide dismutase1

2000 • 109 citations

Increased hsp22 RNA Levels in Drosophila Lines Genetically Selected for Increased Longevity

2000 • 103 citations

Genetic analysis of hemopoietic cell cycling in mice suggests its involvement in organismal life span

1999 • 94 citations

An ecological study of association between coronary heart disease mortality rates in men and the relative frequencies of common allelic variations in the gene coding for apolipoprotein E

1998 • 91 citations

Expression of bovine superoxide dismutase in Drosophila melanogaster augments resistance of oxidative stress.

1991 • 91 citations

Adaptive evolution of a candidate gene for aging inDrosophila

2000 • 90 citations

History and prospects: symposium on organisms with slow aging

2001 • 90 citations

Polymorphisms at the Werner locus: I. Newly identified polymorphisms, ethnic variability of 1367Cy/Arg, and its stability in a population of Finnish centenarians

1999 • 84 citations

Neuroendocrine Influences and Repercussions of the Menopause

1999 • 83 citations

LIVING TO 100: LESSONS IN LIVING TO YOUR MAXIMUM POTENTIAL AT ANY AGE

1999 • 76 citations

The genetic and molecular mechanisms of motor neuron disease

1998 • 74 citations

Insulin Inhibits the Activation of Transcription by a C-terminal Fragment of the Forkhead Transcription Factor FKHR

2000 • 65 citations

Genetic analysis of the age at menopause by using estimating equations and Bayesian random effects models

2000 • 62 citations

Brain Poly(A)RNA During Aging: Stability of Yield and Sequence Complexity in Two Rat Strains

1980 • 52 citations

Common gene variants, mortality and extreme longevity in humans

2000 • 49 citations

The Werner syndrome protein contributes to induction of p53 by DNA damage

2000 • 49 citations

Microglia and Aging in the Brain

2002 • 43 citations

Latent capacities for gametogenic cycling in the semelparous invertebrate Nereis.

1994 • 35 citations

Ageing and immortality

2000 • 32 citations

Genetic analysis of extended life span in Drosophila melanogaster. I. RAPD screen for genetic divergence between selected and control lines.

1998 • 25 citations

Influence of APOE genotype on familial aggregation of AD in an urban population

1999 • 22 citations

Reproductive longevity and increased life expectancy

2000 • 15 citations

Latent capacities for gametogenic cycling in the semelparous invertebrate Nereis.

1994 • 3 citations