Increased hsp22 RNA Levels in Drosophila Lines Genetically Selected for Increased Longevity

Green Fluorescent Protein as a Marker for Gene Expression

1994 • 6,572 citations

THE HEAT-SHOCK RESPONSE

1986 • 4,580 citations

Protein Oxidation and Aging

1992 • 2,687 citations

THE FUNCTION OF HEAT-SHOCK PROTEINS IN STRESS TOLERANCE: DEGRADATION AND REACTIVATION OF DAMAGED PROTEINS

1993 • 2,177 citations

Alpha-crystallin can function as a molecular chaperone.

1992 • 1,822 citations

Small heat shock proteins are molecular chaperones.

1993 • 1,376 citations

Evolutionary biology of aging

1991 • 1,333 citations

Thermotolerance and extended life-span conferred by single-gene mutations and induced by thermal stress.

1995 • 847 citations

LABORATORY EVOLUTION OF POSTPONED SENESCENCE INDROSOPHILA MELANOGASTER

1984 • 774 citations

Aging and resistance to oxidative damage in Caenorhabditis elegans.

1993 • 720 citations

Heat shock resistance conferred by expression of the human HSP27 gene in rodent cells.

1989 • 699 citations

Laboratory Evolution of Postponed Senescence in Drosophila melanogaster

1984 • 641 citations

SELECTION FOR DELAYED SENESCENCE IN DROSOPHILA MELANOGASTER

1984 • 562 citations

Sequence, structure, and codon preference of theDrosophilaribosomal protein 49 gene

1984 • 523 citations

Implications for bcd mRNA localization from spatial distribution of exu protein in Drosophila oogenesis

1994 • 482 citations

A Genetic Pathway Conferring Life Extension and Resistance to UV Stress in Caenorhabditis elegans

1996 • 390 citations

Oxidative stress and ageing in Caenorhabditis elegans

1993 • 383 citations

Structural and functional similarities of bovine alpha-crystallin and mouse small heat-shock protein. A family of chaperones.

1993 • 375 citations

Constitutive expression of human hsp27, Drosophila hsp27, or human alpha B-crystallin confers resistance to TNF- and oxidative stress-induced cytotoxicity in stably transfected murine L929 fibroblasts.

1995 • 344 citations

DIRECT AND CORRELATED RESPONSES TO SELECTION ON AGE AT REPRODUCTION INDROSOPHILA MELANOGASTER

1992 • 311 citations

Selection on stress resistance increases longevity in Drosophila melanogaster

1992 • 304 citations

Drosophila has one myosin heavy-chain gene with three developmentally regulated transcripts

1983 • 286 citations

RESISTANCE TO ENVIRONMENTAL STRESS IN DROSOPHILA MELANOGASTER SELECTED FOR POSTPONED SENESCENCE

2004 • 270 citations

The Effects of Temperature and of Egg-Laying on the Longevity of Drosophila Subobscura

1958 • 264 citations

Selection for Delayed Senescence in Drosophila melanogaster

1984 • 239 citations

Increased survival after treatments with anticancer agents of Chinese hamster cells expressing the human Mr 27,000 heat shock protein.

1991 • 227 citations

14 Expression and Function of the Low-molecular-weight Heat Shock Proteins

1994 • 223 citations

Detection of Inactive Enzyme Molecules in Ageing Organisms

1970 • 220 citations

Thermotolerance of a Long-lived Mutant of Caenorhabditis elegans

1994 • 208 citations

Desiccation, Flight, Glycogen, and Postponed Senescence in Drosophila melanogaster

1992 • 192 citations

Heat-Induced Longevity Extension in Drosophila. I. Heat Treatment, Mortality, and Thermotolerance

1997 • 177 citations

Muscle-specific expression of Drosophila hsp70 in response to aging and oxidative stress.

1995 • 171 citations

Expression and function of the low-molecular-weight heat shock proteins

1994 • 152 citations

Elevated paraquat resistance can be used as a bioassay for longevity in a genetically based long‐lived strain of Drosophila

1991 • 142 citations

A Coordinate Upregulation of Antioxidant Gene Activities Is Associated With the Delayed Onset of Senescence in a Long-Lived Strain of Drosophila

1995 • 140 citations

Direct and Correlated Responses to Selection on Age at Reproduction in Drosophila melanogaster

1992 • 130 citations

Analysis of the resistance to heat and hydrogen peroxide stresses in COS cells transiently expressing wild type or deletion mutants of the Drosophila 27‐kDa heat‐shock protein

1993 • 129 citations

Aging-Specific Expression ofDrosophila hsp22

1999 • 116 citations

Successful selection for increased longevity in Drosophila: Analysis of the survival data and presentation of a hypothesis on the genetic regulation of longevity

1987 • 104 citations

Comparative biochemical and stress analysis of genetically selected drosophila strains with different longevities

1995 • 88 citations

Prolongation of the Life of Drosophila subobscura by a Brief Exposure of Adults to a High Temperature

1958 • 68 citations

Oxidative stress and aging inCaenorhabditis elegans

2000 • 67 citations

Aging results in an unusual expression of Drosophila heat shock proteins.

1988 • 62 citations

Drosophila AP3, a presumptive DNA repair protein, is homologous to human ribosomal associated protein PO

1991 • 54 citations

Sequence requirements for upregulated expression of Drosophila hsp70 transgenes during aging☆

1999 • 54 citations

Antibody to a human DNA repair protein allows for cloning of a Drosophila cDNA that encodes an apurinic endonuclease.

1989 • 51 citations

Transgenes in the Analysis of Life Span and Fitness

1999 • 50 citations

Changes in protein turnover after heat shock are related to accumulation of abnormal proteins in aging Drosophila melanogaster

1990 • 16 citations

Deleted Work

1955 • 0 citations