Nuclear Receptor Response Elements Mediate Induction of Intestinal MDR1 by Rifampin

Functional polymorphisms of the human multidrug-resistance gene: Multiple sequence variations and correlation of one allele with P-glycoprotein expression and activity in vivo

2000 • 2,358 citations

The human orphan nuclear receptor PXR is activated by compounds that regulate CYP3A4 gene expression and cause drug interactions.

1998 • 1,535 citations

An Orphan Nuclear Receptor Activated by Pregnanes Defines a Novel Steroid Signaling Pathway

1998 • 1,497 citations

LXR, a nuclear receptor that defines a distinct retinoid response pathway.

1995 • 1,089 citations

The role of intestinal P-glycoprotein in the interaction of digoxin and rifampin

1999 • 911 citations

SXR, a novel steroid and xenobioticsensing nuclear receptor

1998 • 903 citations

Identification of a human nuclear receptor defines a new signaling pathway for CYP 3 A induction

1998 • 852 citations

Orphan Nuclear Receptors Constitutive Androstane Receptor and Pregnane X Receptor Share Xenobiotic and Steroid Ligands

2000 • 805 citations

The Nuclear Orphan Receptor CAR-Retinoid X Receptor Heterodimer Activates the Phenobarbital-Responsive Enhancer Module of the CYP2B Gene

1998 • 697 citations

Role of intestinal P-glycoprotein (mdr1) in interpatient variation in the oral bioavailability of cyclosporine*

1997 • 675 citations

Humanized xenobiotic response in mice expressing nuclear receptor SXR

2000 • 655 citations

The Orphan Human Pregnane X Receptor Mediates the Transcriptional Activation ofCYP3A4by Rifampicin through a Distal Enhancer Module

1999 • 645 citations

Immunohistochemical localization in normal tissues of different epitopes in the multidrug transport protein P170: evidence for localization in brain capillaries and crossreactivity of one antibody with a muscle protein.

1989 • 606 citations

Modulators and substrates of P-glycoprotein and cytochrome P4503A coordinately up-regulate these proteins in human colon carcinoma cells.

1996 • 487 citations

An altered pattern of cross-resistance in multidrug-resistant human cells results from spontaneous mutations in the mdr1 (P-glycoprotein) gene

1988 • 430 citations

The barrier function of CYP3A4 and P-glycoprotein in the small bowel

1997 • 390 citations

Chicken ovalbumin upstream promoter transcription factor (COUP-TF) dimers bind to different GGTCA response elements, allowing COUP-TF to repress hormonal induction of the vitamin D3, thyroid hormone, and retinoic acid receptors.

1992 • 388 citations

Human colonic adenocarcinoma cells

1976 • 375 citations

Comparative analysis of cytochrome P4503A induction in primary cultures of rat, rabbit, and human hepatocytes.

1995 • 233 citations

A chemiluminescent assay for quantitation of β-galactosidase in the femtogram range: Application to quantitation of β-galactosidase in lacZ-transfected cells

1991 • 223 citations

Synergistic activation of the chicken mim-1 gene by v-myb and C/EBP transcription factors.

1993 • 198 citations

The function of Gp170, the multidrug-resistance gene product, in the brush border of rat intestinal mucosa

1992 • 143 citations

Multidrug resistance gene expression is controlled by steroid hormones in the secretory epithelium of the uterus

1990 • 103 citations

Modulation of multidrug resistance gene expression by dexamethasone in cultured hepatoma cells.

1993 • 84 citations

Two-Stage Glucocorticoid Induction ofCYP3A23through Both the Glucocorticoid and Pregnane X Receptors

2000 • 74 citations

Molecular dissection of the human multidrug resistance P-glycoprotein

1999 • 70 citations

[33] Induction protocols for cytochromes P450IIIA in Vivo and in primary cultures of animal and human hepatocytes

1991 • 69 citations

Tissue-specific enhancer of the human multidrug-resistance (MDR1) gene.

1990 • 69 citations

Interleukin 1 beta down-regulates collagen and augments collagenase expression in human intestinal smooth muscle cells

1996 • 62 citations

Modulation of MDR1 and CYP3A Expression by Dexamethasone: Evidence for an Inverse Regulation in Adrenals

1998 • 53 citations

Molecular dissection of the human multidrug resistance P-glycoprotein

1999 • 50 citations

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