Evidence That Ligand and Metal Ion Binding to Integrin α4β1 Are Regulated through a Coupled Equilibrium

Integrins: Versatility, modulation, and signaling in cell adhesion

1992 • 9,986 citations

Traffic signals for lymphocyte recirculation and leukocyte emigration: The multistep paradigm

1994 • 7,068 citations

Integrins and Signal Transduction Pathways: the Road Taken

1995 • 3,002 citations

VCAM-1 on activated endothelium interacts with the leukocyte integrin VLA-4 at a site distinct from the VLA-4/Fibronectin binding site

1990 • 1,836 citations

Direct expression cloning of vascular cell adhesion molecule 1, a cytokine-induced endothelial protein that binds to lymphocytes

1989 • 1,715 citations

Linked Functions and Reciprocal Effects in Hemoglobin: A Second Look

1964 • 1,613 citations

Integrins.

1991 • 1,369 citations

Ligand Binding to Integrins

2000 • 1,332 citations

Crystal structure of the A domain from the a subunit of integrin CR3 (CD11 b/CD18)

1995 • 893 citations

Identification and characterization of the T lymphocyte adhesion receptor for an alternative cell attachment domain (CS-1) in plasma fibronectin.

1989 • 807 citations

Regulated expression and binding of three VLA (β1) integrin receptors on T cells

1990 • 634 citations

Lymphoid cells recognize an alternatively spliced segment of fibronectin via the integrin receptor α4β1

1990 • 616 citations

Folding of the N-terminal, ligand-binding region of integrin α-subunits into a β-propeller domain

1997 • 414 citations

The pathophysiologic role of alpha 4 integrins in vivo.

1994 • 380 citations

Structure of the Integrin VLA‐4 and its Cell‐Cell and Cell‐Matrix Adhesion Functions

1990 • 345 citations

Characterization of the cell surface heterodimer VLA-4 and related peptides.

1987 • 340 citations

Regulation of Integrin α5β1-Fibronectin Interactions by Divalent Cations

1995 • 325 citations

cDNA cloning and complete primary structure of the alpha subunit of a leukocyte adhesion glycoprotein, p150,95.

1987 • 277 citations

Crystal Structure of the I Domain from Integrin α2β1

1997 • 275 citations

Multiple activation states of VLA-4. Mechanistic differences between adhesion to CS1/fibronectin and to vascular cell adhesion molecule-1.

1993 • 266 citations

Chemokine stromal cell-derived factor-1α modulates VLA-4 integrin-mediated multiple myeloma cell adhesion to CS-1/fibronectin and VCAM-1

2001 • 252 citations

Vascular cell adhesion molecule 1 induces T-cell antigen receptor-dependent activation of CD4+T lymphocytes.

1991 • 234 citations

Integrin activation: the link between ligand binding and signal transduction

1996 • 227 citations

Ligand and cation binding are dual functions of a discrete segment of the integrin β3 subunit: Cation displacement is involved in ligand binding

1994 • 220 citations

Osteopontin is a ligand for the α4β1 integrin

1998 • 214 citations

Selective, Tight-Binding Inhibitors of Integrin α4β1 That Inhibit Allergic Airway Responses

1999 • 207 citations

Identification and Characterization of the CXCR4 Chemokine Receptor in Human T Cell Lines: Ligand Binding, Biological Activity, and HIV-1 Infectivity

1998 • 167 citations

The regulation of integrin function by Ca2+

2000 • 155 citations

Activation-dependent recognition by hematopoietic cells of the LDV sequence in the V region of fibronectin.

1992 • 140 citations

A structural basis for integrin activation by the cytoplasmic tail of the α _IIb -subunit

2000 • 136 citations

The role of the divalent cation in the structure of the I domain from the CD11a/CD18 integrin

1996 • 134 citations

T cell receptor-dependent, antigen-specific stimulation of a murine T cell clone induces a transient, VLA protein-mediated binding to extracellular matrix.

1991 • 125 citations

Ca(2+)-binding properties of the platelet glycoprotein IIb ligand-interacting domain.

1992 • 121 citations

Synthetic fibronectin peptides suppress arthritis in rats by interrupting leukocyte adhesion and recruitment.

1994 • 116 citations

The crystal structure of an N-terminal two-domain fragment of vascular cell adhesion molecule 1 (VCAM-1): a cyclic peptide based on the domain 1 C-D loop can inhibit VCAM-1-alpha 4 integrin interaction.

