Separate Domains of the Ran GTPase Interact with Different Factors To Regulate Nuclear Protein Import and RNA Processing

The GTPase superfamily: conserved structure and molecular mechanism

1991 • 3,365 citations

Cdi1, a human G1 and S phase protein phosphatase that associates with Cdk2

1993 • 1,531 citations

ANIMAL CELL CYCLES AND THEIR CONTROL

1992 • 1,239 citations

The leucine-rich repeat: a versatile binding motif

1994 • 1,209 citations

The GTP-binding protein Ran/TC4 is required for protein import into the nucleus

1993 • 760 citations

Catalysis of guanine nucleotide exchange on Ran by the mitotic regulator RCC1

1991 • 703 citations

The two-hybrid system: an assay for protein-protein interactions

1994 • 649 citations

Inhibition of nuclear protein import by nonhydrolyzable analogues of GTP and identification of the small GTPase Ran/TC4 as an essential transport factor [published erratum appears in J Cell Biol 1994 Jan;124(1-2):217]

1993 • 544 citations

RanGAP1 induces GTPase activity of nuclear Ras-related Ran.

1994 • 526 citations

RECOMBINANT INBRED STRAINS: USE IN GENE MAPPING

1978 • 351 citations

Purification of a Ran-interacting protein that is required for protein import into the nucleus.

1994 • 318 citations

The signal recognition particle receptor mediates the GTP-dependent displacement of SRP from the signal sequence of the nascent polypeptide

1989 • 293 citations

Characterization of Four Novel ras-Like Genes Expressed in a Human Teratocarcinoma Cell Line

1990 • 285 citations

Mitotic regulator protein RCC1 is complexed with a nuclear ras-related polypeptide.

1991 • 281 citations

The two steps of nuclear import, targeting to the nuclear envelope and translocation through the nuclear pore, require different cytosolic factors

1992 • 278 citations

Characterization of proteins that interact with the cell-cycle regulatory protein Ran/TC4

1993 • 261 citations

Premature initiation of mitosis in yeast lacking RCC1 or an interacting GTPase

1991 • 231 citations

Confidence limits for estimates of gene linkage based on analysis of recombinant inbred strains

1985 • 230 citations

The yeast RNA1 gene product necessary for RNA processing is located in the cytosol and apparently excluded from the nucleus.

1990 • 228 citations

Isolation and characterization of the active cDNA of the human cell cycle gene (RCC1) involved in the regulation of onset of chromosome condensation.

1987 • 208 citations

Characterization of four novel ras-like genes expressed in a human teratocarcinoma cell line.

1990 • 202 citations

Ran/TC4: a small nuclear GTP-binding protein that regulates DNA synthesis.

1993 • 195 citations

Loss of RCC1, a nuclear DNA-binding protein, uncouples the completion of DNA replication from the activation of cdc2 protein kinase and mitosis.

1991 • 195 citations

RCC1 in the cell cycle: the regulator of chromosome condensation takes on new roles

1993 • 192 citations

Regulation of RNA processing and transport by a nuclear guanine nucleotide release protein and members of the Ras superfamily.

1993 • 183 citations

A G protein involved in nucleocytoplasmic transport: the role of Ran

1994 • 159 citations

A yeast mutant, PRP20, altered in mRNA metabolism and maintenance of the nuclear structure, is defective in a gene homologous to the human gene RCC1 which is involved in the control of chromosome condensation

1990 • 152 citations

Nuclear PRP20 protein is required for mRNA export.

1993 • 148 citations

GSP1 and GSP2, genetic suppressors of the prp20-1 mutant in Saccharomyces cerevisiae: GTP-binding proteins involved in the maintenance of nuclear organization.

1993 • 145 citations

Defects in mRNA 3'-end formation, transcription initiation, and mRNA transport associated with the yeast mutation prp20: possible coupling of mRNA processing and chromatin structure.

1992 • 142 citations

Evidence for a dual role for TC4 protein in regulating nuclear structure and cell cycle progression.

1994 • 139 citations

A mutant form of the Ran/TC4 protein disrupts nuclear function in Xenopus laevis egg extracts by inhibiting the RCC1 protein, a regulator of chromosome condensation.

1994 • 138 citations

A fission yeast RCC1-related protein is required for the mitosis to interphase transition.

1994 • 134 citations

A family of proteins that stabilize the Ran/TC4 GTPase in its GTP-bound conformation

1994 • 116 citations

Loss of RCC1 leads to suppression of nuclear protein import in living cells.

1994 • 109 citations

RCC1, a Regulator of Mitosis, Is Essential for DNA Replication

1992 • 106 citations

A murine homolog of the yeast RNA1 gene is required for postimplantation development.

1994 • 95 citations

A functional homologue of the RNA1 gene product in Schizosaccharomyces pombe: purification, biochemical characterization, and identification of a leucine-rich repeat motif.

1993 • 93 citations

A small nuclear GTP-binding protein from tomato suppresses a Schizosaccharomyces pombe cell-cycle mutant.

1994 • 84 citations

Effects of mutant Ran/TC4 proteins on cell cycle progression.

1994 • 77 citations

A linkage map of mouse chromosome 12: localization of Igh and effects of sex and interference on recombination.

1988 • 74 citations

Chromosome condensation caused by loss of RCC1 function requires the cdc25C protein that is located in the cytoplasm.

1992 • 71 citations

Small GTP-binding proteins of the ras family: a conserved functional mechanism?

1991 • 65 citations

Structural and functional analyses of Saccharomyces cerevisiae wild-type and mutant RNA1 genes.

1989 • 65 citations

Interaction of the pim1/spi1 mitotic checkpoint with a protein phosphatase.

1993 • 45 citations

mRNA nuclear export

1994 • 38 citations

Tissue-specific expression of Ran isoforms in the mouse

1994 • 38 citations

Checkpoint controls that couple mitosis to completion of DNA replication

1992 • 32 citations

Mouse chromosome 15

1997 • 23 citations

Counting cells with the new stereology

1992 • 20 citations

The nuclear GTPase cycle: promoting peripheralization?

1995 • 14 citations

Mouse chromosome 15

1993 • 5 citations

A GTPase Cycle Coupled to the Cell Cycle

1994 • 1 citations