The two steps of nuclear import, targeting to the nuclear envelope and translocation through the nuclear pore, require different cytosolic factors

A short amino acid sequence able to specify nuclear location

1984 • 2,529 citations

Two interdependent basic domains in nucleoplasmin nuclear targeting sequence: Identification of a class of bipartite nuclear targeting sequence

1991 • 1,501 citations

Nuclear protein import in permeabilized mammalian cells requires soluble cytoplasmic factors.

1990 • 909 citations

Nuclear envelope permeability

1975 • 808 citations

Identification and characterization of a nuclear pore complex protein

1986 • 610 citations

Nuclear protein localization

1991 • 570 citations

Construction and characterization of an SV40 mutant defective in nuclear transport of T antigen

1984 • 566 citations

A polypeptide domain that specifies migration of nucleoplasmin into the nucleus

1982 • 556 citations

How proteins enter the nucleus

1991 • 555 citations

Nuclear protein migration involves two steps: Rapid binding at the nuclear envelope followed by slower translocation through nuclear pores

1988 • 551 citations

Protein Import into the Cell Nucleus

1986 • 544 citations

Nuclear import can be separated into distinct steps in vitro: Nuclear pore binding and translocation

1988 • 535 citations

Monoclonal antibodies identify a group of nuclear pore complex glycoproteins.

1987 • 533 citations

Correlation between structure and mass distribution of the nuclear pore complex and of distinct pore complex components.

1990 • 510 citations

Inhibition of in vitro nuclear transport by a lectin that binds to nuclear pores.

1987 • 510 citations

Purification of a membrane-associated protein complex required for protein translocation across the endoplasmic reticulum.

1980 • 502 citations

Synthetic peptides as nuclear localization signals

1986 • 472 citations

Nuclear pore complex glycoproteins contain cytoplasmically disposed O-linked N-acetylglucosamine.

1987 • 428 citations

Induction of nuclear transport with a synthetic peptide homologous to the SV40 T antigen transport signal

1986 • 394 citations

Cytosolic proteins that specifically bind nuclear location signals are receptors for nuclear import

1991 • 391 citations

The rate of nuclear cytoplasmic protein transport is determined by the casein kinase II site flanking the nuclear localization sequence of the SV40 T-antigen.

1991 • 351 citations

Nuclear pore complex contains a family of glycoproteins that includes p62: glycosylation through a previously unidentified cellular pathway.

1987 • 330 citations

The trimethylguanosine cap structure of U1 snRNA is a component of a bipartite nuclear targeting signal

1990 • 309 citations

Nuclear segregation of U2 snRNA requires binding of specific snRNP proteins

1985 • 307 citations

Facilitated nuclear transport of histone H1 and other small nucleophilic proteins

1990 • 278 citations

The effects of variations in the number and sequence of targeting signals on nuclear uptake.

1988 • 273 citations

Reversible inhibition of protein import into the nucleus by wheat germ agglutinin injected into cultured cells

1987 • 233 citations

An Essential Signaling Role for the m ₃ G Cap in the Transport of U1 snRNP to the Nucleus

1990 • 228 citations

Identification of specific binding proteins for a nuclear location sequence

1989 • 219 citations

Mutations in the nuclear lamin proteins resulting in their aberrant assembly in the cytoplasm.

1988 • 217 citations

The effect of protein context on nuclear location signal function

1987 • 214 citations

p34cdc2-mediated phosphorylation at T124 inhibits nuclear import of SV-40 T antigen proteins.

1991 • 203 citations

Interactions and structure of the nuclear pore complex revealed by cryo-electron microscopy.

1989 • 193 citations

Nuclear transport kinetics depend on phosphorylation-site-containing sequences flanking the karyophilic signal of the Simian virus 40 T-antigen.

1989 • 175 citations

A nuclear localization signal binding protein in the nucleolus.

1990 • 160 citations

Nuclear transport of adenovirus DNA polymerase is facilitated by interaction with preterminal protein

1988 • 155 citations

Diversity in the signals required for nuclear accumulation of U snRNPs and variety in the pathways of nuclear transport.

1991 • 144 citations

An N-ethylmaleimide-sensitive cytosolic factor necessary for nuclear protein import: requirement in signal-mediated binding to the nuclear pore.

1990 • 128 citations

Immunological identification and localization of the predominant nuclear protein of the amphibian oocyte nucleus

1980 • 111 citations

Multiple pathways in nuclear transport: the import of U2 snRNP occurs by a novel kinetic pathway.

1991 • 105 citations

Identification of four nuclear transport signal-binding proteins that interact with diverse transport signals.

1989 • 101 citations

Yeast proteins that recognize nuclear localization sequences.

1989 • 99 citations

Microinjected U snRNAs are imported to oocyte nuclei via the nuclear pore complex by three distinguishable targeting pathways.

1992 • 93 citations

Identification of a human protein that interacts with nuclear localization signals.

1989 • 62 citations

Interaction of a nuclear location signal with isolated nuclear envelopes and identification of signal-binding proteins by photoaffinity labeling.

1989 • 44 citations