DNA curvature controls termination of plus strand DNA synthesis at the centre of HIV-1 genome 1 1Edited by J. Karn

Rapid and efficient site-specific mutagenesis without phenotypic selection.

1985 • 7,573 citations

[19] Rapid and efficient site-specific mutagenesis without phenotypic selection

1987 • 5,413 citations

Crystal structure of human immunodeficiency virus type 1 reverse transcriptase complexed with double-stranded DNA at 3.0 A resolution shows bent DNA.

1993 • 1,097 citations

The structure of an oligo(dA)·oligo(dT) tract and its biological implications

1987 • 975 citations

Sequence periodicities in chicken nucleosome core DNA

1986 • 930 citations

Empirical estimation of protein-induced DNA bending angles: applications to λ site-specific recombination complexes

1988 • 672 citations

A bifurcated hydrogen-bonded conformation in the d(A.T) base pairs of the DNA dodecamer d(CGCAAATTTGCG) and its complex with distamycin.

1987 • 671 citations

A detailed model of reverse transcription and tests of crucial aspects

1979 • 621 citations

SEQUENCE-DIRECTED CURVATURE OF DNA

1990 • 490 citations

Mechanism and fidelity of HIV reverse transcriptase.

1992 • 484 citations

Curved DNA without A-A: experimental estimation of all 16 DNA wedge angles.

1991 • 466 citations

Sequence-dependent DNA Structure

1993 • 445 citations

HIV-1 Reverse Transcription A Termination Step at the Center of the Genome

1994 • 381 citations

The structure of unliganded reverse transcriptase from the human immunodeficiency virus type 1.

1995 • 368 citations

Promoters responsive to DNA bending: a common theme in prokaryotic gene expression

1994 • 322 citations

A second origin of DNA plus-strand synthesis is required for optimal human immunodeficiency virus replication

1992 • 294 citations

Bending and curvature calculations in B-DNA

1994 • 281 citations

Intercalation, DNA Kinking, and the Control of Transcription

1996 • 279 citations

Human immunodeficiency virus 1 reverse transcriptase

1989 • 244 citations

Definitions and nomenclature of nucleic acid structure parameters

1989 • 241 citations

Crystal lattice packing is important in determining the bend of a DNA dodecamer containing an adenine tract.

1989 • 231 citations

Propeller-Twisting of Base-pairs and the Conformational Mobility of Dinucleotide Steps in DNA

1996 • 227 citations

Template-directed pausing of DNA synthesis by HIV-1 reverse transcriptase during polymerization of HIV-1 sequences in vitro

1993 • 205 citations

Primary structure of the silk fibroin light chain determined by cDNA sequencing and peptide analysis

1989 • 193 citations

The intrinsic curvature of DNA in solution

1988 • 189 citations

Pre-bending of a promoter sequence enhances affinity for the TATA-binding factor

1995 • 180 citations

Protein-induced bending and DNA cyclization.

1992 • 163 citations

Structural details of an adenine tract that does not cause DNA to bend

1988 • 159 citations

Dependence of DNA helix flexibility on base composition

1983 • 158 citations

A single-stranded gap in human immunodeficiency virus unintegrated linear DNA defined by a central copy of the polypurine tract

1991 • 148 citations

Crystal structure of CATGGCCATG and its implications for A-tract bending models.

1993 • 145 citations

Sequence Elements Responsible for DNA Curvature

1994 • 137 citations

Structural basis for DNA bending.

1989 • 136 citations

Validity of the nearest-neighbor approximation in the evaluation of the electrophoretic manifestations of DNA curvature

1990 • 128 citations

Physiological Concentration of Magnesium Ions Induces a Strong Macroscopic Curvature in GGGCCC-containing DNA

1994 • 127 citations

Reduced Frameshift Fidelity and Processivity of HIV-1 Reverse Transcriptase Mutants Containing Alanine Substitutions in Helix H of the Thumb Subdomain

1995 • 121 citations

Strand Transfer Mediated by Human Immunodeficiency Virus Reverse Transcriptase in Vitro Is Promoted by Pausing and Results in Misincorporation

1995 • 119 citations

(A-T)_ntracts embedded in random sequence DNA — formation of a structure which is chemically reactive and torsionally deformable

1986 • 113 citations

MPD and DNA Bending in Crystals and in Solution

1996 • 112 citations

Structure/function studies of human immunodeficiency virus type 1 reverse transcriptase. Alanine scanning mutagenesis of an alpha-helix in the thumb subdomain.

1994 • 106 citations

Mechanism of HIV-1 reverse transcriptase. Termination of processive synthesis on a natural DNA template is influenced by the sequence of the template-primer stem

1993 • 80 citations

A theoretical model of DNA curvature

1988 • 74 citations

An Expanded Model of Replicating Human Immunodeficiency Virus Reverse Transcriptase

1995 • 68 citations

Bending and Torsional Flexibility of G/C-rich Sequences as Determined by Cyclization Assays

1995 • 67 citations

New Concepts in Protein-DNA Recognition: Sequence-directed DNA Bending and Flexibility

1994 • 63 citations

Hydroxyl radical footprint analysis of human immunodeficiency virus reverse transcriptase-template.primer complexes.

1993 • 63 citations

Periodical polydeoxynucleotides and DNA curvature

1989 • 59 citations

One- and two-dimensional NMR studies on the conformation of DNA containing the oligo(dA)oligo(dT) tract

1988 • 59 citations

Molecular Modelling of (A4T4NN)n and (T4A4NN)n: Sequence Elements Responsible for Curvature

1996 • 56 citations

Parameters that influence processive synthesis and site-specific termination by human immunodeficiency virus reverse transcriptase on RNA and DNA templates

1992 • 54 citations

Variable center to center distance of nucleosomes in chromatin

1982 • 54 citations

Role of the "Helix Clamp" in HIV-1 Reverse Transcriptase Catalytic Cycling as Revealed by Alanine-scanning Mutagenesis

1996 • 50 citations

The ‘helix clamp’ in HIV-1 reverse transcrptase: a new nucleic acide binding motif common in nucleic acid polymerases

1994 • 44 citations

Synthesis of DNA by human immunodeficiency virus reverse transcriptase is preferentially blocked at template oligo(deoxyadenosine) tracts.

1990 • 41 citations

Expression, Purification, and Crystallization of the HIV-1 Reverse Transcriptase (RT)

1990 • 38 citations

The non-B-DNA structure of d(CA/TG)n differs from thatof Z-DNA.

1994 • 37 citations

Theoretical studies of DNA-RNA hybrid conformations

1994 • 20 citations

Human immunodeficiency virus type 1 reverse transcriptase tG:T mispair formation on RNA and DNA templates with mismatched primers: a kinetic and thermodynamic study.

1995 • 13 citations

Circular Structures in Retroviral and Cellular Genomes

1995 • 7 citations

Prevention Research and Vaccine Preparedness: Conference Summary

1995 • 2 citations