Xenobiotic export pumps, endothelin signaling, and tubular nephrotoxicants—a case of molecular hijacking

Cellular localization of the multidrug-resistance gene product P-glycoprotein in normal human tissues.

1987 • 2,788 citations

Endothelins: molecular biology, biochemistry, pharmacology, physiology, and pathophysiology.

1994 • 1,631 citations

Pharmacology of drugs that alter multidrug resistance in cancer.

1990 • 970 citations

Nuclear Receptor Response Elements Mediate Induction of Intestinal MDR1 by Rifampin

2001 • 843 citations

Conjugate export pumps of the multidrug resistance protein (MRP) family: localization, substrate specificity, and MRP2-mediated drug resistance

1999 • 796 citations

Mechanisms mediating renal secretion of organic anions and cations

1993 • 484 citations

Disrupted Bile Acid Homeostasis Reveals an Unexpected Interaction among Nuclear Hormone Receptors, Transporters, and Cytochrome P450

2001 • 381 citations

In vivo targeting of inducible NO synthase with oligodeoxynucleotides protects rat kidney against ischemia.

1996 • 348 citations

Nitric oxide: a mediator in rat tubularhypoxia/reoxygenation injury.

1994 • 323 citations

Xenobiotic Transport across Isolated Brain Microvessels Studied by Confocal Microscopy

2000 • 310 citations

Multiple physiological functions for multidrug transporter P-glycoprotein?

2000 • 305 citations

Up-regulation of Multidrug Resistance P-glycoprotein via Nuclear Factor-κB Activation Protects Kidney Proximal Tubule Cells from Cadmium- and Reactive Oxygen Species-induced Apoptosis

2000 • 305 citations

Molecular aspects of hepatobiliary transport

1997 • 304 citations

Expression of the conjugate export pump encoded by the mrp2 gene in the apical membrane of kidney proximal tubules.

1997 • 294 citations

Proximal tubular cell synthesis and secretion of endothelin-1 on challenge with albumin and other proteins

1995 • 246 citations

Nitric oxide in renal health and disease

1997 • 211 citations

Cyclic AMP stimulates sorting of the canalicular organic anion transporter (Mrp2/cMoat) to the apical domain in hepatocyte couplets

1998 • 139 citations

Endothelin receptor subtypes and their role in transmembrane signaling mechanisms

1995 • 129 citations

P-glycoprotein-mediated secretion of a fluorescent cyclosporin analogue by teleost renal proximal tubules

1995 • 107 citations

Endothelin B receptor-mediated regulation of ATP-driven drug secretion in renal proximal tubule.

2000 • 97 citations

Effect of hypoxia on proximal tubules isolated from nitric oxide synthase knockout mice

1998 • 96 citations

Potentiation by Nitric Oxide of Cyclosporin A and FK506-Induced Apoptosis in Renal Proximal Tubule Cells

2000 • 86 citations

The paracrine endothelin system: pathophysiology and implications in clinical medicine.

1997 • 85 citations

Endothelin's biphasic effect on fluid absorption in the proximal straight tubule and its inhibitory cascade.

1994 • 83 citations

Multiple pathways of organic anion secretion in renal proximal tubule revealed by confocal microscopy

1996 • 75 citations

Nitric oxide mediates cyclosporine-induced apoptosis in cultured renal cells

2000 • 69 citations

Comparative insights into the mechanisms of renal organic anion and cation secretion

1991 • 62 citations

Fluorescence imaging study of organic anion transport from renal proximal tubule cell to lumen

1996 • 60 citations

Nitric oxide activates PKCα and inhibits Na⁺-K⁺-ATPase in opossum kidney cells

1999 • 58 citations

Nephrotoxicants Induce Endothelin Release and Signaling in Renal Proximal Tubules: Effect on Drug Efflux

2001 • 54 citations

Short- and Long-Term Influences of Heavy Metals on Anionic Drug Efflux from Renal Proximal Tubule

2002 • 51 citations

Role of NO in endothelin-regulated drug transport in the renal proximal tubule

2002 • 48 citations

Effects of endothelin on rat renal proximal tubule Na(+)-Pi cotransport and Na+/H+ exchange

1994 • 47 citations

Physiologic and pathophysiologic roles of endothelin in the kidney

1994 • 44 citations

Role of Angiotensin II, Endothelin-1, and Nitric Oxide in HgCl2-Induced Acute Renal Failure

1998 • 43 citations

Effects of endothelin in radiocontrast-induced nephropathy in rats are mediated through endothelin-A receptors.

1996 • 41 citations

Endothelin release by rabbit proximal tubule cells: Modulatory effects of cyclosporine A, tacrolimus, HGF and EGF

1998 • 39 citations

Endothelin: a mediator of renal disease progression.

1997 • 37 citations

Renal protection by a dual ETA/ETB endothelin antagonist, L-754,142, after aortic cross-clamping in the dog.

1997 • 33 citations

Receptor phosphorylation does not mediate cross talk between muscarinic M₃and bradykinin B₂receptors

1999 • 32 citations

Heat-shock-stimulated transepithelial daunomycin secretion by flounder renal proximal tubule primary cultures

1995 • 30 citations

Different endothelin receptor subtypes are involved in phospholipid signalling in the proximal tubule of rat kidney

1996 • 15 citations