Insights Into the Molecular Mechanism of Chronic Fibrosis: The Role of Connective Tissue Growth Factor in Scleroderma

Transforming growth factor-beta stimulates the expression of fibronectin and collagen and their incorporation into the extracellular matrix.

1986 • 2,499 citations

REGULATION OF IMMUNE RESPONSES BY TGF-β

1998 • 1,908 citations

Identification of Smad7, a TGFβ-inducible antagonist of TGF-β signalling

1997 • 1,774 citations

Signal Transduction by the TGF-β Superfamily

2002 • 1,255 citations

Human Smad3 and Smad4 Are Sequence-Specific Transcription Activators

1998 • 916 citations

Mice lacking Smad3 show accelerated wound healing and an impaired local inflammatory response

1999 • 912 citations

Connective tissue growth factor: a cysteine-rich mitogen secreted by human vascular endothelial cells is related to the SRC-induced immediate early gene product CEF-10.

1991 • 878 citations

Connective-tissue growth factor (CTGF) modulates cell signalling by BMP and TGF-β

2002 • 866 citations

Stimulation of Fibroblast Cell Growth, Matrix Production, and Granulation Tissue Formation by Connective Tissue Growth Factor

1996 • 754 citations

Connective tissue growth factor: a mediator of TGF-β action on fibroblasts

1997 • 743 citations

Regulation of connective tissue growth factor gene expression in human skin fibroblasts and during wound repair.

1993 • 706 citations

Connective tissue growth factor coordinates chondrogenesis and angiogenesis during skeletal development

2003 • 702 citations

The CCN Family of Angiogenic Regulators: The Integrin Connection

1999 • 656 citations

Independent Regulation of Collagenase, 72-kDa Progelatinase, and Metalloendoproteinase Inhibitor Expression in Human Fibroblasts by Transforming Growth Factor-β

1989 • 649 citations

The modular architecture of a new family of growth regulators related to connective tissue growth factor

1993 • 634 citations

Connective tissue growth factor mediates transforming growth factor β‐induced collagen synthesis: down‐regulation by cAMP

1999 • 623 citations

Transforming Growth Factor-β Signaling Through the Smad Pathway: Role in Extracellular Matrix Gene Expression and Regulation

2002 • 622 citations

High glucose and hyperinsulinemia stimulate connective tissue growth factor expression: A potential mechanism involved in progression to fibrosis in nonalcoholic steatohepatitis

2001 • 537 citations

A novel transforming growth factor beta response element controls the expression of the connective tissue growth factor gene.

1996 • 526 citations

Connective Tissue Growth Factor: What's in a Name?

2000 • 483 citations

Transcriptional and post-transcriptional regulation of 72-kDa gelatinase/type IV collagenase by transforming growth factor-beta 1 in human fibroblasts. Comparisons with collagenase and tissue inhibitor of matrix metalloproteinase gene expression

1991 • 461 citations

Role and interaction of connective tissue growth factor with transforming growth factor-? in persistent fibrosis: A mouse fibrosis model

1999 • 461 citations

Fisp12/Mouse Connective Tissue Growth Factor Mediates Endothelial Cell Adhesion and Migration through Integrin α_vβ₃, Promotes Endothelial Cell Survival, and Induces Angiogenesis In Vivo

1999 • 447 citations

Connective Tissue Growth Factor Gene Expression in Tissue Sections From Localized Scleroderma, Keloid, and Other Fibrotic Skin Disorders

1996 • 438 citations

CTGF and SMADs, Maintenance of Scleroderma Phenotype Is Independent of SMAD Signaling

2001 • 419 citations

Transient gene transfer and expression of Smad7 prevents bleomycin-induced lung fibrosis in mice

1999 • 400 citations

Connective Tissue Growth Factor Induces the Proliferation, Migration, and Tube Formation of Vascular Endothelial Cells In Vitro, and Angiogenesis In Vivo

