MHC class II transport from lysosomal compartments to the cell surface is determined by stable peptide binding, but not by the cytosolic domains of the alpha- and beta-chains.

B lymphocytes secrete antigen-presenting vesicles.

1996 • 3,198 citations

SRα Promoter: an Efficient and Versatile Mammalian cDNA Expression System Composed of the Simian Virus 40 Early Promoter and the R-U5 Segment of Human T-Cell Leukemia Virus Type 1 Long Terminal Repeat

1988 • 1,351 citations

Inflammatory stimuli induce accumulation of MHC class II complexes on dendritic cells

1997 • 1,143 citations

The Biochemistry and Cell Biology of Antigen Processing and Presentation

1993 • 1,022 citations

Maturation Stages of Mouse Dendritic Cells in Growth Factor–dependent Long-Term Cultures

1997 • 860 citations

Assembly, Transport, and Function of MHC Class II Molecules

1994 • 791 citations

CAPTURE AND PROCESSING OF EXOGENOUS ANTIGENS FOR PRESENTATION ON MHC MOLECULES

1997 • 779 citations

Developmental regulation of MHC class II transport in mouse dendritic cells

1997 • 754 citations

Segregation of MHC class II molecules from MHC class I molecules in the Golgi complex for transport to lysosomal compartments

1991 • 663 citations

Membrane transport in the endocytic pathway

1995 • 644 citations

MHC class II-associated invariant chain contains a sorting signal for endosomal compartments

1990 • 565 citations

Intracellular transport of class II MHC molecules directed by invariant chain

1990 • 548 citations

Transient accumulation of new class II MHC molecules in a novel endocytic compartment in B lymphocytes

1994 • 442 citations

Isolation and characterization of the intracellular MHC class II compartment

1994 • 426 citations

MHC class II structure, occupancy and surface expression determined by post-endoplasmic reticulum antigen binding

1991 • 394 citations

Antigen processing and class II MHC peptide-loading compartments in human B-lymphoblastoid cells

1994 • 349 citations

A role for peptide in determining MHC class II structure

1991 • 275 citations

Antigen presentation mediated by recycling of surface HLA-DR molecules

1995 • 271 citations

Major Histocompatibility Complex Class II Compartments in Human and Mouse B Lymphoblasts Represent Conventional Endocytic Compartments

1997 • 233 citations

Separation of subcellular compartments containing distinct functional forms of MHC class II.

1994 • 221 citations

Cell surface HLA-DR-invariant chain complexes are targeted to endosomes by rapid internalization.

1993 • 221 citations

Direct vesicular transport of MHC class II molecules from lysosomal structures to the cell surface.

1996 • 210 citations

Extensive trafficking of MHC class II-invariant chain complexes in the endocytic pathway and appearance of peptide-loaded class II in multiple compartments

1995 • 198 citations

Peptides determine the lifespan of MHC class II molecules in the antigen-presenting cell

1994 • 175 citations

How MHC class II molecules reach the endocytic pathway.

1995 • 173 citations

Peptide binding inhibits protein aggregation of invariant-chain free class II dimers and promotes surface expression of occupied molecules

1993 • 157 citations

Invariant chain cleavage and peptide loading in major histocompatibility complex class II vesicles.

1995 • 150 citations

MHC class II function preserved by low-affinity peptide interactions preceding stable binding

1994 • 135 citations

Related Leucine-based Cytoplasmic Targeting Signals in Invariant Chain and Major Histocompatibility Complex Class II Molecules Control Endocytic Presentation of Distinct Determinants in a Single Protein

1997 • 135 citations

Major histocompatibility complex class II compartments in human B lymphoblastoid cells are distinct from early endosomes.

1995 • 130 citations

Early endosomes and a late endocytic compartment generate different peptide-class II MHC complexes via distinct processing mechanisms.

1997 • 121 citations

Role of B cell receptor Igα and Igβ subunits in MHC class II-restricted antigen presentation

1995 • 115 citations

Ii Chain Controls the Transport of Major Histocompatibility Complex Class II Molecules to and from Lysosomes

1997 • 92 citations

Isoforms of the invariant chain regulate transport of MHC class II molecules to antigen processing compartments.

1996 • 83 citations

Chemistry and functional role of the invariant chain

1992 • 76 citations

HLA-DM: An in vivo facilitator of MHC class II peptide loading

1995 • 74 citations

Invariant chain retains MHC class II molecules in the endocytic pathway.

1993 • 73 citations

Structural compartmentalization of MHC class II signaling function

1993 • 71 citations

Intracellular Pathway for the Generation of Functional MHC Class II Peptide Complexes in Immature Human Dendritic Cells

1998 • 64 citations

Characterization of transport of newly assembled, T cell-stimulatory MHC class II-peptide complexes from MHC class II compartments to the cell surface.

1997 • 53 citations

A segment of the MHC class II β chain plays a critical role in targeting class II molecules to the endocytic pathway

1994 • 50 citations

Detection of functional class II-associated antigen: role of a low density endosomal compartment in antigen processing.

1995 • 47 citations

Late events in the intracellular sorting of major histocompatibility complex class II molecules are regulated by the 80‐82 segment of the class II β chain

1997 • 21 citations

Truncated MHC class II cytoplasmic and transmembrane domains: Effect on plasma membrane expression

1995 • 10 citations