Nitric oxide mediates cyclosporine-induced apoptosis in cultured renal cells

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1991 • 15,563 citations

Apoptosis by Death Factor

1997 • 5,038 citations

p21 is a universal inhibitor of cyclin kinases

1993 • 3,408 citations

Mechanisms and Genes of Cellular Suicide

1995 • 2,514 citations

Oxidative stress as a mediator of apoptosis

1994 • 2,210 citations

WAF1/CIP1 is induced in p53-mediated G1 arrest and apoptosis.

1994 • 2,025 citations

The p21 inhibitor of cyclin-dependent kinases controls DNA replication by interaction with PCNA

1994 • 1,669 citations

The biochemistry of programmed cell death

1995 • 997 citations

Nitric Oxide: Pathophysiological Mechanisms

1995 • 876 citations

Induction of nitrite/nitrate synthesis in murine macrophages by BCG infection, lymphokines, or interferon-gamma.

1987 • 722 citations

Nitric Oxide: Cytotoxicity versus Cytoprotection— How, Why, When, and Where?

1997 • 510 citations

Mesangial cell apoptosis: the major mechanism for resolution of glomerular hypercellularity in experimental mesangial proliferative nephritis.

1994 • 406 citations

Programmed cell death, apoptosis and killer genes

1993 • 396 citations

Apoptotic Cell Death Triggered by Nitric Oxide in Pancreatic β-Cells

1995 • 343 citations

ENDOTHELIAL CELL AND HEPATOCYTE DEATHS OCCUR BY APOPTOSIS AFTER ISCHEMIA-REPERFUSION INJURY IN THE RAT LIVER1,2

1999 • 333 citations

Cyclosporine nephrotoxicity

1986 • 323 citations

Apoptosis in glomerular sclerosis

1996 • 257 citations

Embryonic lethalities and endothelial tumors in chimeric mice expressing polyoma virus middle T oncogene

1988 • 255 citations

Progressive growth in immunodeficient mice and host cell recruitment by mouse endothelial cells transformed by polyoma middle-sized T antigen: implications for the pathogenesis of opportunistic vascular tumors.

1994 • 168 citations

Glomerular mesangial cells and inflammatory macrophages ingest neutrophils undergoing apoptosis

1992 • 163 citations

Apoptosis in the repair process of experimental proliferative glomerulonephritis

1995 • 163 citations

Cyclosporin A Inhibits Apoptosis of Human Endothelial Cells by Preventing Release of Cytochrome C From Mitochondria

1998 • 158 citations

CYCLOSPORINE STIMULATES EXPRESSION OF TRANSFORMING GROWTH FACTOR-β IN RENAL CELLS POSSIBLE MECHANISM OF CYCLOSPORINES ANTIPROLIFERATIVE EFFECTS

1995 • 131 citations

Nitric oxide and superoxide induced p53 and Bax accumulation during mesangial cell apoptosis

1997 • 119 citations

Nature and extent of glomerular injury induced by cyclosporine in heart transplant patients

1991 • 115 citations

Murine endothelioma cell lines transformed by polyoma middle T oncogene as target for and producers of cytokines.

1991 • 108 citations

Cyclosporine nephropathy: pathophysiology and clinical impact.

1996 • 101 citations

Cyclosporin A blocks apoptosis by inhibiting the DNA binding activity of the transcription factor Nur77.

1995 • 99 citations

APOPTOSIS IN THE HUMAN ALLOGRAFTED KIDNEY

1995 • 89 citations

Neutrophil fate in experimental glomerular capillary injury in the rat. Emigration exceeds in situ clearance by apoptosis.