1999 • 399 citations

Stimulation of Type I Collagen Transcription in Human Skin Fibroblasts by TGF-β: Involvement of Smad 3

1999 • 388 citations

NOV (nephroblastoma overexpressed) and the CCN family of genes: structural and functional issues

2001 • 347 citations

Inhibition of Renal Fibrosis by Gene Transfer of Inducible Smad7 Using Ultrasound-Microbubble System in Rat UUO Model

2003 • 339 citations

The Angiogenic Factors Cyr61 and Connective Tissue Growth Factor Induce Adhesive Signaling in Primary Human Skin Fibroblasts

2001 • 304 citations

Connective Tissue Growth Factor Gene Regulation

2003 • 301 citations

Anti-TGF-beta treatment prevents skin and lung fibrosis in murine sclerodermatous graft-versus-host disease: a model for human scleroderma.

1999 • 297 citations

Mice Lacking Smad3 Are Protected Against Cutaneous Injury Induced by Ionizing Radiation

2002 • 281 citations

Tumor Necrosis Factor α Suppresses the Induction of Connective Tissue Growth Factor by Transforming Growth Factor-β in Normal and Scleroderma Fibroblasts

2000 • 252 citations

Effects of CTGF/Hcs24, a Product of a Hypertrophic Chondrocyte-Specific Gene, on the Proliferation and Differentiation of Chondrocytes in Culture1

2000 • 250 citations

Anti-TGF-β Treatment Prevents Skin and Lung Fibrosis in Murine Sclerodermatous Graft-Versus-Host Disease: A Model for Human Scleroderma

1999 • 248 citations

Transforming Growth Factor-β Repression of Matrix Metalloproteinase-1 in Dermal Fibroblasts Involves Smad3

2001 • 247 citations

Connective tissue growth factor (CTGF/CCN2) in hepatic fibrosis

2003 • 244 citations

Cyr61 and Fisp12 Are Both ECM-Associated Signaling Molecules: Activities, Metabolism, and Localization during Development

1997 • 240 citations

Identification of integrin αMβ2 as an adhesion receptor on peripheral blood monocytes for Cyr61 (CCN1) and connective tissue growth factor (CCN2): immediate-early gene products expressed in atherosclerotic lesions

2002 • 232 citations

Serum levels of connective tissue growth factor are elevated in patients with systemic sclerosis: association with extent of skin sclerosis and severity of pulmonary fibrosis.

2000 • 227 citations

Connective tissue growth factor: A new and important player in the pathogenesis of fibrosis

2002 • 212 citations

Activation-dependent Adhesion of Human Platelets to Cyr61 and Fisp12/Mouse Connective Tissue Growth Factor Is Mediated through Integrin αIIbβ3

1999 • 203 citations

Purification and Characterization of Novel Heparin-binding Growth Factors in Uterine Secretory Fluids

1997 • 202 citations

The Low Density Lipoprotein Receptor-related Protein/α2-Macroglobulin Receptor Is a Receptor for Connective Tissue Growth Factor

2001 • 200 citations

Delayed Wound Healing in Immunodeficient TGF-β1 Knockout Mice

2000 • 193 citations

Expression and regulation of intracellular SMAD signaling in scleroderma skin fibroblasts

2003 • 187 citations

Smad3/AP-1 interactions control transcriptional responses to TGF-β in a promoter-specific manner

2001 • 180 citations

Autocrine Overexpression of CTGF Maintains Fibrosis: RDA Analysis of Fibrosis Genes in Systemic Sclerosis

2000 • 178 citations

Tumor Necrosis Factor-α Inhibits Transforming Growth Factor-β /Smad Signaling in Human Dermal Fibroblasts via AP-1 Activation

2000 • 172 citations

Persistent Down-Regulation of Fli1, a Suppressor of Collagen Transcription, in Fibrotic Scleroderma Skin

2003 • 165 citations

Fli-1 Inhibits Collagen Type I Production in Dermal Fibroblasts via an Sp1-dependent Pathway

2001 • 163 citations

Transforming growth factor-beta stimulates wound healing and modulates extracellular matrix gene expression in pig skin: incisional wound model.