1995 • 115 citations

Two integrin-binding peptides abrogate T cell-mediated immune responses in vivo.

1991 • 113 citations

A structure prediction for the ligand‐binding region of the integrin β subunit: evidence for the presence of a von Willebrand factor A domain

1997 • 104 citations

Blockade of very late antigen-4 integrin binding to fibronectin with connecting segment-1 peptide reduces accelerated coronary arteriopathy in rabbit cardiac allografts.

1995 • 101 citations

Vascular Cell Adhesion Molecule (VCAM)-Ig Fusion Protein Defines Distinct Affinity States of the Very Late Antigen-4 (VLA-4) Receptor

1995 • 98 citations

Divalent Cations and Ligands Induce Conformational Changes That Are Highly Divergent among β1 Integrins

1998 • 95 citations

An Allosteric Ca2+ Binding Site on the β3-Integrins That Regulates the Dissociation Rate for RGD Ligands

1996 • 87 citations

Correlation of CD2 binding and functional properties of multimeric and monomeric lymphocyte function-associated antigen 3.

1989 • 85 citations

Structure/function studies on vascular cell adhesion molecule-1.

1992 • 81 citations

Potent α4β1 Peptide Antagonists as Potential Anti-Inflammatory Agents

1997 • 80 citations

Integrin-dependent Leukocyte Adhesion Involves Geranylgeranylated Protein(s)

1999 • 79 citations

Adhesion to fibronectin primes eosinophils via alpha 4 beta 1 (VLA-4).

1994 • 79 citations

The Src Kinase p56 Up-regulates VLA-4 Integrin Affinity

2001 • 78 citations

Multiple Activation States of Integrin α4β1 Detected through Their Different Affinities for a Small Molecule Ligand

1999 • 71 citations

Alpha 4 beta 1 (CD49d/CD29) integrin costimulation of human T cells enhances transcription factor and cytokine induction in the absence of altered sensitivity to anti-CD3 stimulation.

1996 • 68 citations

Tissue Transglutaminase, Coagulation Factor XIII, and the Pro-polypeptide of von Willebrand Factor Are All Ligands for the Integrins α9β1 and α4β1

2000 • 68 citations

A New Model of Dual Interacting Ligand Binding Sites on Integrin αIIbβ3

1999 • 61 citations

Multiple loop structures critical for ligand binding of the integrin α4 subunit in the upper face of the β-propeller mode 1

1997 • 60 citations

Blockade of Late-phase Airway Responses and Airway Hyperresponsiveness in Allergic Sheep with a Small-molecule Peptide Inhibitor of VLA-4

1997 • 58 citations

A cyclic hexapeptide is a potent antagonist of alpha 4 integrins.

1997 • 51 citations

A Minimized Human Integrin α5β1 That Retains Ligand Recognition

2000 • 46 citations

A Direct Binding Assay for the Vascular Cell Adhesion Molecule-1 (VCAM1) Interaction with α4 Integrins

1995 • 39 citations

Analysis of ligand-induced and ligand-attenuated epitopes on the leukocyte integrin alpha4beta1: VCAM-1, mucosal addressin cell adhesion molecule-1, and fibronectin induce distinct conformational changes.

1998 • 37 citations

Analysis of Ligand-Induced and Ligand-Attenuated Epitopes on the Leukocyte Integrin α4β1: VCAM-1, Mucosal Addressin Cell Adhesion Molecule-1, and Fibronectin Induce Distinct Conformational Changes

1998 • 35 citations

Identification of Ligand Binding Sites on Integrin α4β1 through Chemical Cross-Linking

1998 • 29 citations

The increased potency of cross-linked lymphocyte function-associated antigen-3 (LFA-3) multimers is a direct consequence of changes in valency.

1991 • 23 citations

Potent cyclic peptide inhibitors of VLA-4 (?4?1 integrin)-mediated cell adhesion. Discovery of compounds like cyclo(MePhe-Leu-Asp-Val-d-Arg-d-Arg) (ZD7349) compatible with depot formulation

2000 • 20 citations

Costimulation of fibronectin receptor promotes Fc gamma R-mediated rescue of IL-3-dependent bone marrow-derived cells from apoptosis.

1996 • 15 citations