A mutant form of the Ran/TC4 protein disrupts nuclear function in Xenopus laevis egg extracts by inhibiting the RCC1 protein, a regulator of chromosome condensation.

Eukaryotic proteins expressed in Escherichia coli: An improved thrombin cleavage and purification procedure of fusion proteins with glutathione S-transferase

1991 • 1,779 citations

The GTP-binding protein Ran/TC4 is required for protein import into the nucleus

1993 • 760 citations

Inhibition of NIH 3T3 Cell Proliferation by a Mutant ras Protein with Preferential Affinity for GDP

1988 • 757 citations

Catalysis of guanine nucleotide exchange on Ran by the mitotic regulator RCC1

1991 • 703 citations

Initiation of DNA replication in nuclei and purified DNA by a cell-free extract of Xenopus eggs

1986 • 622 citations

Nuclear reconstitution in vitro: Stages of assembly around protein-free DNA

1987 • 550 citations

Inhibition of nuclear protein import by nonhydrolyzable analogues of GTP and identification of the small GTPase Ran/TC4 as an essential transport factor [published erratum appears in J Cell Biol 1994 Jan;124(1-2):217]

1993 • 544 citations

Nuclear import can be separated into distinct steps in vitro: Nuclear pore binding and translocation

1988 • 535 citations

Completion of DNA replication is monitored by a feedback system that controls the initiation of mitosis in vitro: Studies in Xenopus

1990 • 354 citations

Expression of p21 proteins in Escherichia coli and stereochemistry of the nucleotide-binding site.

1986 • 287 citations

Characterization of Four Novel ras-Like Genes Expressed in a Human Teratocarcinoma Cell Line

1990 • 285 citations

Premature chromosome condensation in a ts DNA-mutant of BHK cells

1978 • 260 citations

Roles of cytosol and cytoplasmic particles in nuclear envelope assembly and sperm pronuclear formation in cell-free preparations from amphibian eggs.

1984 • 254 citations

Steps in the assembly of replication-competent nuclei in a cell-free system from Xenopus eggs.

1988 • 236 citations

Premature initiation of mitosis in yeast lacking RCC1 or an interacting GTPase

1991 • 231 citations

Changes in the nuclear lamina composition during early development of Xenopus laevis

1985 • 214 citations

Ran/TC4: a small nuclear GTP-binding protein that regulates DNA synthesis.

1993 • 195 citations

Loss of RCC1, a nuclear DNA-binding protein, uncouples the completion of DNA replication from the activation of cdc2 protein kinase and mitosis.

1991 • 195 citations

RCC1 in the cell cycle: the regulator of chromosome condensation takes on new roles

1993 • 192 citations

Chromatin Transitions during Early Xenopus Embryogenesis: Changes in Histone H4 Acetylation and in Linker Histone Type

1993 • 186 citations

Regulation of RNA processing and transport by a nuclear guanine nucleotide release protein and members of the Ras superfamily.

1993 • 183 citations

Chapter 17 Systems for the Study of Nuclear Assembly, DNA Replication, and Nuclear Breakdown in Xenopus laevis Egg Extracts

1991 • 180 citations

A G protein involved in nucleocytoplasmic transport: the role of Ran

1994 • 159 citations

A yeast mutant, PRP20, altered in mRNA metabolism and maintenance of the nuclear structure, is defective in a gene homologous to the human gene RCC1 which is involved in the control of chromosome condensation

1990 • 152 citations

A trypsin-sensitive receptor on membrane vesicles is required for nuclear envelope formation in vitro.

1988 • 148 citations

GSP1 and GSP2, genetic suppressors of the prp20-1 mutant in Saccharomyces cerevisiae: GTP-binding proteins involved in the maintenance of nuclear organization.

1993 • 145 citations

Defects in mRNA 3'-end formation, transcription initiation, and mRNA transport associated with the yeast mutation prp20: possible coupling of mRNA processing and chromatin structure.

1992 • 142 citations

Evidence for a dual role for TC4 protein in regulating nuclear structure and cell cycle progression.

1994 • 139 citations

A fission yeast RCC1-related protein is required for the mitosis to interphase transition.

1994 • 134 citations

A family of proteins that stabilize the Ran/TC4 GTPase in its GTP-bound conformation

1994 • 116 citations

RCC1, a Regulator of Mitosis, Is Essential for DNA Replication

1992 • 106 citations

Assembly of spaced chromatin promoted by DNA synthesis in extracts from Xenopus eggs.

1988 • 106 citations

Yeast pheromone response pathway: characterization of a suppressor that restores mating to receptorless mutants.

1989 • 98 citations

Premature chromosome condensation is induced by a point mutation in the hamster RCC1 gene.

1990 • 91 citations

Amino acid residues in the Ras-like GTPase Rab3A that specify sensitivity to factors that regulate the GTP/GDP cycling of Rab3A

1992 • 82 citations

Effects of mutant Ran/TC4 proteins on cell cycle progression.

1994 • 77 citations

The synthesis of protein(S) for chromosome condensation may be regulated by a post‐transcriptional mechanism

1981 • 64 citations

Absence of Somatic Histone H1 in Oocytes and Preblastula Embryos of Xenopus laevis

1993 • 53 citations

The Saccharomyces cerevisiae SDC25 C-domain gene product overcomes the dominant inhibitory activity of Ha-Ras Asn-17.

1993 • 52 citations

Exposure to caffeine and suppression of DNA replication combine to stabilize the proteins and RNA required for premature mitotic events

1987 • 40 citations

Yeast Pheromone Response Pathway: Characterization of a Suppressor That Restores Mating to Receptorless Mutants

1989 • 38 citations

Premature Chromosome Condensation Is Induced by a Point Mutation in the Hamster RCC1 Gene

1990 • 35 citations

Cloning of Xenopus RCC1 cDNA, a Homolog of the Human RCC1 Gene: Complementation of tsBN2 Mutation and Identification of the Product1

1990 • 34 citations

GSP1 and GSP2, Genetic Suppressors of the prp20-1 Mutant in Saccharomyces cerevisiae: GTP-Binding Proteins Involved in the Maintenance of Nuclear Organization

1993 • 33 citations

Prp2o, the Saccharomyces cerevisiae homolog of the regulator of chromosome condensation, rcc1, interacts with double-stranded dna through a multi-component complex containing gtp-binding proteins

1993 • 30 citations

Effects of Mutant Ran/TC4 Proteins on Cell Cycle Progression

1994 • 20 citations

The Saccharomyces cerevisiae SDC25 C-Domain Gene Product Overcomes the Dominant Inhibitory Activity of Ha-Ras Asn-17

1993 • 17 citations

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