1991 • 159 citations

CTGF/Hcs24 induces chondrocyte differentiation through a p38 mitogen‐activated protein kinase (p38MAPK), and proliferation through a p44/42 MAPK/extracellular‐signal regulated kinase (ERK)

2001 • 157 citations

The Role of p42/44 MAPK and Protein Kinase B in Connective Tissue Growth Factor Induced Extracellular Matrix Protein Production, Cell Migration, and Actin Cytoskeletal Rearrangement in Human Mesangial Cells

2002 • 148 citations

TGF-β signaling from receptors to the nucleus

1999 • 141 citations

Adenoviral Gene Transfer of Connective Tissue Growth Factor in the Lung Induces Transient Fibrosis

2003 • 131 citations

Identification of a Novel Integrin α6β1 Binding Site in the Angiogenic Inducer CCN1 (CYR61)

2003 • 130 citations

Anti-sclerotic Effect of Transforming Growth Factor-β Antibody in a Mouse Model of Bleomycin-Induced Scleroderma

1999 • 121 citations

Sustained Activation of Fibroblast Transforming Growth Factor-β/Smad Signaling in a Murine Model of Scleroderma

2003 • 121 citations

TGF-β: A Balancing Act

1998 • 116 citations

Blocking Sp1 Transcription Factor Broadly Inhibits Extracellular Matrix Gene Expression In Vitro and In Vivo: Implications for the Treatment of Tissue Fibrosis

2001 • 115 citations

Constitutive Connective Tissue Growth Factor Expression in Scleroderma Fibroblasts Is Dependent on Sp1

2003 • 114 citations

Gene transfer of Smad7 using electroporation of adenovirus prevents renal fibrosis in post-obstructed kidney

2002 • 105 citations

CTGF/Hcs24, hypertrophic chondrocyte‐specific gene product, interacts with perlecan in regulating the proliferation and differentiation of chondrocytes

2003 • 103 citations

Expression of TGF-β1, -β2 and -β3 in localized and systemic scleroderma

1999 • 102 citations

The heparin-binding 10 kDa fragment of connective tissue growth factor (CTGF) containing module 4 alone stimulates cell adhesion

2003 • 96 citations

Induction of the AP-1 members c-Jun and JunB by TGF-β/Smad suppresses early Smad-driven gene activation

2001 • 95 citations

Involvement of CTGF, a Hypertrophic Chondrocyte-Specific Gene Product, in Tumor Angiogenesis

2001 • 92 citations

FAST-2 Is a Mammalian Winged-Helix Protein Which Mediates Transforming Growth Factor β Signals

1999 • 88 citations

Microfibrillar elements of the dermal matrix

1997 • 82 citations

Connective Tissue Growth Factor Is Secreted through the Golgi and Is Degraded in the Endosome

2001 • 81 citations

Cartilage Wound Healing: An Overview

1995 • 80 citations

CTGF expression during mouse embryonic development

2003 • 80 citations

Differentiation-Dependent Expression of Connective Tissue Growth Factor and Lysyl Oxidase Messenger Ribonucleic Acids in Rat Granulosa Cells*

2001 • 77 citations

Localization of Connective Tissue Growth Factor during the Period of Embryo Implantation in the Mouse1

1998 • 72 citations

Collagen: Its structure and function in normal and pathological connective tissues

1974 • 62 citations

Possible Roles of CTGF/Hcs24 in the Initiation and Development of Ossification of the Posterior Longitudinal Ligament

2002 • 53 citations

Establishment of a recombinant expression system for connective tissue growth factor (CTGF) that models CTGF processing in utero

2003 • 49 citations

Cytokine directed therapy in scleroderma: rationale, current status, and the future

2002 • 48 citations

Systemic sclerosis

2002 • 37 citations