1997 • 85 citations

Pathophysiology of cyclosporin A nephrotoxicity: experimental and clinical observations

1992 • 84 citations

APOPTOSIS IN THE HUMAN ALLOGRAFTED KIDNEY

1995 • 80 citations

Nuclear Signaling by Endothelin-1

1995 • 69 citations

A possible role for nitric oxide in modulating the functional cyclosporine toxicity by arginine

1995 • 63 citations

Cyclosporine a nephrotoxicity: Role of thromboxane and reactive oxygen species

1998 • 57 citations

Fatty acid metabolism and cell proliferation: IV. Effect of prostanoid biosynthesis from endogenous fatty acid release with cyclosporin‐A

1983 • 57 citations

Cyclosporin A Induces Apoptosis in Childhood Acute Lymphoblastic Leukemia Cells

1998 • 49 citations

Alternative cyclosporine metabolic pathways and toxicity

1995 • 48 citations

Apoptosis and renal scarring.

1996 • 46 citations

Effects of Cyclosporin A on the Synthesis, Excretion, and Metabolism of Endothelin in the Rat

1996 • 46 citations

Visualization of cyclosporin A and Ca2+-sensitive cyclical mitochondrial depolarizations in cell culture

1999 • 45 citations

Metallopeptidase inhibitors induce an up-regulation of endothelin-converting enzyme levels and its redistribution from the plasma membrane to an intracellular compartment

1996 • 43 citations

Endothelin-1 activates c-Jun NH2-terminal kinase in mesangial cells

1997 • 41 citations

Prostanoid-induced expression of matrix metalloproteinase-1 messenger ribonucleic acid in rat osteosarcoma cells.

1994 • 38 citations

Apoptosis and Expression of Bax Protein and Fas Antigen in Glomeruli of a Remnant-Kidney Model

1998 • 38 citations

Glucocorticoids and cyclosporine induce apoptosis in mitogen-activated human peripheral mononuclear cells

1997 • 38 citations

Effect of angiotensin II and thromboxane A2 on the production of matrix metalloproteinase by human aortic smooth muscle cells.

1995 • 36 citations

PREVENTION OF BONE MARROW AND CARDIAC GRAFT REJECTION IN AN H-2 HAPLOTYPE DISPARATE MOUSE COMBINATION BY AN ANTI-LFA-1 ANTIBODY

1995 • 36 citations

Generation of Nitric Oxide from Streptozotocin (STZ) in the Presence of Copper(II) plus Ascorbate: Implication for the Development of STZ-Induced Diabetes

1998 • 35 citations

Nitric oxide donor-induced apoptosis in smooth muscle cells is modulated by protein kinase C and protein kinase A

1997 • 32 citations

Tubulointerstitial responses in the progression of glomerular diseases: Albuminuria modulates αvβ5 integrin

1996 • 32 citations

Functional Consequences of the Binding of Gliadin to Cultured Rat Mesangial Cells: Bridging Immunoglobulin A to Cells and Modulation of Eicosanoid Synthesis and Altered Cytokine Production

1994 • 28 citations

IMPLICATION OF CYCLOSPORINE IN UP-REGULATION OF Bcl-2 EXPRESSION AND MAINTENANCE OF CD8 LYMPHOCYTOSIS IN CYTOMEGALOVIRUS-INFECTED ALLOGRAFT RECIPIENTS

1995 • 26 citations

Cellular mechanisms of cyclosporine A-associated side-effects: role of endothelin.

1997 • 22 citations

Cyclosporin A induces transcription of transforming growth factor beta in a cultured murine proximal tubular cell line.

1996 • 20 citations

Apoptosis: potential role in renal diseases

1998 • 18 citations

Effect of cyclosporin on apoptosis in human cultured monocytic THP-1 cells and synovial macrophages.

1998 • 18 citations

Augmentation of Apoptosis in Bronchial Exuded Rat Eosinophils by Cyclosporin A

1996 • 17 citations

Distinct Signaling Pathways Mediate Induction of c-fos by PGE2 in Glomerular Mesangial Cells

1997 • 3 citations

Book ReviewSurfactant Replacement Therapy

1989 • 2 citations

Fas antigen expression and apoptosis induction of in vitro cultured hepatocytes with high concentrations of cyclosporine A.

1996 • 2 citations