Integrin Activation Involves a Conformational Change in the α1 Helix of the β Subunit A-domain

SETOR: Hardware-lighted three-dimensional solid model representations of macromolecules

1993 • 1,295 citations

Crystal Structure of the Extracellular Segment of Integrin αVβ3

2001 • 1,256 citations

Structural Basis of Collagen Recognition by Integrin α2β1

2000 • 945 citations

Crystal structure of the A domain from the a subunit of integrin CR3 (CD11 b/CD18)

1995 • 893 citations

‘Knobs-into-holes’ engineering of antibody C_H3 domains for heavy chain heterodimerization

1996 • 693 citations

Accurate modeling of protein conformation by automatic segment matching

1992 • 558 citations

Interactions of protein antigens with antibodies.

1996 • 543 citations

Divalent cation regulation of the function of the leukocyte integrin LFA-1.

1992 • 492 citations

Two conformations of the integrin A-domain (I-domain): a pathway for activation?

1995 • 400 citations

Protein folding by restrained energy minimization and molecular dynamics

1983 • 371 citations

Integrin Structure

2000 • 371 citations

Regulation of Integrin α5β1-Fibronectin Interactions by Divalent Cations

1995 • 325 citations

Reversibly locking a protein fold in an active conformation with a disulfide bond: Integrin αL I domains with high affinity and antagonist activityin vivo

2001 • 214 citations

Identification of a regulatory region of integrin beta 1 subunit using activating and inhibiting antibodies

1993 • 206 citations

Locking in alternate conformations of the integrin αLβ2 I domain with disulfide bonds reveals functional relationships among integrin domains

2001 • 184 citations

NMR and mutagenesis evidence for an I domain allosteric site that regulates lymphocyte function-associated antigen 1 ligand binding

2000 • 165 citations

Association of the Membrane Proximal Regions of the α and β Subunit Cytoplasmic Domains Constrains an Integrin in the Inactive State

2001 • 163 citations

Defining the Topology of Integrin α5β1-Fibronectin Interactions Using Inhibitory Anti-α5 and Anti-β1 Monoclonal Antibodies

1997 • 160 citations

Identification of a novel anti‐integrin monoclonal antibody that recognises a ligand‐induced binding site epitope on the β1 subunit

1995 • 151 citations

Conformational changes in tertiary structure near the ligand binding site of an integrin I domain

1999 • 143 citations

An Isoleucine-based Allosteric Switch Controls Affinity and Shape Shifting in Integrin CD11b A-domain

2000 • 142 citations

In vivo functions of integrins: lessons from null mutations in mice

2000 • 141 citations

A point mutation of integrin beta 1 subunit blocks binding of alpha 5 beta 1 to fibronectin and invasin but not recruitment to adhesion plaques.

1992 • 138 citations

The Inhibitory Anti-β1 Integrin Monoclonal Antibody 13 Recognizes an Epitope That Is Attenuated by Ligand Occupancy

1996 • 130 citations

Muscle β1D Integrin Reinforces the Cytoskeleton–Matrix Link: Modulation of Integrin Adhesive Function by Alternative Splicing

1997 • 129 citations

Identification of putative ligand-binding sites of the integrin α4β1 (VLA-4, CD49d/CD29)

1995 • 128 citations

A structure prediction for the ligand‐binding region of the integrin β subunit: evidence for the presence of a von Willebrand factor A domain

1997 • 104 citations

Regulation of integrin function: evidence that bivalent-cation-induced conformational changes lead to the unmasking of ligand-binding sites within integrin α5β1

1998 • 99 citations

Structural and Functional Studies with Antibodies to the Integrin β2 Subunit

2000 • 96 citations

Molecular Basis of Ligand Recognition by Integrin α5β1

2000 • 95 citations

Getting integrins into shape: recent insights into how integrin activity is regulated by conformational changes

1996 • 94 citations

Integrin antagonists

1999 • 86 citations

Critical Residues for Ligand Binding in an I Domain-like Structure of the Integrin β1 Subunit

1996 • 85 citations

Molecular Basis of Ligand Recognition by Integrin α5β1

2000 • 71 citations

Fine mapping of inhibitory anti-α5 monoclonal antibody epitopes that differentially affect integrin–ligand binding

1999 • 53 citations

Generation of a Minimal α5β1 Integrin-Fc Fragment

2001 • 50 citations

Characterization of a gain of function mutation of integrin alpha IIb beta 3 (platelet glycoprotein IIb-IIIa).

1992 • 43 citations

DNA curvature controls termination of plus strand DNA synthesis at the centre of HIV-1 genome 1 1Edited by J. Karn

1997 • 40 citations

The GeneMine system for genome/proteome annotation and collaborative data mining

2001 • 39 citations

The Top of the Inserted-like Domain of the Integrin Lymphocyte Function-associated Antigen-1 β Subunit Contacts the α Subunit β-Propeller Domain near β-Sheet 3

2000 • 37 citations

Amino acid motifs required for isolated β cytoplasmic domains to regulate ‘in trans’ β1 integrin conformation and function in cell attachment

1999 • 36 citations

Structure-Function of the Putative I-domain within the Integrin β2 Subunit

2001 • 27 citations

Evidence That Ligand and Metal Ion Binding to Integrin α4β1 Are Regulated through a Coupled Equilibrium

2001 • 23 citations

Epitopes of adhesion-perturbing monoclonal antibodies map within a predicted α-helical domain of the integrin β1 subunit

1997 • 15 citations