In vivo targeting of inducible NO synthase with oligodeoxynucleotides protects rat kidney against ischemia.

Basic local alignment search tool

1990 • 87,358 citations

Basic Local Alignment Search Tool

1990 • 12,947 citations

Analysis of nitrate, nitrite, and [15N]nitrate in biological fluids

1982 • 11,668 citations

Nitric oxide synthases in mammals

1994 • 2,762 citations

A redox-based mechanism for the neuroprotective and neurodestructive effects of nitric oxide and related nitroso-compounds

1993 • 2,423 citations

Peroxynitrite-induced membrane lipid peroxidation: The cytotoxic potential of superoxide and nitric oxide

1991 • 2,215 citations

Effects of Cerebral Ischemia in Mice Deficient in Neuronal Nitric Oxide Synthase

1994 • 1,578 citations

NMDA-dependent superoxide production and neurotoxicity

1993 • 1,188 citations

DNA damage and mutation in human cells exposed to nitric oxide in vitro.

1992 • 980 citations

Inflammation, immunoregulation, and inducible nitric oxide synthase

1993 • 877 citations

Molecular cloning and functional expression of an inducible nitric oxide synthase from a murine macrophage cell line.

1992 • 877 citations

Antisense c-myb oligonucleotides inhibit intimal arterial smooth muscle cell accumulation in vivo

1992 • 749 citations

Gene inhibition using antisense oligodeoxynucleotides

1994 • 746 citations

Superoxide and peroxynitrite inatherosclerosis.

1994 • 674 citations

Nitric Oxide Measured by a Porphyrinic Micro Sensor in Rat Brain after Transient Middle Cerebral Artery Occlusion

1993 • 632 citations

Pharmacokinetics, biodistribution, and stability of oligodeoxynucleotide phosphorothioates in mice.

1991 • 551 citations

In vivo expression of inducible nitric oxide synthase in experimentally induced neurologic diseases.

1993 • 484 citations

The role of nitric oxide in the pathogenesis of spontaneous murine autoimmune disease: increased nitric oxide production and nitric oxide synthase expression in MRL-lpr/lpr mice, and reduction of spontaneous glomerulonephritis and arthritis by orally administered NG-monomethyl-L-arginine.

1994 • 447 citations

Topography of nitric oxide synthesis by localizing constitutive NO synthases in mammalian kidney

1995 • 368 citations

Human immunodeficiency virus type 1 coat protein neurotoxicity mediated by nitric oxide in primary cortical cultures.

1993 • 348 citations

Nitric oxide and prostanoids protect the renal outer medulla from radiocontrast toxicity in the rat.

1994 • 347 citations

Molecular mechanisms of nitric oxide regulation. Potential relevance to cardiovascular disease.

1993 • 339 citations

Nitric oxide: a mediator in rat tubularhypoxia/reoxygenation injury.

1994 • 323 citations

Cloning of Inducible Nitric Oxide Synthase in Rat Vascular Smooth Muscle Cells

1993 • 319 citations

Endogenous nitric oxide enhances prostaglandin production in a model of renal inflammation.

1994 • 314 citations

Oligonucleotides as Research, Diagnostic, and Therapeutic Agents

1995 • 262 citations

Disposition of the 14C-labeled phosphorothioate oligonucleotide ISIS 2105 after intravenous administration to rats.

1993 • 260 citations

Differential expression and induction of mRNAs encoding two inducible nitric oxide synthases in rat kidney

1994 • 255 citations

Ablation of transplanted HTLV-I tax-transformed tumors in mice by antisense inhibition of NF-kappa B

1993 • 249 citations

Transcatheter delivery of c-myc antisense oligomers reduces neointimal formation in a porcine model of coronary artery balloon injury.

1994 • 245 citations

Inhibition of protein kinase C-alpha expression in mice after systemic administration of phosphorothioate antisense oligodeoxynucleotides.

1994 • 242 citations

In vivo treatment of human leukemia in a scid mouse model with c-myb antisense oligodeoxynucleotides.

1992 • 223 citations

Approaches toward Selective Inhibition of Nitric Oxide Synthase

1994 • 186 citations

Practical nitric oxide measurement employing a nitric oxide-selective electrode

1994 • 180 citations

Inhibition of Nitric Oxide Limits Infarct Size in the in Situ Rabbit Heart

1993 • 160 citations

Transport of phosphorothioate oligonucleotides in kidney: Implications for molecular therapy

1995 • 130 citations

Increased nitric oxide synthase activity despite lack of response to endothelium-dependent vasodilators in postischemic acute renal failure in rats.

1995 • 118 citations

Cyclic RGD peptides ameliorate ischemic acute renal failure in rats

1994 • 109 citations

Antisense oligodeoxynucleotides to inducible NO synthase rescue epithelial cells from oxidative stress injury

1996 • 101 citations

Role of nitric oxide in renal hemodynamic abnormalities of cyclosporin nephrotoxicity

1994 • 90 citations

Spectrophotometric quantitation of anchorage-dependent cell numbers using the bicinchoninic acid protein assay reagent

1990 • 80 citations

Responses to hemorrhagic arterial pressure reduction in different ischemic renal failure models

1994 • 71 citations

Galanin antisense oligonucleotides reduce galanin levels in dorsal root ganglia and induce autotomy in rats after axotomy.

1994 • 70 citations

Role of nitric oxide (EDRF) in radiocontrast acute renal failure in rats

1994 • 67 citations

TNF-alpha and IFN-gamma induce expression of nitric oxide synthase in cultured rat medullary interstitial cells

1995 • 19 citations